ライフサイエンスコーパス: Tfh cell

1 tions with CD4(+) follicular helper T cells (TFH cells).

2 se development of follicular helper T cells (TFH cells).

3 a cell type with properties of both Treg and TFH cells.

4 tigen uptake and antigen presentation to the Tfh cells.

5 irements for their differentiation: Th17 and Tfh cells.

6 ated interference increased the frequency of TFH cells.

7 ndependent method to identify Ag-specific GC Tfh cells.

8 in the expansion and function of pathogenic TFH cells.

9 ethod identified 85-fold more Ag-specific GC Tfh cells.

10 receptors to form Th1-, Th2-, and Th17-like Tfh cells.

11 iR-155 exhibited decreases in GC B cells and Tfh cells.

12 elated to an effect on PD-L1(hi) B cells and Tfh cells.

13 by impaired differentiation and function of Tfh cells.

14 differentiation in the presence of residual Tfh cells.

15 s are germinal center-homing CXCR5(+)Bcl6(+) Tfh cells.

16 s that regulate the differentiation of human TFH cells.

17 mportant for the function and homeostasis of Tfh cells.

18 the presence of IL-12 and IL-21 to generate TFH cells.

19 ut-homing alpha4beta7 integrin expression on Tfh cells.

20 -1 included TFR cells in their definition of TFH cells.

21 ulating Tfr cells, leading to suppression of Tfh cells.

22 ncreased recruitment of T follicular helper (TFH) cells.

23 pment and maturation of T follicular helper (Tfh) cells.

24 ukin-4 (IL-4)-committed T follicular helper (Tfh) cells.

25 per 17 (Th17) cells and T follicular helper (Tfh) cells.

26 in germinal center (GC) T follicular helper (Tfh) cells.

27 ion and accumulation of T follicular helper (TFH) cells.

28 .8% after therapy), and decreased numbers of Tfh cells (12% +/- 1.3% before therapy vs 8% +/- 0.9% af

29 sting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and

30 rominently expressed on T follicular helper (TFH) cells, a specialized CD4(+) T cell subset that orch

31 surement of Ag-specific T follicular helper (TFH) cell activity in rhesus macaques has not previously

32 T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal d

33 Studying vaccine-specific GC Tfh cells after protein immunizations has been challengi

34 n-induced markers (AIM) on the surface of GC Tfh cells after stimulation.

35 cells into systemic sites, boosted systemic Tfh cell and auto-antibody responses that exacerbated ar

36 Added to TFH cell and B-cell cocultures, they inhibited B-cell di

37 tigen retention in lymph nodes and increased Tfh cell and germinal center B-cell numbers.

38 Animal data suggest that Tfh cells and B cells migrate to the allograft and are i

39 ells modulated IL-21 receptor expressions on TFH cells and B cells, and their suppressive activities

40 ells induced a distinct suppressive state in TFH cells and B cells, in which effector transcriptional

41 red B cell follicles and eradicated infected TFH cells and B cells.

42 ion had phenotypic or functional features of Tfh cells and contribute to the production of HCV-specif

43 We first assessed miRNA expression in TFH cells and defined a TFH-specific miRNA signature.

44 nizations, and the putative central roles of Tfh cells and GC in the generation of HIV bnAbs.

45 deficiency induces excessive development of TFH cells and GC responses in a T-cell-intrinsic manner.

46 and estradiol (E2) co-treatment ameliorated TFH cells and GC responses in male mice.

47 gamma(KO) mice induced higher proportions of TFH cells and germinal center (GC) B cells following imm

48 c H1N1 IAV strains, even in mice that lacked TFH cells and germinal centers.

49 Tfh cells and IL-21 are involved in infectious and autoi

50 ates the ontogeny and homeostasis of B6.Sle1 TFH cells and influences the function of TFH cells durin

51 ndicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate

52 ETV5 expression is derepressed in Cic null TFH cells and knockdown of Etv5 suppresses the enhanced

53 ells or CD25 in dendritic cells have reduced Tfh cells and mount defective T-cell-dependent plasma ce

54 characteristics of both follicular and blood Tfh cells and of the IL-21/IL-21R system in the context

55 evidenced by reduced expression of CD40L on Tfh cells and reduced B cell proliferation in treated mi

56 ith acute HCV infection expressed markers of Tfh cells and secreted interleukin 21 in response to HCV

57 e observed the development of IL-4-producing TFH cells and TH2 cells in draining lymph nodes after ai

58 onally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were incr

59 cells, which is essential for the homing of Tfh cells and the development of B cell follicles.

60 ifficulty of quantifying antigen-specific GC Tfh cells and the difficulty of tracking GC in human and

61 This vaccine enhanced the numbers of Tfh cells and the GC responses, resulting in upregulated

62 o control infections that target B cells and TFH cells and to treat B cell-derived malignancies.

63 uency of total and SIV Env-specific IL-21(+) TFH cells and total germinal center B cells, the size an

64 d carry important implications for targeting Tfh cells and/or B cells therapeutically.

65 te interactions between T follicular helper (Tfh) cells and B cells are essential for promoting prote

66 induced higher rates of T follicular helper (Tfh) cells and germinal center (GC) B cells from drainin

67 to the hypothesis that T follicular helper (Tfh) cells and germinal centers (GC) play a critical rol

68 r frequency of virus-specific follicular Th (Tfh) cells and increased the Th1 to Tfh ratio.

69 T follicular helper (TFH) cells and infiltrating stromal cells have been show

70 ive replication in both T follicular helper (TFH) cells and non-TFH memory cells.

71 y T cells that suppress T follicular helper (Tfh) cells and the generation of high affinity antibody-

72 f CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of their depende

73 which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists

74 owed more robust Id2 expression than that of TFH cells, and depletion of Id2 via RNA-mediated interfe

75 onal and phenotypic similarities to lymphoid Tfh cells, and hence representing peripheral Tfh (pTfh)

76 e highly dependent on the activity of CD4(+) Tfh cells, and may be constrained by host tolerance cont

77 s share some phenotypic characteristics with TFH cells, and studies that showed that TFH cells are hi

78 s the diversity among IL-21 producing CD4(+) Tfh cells, and the interrelationship between the intesti

79 These circulating Tfh cells are able to help B cells in vitro and to move

80 As Tfh cells are also required for the development of plasm

81 ly, our results indicate that IL-4-producing Tfh cells are central orchestrators of the type 2 immune

82 Differentiation and function of TFH cells are controlled by the master gene BCL6, but it

83 ions has been challenging, as Ag-specific GC Tfh cells are difficult to identify by conventional intr

84 Influenza specific TFH cells are generated in similar numbers in young and

85 with TFH cells, and studies that showed that TFH cells are highly permissive to HIV-1 included TFR ce

86 Although TFH cells are important in anti-viral humoral immunity,

87 ummary, AIM demonstrates that Ag-specific GC Tfh cells are intrinsically stingy producers of cytokine

88 Our data indicate that Tfh cells are largely responsible for switching B cells

89 Thus, our data demonstrate that Tfh cells are precursors of HDM-specific Th2 cells and r

90 Circulating Tfh cells are produced by movement of Tfh cells from lym

91 Th17 and TfH cells are thought to promote tissue inflammation and

92 Moreover, although Tfh cells are uniquely defined by expression of the foll

93 T follicular helper (Tfh) cells are a CD4(+) T cell subset critical for long-

94 T follicular helper (Tfh) cells are a subset of CD4(+) T lymphocytes that pro

95 T follicular helper (Tfh) cells are a subset of T cells carrying the CD4 anti

96 T follicular helper (TFH) cells are essential in the induction of high-affini

97 evidence suggests that T follicular helper (Tfh) cells are the primary producer of IL-4 in the react

98 Follicular helper T cells (TFH cells) are CD4(+) T cells specialized in helping B c

99 dence on BCL6 that led to the recognition of Tfh cells as an independent helper subset and accelerate

100 work identified PD-1(+) follicular helper T (Tfh) cells as an important cellular compartment for vira

101 A reduction of Tfh cell-associated molecules is linked with increased e

102 sized that integrins play a decisive role in Tfh cell biology.

103 for differentiation of T follicular helper (TFH) cells, but not TH1 effectors, elicited by viral inf

104 Altogether, mTOR acts as a central node in Tfh cells by linking immune signals to anabolic metaboli

105 ic germinal center (GC) T follicular helper (Tfh) cells by cytokine production has been particularly

106 Virus-specific Tfh cells can be detected in blood samples from patients

107 Abnormal development of follicular helper T (TFH) cells can induce the GC response to self-antigens,

108 and promotes the induction of follicular Th (TFH) cells, CD4(+) T cells that support B cell affinity

109 lated to that of CD4(+) T follicular helper (TFH) cells, CD8(+) T cell memory precursors and haematop

110 Therapy inhibited excessive accumulation of Tfh cells coexpressing IL-21 and IFN-gamma, and suppress

111 e cytokines showed a significant decrease in Tfh cells compared with in wild-type mice.

112 ession of Aiolos was elevated in Ag-specific TFH cells compared with that observed in non-TFH effecto

113 Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogr

114 Follicular T-helper (Tfh) cells contribute to pathogen-specific antibody resp

115 Genetic depletion of Tfh cells decreased IgE antibody levels and protected mi

116 i) PD-1(hi) circulating T follicular helper (Tfh) cells decreased after rituximab treatment.

117 dies on the mechanisms of induction of GFP(+)Tfh cells demonstrated that they required the intestinal

118 t that deficient activities might impair the TFH cell-dependent control of humoral immunity and might

119 ate cellular responses, but their control of TFH cell-dependent humoral immune responses is unknown.

120 responses during the sensitization phase or Tfh cell depletion prevented Th2 cell-mediated responses

121 IL-21, a Tfh cell-derived cytokine, provides instructional cues f

122 duction, and autoantibodies, indicating that Tfh cell-derived IL-21 is critical for pathological B ce

123 Additionally, Tfh cell-derived IL-4 was required to maintain the Th2 r

124 T-cell homeostasis and negatively regulates TFH cell development and autoimmunity.

125 e sought to assess the role of Breg cells on TFH cell development and function.

126 these studies suggest that requirements for Tfh cell development change in lymphopenia-associated au

127 r 9 and CD40 activation of B cells prevented TFH cell development.

128 responses, but inhibits T follicular helper (TFH) cell development.

129 Following challenge exposure to HDM, Tfh cells differentiated into IL-4 and IL-13 double-prod

130 ions upon viral infection because of reduced Tfh cell differentiation and defective expression of pro

131 icipate in regulation of genes important for Tfh cell differentiation and function.

132 and 2 (mTORC1 and mTORC2) are essential for Tfh cell differentiation and GC reaction under steady st

133 IL-10 influences the balance between Th1 and Tfh cell differentiation and negatively regulates the de

134 LRBA deficiency reflects impaired control of TFH cell differentiation because of profoundly decreased

135 SFB induced PP Tfh cell differentiation by limiting the access of inter

136 ic cells in the outer T zone further augment Tfh cell differentiation by producing membrane and solub

137 cient regulatory T cells suppressed in vitro TFH cell differentiation in a CTLA4-dependent manner.

138 nd knockdown of Etv5 suppresses the enhanced TFH cell differentiation in Cic-deficient CD4(+) T cells

139 Mechanisms underlying Tfh cell differentiation in peripheral and mucosal lymph

140 Activin A's ability to drive TFH cell differentiation in vitro was conserved in non-h

141 Furthermore, Tfh cell differentiation is defective in antibiotic-trea

142 Mechanistically, SOCE controlled Tfr and Tfh cell differentiation through NFAT-mediated IRF4, BAT

143 -6, a transcriptional repressor critical for Tfh cell differentiation, and inhibition of LFA-1 abolis

144 pression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abundance and supp

145 e, the role of miR-31 is restricted to human TFH cell differentiation, reflecting a species specifici

146 y regulating Id3 to restrain germinal center TFH cell differentiation.

147 dentified activin A as a potent regulator of TFH cell differentiation.

148 effects of IL-6 on both Th1/Th2 skewing and Tfh cell differentiation.

149 g that Etv5 is a critical CIC target gene in TFH cell differentiation.

150 lyses included in vitro follicular helper T (TFH) cell differentiation and cTFH/naive B-cell cocultur

151 We propose that ICOS(+)PD-1(+)CXCR3(+) Tfh cells directly contribute to the generation of high-

152 suggest that water-in-oil adjuvants promote Tfh cell-dominated responses by triggering endogenous al

153 le1 TFH cells and influences the function of TFH cells during aberrant germinal center B cell respons

154 cells were required to expand IL-4-committed Tfh cells during the sensitization phase, but did not di

155 IL-21 and IFN-gamma are coexpressed by Tfh cells during viral infections, but transcriptional r

156 lts define unique functions for LFA-1 in the Tfh cell effector program and suggest that integrin acti

157 n mice with viral infections, virus-specific Tfh cells expand and are required to contain the infecti

158 or raptor deletion ameliorates the aberrant TFH cell expansion in mice lacking Def6.

159 helper (TFH) cells, is critical as aberrant TFH cell expansion is associated with autoimmune disease

160 Here we show that Tfh cells expressed a highly active form of leukocyte fu

161 As the GC response evolved, TFH cells extinguished IL-21 production and switched to

162 pted as being important for the induction of Tfh cell fate decision, other molecules may play key rol

163 onal induction of Irf4 expression redirected Tfh cell fate trajectories toward those of Teff.

164 quantified SIV Env-specific IL-21-producing TFH cells for the first time, to our knowledge, in a non

165 young and aged animals during infection, but TFH cells from aged mice exhibit significant differences

166 a) demonstrated a more diverse repertoire of TFH cells from female CKO mice than of those from wild-t

167 lating Tfh cells are produced by movement of Tfh cells from lymph nodes after dendritic cell contact.

168 This diverted Tfh cells from systemic (non-gut) inflamed sites such as

169 ged environment thus impact antigen specific TFH cell function and formation, which contribute to red

170 es, which are known to antagonize peripheral Tfh cell function.

171 entiation, and inhibition of LFA-1 abolished Tfh cell generation and prevented protective humoral imm

172 DCs specifically enhanced the development of Tfh cells, germinal center B cells and antibody response

173 T follicular helper (TFH) cells have been shown to be critically required for

174 ary lymphoid follicles, follicular helper T (TFH) cells have previously been shown to be highly permi

175 However, the degree of Tfh cell heterogeneity and function is not fully underst

176 nd is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN-gamma production and for promotio

177 Similar to CD4(+) T follicular helper (Tfh) cells, IL-21-producing CD8(+) T cells generated in

178 We sought to investigate the roles of TFH cells in allergic immune responses.

179 restingly, OX40 was coexpressed with ICOS on Tfh cells in and around the GC, and ICOS-ICOSL interacti

180 c deletion of ICOS impacted the expansion of TFH cells in B6.Sle1 mice and inhibited the differentiat

181 Here we develop mathematical models of Tfh cells in germinal centers to explicitly define the m

182 ssay identified >10-fold more Ag-specific GC Tfh cells in HIV Env protein-immunized macaques (BG505 S

183 (AIM) methodology to identify Ag-specific GC Tfh cells in human lymphoid tissue.

184 AIM also detected non-Tfh cells in lymphoid tissue.

185 thors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and

186 Thus, TFH cells in the B cell follicle progressively different

187 and reveal an unexpected role of B cells and Tfh cells in the pathogenesis of allergic asthma.

188 These findings suggest a role for Tfh cells in the pathogenesis of human T1D and carry imp

189 lity, restricted expansion of antigen-pulsed Tfh cells in vitro, and possessed a unique gene expressi

190 repertoire of different follicular helper T (Tfh) cells in germinal centers.

191 ted B-cell receptors by follicular helper T (TFH) cells in germinal centres.

192 ntibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction.

193 ytokine secreted by CD4 T follicular helper (Tfh) cells, in belatacept-treated animals.

194 (+) T cells, especially T follicular helper (Tfh) cells, in HIV-infected lymph nodes.

195 o be selective for Treg, Th1, Th2, Th17, and Tfh cells, including CD194 (CCR4)(+)FOXP3(+) Treg and CD

196 Our results suggest that the SIV-specific TFH cells, initially induced by replicating adenovirus-r

197 the impact of HIV antigenemia on B cells and Tfh cell interactions warrants further exploration.

198 by driving differentiation and egress of PP Tfh cells into systemic sites, boosted systemic Tfh cell

199 fector cells, as the biological role of a GC Tfh cell is to provide help to individual B cells within

200 The function of a GC Tfh cell is to selectively help adjacent GC B cells via

201 on, generating balanced responses of Th1 and Tfh cells is important to induce effective cell-mediated

202 CXCR5(+)PD-1(+)ICOS(+)-activated circulating Tfh cells is increased both in children with newly diagn

203 stinal helminth infection, IL-4 derived from Tfh cells is required for IgE class switching and plasma

204 The recently described T follicular helper (Tfh) cell is required for the production of high affinit

205 production of IL-21 by T follicular helper (Tfh) cells is vital in driving the germinal centre react

206 ranscription factor for T follicular helper (TFH) cells, is critical as aberrant TFH cell expansion i

207 A new T-cell subset, follicular helper T (TFH) cells, is specialized in supporting B-cell maturati

208 ed the interaction between MZB cells and pre-TFH cells, leading to PDL1-mediated suppression of TFH c

209 genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6, Tcf7 and Cxcr5.

210 eukin 2 to CD4(+) T cells, thereby enhancing Tfh cell master regulator Bcl-6 in a dendritic cell-depe

211 Human Breg cells control TFH cell maturation, expand follicular regulatory T cell

212 on stimulated human T cells, characterizing TFH cell maturation.

213 Cytokine production by GC Tfh cells may be intrinsically limited in comparison wit

214 GC B cells via cognate interaction; thus, GC Tfh cells may be stingy cytokine producers, fundamentall

215 llicular regulatory T cells, and inhibit the TFH cell-mediated antibody secretion.

216 proliferative response of human preexisting Tfh cells more efficiently than belatacept.

217 lls, leading to PDL1-mediated suppression of TFH cell motility, alteration of TFH cell differentiatio

218 ter contact with follicular dendritic cells, Tfh cells move into the germinal centre and provide help

219 +) T cells resulted in a marked reduction in TFH cell numbers and IgE antibody levels, but type 2 cyt

220 ons between B cells and follicular helper T (Tfh) cells occurring in lymphoid germinal centers.

221 tion expansion of follicular helper T cells (TFH cells) occurs in patients with lupus.

222 found to be polyclonal and related to GFP(-)Tfh cells of Peyer's Patches in TCR repertoire compositi

223 une responses toward antibody production via Tfh cells or inflammation by Teff cells.

224 er, less is known about human virus-specific Tfh cells or their functions during infection.

225 Follicular Th (Tfh) cells orchestrate physiological germinal center (GC

226 ), and positive correlations with numbers of Tfh cells (P = .03) and serum levels of cryoglobulin (P

227 4+CXCR5+interleukin 21+ follicular T-helper (Tfh) cells (P < .01).

228 Tfh cells play a key role in peanut allergy, and the IL-

229 icacy of HIV/SIV vaccine candidates and that TFH cells play a pivotal role in aiding B cell maturatio

230 TFH cells play critical roles in the regulation of IgE a

231 ng of TET2 obviously diminished NaCl-induced Tfh cell polarization in vitro.

232 type I IFN signaling is required for optimal Tfh cell polarization.

233 essive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and

234 ubsets, including similarity between Th1-Th2-Tfh cell populations and Th17 cells, as well as similari

235 the differentiation of T follicular helper (TFH) cell populations.

236 ubpopulation of GFP(+), high IL-21 producing Tfh cells present only in Peyer's Patches.

237 (DCs) are important for T follicular helper (Tfh) cell priming, how this process is regulated in vivo

238 rminal center CD4(+) T follicular helper (GC Tfh) cells problematic.

239 have impeded our understanding of the GC and Tfh-cell processes involved in bnAb generation, includin

240 TFH cells produce high amounts of dopamine and release i

241 Whereas Group A Streptococcus-specific GC Tfh cells produced minimal detectable cytokines by intra

242 T-bet is important for Tfh cell production of IFN-gamma, but not IL-21, and for

243 OX40 deficiency in Tfh cells profoundly impaired the acquisition of germina

244 TFH cell programming by activin A was antagonized by the

245 We found that TFH cells progressed through transcriptionally and funct

246 T follicular helper (Tfh) cells promote affinity maturation of B cells in ger

247 Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival

248 The initial induction of Tfh cell properties occurs within the first few days aft

249 Tfh cells provide both costimulation and stimulatory cyt

250 Follicular CD4(+) Th (Tfh) cells provide B cell help in germinal center reacti

251 by formulating vaccines that modify the Tfr:Tfh cell ratio.

252 ne assays missed 98% of Ag-specific human GC Tfh cells, reflecting the biology of these cells, which

253 riguingly, this suggests that broadening the Tfh cell repertoire by vaccination may speed up the evol

254 ey can be rescued by a large fraction of the Tfh cell repertoire in the germinal center.

255 the Tfh cell response or the breadth of the Tfh cell repertoire markedly facilitates the evolution o

256 ereby modulated antigen presentation and the TFH cell repertoire to contribute to autoimmunity.

257 ce did not generate an excessive primary CD4 TFH cell response nor an enhanced alloantibody reaction.

258 Increasing either the magnitude of the Tfh cell response or the breadth of the Tfh cell reperto

259 sets are well defined, those responsible for Tfh cell responses are still poorly understood.

260 Impairment of Tfh cell responses during the sensitization phase or Tfh

261 a agonist pioglitazone significantly reduced TFH cell responses in female mice while pioglitazone and

262 tionship between the intestinal bacteria and Tfh cell responses in the gut.

263 pathogen-associated molecular patterns, the Tfh cell responses observed were dependent, in part, on

264 orter 1-mediated glucose metabolism promoted Tfh cell responses.

265 ine responses, impaired follicular helper T (TFH) cell responses and reduced numbers of plasma cells.

266 T follicular helper (TFH) cell responses are essential for generation of prot

267 e roles of PPARgamma in follicular helper T (TFH) cell responses regarding gender specificity.

268 In patients with chronic infection, Tfh cells seem to disappear from the blood but are detec

269 TORC2 in T cells exerted distinct effects on Tfh cell signature gene expression, whereas increased mT

270 In contrast to PD-1(+) Tfh cells, SIV-enriched CTLA-4(+)PD-1(-) CD4(+) T cells

271 thermore, formation of memory TH1 and memory TFH cells strongly depended on Tcf1 long isoforms.

272 viously included in the follicular helper T (TFH) cell subset, which consists of cells that are highl

273 n of humoral responses: T follicular helper (Tfh) cells support germinal center formation and provide

274 Follicular helper T (TFH) cells support terminal B-cell differentiation.

275 LRBA-deficient TFH cells supported in vitro antibody production by naiv

276 TFH cells supported the sustained production of IgE anti

277 40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area.

278 uately supported Bcl6 and ICOS expression in TFH cells, Tcf1 long isoforms remained important for sup

279 d phenotype and reduced the diversity of the TFH cell TCR repertoire.

280 ly capturing and presenting more peptides to Tfh cells than other lineages of more specific B cells.

281 in mice, we show that OX40 was expressed on Tfh cells that accumulated at the T/B borders in the whi

282 TfH cells that co-express Th17 markers (CXCR5(+)Th17) en

283 nown to be regulated by follicular helper T (TfH) cells, the mechanism by which B cells initially see

284 The promise of targeting TFH cells therapeutically has been limited by fragmentar

285 peripheral blood counterparts of lymph node Tfh cells to assess the immune response and the influenc

286 However, the contribution of ICOS and TFH cells to autoantibody profiles under pathological co

287 encing was performed using TCR-stimulated GC Tfh cells to identify candidate markers.

288 find that TFR cells are more permissive than TFH cells to R5-tropic HIV-1 ex vivo TFR cells expressed

289 Interleukin-4 high (IL-4(hi)) FL-TFH cells, unlike FL B cells themselves, triggered CXCL1

290 STAT4, phosphorylated in Tfh cells upon infection, is required for expression of

291 Markers of Tfh cells were barely detectable in the peripheral blood

292 del, we demonstrated that Peyer's patch (PP) Tfh cells were essential for gut commensal segmented fil

293 GFP(+)Tfh cells were found to be polyclonal and related to GFP

294 ymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipien

295 A large number of follicular helper T (Tfh) cells were also detected in draining lymph nodes of

296 y impaired formation of follicular helper T (Tfh) cells, which are essential for humoral immunity.

297 of cognate peptides to follicular helper T (Tfh) cells, which provide survival signals to the B cell

298 fic microbiota regulate T follicular helper (Tfh) cells, whose excessive responses can inflict antibo

299 he multiple correlations of SIV Env-specific TFH cells with systemic and mucosal SIV-specific B cell

300 ifying vaccine induction of HIV/SIV-specific TFH cells would greatly benefit vaccine development.