ライフサイエンスコーパス: Tc2 cell

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1 ificantly higher levels on Tc1 cells than on Tc2 cells.

2 t in 10-fold higher numbers than control Th2/Tc2 cells.

3 ogression than that of functionally distinct Tc2 cells.

4 pe and function from T cytotoxic 1 (Tc1) and Tc2 cells.

5 utic efficiency when compared with wild-type Tc2 cells.

6 ive CD8(+) T cell differentiation to Tc17 or Tc2 cells.

7 rejection more effectively than control Th2/Tc2 cells.

8 ively transferred ovalbumin-specific Tc1 and Tc2 cells accumulated at the tumor site by day 2 after t

9 Tc2 cells achieved a comparable reduction in lung tumor

10 ) T cells differentiate into IL-13-producing Tc2 cells and play a major role in a bleomycin-induced m

11 underwent more efficient expansion than did Tc2 cells, and only Tc1 cells were detected at the site

12 Type 2 immunity consists of GATA-3(+) ILC2s, TC2 cells, and TH2 cells producing IL-4, IL-5, and IL-13

13 egulation of pulmonary fibrosis and identify Tc2 cells as key mediators of fibrogenesis.

14 Both Tc1 and Tc2 cells can mediate murine cardiac allograft rejection

15 ed cytokine secretion did not inhibit Tc1 or Tc2 cell cytolytic function.

16 In contrast, Tc2 cells derived from select cytokine gene-deficient mi

17 In contrast, both Tc1 and Tc2 cells, derived from either FasL or TNF-alpha/lymphot

18 arily vascularized allograft, and if Tcl and Tc2 cells differ in their ability to mediate rejection.

19 T-cytotoxic 1 (Tc1) cells, but not by Th2 or Tc2 cells, establishing Bonzo as a differential marker o

20 vely transferred allo-(H-2d)-reactive Tcl or Tc2 cells from H-2b mice into each recipient.

21 Transfer of perforin-deficient Tc2 cells generated from perforin gene knockout mice sho

22 h1 cytotoxic (Tc1) cytokines, but not Th2 or Tc2, cell generation.

23 Tc1 and Tc2 cells had similar adenosine signaling, as measured b

24 Tc2 cell IL-4 and IL-5 secretion was not reduced by CGS,

25 Differentiation of these Tc2 cells in the lung requires IL-21, and bleomycin trea

26 convert from IFN-gamma(+) (Tc1) to IL-13(+) (Tc2) cells in the presence of IL-4.

27 adoptively transferred OVA-specific Tc1 and Tc2 cells induce considerable suppression, but not cure,

28 CGS greatly reduced Tc1 and Tc2 cell interleukin 2 (IL-2) and tumor necrosis factor

29 Transfer of Tc2 cells into IFN-gamma-deficient tumor-bearing mice wa

30 speculate that the effectiveness of Tc1 and Tc2 cells may depend on different mechanisms.

31 Conversely, donor Tc2 cell numbers markedly diminished at later times, sug

32 Tc1 cells persisted, whereas Tc2 cell numbers progressively diminished over time.

33 We conclude that Tc2 cells potently inhibit marrow graft rejection withou

34 graft vasculitis, although IL-4high IL-5high Tc2 cells promote recruitment of secondary effectors lik

35 n-2/interferon-gamma (IL-2/IFN-gamma) or TH2/TC2 cells secreting IL-4/IL-5/IL-10.

36 leens of tumor-bearing mice receiving Tc1 or Tc2 cells showed markedly enhanced tumor Ag-specific cyt

37 omplexes were not expressed by either Tc1 or Tc2 cells, suggesting that CD49d is solely expressed in

38 fferential expression of VLA-4 on Tc1 versus Tc2 cells, Tc1 cells alone were competent to adhere to p

39 pothesized that rapamycin would generate Th2/Tc2 cells (Th2/Tc2.R cells) that abrogate fully MHC-disp

40 gressive response and that non-host-reactive Tc2 cells therefore facilitate engraftment across geneti

41 At 650 cGy irradiation, the addition of Tc2 cells to the F1 marrow resulted in extensive F1 chim

42 VLA-4 expression on Tc2 cells was down-regulated in an interleukin (IL)-4 do

43 f IFN-gammahigh Tc1, but not of IFN-gammalow Tc2 cells was followed by the development of graft vascu

44 on of a panel of homing receptors on Tc1 and Tc2 cells, we found that very late antigen (VLA)-4 (a he

45 Donor Tc1 and Tc2 cells were generated that preferentially secreted ty

46 type 1 cytotoxic T lymphocytes (Tc1) and Th2/Tc2 cells were generated using an antigen-presenting cel

47 Rapamycin-generated Th2/Tc2 cells were less likely to die after adoptive transfe

48 ts, IL-5-producing CD8(+) T cells, so-called Tc2 cells, which in healthy donors can only be detected

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