ライフサイエンスコーパス: Tax protein

1 CD8(+) T cell response narrowly targeted the Tax protein.

2 paB competed with HDAC1 for association with Tax protein.

3 , is present in the C terminus of the HTLV-3 Tax protein.

4 so repressed by a p300/CBP-binding deficient Tax protein.

5 ells, we find that JMJD2A binds to the viral Tax protein.

6 cted baboons is largely directed against the Tax protein.

7 both T-cell costimulatory signals and HTLV-I Tax protein.

8 cytotoxic effects compared to the wild-type Tax protein.

9 human T-cell leukemia virus type 1 (HTLV-1) Tax protein.

10 the human T-cell lymphotrophic virus type I Tax protein.

11 the human T-cell leukemia type 1 LTR by the Tax protein.

12 HTLV-I-transformed T cells that express the Tax protein.

13 ates expression of viral tax/rex RNA and the Tax protein.

14 orted for human T-cell leukemia virus type 1 Tax protein.

15 e that these patients have antibodies to the tax protein.

16 ted by expression vectors encoding the 40-kd Tax protein, a potent transactivator in HTLV-I.

17 ld as Tax was expressed, suggesting that the Tax protein activates IL-15 transcription.

18 The human T-cell leukemia virus type 1 Tax protein activates the expression of cellular immedia

19 human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates the HTLV-1 long terminal repeat an

20 -cell leukemia virus type 1 (HTLV-1)-encoded Tax protein activates viral transcription through intera

21 f the IL-2 promoter and CD28RE to the HTLV-1 Tax protein and demonstrate that the TATA-proximal AP-1

22 This is seen both in vitro using purified Tax protein and in vivo in cells transduced with Tax exp

23 somes derived from infected cells to contain Tax protein and proinflammatory mediators as well as vir

24 Both the HBZ and Tax proteins are implicated in the development of adult

25 we utilized the human T-cell leukemia type 1 Tax protein as a molecular tool to investigate the mecha

26 n that the human T-lymphotropic virus type I Tax protein can inhibit p53 function.

27 A mutant Tax protein deficient in transactivation of genes by the

28 Our analysis also revealed that Tax proteins deficient for dimerization fail to localize

29 The HTLV-1 Tax protein directly binds P/CAF in vitro and co-immunop

30 human T-cell leukemia virus type-1 (HTLV-1) Tax protein directly interacts with Chk2 and the kinase

31 The human T-cell leukemia virus Tax protein directs binding of a host factor, cAMP respo

32 The Tax protein, encoded by the human T-cell leukemia virus

33 -cell leukemia virus type-1 (HTLV-I)-encoded Tax protein enhances viral gene transcription through in

34 Here, we show that the Tax proteins exhibit differential modes of IKK activatio

35 gnize the Tax11-19 immunodominant epitope of Tax protein expressed by human T-cell leukemia virus (HT

36 served a positive correlation between HTLV-I Tax protein expression and IL-15 promoter activity in HT

37 th the HTLV-1 proviral DNA load ex vivo, the Tax protein expression in vitro, and the Tax-specific CD

38 mpared with HTLV-1 proviral DNA load, HTLV-1 Tax protein expression, HTLV-1 Tax-specific CD8(+) T-cel

39 ion and restore cytoplasmic tax/rex mRNA and Tax protein expression.

40 The human T-cell leukemia virus type I Tax protein forms a ternary complex on DNA in associatio

41 Retroviral Tax proteins from human T cell leukemia virus type 1 and

42 Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic pr

43 The HTLV-1 Tax protein has been strongly linked to oncogenesis and

44 Interestingly, expression of wild-type Tax protein in cells was also correlated with the induct

45 ntiviral shRNAs similarly provoked a loss of Tax protein in HTLV-1-transformed cells.

46 ed by the human T-cell leukemia virus type 1 Tax protein in human Jurkat T-cells.

47 of T-tropic HIV-1 infection, whereas soluble Tax protein increased susceptibility to both M- and T-tr

48 We found that the HTLV-1 Tax protein increases cellular autophagosome accumulatio

49 The human T-cell leukemia virus Tax protein influences transcription through interaction

50 es have demonstrated that the HTLV-1-encoded Tax protein inhibits the function of tumor suppressor p5

51 idea that a major structural element of the Tax protein inserts into the major or minor grooves of t

52 We now present evidence that the HTLV-1 Tax protein interacts directly with Chk1 and impairs its

53 th T-cell costimulatory signals and the HTLV Tax protein involves stimulation of I kappa B kinase (IK

54 The human T-cell leukemia virus-encoded tax protein is a potent activator of many viral and cell

55 HTLV-I Tax protein is a potent transcriptional activator of vir

56 human T-cell leukemia virus (HTLV-I)-encoded Tax protein is a potent transcriptional activator that s

57 We have also shown that the HTLV-I-encoded Tax protein is able to activate Tpl2/Cot in transfected

58 These findings suggest that the Tax protein is at least partially responsible for the p5

59 The HTLV-I Tax protein is essential for clinical manifestations bec

60 7-fold in Jurkat cells stably expressing the Tax protein (Jurkat-Tax) than in Jurkat E6.1 cells and w

61 ds to the human T-cell leukemia virus type I Tax protein, leading to the translocation of Int-6 to th

62 he human T-cell lymphotrophic virus, type I, Tax protein leads to enhanced phosphorylation of IKKgamm

63 ation of the NF-kappaB pathway by the HTLV-1 Tax protein leads to transcriptional inactivation of c-M

64 ated via the activation domain of the HTLV-1 Tax protein, may be involved.

65 e chromatin environment, the virally encoded Tax protein mediates the recruitment of the coactivators

66 In a cotransfection assay, the Tax protein of both HTLV-I and HTLV-II specifically acti

67 Although the Tax protein of HTLV-1 has been strongly implicated as a

68 o mediate transcriptional stimulation by the Tax protein of HTLV-1.

69 The Tax protein of human T cell leukemia virus type 1 is a v

70 he complex of HLA-A2, and a peptide from the Tax protein of human T lymphotropic virus type 1.

71 The Tax protein of human T-cell leukemia virus type 1 (HTLV-

72 The Tax protein of human T-cell leukemia virus type 1 (HTLV-

73 The Tax protein of human T-cell leukemia virus type 1 (HTLV-

74 The Tax protein of human T-cell leukemia virus type 1 (HTLV-

75 owth factor-B (PDGF-B) proto-oncogene by the Tax protein of human T-cell leukemia virus type 1 has be

76 The Tax protein of human T-cell leukemia virus type I has be

77 The Tax protein of human T-cell lymphotropic virus type 1 (H

78 The Tax protein of human T-lymphotropic virus (HTLV)-1 activ

79 The Tax protein of human T-lymphotropic virus type 1 (HTLV-1

80 The Tax protein of the Human T-cell Leukemia Virus (HTLV) ac

81 The Tax protein of the human T-cell leukemia virus type I (H

82 Tax protein of the human T-cell lymphotropic virus type

83 In transient expression assays, the extended Tax protein of the prototype HTLV-2a subtype.

84 The Tax protein of this virus is thought to contribute to ce

85 f the pX region, which demonstrated that the Tax proteins of the Brazilian viruses differed from that

86 omparison of the action of HTLV-1 and HTLV-2 Tax proteins on p53 function will provide important insi

87 ption of HAM/TSP IgG with recombinant HTLV-I tax protein or preincubation of CNS tissue with the mono

88 Human T-cell leukemia virus type I (HTLV-I) Tax protein persistently stimulates the activity of Ikap

89 Interestingly, RNF4 modification of Tax protein results in relocalization of the oncoprotein

90 bafilomycin A increased the stability of the Tax protein, suggesting that cellular degradation of Tax

91 nize an immunodominant peptide of the HTLV-I Tax protein, Tax11-19.

92 reover, a double mutation (D22A,C23S) in the Tax protein that abrogated the Tax/Ets1 interaction also

93 The HTLV-1 genome encodes the Tax protein that plays essential regulatory roles in HTL

94 s-activation of the IL-15 gene by the HTLV-I Tax protein through an NF-kappaB motif and suggest a pot

95 is transcriptionally regulated by the HTLV-I Tax protein through the action of NF-kappaB.

96 responses that recognize the immunodominant Tax protein to the tax sequences present in two individu

97 The human T-cell leukemia virus type 1 Tax protein transforms human T lymphocytes, which can le

98 a phosphoryl mapping of mammalian-expressed Tax protein using a combination of affinity purification

99 if the human T-cell leukemia virus (HTLV-I) Tax protein, which also interacts with CR2, competes wit

100 nteraction is mediated by the HTLV-1-encoded Tax protein, which has potent oncogenic properties.

101 ion of human T cell leukemia virus 1-encoded Tax protein, which resembles K13 in inducing constitutiv

102 which express low levels of HTLV-1 RNAs and Tax protein, with phorbol esters (i.e., phorbol12-myrist