1                                              TSH beta promoter activity in thyrotropes is conferred b

2 imulating hormone alpha-subunit [TSH alpha], TSH beta, and hypothalamic thyrotropin-releasing hormone

3 thyroid-stimulating hormone (TSH) levels and TSH-beta subunit gene expression.

4 ds can suppress serum TSH levels in vivo and TSH-beta promoter activity in vitro.

5                        Cross-sectionally, AT TSH-beta (TSHB) mRNA was evaluated in 4 independent coho

6 ine residue (C105V) in the thyrotropin-beta (TSH-beta) subunit gene was found in two related families

7            While Pit-1 appears necessary for TSH beta promoter activity in thyrotropes, this transcri

8 ne (T3)-suppressible serum TSH and pituitary TSH-beta mRNA.

9 it (alpha-GSU) and thyrotropin beta subunit (TSH-beta) genes is stimulated by thyrotropin-releasing h

10 ing of the tissue-specific expression of the TSH beta gene.

11 nvestigate tissue-specific expression of the TSH beta promoter.

12 n is able to independently interact with the TSH beta promoter, but neither alone can maintain promot

13 a disulfide bond between C19 and C105 in the TSH-beta subunit is predicted to form the "buckle" of a

14 ed synergistically in TRH stimulation of the TSH-beta promoter, and amino acids 1-450 of CBP were suf

15                 This natural mutation of the TSH-beta subunit confirms the importance of the seat bel

16  regulated promoters in the H-P-T axis (TRH, TSH-beta, and TSH-alpha).