ライフサイエンスコーパス: TSP

1 TSP-1 binds to matrix components, proteases, cytokines,

2 TSP-1 blockade also prevents the PH in a second model, c

3 TSP-1 converts latent transforming growth factor-beta1 (

4 TSP-1 deficiency resulted in significantly reduced TGF-b

5 TSP-1 disruption abrogated age-associated capillary rare

6 TSP-1 disruption did not affect inflammatory gene expres

7 TSP-1 disruption did not significantly affect weight gai

8 TSP-1 expression was induced in endothelial cells (ECs)

9 TSP-1 functioned in a positive feedback loop to stabiliz

10 TSP-1 induced in ECs by reactive oxygen species (ROS) mo

11 TSP-1 plays no direct role in the regulation of its own

12 TSP-1 tethering of ERK in the cytoplasm promoted a level

13 TSP-1 upregulation in the diabetic heart prevents chambe

14 TSP-2 gene and protein expression were significantly up-

15 TSP-2 knockdown induced anti-inflammatory M2 macrophage

16 TSP-4-knockout (Thbs4(-/-)) and wild-type (WT) mice were

17 TSPs are also critically important in the development an

18 TSPs mediate a range of processes at the surface of the

19 + transients, synaptogenic thrombospondin 1 (TSP-1) release, and synapse formation.

20 Basal muscle expression of thrombospondin 1 (TSP-1) was approximately 900% greater in 14d- and 28d-tr

21 (VEGF), but high levels of thrombospondin 1 (TSP-1), predicted liver dysfunction after resection.

22 he anti-angiogenic protein thrombospondin-1 (TSP-1 PM).

23 d the CD47-binding partner thrombospondin-1 (TSP-1) and that treatment of aged erythrocytes with a TS

24 Thrombospondin-1 (TSP-1) inhibits growth factor signaling at the receptor

25 Thrombospondin-1 (TSP-1) is a glycoprotein considered as a key actor withi

26 Thrombospondin-1 (TSP-1) is a large extracellular matrix protein secreted

27 Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted in

28 Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose

29 how TGF-beta activation by thrombospondin-1 (TSP-1) is both required and sufficient for the developme

30 Thrombospondin-1 (TSP-1) is one of the anti-angiogenic factors whose synth

31 creasing evidence suggests thrombospondin-1 (TSP-1), a potent proatherogenic matricellular protein, a

32 ors, including endostatin, thrombospondin-1 (TSP-1), and pigment epithelium-derived factor (PEDF), as

33 f a synaptogenic molecule, thrombospondin-1 (TSP-1), apart from supporting neuronal integrity.

34 The matricellular protein, thrombospondin-1 (TSP-1), is prominently expressed during tissue repair.

35 the angiogenesis inhibitor thrombospondin-1 (TSP-1).

36 ed pinpoint this factor as thrombospondin-1 (TSP-1).

37 ein contains an N-terminal thrombospondin-1 (TSP-N) domain, five cysteine-rich domains, and six EGF-l

38 retinal space mediated by thrombospsondin-1 (TSP-1) activation of CD47.

39 anti-angiogenic peptides (thrombospondin-1, TSP-1; and endostatin) as well as pro-angiogenic factors

40 f intraluminal delivery of thrombospondin-2 (TSP-2) small interfering RNA (siRNA).

41 late (TSP)), P=0.014; high dose (247 mg/m(3) TSP), P=0.02) and significant tumor metastasis to variou

42 Thrombospondin-4 (TSP-4) expression increases dramatically in hypertrophic

43 in endothelial cells (EC) thrombospondin-4 (TSP-4), a secreted extracellular matrix (ECM) protein, i

44 surface-exposed EC2 domain from Sm-TSP-2, a TSP from Schistosoma mansoni and one of the better prosp

45 We generated a TSP-1-deficient mouse model of a partial hepatectomy (PH

46 Eighty healthy humans were tested with a TSP protocol and underwent structural and resting-state

47 d that treatment of aged erythrocytes with a TSP-1-derived peptide enabled their phagocytosis by huma

48 s of hUTC-conditioned media was spared after TSP knockdown, indicating that hUTCs secrete additional

49 We examined thrombospondin-1 (THBS1, alias TSP-1) expression in human synovial tissue (ST) during t

50 a demonstrate that NOL7 significantly alters TSP-1 expression and may be a master regulator that coor

51 a demonstrate that NOL7 significantly alters TSP-1 expression and may be a master regulator that coor

52 odies confirmed localization of Ov-TSP-2 and TSP-3 to the adult fluke tegument.

53 Ov-TSP-2 and TSP-3 were detected in whole worm extracts and excretory

54 PM2.5 and TSP atmospheric SigmaOPE concentrations varied over an o

55 For PbA in PM2.5 and TSP, slopes were generally positive but not significant.

56 Stroke increases CD36 and TSP-1/2 mRNA levels in the ipsilateral hemisphere at acu

57 TSP-2 gene expression (3.1-fold) at 24 h and TSP-2 protein expression, cell proliferation, and collag

58 We identified pretransplant weight loss and TSP as strong independent predictors of relapse and deat

59 Using Thbs4(-/-) mice and TSP-4 shRNA, we found that TSP-4 mediated pro-angiogenic

60 The T3R and TSP-C domains as well as wild-type Thbs4 and the calcium

61 protein, Nell2, which lacks only the T3R and TSP-C domains, did not cause these effects.

62 cytes, as were the type III repeat (T3R) and TSP-C domains, while the LamG domain localized to the Go

63 r to control levels, but both basal VEGF and TSP-1 were elevated (P < 0.05).

64 Upregulation of pro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribut

65 We proposed two frameworks, by averaging TSP scores or by combining P-values from individual stud

66 l basis for the physical interaction between TSP-1 and BMP-4.

67 r therapy, a reciprocal relationship between TSP-1 and NR4A2 expression levels was measured in patien

68 ide a general model for interactions between TSPs, membranes, and other proteins.

69 to undergo a conformational change and bind TSP-1.

70 poptosis in the myocardium was unaffected by TSP-4 deficiency, suggesting that increased reactive fib

71 identified three potential biomarkers CD163, TSP-1 and IL-1RII whose response to steroids was signifi

72 iated antiangiogenic pathway induced by CD36-TSP-1 interaction that inhibits VEGFR2 signaling and the

73 We hypothesized that CD36-TSP-1 interaction recruits Src homology 2 domain-contain

74 In the developing CNS, TSP-1 is involved in neuronal migration and adhesion, ne

75 the total suspended particle concentration (TSP) in the sampling area.

76 In contrast, TSP was negatively correlated with FC between individual

77 At D14 and D28, TSP-1 protein was not different compared to baseline lev

78 heart, we generated and characterized db/db TSP-1(-/-) (dbTSP) mice.

79 Our work defines TSP-1 as a novel immediate early gene that could be a po

80 gest an important role for astrocyte-derived TSPs, acting through alpha2delta-1, in maturation of a p

81 crop critical temperature thresholds during TSP exist in real world cropping landscapes?

82 o the large extracellular loop (LEL) of each TSP were produced in recombinant form and antibodies wer

83 Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were a

84 NOL7 also increases endogenous TSP-1 mRNA half-life.

85 pronociceptive individuals have an enhanced TSP response compared with antinociceptive individuals,

86 riptional networks, suggesting that enhanced TSP-1 expression may help restore tissue homeostasis dur

87 udy indicates that individuals with enhanced TSP have facilitated ascending nociceptive processing an

88 l of a partial hepatectomy (PH) and explored TSP-1 induction, progression of liver regeneration, and

89 Following Schistosoma exposure, TSP-1 levels in the lung increase, via recruitment of ci

90 nsitive periods (anthesis and grain-filling; TSP) of wheat crop development.

91 Finally, TSP-dependent H2S production was observed in yeast, worm

92 rating liver were the responsible factor for TSP-1 induction.

93 For TSPs using electrocautery, the frequency of coring was a

94 ticle size distributions were generated from TSP samples only, while steroid analysis was conducted o

95 ted extracellular matrix (ECM) proteins from TSP family, which consists of five homologous members.

96 Furthermore, TSP was positively correlated with the extent of imbalan

97 Furthermore, TSP-2-null astrocytes were deficient in supporting the r

98 ular pair-wise gene evaluation methods, e.g. TSP and TSG, are helpless for discovering pair-wise inte

99 Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechan

100 vely, pronociceptive subjects showed greater TSP responses.

101 HAM/TSP patients had significantly higher Ab responses for G

102 al disability scores were measured in 18 HAM/TSP patients, 4 asymptomatic carriers (ACs) of HTLV-1, 1

103 In 2 HAM/TSP patients, spinal cord cross-sectional area was measu

104 asymptomatic carriers of HTLV-1 (AC), 47 HAM/TSP, 74 relapsing-remitting MS [RRMS], 17 secondary prog

105 y exert therapeutic benefits for ATL and HAM/TSP patients.

106 -I-seronegative donors, ACs, and ATL and HAM/TSP patients.

107 asymptomatic carriers (ACs) and ATL and HAM/TSP patients.

108 a (ATL), an aggressive blood cancer, and HAM/TSP, a progressive neurological and inflammatory disease

109 Both HAM/TSP patients followed longitudinally showed thoracic thi

110 Definite HAM/TSP developed in 5 (1.47%) patients.

111 Of 414 subjects, 76 had definite HAM/TSP, 87 had possible or probable HAM/TSP, and 251 subjec

112 with subject information to distinguish HAM/TSP patients from ACs (odds ratio = 14.12) and from ATL

113 noprecipitation system could distinguish HAM/TSP patients from ACs at a true-positive rate of 85.42%

114 patients who do not fulfill criteria for HAM/TSP present with neurological complaints related to sens

115 lls may be a viable treatment option for HAM/TSP.

116 ent of isolated PBMCs and CNS cells from HAM/TSP patients with an antibody that targets CCR4+ T cells

117 nal cord cross-sectional area (SCCSA) in HAM/TSP and MS patients to that of healthy volunteers (HVs).

118 rage spinal cord cross-sectional area in HAM/TSP and progressive MS show spinal cord atrophy.

119 ytokines, are prominently deregulated in HAM/TSP and underlie many of the characteristic immune abnor

120 cervical cord, most of the pathology in HAM/TSP is seen in the thoracolumbar cord, which in turn may

121 b responses for all 3 Ags were higher in HAM/TSP patients than in ATL patients.

122 The entire spinal cord in HAM/TSP patients was thin compared to HVs, whereas only the

123 In HAM/TSP patients, SCCSA extensively correlated with Ambulati

124 We further hypothesize in HAM/TSP that is possible that neuroglial loss from a thoraci

125 the more extensive cord atrophy seen in HAM/TSP.

126 o T9 spinal cord cross-sectional area in HAM/TSP.

127 The incidence of HAM/TSP and new signs and neurologic symptoms were computed

128 uation of CSF and spinal cord lesions of HAM/TSP patients revealed the presence of abundant CD4+CCR4+

129 plays a key role in the pathogenesis of HAM/TSP.

130 myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma.

131 myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS).

132 myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS).

133 myelopathy/tropical spastic paraparesis (HAM/TSP) are known to be caused by HTLV-I infection.

134 myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive inflammatory myelopathy occurring

135 myelopathy/tropical spastic paraparesis (HAM/TSP), observed in up to 5% of infected individuals.

136 myelopathy/tropical spastic paraparesis (HAM/TSP).

137 myelopathy/tropical spastic paraparesis (HAM/TSP).

138 myelopathy/tropical spastic paraparesis (HAM/TSP).

139 ite HAM/TSP, 87 had possible or probable HAM/TSP, and 251 subjects had no neurologic manifestation an

140 thus a promising therapeutic approach to HAM/TSP with the potential of being more effective than sing

141 s showed atrophy in a pattern similar to HAM/TSP.

142 perative alpha-granule release profile (high TSP-1/low VEGF) showed substantially worse postoperative

143 V. myrtillus berries showed much higher TSP, TMA, RSA and FRAP values than V. uliginosum subsp.

144 ecipitation confirmed that recombinant human TSP-1 can bind BMP-2 and -4 and antagonize their effects

145 1 in diabetic atherosclerosis, hyperglycemic TSP-1(-/-)/ApoE(-/-) double knockout mice were compared

146 We have identified TSP-1 as an inhibitory element in regulating liver regen

147 has emerged over the past decade identifies TSPs as important mediators of cellular homeostasis, ass

148 Our data identify TSP-1 as a p53 target that contributes to maintaining Ra

149 e found large interindividual differences in TSP responses, which were positively correlated with fun

150 Significant increases in TSP, AC and 5-CQA levels were observed for each sample f

151 te (EHDPP; 610 +/- 220 pg m(-3)) measured in TSP samples were significantly higher than nighttime con

152 the production of BrM components, including TSP-1, PEDF, and tropoelastin in vitro and increased the

153 for all machine learning methods, including TSP.

154 ied with inhibition of hyperglycemia-induced TSP-1 expression and reduced protein O-glycosylation fol

155 We found that oncogenic Kras-induced TSP-1 upregulation in a p53-dependent manner.

156 g-standing cardiovascular benefits, inhibits TSP-1 expression in glucose-stimulated human aortic smoo

157 Interestingly, TSP-1 counteracted the increased neuronal excitability a

158 p-Scoring Pair (TSP), k-Top-Scoring Pairs (k-TSP), Top-Scoring Triplet (TST) and Differential Rank Co

159 nes raise this threshold which leads to less TSP-1 production, while signals that promote the generat

160 n uveitis, in the presence of TLR-4 ligands, TSP-1 is initially produced by recruited macrophages but

161 tients in the metabolic high-risk group (low TSP and weight loss) had an increased risk for relapse (

162 cytometry analysis revealed that, in males, TSP-1 knockout reduced macrophage infiltration and phago

163 hway from the sensory thalamus that mediates TSP.

164 t-like synoviocytes (FLSs) expressed minimal TSP-1 mRNA levels with high transcript levels of NR4A2,

165 therapeutic strategies designed to modulate TSP-1 synthesis in conditions that simulate tumor and pe

166 Moreover, TSP-1 inhibited the action of serum BMPs.

167 ic paraparesis/HTLV-1-associated myelopathy (TSP/HAM).

168 betic db/db mice exhibited marked myocardial TSP-1 upregulation in the interstitial and perivascular

169 how that in cultured rat spinal cord neurons TSP-1 decreased neuronal excitability by reducing the ac

170 red rice codon usage comprises up to 7.8% of TSP in hypoxic transgenic seedlings.

171 nd gabapentin, a high-affinity antagonist of TSP binding to the alpha2delta-1 calcium channel subunit

172 Lastly, the plasma concentration of TSP-1 is significantly increased in subjects with sclero

173 consistent with evolutionary conservation of TSP-mediated H2S as a mediator of DR benefits with broad

174 The contribution of TSP-1 upregulation to the modulation of tumorigenesis in

175 In these mice, deletion of TSP-1 ameliorated loss in volume and mass of the moderat

176 ogical assessment indicated that deletion of TSP-1 reduced inflammatory cell infiltration of muscle f

177 expression levels and tissue distribution of TSP-1.

178 ort that the von Willebrand type C domain of TSP-1 is likely responsible for this BMP-2/4-binding act

179 lloproteinase-9, the downstream effectors of TSP-2.

180 The effects of TSP-1 on GlyRs were dependent on the activation of excit

181 We investigated the effects of TSP-1 on neurons with mature synapses using immunocytoch

182 ro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribute to stimulation of tumor growt

183 of this study was to address the function of TSP-4 in the heart.

184 Recent studies of the functions of TSP in the cardiovascular system, diabetes and aging, wh

185 Our study showed a direct influence of TSP-4 on heart function and to identify the mechanism of

186 provide new insights into the involvement of TSP-1 in the BMP-2/-4 mechanisms of action.

187 Lack of TSP-1 prevented lesion formation in hyperglycemic ApoE(-

188 First, we found that levels of TSP-1 are elevated in blood of non-ambulant dysferlinopa

189 LSs resulted in inverse expression levels of TSP-1 compared with NR4A2, IL-8, and VEGF.

190 T2 MRI parameters revealed that loss of TSP-1 modestly inhibited inflammation only in gluteal mu

191 Thus, modulation of TSP-1 expression is achieved through anti-tumor necrosis

192 that together make up the complex network of TSP-1 regulation both at the transcriptional and post-tr

193 In the presence of TSP-1, AMPARs were less stabilized at synapses, increasi

194 Their production of TSP-1 is regulated by environmental signals that establi

195 myocardial remodeling changed as a result of TSP-4 deficiency in vivo and as a result of incubation o

196 These results suggest a role of TSP-1 in controlling the balance between excitation and

197 To confirm a direct role of TSP-1 in diabetic atherosclerosis, hyperglycemic TSP-1(-

198 To study the role of TSP-1 in remodeling of the diabetic heart, we generated

199 (ApoE(-/-)) mice and elucidated the role of TSP-1 in this process.

200 ein, is not caused by decreased secretion of TSP-4, and is mediated by activation of SMAD3.

201 Macrophages are a source of TSP-1, which they produce in response to TLR4 mediated s

202 mRNAs, suggesting that the stabilization of TSP-1 may be part of a larger novel mechanism.

203 Cellular synthesis of TSP-1 is tightly regulated by different intermediate bio

204 umor growth, in part through upregulation of TSP-1.

205 Upregulation of TSP-4 does not require the synthesis of new protein, is

206 The functions of TSPs in myocardium, vasculature, vascular complications

207 est information on the newfound functions of TSPs that emphasize the importance of ECM in cardiovascu

208 The identity and lineage potential of TSPs remains unclear.

209 nd are deficient in either integrin beta8 or TSP-1, known activators of latent TGF-beta1.

210 Ov-TSP-2 and TSP-3 were detected in whole worm extracts and

211 elonging to the CD63 family (Ov-TSP-2 and Ov-TSP-3) that are abundantly expressed in the tegument pro

212 etraspanins belonging to the CD63 family (Ov-TSP-2 and Ov-TSP-3) that are abundantly expressed in the

213 Antibodies confirmed localization of Ov-TSP-2 and TSP-3 to the adult fluke tegument.

214 ardiac fibroblasts populating collagen pads, TSP-1 incorporation into the matrix did not activate tra

215 Temporal summation of pain (TSP), the perception of increasingly greater pain evoked

216 d stimuli [i.e., temporal summation of pain (TSP)] reflects attributes of their "pain connectome," na

217 The top scoring pair (TSP) algorithm is an example that applies a simple rank-

218 ion algorithms such as the top-scoring pair (TSP) and the top-scoring triplet (TST) have several stre

219 TSP, like its predecessor, Top Scoring Pair (TSP), is a parameter-free classifier relying only on ran

220 analysis and includes the Top-Scoring Pair (TSP), k-Top-Scoring Pairs (k-TSP), Top-Scoring Triplet (

221 er effect than the total suspended particle (TSP) content as a whole on the spatial-temporal variabil

222 n (WSOC) in the total suspended particulate (TSP) load at a high elevation site in the Colorado Rocky

223 ter (PM2.5) and total suspended particulate (TSP) samples.

224 se (100 mg/m(3) total suspended particulate (TSP)), P=0.014; high dose (247 mg/m(3) TSP), P=0.02) and

225 Total suspended particulates (TSP), PM10, and PM2.5 were collected for particle size a

226 expression of the transsulfuration pathway (TSP) enzyme cystathionine gamma-lyase (CGL), resulting i

227 demonstrate that, through this new pathway, TSP-1 is responsible for the remote AC-mediated recovery

228 Three size fractions of particle-bound PbA (TSP, PM10, and PM2.5) data with different averaging time

229 one of the following: polyethylenimine (PEI)+TSP-2 siRNA, saline, PEI only, or PEI+control siRNA.

230 Treatment with PEI+TSP-2 siRNA significantly suppressed TSP-2 gene expressi

231 ing a critical temperature sensitive period (TSP) determines sexual fate of the individual rather tha

232 Changes in total soluble phenolics (TSP), 5-O-caffeoylquinic acid (5-CQA), total carotenoids

233 Total soluble polyphenols (TSP), total monomeric anthocyanins (TMA), radical scaven

234 In an animal preparation, TSP at the level of the fossa ovalis using electrocauter

235 Hamiltonian of a traveling salesman problem (TSP).

236 ter the entry of thymus-seeding progenitors (TSPs).

237 ically relevant thymus settling progenitors (TSPs).

238 ng with serum levels of total serum protein (TSP), albumin, C-reactive protein, and leptin were colle

239 lds are up to 1.8% of total soluble protein (TSP) in transformed rice cells.

240 this work, we studied the tailspike protein (TSP) of the bacteriophage Sf6.

241 ctors as the thrombospondin family proteins (TSPs), TSP1, TSP2, and TSP4.

242 een used to facilitate transseptal puncture (TSP).

243 sult of incubation of cells with recombinant TSP-4 in vitro.

244 Ectopic NR4A2 expression led to reduced TSP-1 mRNA and protein levels with concomitant increases

245 herefore plays a dominant role in regulating TSP-1 production in the target organ during acute inflam

246 em, diabetes and aging, which placed several TSPs in a position of critical regulators, demonstrated

247 Silencing TSP expression in hUTCs, using small RNA interference, e

248 aline-filled basin was developed to simulate TSP with electrocautery and a standard transseptal needl

249 for the functional role of Sm-TSP-2- and Sm-TSP-2-mediated TEMs.

250 re of the surface-exposed EC2 domain from Sm-TSP-2, a TSP from Schistosoma mansoni and one of the bet

251 The identification of further Sm-TSP-2-mediated TEM proteins increases the available cand

252 rther evidence for the functional role of Sm-TSP-2- and Sm-TSP-2-mediated TEMs.

253 , eight potential protein constituents of Sm-TSP-2-mediated TEMs were also identified.

254 ntial vaccine antigens, suggests that the Sm-TSP-2-mediated TEMs could be disrupted via multiple targ

255 icromagnetic simulation framework and solved TSPs of size 26-city and 15-city with an accuracy of 100

256 led to the design of the first serum stable TSP-1 mimetic agonist peptide able to trigger selective

257 In summary, TSP-1 appears to play an accessory role in modulating Mp

258 ith PEI+TSP-2 siRNA significantly suppressed TSP-2 gene expression (3.1-fold) at 24 h and TSP-2 prote

259 Targeting TSP-1-dependent activation of TGF-beta could thus be a t

260 The tetraspanins (TSPs) are a family of integral membrane proteins that ar

261 We conclude that TSP-1 production in endothelial cells depends on not onl

262 genesis models and cultured EC document that TSP-4 mediates upregulation of angiogenesis by TGF-beta1

263 bs4(-/-) mice and TSP-4 shRNA, we found that TSP-4 mediated pro-angiogenic functions in cultured EC a

264 We show here that TSP-1-mediated TGF-beta1 activation plays an important r

265 d healthy controls, supporting the idea that TSP-1 levels are correlated with disease progression.

266 We propose that TSP-1 could regulate bioavailability of BMPs, either pro

267 use model of lung cancer, we have shown that TSP-1 plays a critical and cell-autonomous role in suppr

268 assertion based on sequence similarity that TSP-1 shares with the von Willebrand type C domain of Cr

269 These data suggest that TSP-1 may be a mediator of capillary regression with det

270 Whereas both the TSP-N domain and cysteine-rich domains can bind to retin

271 mississippiensis), eggs incubated during the TSP at 33 degrees C (male producing temperature: MPT) yi

272 minimum and maximum temperatures during the TSP explain a greater amount of variation in wheat crop

273 ming average minimum temperatures during the TSP had a greater negative impact on wheat crop yield th

274 f temperature variation occurring during the TSP on wheat crop yield be detected using remote sensing

275 impacts of temperature variation during the TSP on wheat crop yield in real world cropping landscape

276 ication of 4N1K decapeptide derived from the TSP-1/CD47 binding epitope.

277 n of NR4A2 levels resulted in a shift in the TSP-1/VEGF expression ratio.

278 Inhibition of the TSP abrogated the changes in lifespan, adiposity, and pr

279 letion studies identified a 5' region of the TSP-1 promoter repressed by NR4A2 and proangiogenic tran

280 Our studies demonstrate that the TSP-N domain is responsible for homo-multimer formation

281 Nell1 can form hetero-multimers through the TSP-N domain, but they do not hetero-oligomerize with th

282 rase expression through interaction with the TSP-1 3'UTR at both the mRNA and protein levels.

283 None of the TSPs without cautery caused tissue coring.

284 These results suggest that therapeutic TSP-1 inhibition may have important atheroprotective pot

285 ypical matricellular protein thrombospondin (TSP)-1, a potent angiostatic molecule and crucial activa

286 O-fucosylation sites in the thrombospondin (TSP) type 1 repeats.

287 udy was to determine whether thrombospondin (TSP)-1 promotes macrophage activity and disease progress

288 Thrombospondins (TSPs) are secreted extracellular matrix (ECM) proteins f

289 Astrocyte-derived thrombospondins (TSPs) are likely responsible because TSP1 mimicked the e

290 Moreover, we identified thrombospondins (TSPs) as the hUTC-secreted factors that mediate the syna

291 agonizes the interaction of thrombospondins (TSPs) with the alpha2delta-1 receptor, and thus may reve

292 Thus, TSP-4 is involved in regulating the adaptive responses o

293 In summary, we identified for the first time TSP-1 as a BMP-2/-4 antagonist and presented a structura

294 In contrast to TSP, kTSP has comparable accuracy to standard genomics c

295 the individual neural mechanisms underlying TSP within individuals has implications for developing p

296 In vitro, TSP-1 stimulation increased macrophage, but not endothel

297 recruitment of circulating monocytes, while TSP-1 inhibition or knockout bone marrow prevents TGF-be

298 hagocytic activity, which is consistent with TSP-1-enhanced phagocytosis and pro-inflammatory cytokin

299 ng machinery and specifically interacts with TSP-1 mRNA through its 3'UTR.

300 then crossed dysferlinopathic BlaJ mice with TSP-1 knockout mice and assessed disease progression lon