ライフサイエンスコーパス: TTV

1 TTV contamination was found in ten (56%) of 18 batches o

2 TTV did not worsen the biochemical severity (mean ALT: 5

3 TTV DNA persisted in serum samples taken up to 6 years a

4 TTV DNA sequencing of nine isolates showed the same geno

5 TTV DNA was detected in 96% of tested serum samples.

6 TTV infection is widespread, and its replication is clos

7 TTV infection was detected in four (19%) of 21 patients

8 TTV infection was present in 1% (1 of 100) of blood dono

9 TTV infection was sought by detection of TTV DNA in seru

10 TTV may not be a primary hepatitis virus.

11 TTV viraemia is frequent in the blood-donor population,

12 TTV viraemia was detected in 19 (1.9%) of 1000 non-remun

13 TTV was found in 7.5% of 402 donors and in 11.0% of 347

14 TTVs can provide precise, but complex, constraints on pl

15 Comparison of the sensitivities of 2 TTV polymerase chain reaction (PCR) primer sets showed t

16 NV isolates, 6 prototype TTV isolates, and 7 TTV variants (including SANBAN, TUS01, PMV, and YONBAN).

17 The risk of acquiring TTV alone was only slightly higher in recipients of unmo

18 The high prevalence of active TTV infection in the general population, both in the UK

19 The finding of the additional TTV-related species should be taken into consideration w

20 We used semi-nested PCR to amplify TTV DNA from serum samples from 126 adults, of whom 72 w

21 This suggests that GBV-C and TTV may have different routes of transmission.

22 tected multiple subtypes of the BKV, JCV and TTV.

23 nship between alanine transaminase level and TTV DNA level was observed in 4 patients with long-term,

24 ruses highly divergent from both the TTV and TTV-like minivirus groups.

25 We found no association between TTV and non-A to E hepatitis and no effect of TTV on the

26 o consideration when the association between TTV infections and human diseases of unknown etiology is

27 To assess the association between TTV load in the peripheral blood and AMR, 715 kidney tra

28 We studied the association between TTV viremia and biochemical evidence of hepatitis in blo

29 le databases did not reveal identity between TTV and other viruses.

30 s were also shown to be greater than between TTV genotypes.

31 Between TTVs, improved Doppler surveys, high-contrast imaging ca

32 The expression profile of the circovirus TTV has not yet been fully characterized.

33 Of 21 viremic subjects, 67% cleared TTV within 5 years (38% in 1 year); 33% were viremic thr

34 to sequences derived from the corresponding TTV genome region deposited in GenBank.

35 iteria, alpha-fetoprotein, up-to-7 criteria, TTV, and platelet count were predictors of successful do

36 reaction (PCR) protocols were used to detect TTV DNA in sera of persons infected with hepatitis C vir

37 We detected TTV by PCR using primers from a conserved region in the

38 We detected TTV DNA in 18 (25%) of the 72 patients with chronic live

39 onstrated that genome sequences of different TTV strains are significantly divergent.

40 Of the 123 patients who tested positive for TTV, significant numbers were also infected with human h

41 This trend was striking for TTV and TTMDV and very modest for TTMV in both plasma an

42 blood-borne viruses tested, whereas 15% had TTV alone.

43 had TTV and hepatitis C virus (HCV), 22% had TTV, and at least 2 of the 4 known human blood-borne vir

44 human immunodeficiency virus (HIV): 31% had TTV and hepatitis C virus (HCV), 22% had TTV, and at lea

45 High TTV viremia is not associated with hepatitis after OLT,

46 In a generalized linear model, higher TTV levels were associated with a decreased risk for AMR

47 Human TTV's are epidemiologically associated with several huma

48 Furthermore, an anti-genogroup 1 human TTV antiserum did not react with any of the three TTSuV

49 mined human and swine sera by swine or human TTV-specific PCRs, to determine whether swine TTVs (TTSu

50 versely, liver inflammatory activity impairs TTV replication.

51 ALT was 182 in those TTV-positive and 302 in TTV-negatives.

52 n the biochemical severity (mean ALT: 537 in TTV+; 550 in TTV-) or persistence of hepatitis C.

53 ical severity (mean ALT: 537 in TTV+; 550 in TTV-) or persistence of hepatitis C.

54 CR, this virucidal step seemed to inactivate TTV infectivity.

55 be more evolutionary distant from all known TTV sequences.

56 es demonstrated the existence of three major TTV genotypes.

57 nellovirus are known to infect humans, named TTV, TTMDV, and TTMV.

58 The rate of new TTV infections in 13 patients with non-A to E hepatitis

59 The rate of new TTV infections was 4.7% in 127 nontransfused, and 26.4%

60 o clarify whether longitudinal assessment of TTV load might predict AMR risk and help guide the type

61 blood and blood products, and assessment of TTV's aetiological role in hepatic and extra-hepatic dis

62 biophysical and molecular characteristics of TTV suggest that it is a member of a new family of virus

63 transfection of a full-length viral clone of TTV genotype 6, each of the three virally encoded mRNAs

64 TTV infection was sought by detection of TTV DNA in serum by polymerase chain reaction (PCR) usin

65 atment had little effect on the detection of TTV in factor VIII and IX by PCR, this virucidal step se

66 ur results do not suggest a causal effect of TTV on chronic liver disease in these patients.

67 TV and non-A to E hepatitis and no effect of TTV on the severity or duration of coexistent hepatitis

68 ients increased, so too did the frequency of TTV and TTMDV detection.

69 We investigated the frequency of TTV viraemia in UK blood donors, and the extent to which

70 Additionally, five new groups of TTV sequences were identified.

71 Finally, intravenous inoculation of TTV-positive human serum into chimpanzees demonstrated t

72 The majority of TTV-positive cases had no biochemical or histological ev

73 The presence of TTV viral DNA was confirmed in 7 cases by qPCR.

74 on primers were used to test for presence of TTV, which was found in approximately 10% of US voluntee

75 s and to further determine the prevalence of TTV infection in several groups of patients with liver d

76 cantly underestimated the true prevalence of TTV.

77 The rate of TTV DNA was similar among patients with various liver di

78 The rate of TTV infection among US non-A, non-B, non-C, non-D, non-E

79 cts was associated with an increased risk of TTV infection (relative risk, 4.5; 90% confidence interv

80 vestigated the possible aetiological role of TTV in cryptogenic fulminant hepatic failure (FHF).

81 The role of TTV in liver disease has not been established.

82 tudies are required to determine the role of TTV in the pathogenicity of acute and/or chronic liver d

83 blood-donor population, and transmission of TTV through transfusion of blood components may have occ

84 The common occurrence of TTVs as environmental contaminants and the increasing in

85 e for possible cross-species transmission of TTVs.

86 ce of immunosuppression and HEV infection on TTV replication and liver injury in pediatric patients a

87 ntly more genetically related than any other TTV genotype.

88 ss-sectional AMR screening and, in parallel, TTV quantification.

89 r potential confounders (risk ratio 0.94 per TTV log level; 95% confidence interval 0.90-0.99; P = 0.

90 Prototype TTV formed group 2, PMV formed group 3, and SENV, SANBAN

91 e, and compared 8 SENV isolates, 6 prototype TTV isolates, and 7 TTV variants (including SANBAN, TUS0

92 n and animal parvoviruses and of two related TTV-like viruses highly divergent from both the TTV and

93 indicate that the human anellovirus species TTV and TTMDV are associated with fever in children, whi

94 ct humans, we found that anellovirus species TTV and TTMDV were more prevalent in the plasma and NP s

95 Recently it was found that swine TTV's (TTSuVs) can act as primary pathogens.

96 TV-specific PCRs, to determine whether swine TTVs (TTSuV) DNA can be detected in humans and vice vers

97 We conclude that TTV infection is present among North American blood dono

98 We conclude that TTV is a very common, often persistent infection that is

99 man serum into chimpanzees demonstrated that TTV can be transmitted to primates; no biochemical or hi

100 Taken together, these results indicate that TTV frequently infects Italian hemophiliacs treated with

101 1.34 g/ml; filtration studies indicated that TTV had a particle size of 30-50 nm.

102 ck of significant liver damage, suggest that TTV, similar to hepatitis G virus (HGV), may be an examp

103 The TTV load was assessed in 342 serum samples by use of Taq

104 However, the causative link between the TTV infection and liver disease remains uncertain.

105 -like viruses highly divergent from both the TTV and TTV-like minivirus groups.

106 netic analysis were used to characterise the TTV isolates.

107 using primers from a conserved region in the TTV genome.

108 To assess genetic heterogeneity of the TTV genome in more detail, a sequence analysis of PCR fr

109 ers generated from a conserved region of the TTV genome.

110 ive patients (n = 46) showed only 25% of the TTV levels measured in patients without AMR (P = 0.003).

111 intravenous drug abusers, only 1%-3% of the TTV-positive individuals were coinfected with GB virus C

112 from two initiating AUGs, and therefore, the TTV genome generates at least six proteins.

113 candidate selection could be expanded to the TTV (</=115 cm(3) )/AFP (</=400 ng/mL) criteria in cente

114 high degree of genetic complexity within the TTV population.

115 -A to E cases, the mean ALT was 182 in those TTV-positive and 302 in TTV-negatives.

116 Thus, TTV exists as a "swarm" of at least five closely related

117 s (HEV) infection and could be vulnerable to TTV-associated adverse effects.

118 the coming years, astronomers will translate TTV observations into increasingly powerful constraints

119 The analysis used TTV-like minivirus as an outgroup, to determine a root o

120 er, the method of transit timing variations (TTVs) has blossomed as a new technique for characterizin

121 The small DNA virus TTV was unexpectedly found in all culture-negative sampl

122 ntly described, including Torque teno virus (TTV) and Borrelia burgdorferi.

123 luding JC virus (JCV) and Torque teno virus (TTV) and interestingly, we detected multiple subtypes of

124 Torque Teno virus (TTV) is a ubiquitous infectious agent.

125 onstrated the presence of torque teno virus (TTV) sequences, compared with none in the controls (P=0.

126 prevalent and apathogenic Torque Teno virus (TTV), which might mirror the overall level of immunosupp

127 complete nucleotide sequence of this virus (TTV) isolated from the serum of a West African.

128 ed DNA virus, transfusion-transmitted virus (TTV), has been implicated as a cause of post-transfusion

129 virus, named transfusion-transmitted virus (TTV), was recently detected with high prevalence in Japa

130 NV) distantly related to the large TT virus (TTV) family was recently identified.

131 TT virus (TTV) has been proposed as the causative agent of non-A t

132 The prevalence of the blood-borne TT virus (TTV) in Italian hemophiliacs treated with different prep

133 TT virus (TTV) is a recently discovered infectious agent originall

134 TT virus (TTV) was recently identified in the serum of a patient w

135 Two overlapping sets of TT virus (TTV)-specific polymerase chain reaction primers were use

136 vovirus and two viruses related to TT virus (TTV).

137 A novel DNA virus, TT-virus (TTV), has been reported in patients with non-A-G posttra

138 Torque Teno Viruses (TTVs) are ubiquitous viruses which are highly prevalent

139 cludes human and animal torque teno viruses (TTVs) with extensive genetic diversity.

140 haracteristics including total tumor volume (TTV) and up-to-7 criteria were recorded.

141 the previously proposed total tumor volume (TTV; </=115 cm(3) )/alpha-fetoprotein (AFP; </=400 ng/mL

142 We sought to determine whether TTV infection occurs in North American blood donors and

143 This study cannot distinguish whether TTV is a direct intraocular pathogen, an adjuvant for in

144 n lend importance to the question of whether TTV's can cross-infect across species.

145 liver disease in the UK to find out whether TTV infection is associated with liver damage.

146 infected with HCV alone, regardless of which TTV PCR protocol was used.

147 in UK blood donors, and the extent to which TTV contaminates blood products such as factor VIII and

148 were elevated in 2 of 27 patients (7%) with TTV alone compared with 43 of 56 patients (77%) coinfect

149 l-time polymerase chain reaction, along with TTV genogroups and coinfection with HEV.

150 with 43 of 56 patients (77%) coinfected with TTV and HCV and compared with 16 of 21 patients (76%) wi

151 rity of hepatitis in persons coinfected with TTV and HCV when compared with those infected with HCV a

152 s C, 40.0% were simultaneously infected with TTV.

153 d, whereas only 1 (4.5%) of 22 patients with TTV greater than 200 cm were successfully downstaged.

154 Patients with TTV less than 200 cm may be considered good candidates f

155 Fifty-two (76%) of 68 patients with TTV less than 200 cm were successfully downstaged, where

156 higher for patients beyond Milan, but within TTV/AFP (16 of 38; 42.1%), than for those within Milan (

157 within Milan and 38 beyond Milan, but within TTV/AFP.

158 lan criteria, and 32 beyond Milan but within TTV/AFP.

159 ompared to patients beyond Milan, but within TTV/AFP.

160 78 hemophilic patients (mean age, 29 years), TTV-DNA was found in 123 (69%), in comparison to 22 of 1