ライフサイエンスコーパス: TRPV1 channel

1 6-ARD than in the paralogous thermosensitive TRPV1 channel.

2 rough the pore of the noxious-heat-sensitive TRPV1 channel.

3 nfluences the permeability properties of the TRPV1 channel.

4 ent outward rectification, a property of the TRPV1 channel.

5 le, robust and temporally precise control of TRPV1 channels.

6 hilic compounds act specifically on TRPA1 or TRPV1 channels.

7 s Ca(2+) influx mediated by fly TRPA and rat TRPV1 channels.

8 g was shaped by the distribution of ASIC and TRPV1 channels.

9 s the endogenous phosphoinositide regulating TRPV1 channels.

10 ansient receptor potential vanilloid type-1 (TRPV1) channel.

11 ve transient receptor potential vanilloid 1 (TRPV1) channel.

12 on transient receptor potential vanilloid 1 (TRPV1) channels.

13 ient receptor potential vanilloid subtype 1 (TRPV1) channels.

14 ng transient receptor potential vanilloid-1 (TRPV1) channels.

15 quires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alp

16 ay, using cells expressing recombinant human TRPV1 channels, 4 antagonized capsaicin-induced Ca(2+) i

17 he transient receptor potential vanilloid 1 (TRPV1) channel, a key target of inflammatory mediators s

18 e long-acting antagonists of mouse and human TRPV1 channels, abolishing activity for >1 h after remov

19 in-independent endocytic route, triggered by TRPV1 channel activation and Ca(2+) influx through the r

20 However, whether 12(S)-HpETE underlies TRPV1 channel activation during I/R is unknown.

21 Here we report that TRPV1 channel activation is necessary and sufficient to

22 were depressed by either capsaicin, a potent TRPV1 channel activator, or the endogenously released ei

23 However, their effects on TRPV1 channel activity have not been conclusively determ

24 ress whether noradrenaline can down-regulate TRPV1 channel activity in nociceptors and reduce their s

25 of transient receptor potential vanilloid 1 (TRPV1) channel activity.

26 Other derivatives also inhibited the TRPV1 channel, albeit with low potency, affording a stru

27 lycerol could also induce heat activation of TRPV1 channels, although with a small-conductance state.

28 creened a venom library for activity against TRPV1 channels and found robust inhibitory activity in v

29 esults reveal a previously unknown action of TRPV1 channels and indicate that the postsynaptic genera

30 TM5-TM6 linker forms the outer vestibule of TRPV1 channels and that AG489 is a pore blocker.

31 into ligand binding and allosteric gating of TRPV1 channels and the relevance of accurate polymodal r

32 r channels, transient receptor potential V1 (TRPV1) channels and acid-sensing ion channels (ASICs) is

33 ion channels (M-type K(+), L-type Ca(2+), or TRPV1 channels) and G protein-coupled receptors coupled

34 volves PKCepsilon signaling to sensitize the TRPV1 channel, and contributes to acute thermal hyperalg

35 the activation and deactivation kinetics of TRPV1 channels, and from the measurements we determined

36 arinic acetylcholine receptor and vanilloid (TRPV1) channels, and the GPIIb integrin.

37 he transient receptor potential vanilloid 1 (TRPV1) channel, another element of the endocannabinoid s

38 3D-QSAR models for human TRPV1 channel antagonists were developed based on compar

39 Transient receptor potential vanilloid 1 (TRPV1) channel antagonists may have clinical utility for

40 ceptors), but the extent to which functional TRPV1 channels are expressed in the CNS is debated.

41 TRPV1 channels are gated by a variety of thermal, chemic

42 While TRPV1 channels are not considered to be mechanically gat

43 TRPV1 channels are polymodal in their function and exhib

44 transcription, and, therefore, modulators of TRPV1 channels are potentially useful in the treatment o

45 Functional TRPV1 channels are present in the human airway epitheliu

46 C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but

47 Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous s

48 ient receptor potential vanilloid subtype 1 (TRPV1) channels are essential nociceptive integrators in

49 igned to understand the gating mechanisms of TRPV1 channels based on comparisons between the agonist

50 Inhibition of TRPV1 channels by AG489 is strongly voltage-dependent, w

51 C, consistent with inhibition of presynaptic TRPV1 channels by alpha2 adrenergic receptors.

52 prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8

53 We suggest that modulation of TRPV1 channels by dopamine in nociceptive neurons may re

54 We suggest that modulation of TRPV1 channels by noradrenaline in nociceptive neurons i

55 ed transient receptor potential vanilloid 1 (TRPV1) channels by phosphoinositides is controversial.

56 m of compartment-specific regulation whereby TRPV1 channels can modify synaptic function in the brain

57 5 mum phosphatidylinositol 4,5-bisphosphate, TRPV1 channels demonstrated rapid activation at 33-39 de

58 channels, TRPV4 channels, and AchR channels, TRPV1 channels diffused laterally in the plasma membrane

59 e report the 3D structure of full-length rat TRPV1 channel expressed in the yeast Saccharomyces cerev

60 Here, we show that lidocaine inhibits TRPV1 channels expressed in Xenopus laevis oocytes, wher

61 ore, 4ONE (100 microm) was shown to activate TRPV1 channel-expressing HEK cells.

62 1)KO animals with no apparent differences in TRPV1 channel expression.

63 with neuropathic pain, is an agonist of the TRPV1 channel found in primary afferent nociceptors and

64 amine toxins, AG489 and AG505, which inhibit TRPV1 channels from the extracellular side of the membra

65 in the murine colon, and associated loss of TRPV1 channel function.

66 domain, which cause an opening of the lower TRPV1 channel gate.

67 e external pore in the allosteric control of TRPV1 channel gating and provide essential constraints f

68 As a sensor for noxious stimuli, TRPV1 channel has been described as a key contributor to

69 Mice lacking the TRPV1 channel have altered micturition thresholds sugges

70 on of TRPA1 intrinsic characteristics by the TRPV1 channel have not been examined.

71 functional and structural data suggest that TRPV1 channels have two gates within their permeation pa

72 show that external sodium ions stabilize the TRPV1 channel in a closed state, such that removing the

73 activity at the CB(1) receptor maintains the TRPV1 channel in a sensitized state responsive to noxiou

74 The role of the TRPV1 channel in the development of hyperalgesia is esta

75 flash photorelease of vanilloid can activate TRPV1 channels in <4 ms at 22 degrees C.

76 urther, after PKC stimulation, OEA activated TRPV1 channels in cell-free patches suggesting a direct

77 drenaline strongly inhibited the activity of TRPV1 channels in dorsal root ganglia neurons.

78 nce regarding ligand-dependent activation of TRPV1 channels in light of structural data recently obta

79 We suggest that modulation of presynaptic TRPV1 channels in nociceptive neurons by descending nora

80 hether dopamine can modulate the activity of TRPV1 channels in nociceptive neurons, the effects of do

81 TRPV1 channels in sensory neurons are integrators of pai

82 We conclude that tonic activation of TRPV1 channels in the abdominal viscera by yet unidentif

83 ght activated TRPA1 and, to a lesser extent, TRPV1 channels in the absence of additional photosensiti

84 To address the possible role of TRPV1 channels in the regulation of synaptic transmissio

85 lds for chemical or thermal stimuli, whereas TRPV1 channels in which this region is replaced with a l

86 he transient receptor potential vanilloid 1 (TRPV1) channel in peripheral sensory neurons, thus lower

87 Accordingly, genetic disruption of TRPV1 channels increases islet size whereas CB1R knockou

88 sine residue, Y200, followed by insertion of TRPV1 channels into the surface membrane, explains most

89 The TRPV1 channel is a detector of noxious stimuli, includin

90 The TRPV1 channel is a sensitive detector of pain-producing

91 nergy transfer interaction between TRPA1 and TRPV1 channels is as effective as for TRPV1 or TRPA1 hom

92 The best known agonist of TRPV1 channels is capsaicin, the pungent component of "h

93 he transient receptor potential vanilloid 1 (TRPV1) channel is abundantly expressed in peripheral sen

94 he transient receptor potential vanilloid 1 (TRPV1) channel is an essential component of the cellular

95 he transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat

96 However, the TRPV1 channel itself is not required for the asthmatic-l

97 a TRPV1 antagonist (AMG0347) confirmed that TRPV1 channels located outside the brain tonically inhib

98 Although TRPA1 and TRPV1 channels may be involved in the scratching respons

99 tered micturition thresholds suggesting that TRPV1 channels may play a role in the detection of bladd

100 lease, suggesting that calcium entry through TRPV1 channels may trigger glutamate release independent

101 ptor Potential Vanilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sen

102 nnel blocker QX-314 into these axons via the TRPV1 channel pore.

103 The opening of single TRPV1 channels produced sparklets, representing localize

104 our results provide the first evidence that TRPV1 channels regulate cortical excitability to paired-

105 at transient receptor potential vanilloid 1 (TRPV1) channels regulate glutamate release at central an

106 We demonstrate that the recombinant purified TRPV1 channel retains its structural and functional inte

107 scanning of the C terminus of a cysteineless TRPV1 channel revealed a critical region within which an

108 box linker of TRPM8 channel with the cognate TRPV1 channel sequences produced functional chimeric cha

109 Hypertonic stress-elicited TRPV1 channel stimulation mediates increases in a proinf

110 vation of OVLT neurons critically depends on TRPV1 channels, studies in TRPV1(-/-) mice suggest that

111 and interactions of known activators of the TRPV1 channel such as capsaicin, in a structural model o

112 TRPV1 channels support the detection of noxious and noci

113 A reduces the excitability of the ubiquitous TRPV1 channel, thereby lowering impulse activity in the

114 found effect on the contribution of ASIC and TRPV1 channels, therefore, altering the neuronal excitab

115 kinase C (PKC) in the immediate proximity of TRPV1 channels to enhance phosphorylation efficiency.

116 ic transient receptor potential vanilloid 1 (TRPV1) channels to trigger a form of LTD resulting from

117 , a region thought to form the outer pore of TRPV1 channels, to identify pore mutations that alter to

118 Unlike the related TRPV1 channel, TRPV2 does not appear to bind either calm

119 The inhibitory effect of noradrenaline on TRPV1 channels was dependent on calcium influx and linke

120 g capsaicin-sensitive and insensitive rabbit TRPV1 channels, we show that antagonists require the sam

121 channels expressed in HEK-293 cells, but not TRPV1 channels, were activated by bath-applied CO(2).

122 he transient receptor potential vanilloid 1 (TRPV1) channel, which contributes to pressure sensing an

123 kinase C (PKC), OEA alone directly activated TRPV1 channel with an EC50 of approximately 2 microm at

124 further, and the toxin was found to inhibit TRPV1 channels with a K(i) of 0.3 microM at -40 mV.

125 localized intra-abdominal desensitization of TRPV1 channels with intraperitoneal resiniferatoxin bloc

126 TRPV1 channels with mutations at position 547 were expre

127 te a new form of afferent signaling in which TRPV1 channels within central terminals of peripheral af