ライフサイエンスコーパス: TTC

1 TTC documents dating from 1989 to 2004/5 were retrieved

2 TTC influenced survival outcomes in the overall study co

3 TTC stain was used to mark infarct areas, which were siz

4 (TTC)n repeat in both expansions and contractions drastic

5 TTC-derived infarct volumes were not significantly diffe

6 TTCs did not, however, make SLT investments until 2002,

7 TTCs' efforts to undermine the FCTC were comprehensive,

8 les were from 11-100, 101-1,000, and > 1,000 TTC/100 mL, respectively compared to < 1 TTC/100 mL.

9 000 TTC/100 mL, respectively compared to < 1 TTC/100 mL.

10 effectively bound and internalized the IGF-1-TTC in vitro.

11 Similarly, IGF-1-TTC injected into skeletal muscles was taken up and retr

12 Three monthly IGF-1-TTC injections into muscles of ageing mice did not incre

13 IGF-1-TTC retains IGF-1 activity as indicated by [(3)H]thymidi

14 complex in muscle fibres injected with IGF-1-TTC, compared to the other groups, suggesting preservati

15 IGF-1:TTC exhibited IGF-1 and TTC activity in vitro; it increa

16 ular- or intrathecal administration of IGF-1:TTC had no significant effect on disease progression or

17 tein resulted in substantial levels of IGF-1:TTC in spinal cord tissue extracts.

18 IGF-1:TTC may prove to be neuroprotective in other animal mode

19 Like rhIGF-1, infusion of IGF-1:TTC reduced levels of IGF-1 receptor immunoreactivity in

20 mbar spinal cords of mice infused with IGF-1:TTC were estimated to be approximately 500-fold higher t

21 tanus toxin fragment C fusion protein (IGF-1:TTC) as a secreted product from insect cells.

22 diarrhea with contamination levels below 11 TTC/100 mL, either in adults or children.

23 that HCN3(+) cells coexpress T-type Ca(2+) (TTC) channels and that TTC channel inhibition with R(-)e

24 rved for the destabilization of the (GAA)2T4(TTC)2T4(CTT)2 triplex to the corresponding Watson-Crick

25 (3-)) or 5,10,15-tris(4-tolyl)corrolate (H(3)TTC(3-))) leads to NO labilization.

26 ropean mutational spectrum, 5'-TCC-3' --> 5'-TTC-3' is known to be the most common somatic mutation p

27 enriched for the transition 5'-TCC-3' --> 5'-TTC-3'.

28 d recognises the symmetrical sequence GAAN(7)TTC.

29 Our results demonstrate that ShcV is a TTC for the HopPtoV effector.

30 All TTCs have now invested in snus (and recently in pure nic

31 IGF-1:TTC exhibited IGF-1 and TTC activity in vitro; it increased levels of immunoreac

32 The oligonucleotides TA(C)TAT, AATTTT, and TTC are located approximately (+/- 1 nucleotide) 29, 19,

33 ermeability of the BBB to Evans blue dye and TTC as detected by augmented concentrations of these sub

34 eks the extent of extracellular enhanced and TTC regions were smaller (13.2 +/- 1.4% and 12.0 +/- 1.5

35 rct size determined by (99m)Tc-glucarate and TTC staining (r = 0.96; slope = 0.87).

36 icity in 2 distinct muscle types, as HCN and TTC channels also mediate cardiac pacemaker activity.

37 R imaging (6.6% +/- 0.5 of the LV mass), and TTC staining (7.0% +/- 0.6 of the LV mass).

38 Hemodynamic values were recorded, and TTC staining was used to assess necrosis.

39 nd the second (B), based around the RILs and TTC families, involved marker-based QTL analysis.From (A

40 in 200 mM sodium (pH 5.0) repeats of TCC and TTC have half-lives of approximately 20 min, while the t

41 istochemistry demonstrated that both TTC and TTC-SOD-1 were distributed in a punctate perineuronal an

42 entrality of evidence to debates over SP and TTCs' history of denying harms and manufacturing uncerta

43 7-Anthraquinone stabilizes (TC)n (CCT)n and (TTC)n, although it has the greatest effect on the latter

44 iplexes that are formed at (TC)n (CCT)n and (TTC)n.

45 t analyses with anti-SMN, anti-DTx, and anti-TTC antibodies.

46 unolabeling of SDT-treated neurons with anti-TTC and anti-SMN antibodies showed staining restricted t

47 At TTC analysis, seven dogs had evidence of myocardial infa

48 t was similar to that of infarcted tissue at TTC staining (mean, 13.6% +/- 6.0; range, 7.8%-30.9%).

49 ATC/TTC haplotype cells significantly increased transmigrati

50 When stimulated with Poly I:C, ATC/TTC haplotype, cells significantly up-regulated the IL-8

51 a provides evidence that carriage of the ATC/TTC haplotype in itself may increase the influx of neutr

52 To test whether ATC/TTC haplotype is functional, we used a trans-well assay

53 We evaluated the association between TTC and survival according to breast cancer subtype and

54 We investigated the association between TTC in drinking water and diarrhea using data from seven

55 intramuscular injection, and exhibited both TTC- and IGF-1 activity in the CNS following intrathecal

56 Immunohistochemistry demonstrated that both TTC and TTC-SOD-1 were distributed in a punctate perineu

57 +/-1.8% of LV mass by MRI and 27.5+/-1.7% by TTC (P=NS).

58 rons in amounts similar to those achieved by TTC.

59 nd correlated with infarct volume defined by TTC staining at 24 h after MCAO.

60 ld exist naturally if Phe-508 was encoded by TTC, has wild type-like mRNA structure, and enhanced exp

61 Cerebral infarction was visualized by TTC staining on day 3 post-surgery.

62 or neurone loss, a tetanus toxin fragment-C (TTC) fusion protein was created to target IGF-1 to motor

63 of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector to enhance delivery of po

64 exogenous protein (tetanus toxin fragment C; TTC), and a viral vector (recombinant adeno-associated v

65 alleles of HLA-C and CDSN (HLA-Cw6 and CDSN*TTC) were genotyped in 678 families with early-onset pso

66 aplotypes retaining HLA-Cw6 but lacking CDSN*TTC were significantly associated with psoriasis, wherea

67 oriasis, whereas recombinants retaining CDSN*TTC but lacking HLA-Cw6 were not associated, despite goo

68 531 (TCG-->TTG or TTC), and 526 (CAC-->CGC, TTC, AAC, or CAA) demonstrated an association with highe

69 tion next to a candidate type III chaperone (TTC) gene, shcV, and within a pathogenicity island in th

70 cessory proteins called type III chaperones (TTCs) to be secreted via the TTSS.

71 time to initiation of adjuvant chemotherapy (TTC) after definitive surgery is unknown.

72 on via 2,3,5-triphenyl tetrazolium chloride (TTC) staining.

73 sed by 2,3,5-triphenyl tetrazolium chloride (TTC).

74 d using 2,3,5-triphenyltetrazolium chloride (TTC) or hematoxylin and eosin (H&E) stains.

75 assessed with triphenyltetrazolium chloride (TTC) staining and a transmission electron microscope (TE

76 with 2, 3, 5-triphenyltetrazolium chloride (TTC) staining for stroke volume measurement.

77 Triphenyltetrazolium chloride (TTC) staining indicated that pretreatment with MANF sign

78 determined by triphenyltetrazolium chloride (TTC) staining versus (99m)Tc-glucarate imaging ex vivo.

79 ized by 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin-eosin (H&E) staining, the ter

80 ents by 2,3,5-triphenyltetrazolium chloride (TTC) staining.

81 analysis, and triphenyltetrazolium chloride (TTC) staining.

82 staining with triphenyltetrazolium chloride (TTC) was used to confirm and quantify heterogeneous micr

83 Triphenyltetrazolium chloride (TTC) was used to delineate infarctions at postmortem.

84 lood flow and triphenyltetrazolium chloride (TTC)-stained tissue samples for infarct assessment by us

85 with 2, 3, 5-triphenyltetrazolium chloride (TTC).

86 arly as measured by thermotolerant coliform (TTC) bacteria, a WHO-approved indicator of drinking wate

87 scherichia coli or thermotolerant coliforms (TTC) were included provided they associated results with

88 er was assayed for thermotolerant coliforms (TTC), an indicator of faecal contamination.

89 isease-free survival, and time to colostomy (TTC) with pretreatment and treatment variables.

90 opposed by transnational tobacco companies (TTCs) whose responses to the UK government's public cons

91 r examines transnational tobacco companies' (TTCs') efforts to influence policy there, paying particu

92 ms to explore transnational tobacco company (TTC) interests in SLT and pure nicotine in Europe from t

93 sing the threshold of toxicological concern (TTC) approach.

94 rm daily threshold of toxicological concern (TTC) of 1.5 mug/g and the potential for quantitative ana

95 s (SML) and threshold toxicological concern (TTC) recommended values according to the Cramer classifi

96 CT)n, but stabilizes triplexes that contain (TTC)n.

97 iated by transnational tobacco corporations (TTCs) to try to undermine the proposed convention.

98 inbred lines (RILs) and a triple test cross (TTC), the latter produced by crossing the RILs to Col, L

99 n repeat expansion during replication of a d(TTC)n repeat template.

100 Delayed TTC was particularly detrimental among patients with tri

101 the first dose of chemotherapy, and delayed TTC was defined as 91 or more days from surgery to the f

102 FS) estimates were similar for the different TTC categories.

103 C linked to the enzyme superoxide dismutase (TTC-SOD-1).

104 HopO1-1 secretion and translocation and each TTC was able to bind the other's cognate effectors in ye

105 highly profitable) cigarettes while ensuring TTCs' long-term future should cigarette sales decline fu

106 e tumor diameter independently predicted for TTC (P = .008).

107 ft ventricle was sectioned into 4 slices for TTC staining.

108 bilize the (TTC)6.(GAA)6 composite function (TTC)6 triplex.

109 analyses of (TTC)6.(GAA)6 composite function(TTC)6 triplex detected ions due to both triplex and sing

110 and formation of triplex DNA at expanded GAA TTC repeats have been shown to regulate the FXN gene sil

111 of heterochromatin at the long expanded GAA TTC repeats, which is enriched in hypoacetylated histone

112 to the pUC control DNA) and that the GAA GAA TTC triplex further lowers the nucleosome assembly effic

113 ylation on the GAA TTC duplex or the GAA GAA TTC triplex has been measured in vitro.

114 ments for the GAA TTC duplex and the GAA GAA TTC triplex, and on the effect of histone acetylation, t

115 ved from the human FXN gene, and the GAA GAA TTC triplex, were examined for their ability to assemble

116 ng the formation of nucleosome arrays on GAA TTC-containing plasmids, the triplex structure was shown

117 In this study, GAA TTC repeating DNAs derived from the human FXN gene, and

118 irst direct binding measurements for the GAA TTC duplex and the GAA GAA TTC triplex, and on the effec

119 onstitution assays demonstrated that the GAA TTC duplex excludes nucleosomes (53% decrease compared t

120 the effect of histone acetylation on the GAA TTC duplex or the GAA GAA TTC triplex has been measured

121 Expansion of a GAA . TTC repeat in the first intron of the frataxin (FXN) gen

122 molecular model of FRDA by inserting 560 GAA*TTC repeats into an intron of a GFP reporter minigene.

123 s and number of tracts (one or two) of a GAA*TTC repeat in Escherichia coli to evaluate the in vivo r

124 of FRDA mutations involve expansion of a GAA*TTC-repeat tract in intron 1, which leads to an FXN mRNA

125 eletions as observed for the CTG*CAG and GAA*TTC repeats.

126 prior work demonstrated that CTG*CAG and GAA*TTC triplet repeats (responsible for DM1 and Friedreich'

127 We previously showed that cloned (GAA*TTC)n sequences replicated in Escherichia coli are more

128 The expanded GAA*TTC repeat sequence associated with Friedreich's ataxia

129 Most FRDA patients have expanded GAA*TTC repeats (up to 1700 triplets), which inhibit the tra

130 We examined instability of the expanded (GAA*TTC)(n) sequence in mammalian cells by analyzing individ

131 ion in Friedreich ataxia is an expanded (GAA*TTC)n sequence, which is highly unstable in human somati

132 edreich ataxia is caused by an expanded (GAA*TTC)n sequence, which is unstable during intergeneration

133 The GFP_(GAA*TTC)(560) minigene recapitulates the molecular hallmarks

134 ion, increase the expression of the GFP_(GAA*TTC)(560) reporter.

135 quence unaffected and (iii) heterozygous GAA*TTC expansion carriers with approximately 50% decrease o

136 plasmids by the association of two long GAA*TTC tracts at lengths that are found in the sequence of

137 ia (FRDA) is caused by hyperexpansion of GAA*TTC repeats located in the first intron of the FXN gene,

138 Replication of (GAA*TTC)n sequences (9-105 triplets) in plasmids propagated

139 othesized that genetic stability of the (GAA*TTC)n sequence may require efficient RecA-dependent reco

140 eplication is known to occur within the (GAA*TTC)n sequence when GAA is the lagging strand template,

141 ect of DSB repair on instability of the (GAA*TTC)n sequence.

142 echanism for genetic instability of the (GAA*TTC)n sequence.

143 echanism for genetic instability of the (GAA*TTC)n sequence.

144 ents is the unstable hyperexpansion of a GAA.TTC triplet repeat in the first intron of the frataxin g

145 as evaluated following replication of a (GAA.TTC)115 sequence in transfected COS1 cells under the con

146 eating tracts of CTG.CAG, CCTG.CAGG, and GAA.TTC are integral to the etiology of myotonic dystrophy t

147 The capacity of (CTG.CAG)n and (GAA.TTC)n repeat tracts in plasmids to induce mutations in D

148 us, intramolecular recombination between GAA.TTC tracts and GAAGGA.TCCTTC repeats also occurred with

149 linked pyrrole-imidazole polyamides bind GAA.TTC tracts with high affinity and disrupt the intramolec

150 diseases caused by expansion of CTG.CAG, GAA.TTC, or CGG.CCG repeat tracts.

151 Expanded GAA.TTC repeats result in decreased transcription and reduce

152 the Friedreich's ataxia (FRDA) expanded GAA.TTC sequence, which forms sticky DNA, are prone to form

153 edreich ataxia is caused by an expanded (GAA.TTC)n sequence in intron 1 of the FXN gene.

154 yeast and reporter construct models for GAA.TTC triplet-repeat expansion have been reported, studies

155 These studies suggest that in FRDA, GAA.TTC triplet-repeat instability occurs in embryonic cells

156 Sticky DNA is a single long GAA.GAA.TTC triplex formed in plasmids harboring a pair of long

157 locus-specific differences for genomic (GAA.TTC)n sequences.

158 However, GAA.TTC triplet repeats were stable in FRDA fibroblasts and

159 shRNA silencing of MSH2 and MSH6 impeded GAA.TTC triplet-repeat expansion.

160 er characterized the role of MutSbeta in GAA.TTC expansion using a functional assay in primary FRDA p

161 Thus, despite its essential role in GAA.TTC expansion, MSH2 is not an attractive therapeutic tar

162 RNA.DNA hybrids have a potential role in GAA.TTC tract instability and in the mechanism underlying re

163 opic expression of MSH2 and MSH3 induced GAA.TTC repeat expansion in the native FXN gene.

164 d ataxia caused primarily by an intronic GAA.TTC triplet repeat expansion in the frataxin (FXN) gene.

165 During propagation of the iPSCs, GAA.TTC triplet repeats expanded at a rate of about two GAA.

166 med in plasmids harboring a pair of long GAA.TTC repeat tracts in the direct repeat orientation.

167 The recombinational properties of long GAA.TTC repeating sequences were analyzed in Escherichia col

168 DNA conformation of genes harboring long GAA.TTC repeats or by chromatin opening.

169 e sticky-DNA conformation formed by long GAA.TTC repeats.

170 c property of transcription through long GAA.TTC tracts.

171 ity on the genetic instabilities of long GAA.TTC, CGG.CCG, and CTG.CAG repeat sequences was studied i

172 In this model, GAA.TTC repeats expand incrementally and continuously.

173 rapeutic target to slow the expansion of GAA.TTC repeats in the future.

174 Interestingly, tracts of (GAA.TTC)(n) (where n = 176 or 80) readily formed sticky DNA

175 ard cross-linking studies on a family of GAA.TTC-containing plasmids showed the presence of sticky DN

176 es extensive RNA.DNA hybrid formation on GAA.TTC templates in bacteria as well as in defined transcri

177 mall pool PCR analysis showed that pure (GAA.TTC)44+ sequences at the FXN locus are unstable in somat

178 fied three other genomic loci with pure (GAA.TTC)44+ sequences.

179 DNAs containing a pair of direct repeat GAA.TTC sequences.

180 expansion of the triplet-repeat sequence GAA.TTC within the first intron of the FXN gene.

181 pansions of the triplet-repeat sequence (GAA.TTC) cause transcriptional repression of the Frataxin ge

182 DNAs harboring a single GAA.TTC repeat are unable to form this type of triplex confo

183 n smaller, so-called 'pre-mutation' size GAA.TTC repeats, that do not cause disease, but are prone to

184 knockdown of either MSH2 or MSH3 slowed GAA.TTC expansion in our system.

185 ic pyrrole-imidazole polyamide targeting GAA.TTC triplet-repeat DNA partially blocked repeat expansio

186 AG.CTG repeat expansion, its role in the GAA.TTC expansion of Friedreich ataxia (FRDA) is less clear.

187 asurements are as follows: length of the GAA.TTC insert; the extent of periodic interruptions within

188 sis is that structures formed within the GAA.TTC repeat during transcription attract DNA repair enzym

189 Increasing the length of the GAA.TTC repeats decreased the intramolecular recombination f

190 ated the expansions and deletions of the GAA.TTC repeats.

191 rrests in the promoter distal end of the GAA.TTC tract and an extensive RNA.DNA hybrid is tightly lin

192 ve correlation between the length of the GAA.TTC tracts and the frequency of intramolecular recombina

193 was found between the propensity of the GAA.TTC tracts to adopt the sticky DNA conformation and the

194 e frequency of recombination between the GAA.TTC tracts was as much as 15 times higher than the non-r

195 that the recombination properties of the GAA.TTC tracts were unique, compared with CTG.CAG repeats, b

196 tudy the mechanism of instability of the GAA.TTC triplet repeats in the human genome.

197 essentially inert, as observed for the (GAA.TTC)176-containing plasmid.

198 tion of the SV40 origin relative to the (GAA.TTC)n sequence, we noted either no instability, predomin

199 repeats expanded at a rate of about two GAA.TTC triplet repeats/replication.

200 Expansion of an unstable GAA.TTC repeat in the first intron of the FXN gene causes Fr

201 ee of frataxin reduction correlates with GAA.TTC tract length, but the mechanism of reduction remains

202 The formation of a GAA/TTC DNA triplex has been implicated in Friedreich's atax

203 the discovery of agents that destabilize GAA/TTC triplexes and as general methods for the characteriz

204 del system, we demonstrate that expanded GAA/TTC repeats represent a threat to eukaryotic genome inte

205 Expansion of triplex-forming GAA/TTC repeats in the first intron of FXN gene results in F

206 Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome

207 In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that ca

208 The destabilization of GAA/TTC DNA triplexes either by pH or by binding to appropri

209 chanisms that regulate the metabolism of GAA/TTC repeats are poorly understood.

210 ms can mediate detrimental metabolism of GAA/TTC tracts in human cells.

211 We suggest that the mechanism of GAA/TTC-induced chromosomal aberrations defined in yeast can

212 there are a number of other polymorphic GAA/TTC loci in the human genome where the size variations t

213 Like GDNF, addition of GDNF:TTC to culture media of neuroblastoma cells expressing G

214 intramuscular injection, mice receiving GDNF:TTC revealed intense GDNF immunostaining associated with

215 esent in the purified conjugate sample, GDNF:TTC, had a molecular weight of approximately 80 kDa as d

216 That GDNF:TTC provided neuroprotection of axotomized motor neurons

217 xamination of one signal, an increased TCC-->TTC mutation rate in Europeans, indicates a burst of mut

218 ctively, these data demonstrate that HCN3(+)/TTC(+) cells are the pacemakers that set the origin and

219 C3000; these operons encode three homologous TTCs, ShcO1, ShcS1, and ShcS2.

220 ion provides insights into the nature of how TTCs function.

221 Factors associated with delays in TTC included low socioeconomic status, breast reconstruc

222 iarrhea increased for each log10 increase in TTC/100 mL by 18% (95% CI: 11, 26%) for children < 5 yea

223 ave failed, and little evidence was found in TTCs' corporate materials that snus is central to their

224 gs with contemporary documentation including TTC investor presentations.

225 uorescence microscopy revealed that injected TTC was not retained solely in a restricted deposit alon

226 (sum of areas with lacking and intermediate TTC staining) was similar among all six groups.

227 distribution was confirmed using HRP-labeled TTC with electron microscopy along with localization wit

228 ntitative fluorimetry, we found that labeled TTC showed vastly superior retention within brain tissue

229 Neurological evaluation and ischemic lesion (TTC stain) were assessed at 24 hours of reperfusion.

230 bgroup analysis according to subtype, longer TTC caused patients with triple-negative breast cancer t

231 Maximum TTC and TBC were up to 25.5 and 16.6 mug/g (fresh weight

232 ion households than controls (geometric mean TTC count of 50 [95% CI 44-57] per 100 ml compared to 12

233 a from available field studies that measured TTC levels in household-drinking water and reported prev

234 Expansions of a (GAA)(n)/(TTC)(n) repeat tract during its transmission from parent

235 in the Friedreich ataxia-associated (GAA)n*(TTC)n repeats from the FRDA gene that were cloned with f

236 To follow the effects of (GAA)n*(TTC)n repeats on gene expression, we have chosen E. coli

237 (GAA)n*(TTC)n repeats were cloned into bacterial plasmids in bot

238 sm seems less likely for the AT-rich (GAA)n*(TTC)n repeats.

239 , and were decreased by cholesterol; neutral TTC partitioned into membranes more strongly than the pr

240 by investing in snus, and recently nicotine, TTCs have eliminated competition between cigarettes and

241 Instead, a 3-nucleotide (TTC) deletion in the MLH1 3'-UTR was found in the patien

242 nd tax structures are an important aspect of TTC competitiveness.

243 of a recombinant fusion protein comprised of TTC linked to the enzyme superoxide dismutase (TTC-SOD-1

244 pport for health-based targets for levels of TTC in drinking water and for interventions to improve d

245 d risk of diarrhea with increasing levels of TTC in drinking water.

246 resulted in a substantial overestimation of TTC-defined infarct volume and a lower inter-observer re

247 nodal status and sex were not predictive of TTC.

248 In contrast, triplets with repeats of TTC, TCC and CTCT melt at 67, 72 and 76 degrees C, respe

249 ch to examine the conceptual significance of TTC critiques.

250 The existence of TTCs that can bind to dissimilar effectors and that can

251 The mass spectrometric analyses of (TTC)6.(GAA)6 composite function(TTC)6 triplex detected i

252 Volumetric calculation based on TTC-derived infarct also correlated significantly strong

253 nfarct size of the left ventricle (% IAR) on TTC staining was smaller in IR30 (49.2 +/- 4.3) than in

254 depicted with MTET imaging with that seen on TTC-stained tissue.

255 9% +/- 3.9% infarct in the left ventricle on TTC staining.

256 There is clear evidence of past and ongoing TTC influence over tobacco advertising and excise policy

257 ged controls injected with saline, IGF-1, or TTC.

258 tetanus toxin (tetanus toxin fragment C, or TTC).

259 in codons 523 (GGG-->GCG), 531 (TCG-->TTG or TTC), and 526 (CAC-->CGC, TTC, AAC, or CAA) demonstrated

260 A Phe377 (TTC(1130-1132)) deletion in exon 9 of the pyrophosphate

261 ependent pretreatment variable that predicts TTC and 5-year colostomy rate in patients with anal carc

262 two spectrally distinct isomers, presumably TTC and TTT cis-trans isomers, for the open-ring merocya

263 We hypothesized that prolonged TTC would be associated with adverse outcomes.

264 ly, positioning of normal- and carrier-size (TTC)n repeats into the sense strand for transcription le

265 from short priming sequences such as 3'-TCC, TTC, and TTT, and the consensus sequence is 3'-Pu(Py)2-3

266 ence intensity of membrane-bound tetracaine (TTC) on solution pH.

267 he complexation of Fe(II) with tetracycline (TTC), oxytetracycline (OTC), or chlorotetracycline (CTC)

268 xpress T-type Ca(2+) (TTC) channels and that TTC channel inhibition with R(-)efonidipine or NNC55-039

269 We conclude that TTC may be a useful vector to enhance neuronal delivery

270 These results indicate that TTC can serve as a non-viral vehicle to substantially im

271 came more affordable post-accession and that TTCs have taken advantage of low excise duties by raisin

272 Interview data suggest that TTCs enjoy high-level political support and continue to

273 ating the global application of tactics that TTCs have previously been found to have employed nationa

274 in edible organs at concentrations above the TTC value should be categorized as contaminants of emerg

275 Although the TTC technique was negative for infarct, histopathologica

276 ot be useful for SMA therapy, the use of the TTC:DTx fusion construct to deliver other passenger prot

277 Our data show that the TTC value of lamotrigine can be reached for a child at a

278 The TTCs' claim that SP will not lead to public health benef

279 ting ligand acridine orange destabilize the (TTC)6.(GAA)6 composite function (TTC)6 triplex.

280 Third, TTCs engaged in 'evidential landscaping', promoting a pa

281 mes were estimated and compared according to TTC and by BC subtype.

282 e categorized into three groups according to TTC: </= 30, 31 to 60, and >/= 61 days.

283 A single point mutation (TCC to TTC; Ser to Phe) was identified in Lec23 Gcs1 cDNA and g

284 Tx) followed by fragment C of tetanus toxin (TTC).

285 cent to areas of 2,3,5-triphenyltetrazolium (TTC)-negative tissue, normally associated with infarcted

286 24 hour 2,3,5-triphenyltetrazoliumchloride (TTC)-derived infarct volumes.

287 third strands consisting of repeats of TTT, TTC, TCC and TCTC.

288 We purposively selected and analysed two TTC submissions using a verification-oriented cross-docu

289 cted for infarct size (IS) measurement using TTC staining.

290 rm the haplotype-I (Hap-I), whereas variants TTC constitute Hap-II.

291 MTET infarct volume correlated with ex vivo TTC analysis data (y = 1.01x + 0.00, R = 0.98, standard

292 ge at diagnosis was 53 years, and median was TTC was 46 days.

293 Unlike the case with TTC, however, immunolabeling of SDT-treated neurons with

294 Analogous to the case with TTC, intrathecal infusion of the fusion protein resulted

295 ately assess infarct size when compared with TTC staining.

296 ution produced an excellent correlation with TTC-defined infarct volume and inter-observer reliabilit

297 ions showed similar robust correlations with TTC-defined infarct volumes for both groups using previo

298 vidence of adverse outcomes among those with TTC of 31 to 60 or 60 to 90 days.

299 he 1970s to the present, comparing them with TTCs' public claims of support for harm reduction.

300 The expansion of the GAA x TTC tract in intron 1 to as many as 1700 repeats elicits