ライフサイエンスコーパス: Tg mice

1 elia of the digestive tract (K14 HPV49 E6/E7-Tg mice).

2 hages in white adipose tissue of wt and AhRR Tg mice.

3 xpression in the airway epithelium of Scnn1b-Tg mice.

4 s remained unchanged in the hearts of female Tg mice.

5 al sensory responses in the barrel cortex of Tg mice.

6 lutamate respiration rates were decreased in TG mice.

7 between AD-tau, CBD-tau, and PSP-tau in non-Tg mice.

8 pon intracerebral inoculation into young APP tg mice.

9 ated in the lung tissue of C57/BL6J-betaENaC-Tg mice.

10 didymal adipose tissue from both wt and AhRR Tg mice.

11 significantly increased in the Col1a1-Menin-Tg mice.

12 , mucus obstruction, and emphysema in Scnn1b-Tg mice.

13 hages following infliximab treatment in hTNF-Tg mice.

14 y to undergo developmental metaplasticity in Tg mice.

15 l administration of bleomycin to WT and STC1 Tg mice.

16 ha(-/-)MR1(-/-), wild-type, and MR1(-/-) non-Tg mice.

17 ith the WT mice and was impaired in the RBP4-Tg mice.

18 d rescued the wound-healing deficiency in KS-TG mice.

19 otentiation, spatial learning, and memory in TG mice.

20 es infection than were DT-treated CLEC4C-DTR-Tg mice.

21 dermal endothelium and hair follicles in KS-TG mice.

22 sufficient to rescue the memory deficits in Tg mice.

23 om db/db mice and normalized in db/dbhnRNP F-Tg mice.

24 ial remodeling and development of AF in CREM-TG mice.

25 ncreased collagen and glycogen deposition in TG mice.

26 on, and the formation of anti-tau Abs in tau-tg mice.

27 irway hyperresponsiveness in juvenile Scnn1b-Tg mice.

28 mediated gene transfer to the brain of P301S-tg mice.

29 tokines in kidneys of cisplatin-treated MIOX-TG mice.

30 compared with mice not fed feces from REG3A-TG mice.

31 uced allergen-induced inflammation in Scnn1b-Tg mice.

32 cits and decreased subsequent plaque load in Tg mice.

33 the CD4(+) population of Grb2(fl/fl) CD4cre(tg) mice.

34 ncreased in lymphocytes of autoimmune ApoA-I(tg) mice.

35 and autoantibodies were also lower in ApoA-I(tg) mice.

36 young and old WT and APP/PS1dE9 transgenic (Tg) mice.

37 scued NKT cell development in IkappaBDeltaN (tg) mice.

38 r behavioral tasks was worse relative to Syn(Tg) mice.

39 female Tsc1 (tg) mice, but not in male Tsc1 (tg) mice.

40 pithelial Na(+) channel (Scnn1b)-transgenic (Tg) mice.

41 r (stg/stg) but not homozygous tottering (tg/tg) mice.

42 rast, mTORC2 signaling was enhanced in Tsc1 (tg) mice.

43 itracer PET imaging in transgenic APPPS1-21 (TG) mice.

44 (ApoA-I(-/-)) and ApoA-I-transgenic (ApoA-I(tg)) mice.

45 nses, and delayed bacterial clearance in SHS-Tg(+) mice.

46 We found that in young Tg mice (1 month), LTP is enhanced at the expense of LTD

47 In Tg mice, 2 different strains of hSOD1 aggregates (denote

48 Nox4 transgene but Cre positive; (2) c-hNox4 Tg mice; (3) angiotensin II (AngII)-infused control mice

49 rease in the incidence of lung metastases in Tg mice (33.3%) compared to WT mice (62.5%).

50 In TNF-Tg mice, a model of inflammatory-erosive arthritis, the

51 oughout the cerebral cortex of tottering (tg/tg) mice, a widely used model of EA2.

52 atal Abeta precursor protein transgenic (APP tg) mice, Abeta deposition emerged in HSCs when cultures

53 oproline, Gly, and Glu) were altered in UCP3 Tg mice across all training and exercise conditions; and

54 n threshold in APPswe;PS1DeltaE9 transgenic (Tg) mice across two different ages.

55 )-transgenic (Tg) mice but not in CLEC4C-DTR-Tg mice after diphtheria toxin (DT) treatment.

56 expression in the muscle and plasma of Glrx TG mice after surgery.

57 hesis were equivalently impaired in Cont and TG mice after TAC.

58 Primary tumors isolated from Tg mice also demonstrated reduced total and mitochondria

59 TWEAK-Tg mice also exhibit adipocyte hypertrophy in the epidid

60 The female Tg mice also failed to develop myocardial hypertrophy.

61 mportantly, T cells from HBZ transgenic (HBZ-Tg) mice also demonstrate enhanced cell proliferation an

62 nse to AD-associated pathology in APP/PS1dE9 Tg mice, an AD mouse model.

63 etention) in old Tg mice compared with young Tg mice and all WT mice.

64 Additionally, saliva collected from TG mice and containing unpurified hNGF was able to signi

65 pharmacologic inhibition of IL-1R in Scnn1b-Tg mice and determined effects on airway epithelial necr

66 used and germ-free mice fed feces from REG3A-TG mice and given DSS developed less-severe forms of col

67 the altered remote memory recall in COMT-Val-tg mice and increased PFC dopamine levels.

68 ccessfully purified from the saliva of these TG mice and its identity was verified.

69 sion was also downregulated in c-rel-/- TCL1-Tg mice and RelA Thr505Ala mutant Emu-Myc mice.

70 reated once with brain extract from aged APP tg mice and the culture medium was continuously suppleme

71 Arthritis was induced in 8-week-old male tg mice and their wild-type (WT) littermates.

72 We then evaluated the responses of Tg mice and their WT littermates to the Food and Drug Ad

73 PGC-1alpha levels were increased by 40% in TG mice and were sustained following TAC.

74 ssues from scrapie-infected "anchorless PrP" Tg mice and wild type mice to determine the contribution

75 ridden during replication of sheep prions in Tg mice and, in the case of residue 96, deer.

76 itional MIOX-overexpressing transgenic (MIOX-TG) mice and MIOX-knockout (MIOX(-/-)) mice with tubule-

77 ses in the barrel cortex of aged transgenic (Tg) mice and of age-matched non-transgenic littermate co

78 -related mutant human APP (hAPP) transgenic (Tg) mice and patient brains.

79 on, the injured retinas of GAPDH transgenic (Tg) mice and wild-type (WT) littermates were analyzed.

80 genic (Club cell 10-kDa protein [CC10]-IL-13 Tg) mice and wild-type littermates were used in this stu

81 inducible overexpression of IL-13 (CC10-Il13(Tg) mice) and is overexpressed by esophageal eosinophils

82 e-brain uptake of (18)F-GE180 in both WT and Tg mice, and a significant increase in whole-brain uptak

83 pressed in ischemic muscles and EC from Glrx TG mice, and exogenous Wnt5a induced sFlt expression and

84 ce, cardiac-specific SIRT2 transgenic (SIRT2-Tg) mice, and their respective littermates (8 to approxi

85 fold in the bone tissues of GILZ transgenic (Tg) mice, and this increase is coupled with a significan

86 ent tau strains occurs in nontransgenic (non-Tg) mice, and to investigate whether there are strain-sp

87 ompared with alpha-synuclein transgenic (Syn(Tg)) mice, animals double transgenic for human alpha-syn

88 ndent dentin mineralization defects in Trps1-Tg mice are a result of downregulation of a group of pro

89 The LFOs in tg/tg mice are mediated in part by neuronal activity as tet

90 Tsc1 (tg) mice are more tolerant to exhaustive exercises and l

91 whereas Sike-overexpressing transgenic (Sike-TG) mice are protected from hypertrophic stimuli.

92 the human GLUT4 promoter (i.e., transgenic [TG] mice) are resistant to obesity-induced insulin resis

93 Using the CD4C/HIV-1(Nef) transgenic (Tg) mice as a model, we report that HIV-1 Nef causes dep

94 iac function in 2-month-old male transgenic (Tg) mice as evidenced by decreased ejection fraction, st

95 ted, aggregated tau in brain tissue of P301S-tg mice, associated with a decrease in detergent-soluble

96 ion in glucose tolerance (AUC, +118% vs. non-Tg mice at 14 mo).

97 slocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX(-/-) mice.

98 Lung metastases were found in 75% of Sulf1-Tg mice but not in wild-type mice.

99 coded mitochondrial enzymes was decreased in TG mice but that mitochondrial number, size, and fatty a

100 -diphtheria toxin receptor (DTR)-transgenic (Tg) mice but not in CLEC4C-DTR-Tg mice after diphtheria

101 span increased significantly in female Tsc1 (tg) mice, but not in male Tsc1 (tg) mice.

102 improved synaptic and cognitive function in TG mice by 2-AG signaling, which upregulates miR-188-3p

103 induced in another set of control and hREG3A-TG mice by administration of trinitrobenzene sulfonic ac

104 le protects from EAE in DRB1*0301.DQ6 double-Tg mice by producing anti-inflammatory IFN-gamma.

105 ized" model of MS induced in HLA-transgenic (Tg) mice by human oligodendrocyte-specific protein (OSP)

106 ng between 0.035 and 0.11 Hz, the LFOs in tg/tg mice can spontaneously develop very high power, refer

107 ressed only in cardiomyocytes in transgenic (TG) mice, causes desmin-related cardiomyopathy, a protei

108 previously found that aging A53T transgenic (Tg) mice closely model PD-like ENS aSyn pathology, makin

109 d patterns of aberrant PAC in stg/stg and tg/tg mice compared to +/+ and stg/+ mice.

110 ked heterogeneous lung function in beta-ENaC-Tg mice compared to wild-type littermate controls; ident

111 capacity were significantly reduced in TWEAK-Tg mice compared with controls.

112 8)F-GE180 (peak-uptake and retention) in old Tg mice compared with young Tg mice and all WT mice.

113 and higher in the RBP4-overexpressing (RBP4-Tg) mice compared with BP in the wild-type (WT) litterma

114 in the interictal EEG of both stg/stg and tg/tg mice, compared to +/+ and stg/+ mice.

115 he pulmonary phenotypes of C57/BL6J-betaENaC-Tg mice, consistent with the characteristics of human CO

116 Compared with WT littermates, CD2-Gata3 Tg mice contained increased numbers of ILC2, which expre

117 We have engineered double transgenic (TG) mice containing the human renin gene with either Hap

118 ted to the catastrophic loss of insulin, hep-tg mice continued to have significantly lower blood gluc

119 a pharmacological approach by generating 3 x Tg mice deficient for 5LO and administering 3 x Tg mice

120 H-2(k/b) double-Tg mice deficient of all endogenous Tcra genes, a defici

121 Col1a1-Trps1 transgenic (Trps1-Tg) mice demonstrate defective dentin secretion and mine

122 After hind limb ischemia surgery Glrx TG mice demonstrated impaired blood flow recovery, assoc

123 ted to a controlled cortical impact, SynCav1 Tg mice demonstrated preserved hippocampus-dependent fea

124 TG mice demonstrated significant age-associated increase

125 Regardless of treatment, TG mice demonstrated significantly lower (18)F-FDG uptak

126 id and bisretinoid levels are normal in RBP4-Tg mice, demonstrating that a retinoid-independent mecha

127 leukemia (T-ALL) occurred in 100% of Sur-TCR-Tg mice derived from 3 separate founders.

128 In these 208 TDP-43 Tg mice, detergent-insoluble 208 TDP-43 CTF was present

129 at transgenic mice overexpressing RBP4 (RBP4-Tg mice) develop progressive retinal degeneration, chara

130 CC10-IL-13 Tg mice developed considerable pulmonary tissue remodeli

131 Vpr-Tg mice developed increased liver triglyceride content a

132 etion of Bacteroidetes (Prevotellaceae); the TG mice developed less-severe colitis following administ

133 A higher proportion of NS5A Tg mice developed liver tumors (39%) than mice that did

134 As opposed to WT mice, BeO-exposed HLA-DP2 Tg mice developed mononuclear infiltrates in a peribronc

135 ANA-12-treated Tg mice developed more gut aSyn aggregation as well as c

136 REG3A TG mice developed only mild colonic inflammation after e

137 However, HFD-fed TG mice developed prominent perivenous steatosis with pe

138 We found that Tg and KO/Tg mice developed significantly smaller tumors than KO a

139 rast to our expectations, Grb2(fl/fl) CD4cre(tg) mice developed a milder form of EAE.

140 initial offset in LTP/LTD threshold in young Tg mice did not accompany changes in the LTP/LTD inducti

141 Unexpectedly, T-bet-tg mice died 2 to 3 weeks after infection due to failure

142 ion of collagen-induced arthritis (CIA), tau-tg mice displayed an increased incidence and an earlier

143 Lungs of STC1 Tg mice displayed none of the above changes.

144 We found that LGP2 TG mice displayed significantly reduced inflammatory med

145 In contrast, Diap3-Tg mice displayed worse thresholds than controls.

146 ked mucus obstruction and Th2 responses, SHS-Tg(+) mice displayed a dramatic suppression of these res

147 The A-Tg+ and A-Tg++ mice displayed severe enamel defects in spite of th

148 romote retinal neurodegeneration, since RBP4-Tg mice do not have coincident retinal vascular patholog

149 nnel function in either wild-type (WT) or tg/tg mice does not induce the high-power state.

150 atives in skeletal muscle and plasma of UCP3 Tg mice (e.g., Asp, Glu, Lys, Tyr, Ser, Met) were signif

151 pletion of Treg cells in BeO-exposed HLA-DP2 Tg mice exacerbated lung inflammation and enhanced granu

152 nthesizing enzyme SMP30 in C57/BL6J-betaENaC-Tg mice, exaggerated pulmonary phenotypes.

153 Already at steady-state conditions, tau-tg mice exhibit peripheral immune activation that is man

154 The female Tsc1 (tg) mice exhibit a higher fat to lean mass ratio at adva

155 SynCav1 Tg mice exhibited increased hippocampal expression of Ca

156 Furthermore, lungs from Tg mice exhibited nearly a 15-fold decrease in the avera

157 Whereas the FA-Tg(+) mice exhibited marked mucus obstruction and Th2 re

158 Tg+ mice exhibited restoration of Fut7 gene expression a

159 AhRR Tg mice express significantly higher levels of AhRR comp

160 A-Tg mice expressed A-antigen on vascular endothelium and

161 Similar to human placenta, placentas of Tg mice expressed APOL1.

162 We demonstrated that Tg mice expressing AID in the skin spontaneously develop

163 maintained in deer following passage through Tg mice expressing cognate PrP, and the influences of na

164 Both patients and Tg mice expressing mutant human SOD1 (hSOD1) develop agg

165 of horses to prions, we produced transgenic (Tg) mice expressing cognate PrP(C) Although disease tran

166 could be shortened, we generated transgenic (Tg) mice expressing guinea pig prion protein (GPPrP).

167 We generated transgenic (Tg) mice expressing human PrP with the V129 polymorphism

168 Furthermore, transgenic (TG) mice expressing lncRNA-BGL3 were generated.

169 enhancement of cardiac function, transgenic (TG) mice expressing non-phosphorylatable TnI protein kin

170 Moreover, we found that in bones of NO66-TG mice, expression of Igf1, Igf1 receptor (Igf1r), runt

171 by PND22, the SHS-exposed Scnn1b-Tg(+) (SHS-Tg(+)) mice failed to resolve these infections.

172 In hFcgammaRIIB-transgenic (Tg) mice, FcgammaRIIB-blocking antibodies effectively de

173 after the HCFD (6%); only 9% of Tlr4-/- NS5A Tg mice fed HCFD developed liver tumors.

174 ase (eNOS) were significantly greater in the Tg mice fed NC than in WT mice, as they are during pregn

175 Livers from NS5A Tg mice fed the HCFD had increased levels of TLR4, NANOG

176 in hippocampus and cortex was highest in old Tg mice followed by old WT, young Tg, and finally young

177 nction was also equally impaired in Cont and TG mice following TAC, as demonstrated by decreased +dP/

178 al microbiota from REG3A-TG mice protect non-TG mice from induction of colitis.

179 80 metabolites accurately discriminated UCP3 Tg mice from WT when modeled within a specific exercise

180 etal muscle-specific TWEAK-transgenic (TWEAK-Tg) mice gain increased body weight ( approximately 16%)

181 More importantly, LGP2 TG mice had a significant survival advantage.

182 Mmp20(+/+)Tg mice had decreased enamel organ cadherin levels compa

183 or neither developing in MR1(+/+) Valpha19i-Tg mice had disparate cytokine profiles in response to R

184 wild-type (WT) mice, cisplatin-treated MIOX-TG mice had even greater increases in urea, creatinine,

185 rations were similar to wild-type mice, APOM Tg mice had larger plasma HDLs enriched in apoM, cholest

186 ata3-tg mice remained resistant, while Gata3-tg mice had lower IFN-gamma and higher IL-4 production w

187 Fecal samples from REG3A-TG mice had lower levels of ROS than feces from control

188 well as constipation, whereas FTY720-treated Tg mice had reduced aSyn aggregation and less constipati

189 e Mmp20 expression and showed that Mmp20(+/+)Tg mice had soft enamel.

190 Similarly, MIOX-TG mice had the highest and MIOX(-/-) mice had the lowes

191 ver, in contrast with FA-Tg(+) mice, the SHS-Tg(+) mice had pronounced epithelial necrosis, alveolar

192 Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time

193 In addition, dentin of double-Tg mice has an irregular mineralization pattern characte

194 enic (Tg) mice uncovered that the Pvalb/Gad1 Tg mice have pronounced sensorimotor gating deficits, in

195 Tsc1 (tg) mice have less fibrosis and inflammation in aged as

196 al microbiota occurred after a few months in TG mice heterozygous for REG3A that harbored a wild-type

197 ct metabolites were altered in liver of UCP3 Tg mice highlights that changes in muscle UCP3 activity

198 s revealed in (DRB1*1501xDQB1*0602)F1 double-Tg mice immunized with hOSP(142-161) peptide, where the

199 on was markedly reduced in apo(a)tg and Lp(a)tg mice in both peritonitis and vascular injury inflamma

200 kines, CXCL1/CXCL2, were suppressed in apo(a)tg mice in the abdominal aortic aneurysm model.

201 the axons of the glial lamina of aged E50K(-tg) mice in vivo.

202 -Trps1;Col1a1-Dspp double transgenic (double-Tg) mice in which Dspp was restored in odontoblasts over

203 jury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus fo

204 We believe that APRIL Tg mice infected by Helicobacter species may represent a

205 bacterial models, we found that SiglecH-DTR-Tg mice injected with DT had altered bacterial uptake an

206 ) was modeled by transplanting hearts from A-Tg mice into sensitized or nonsensitized WT mice.

207 sphorylation (oxphos) genes was prevented in TG mice, mitochondrial function and ATP synthesis were e

208 iation potential rendered Grb2(fl/fl) CD4cre(tg) mice more prone to inflammatory diseases, we used th

209 (+/+) and MR1(-/-) TCR Valpha19i-transgenic (Tg) mice, MR1 expression resulted in significantly incre

210 In TICs from NS5A Tg mice, NANOG and pSTAT3 directly interact to activate

211 In this study, we found that aged Tg mice of both sexes expressing human tau proteins harb

212 ersus WT mice, which were improved in ECIRS1 TG mice on normal chow or HF diet.

213 susceptibility were accurately reproduced in Tg mice or cell-free systems.

214 Here we show that Tg mice overexpressing mutant human aSyn develop ENS pat

215 Here, we generated transgenic (TG) mice overexpressing a flag-tagged NO66 transgene dri

216 Moreover, transgenic (Tg) mice overexpressing anchorless PrP(C) develop a spon

217 a in liver disease, we subjected transgenic (Tg) mice overexpressing CREMalpha under control of the C

218 tected a significant age-related increase in TG mice (P < 0.0001) but did not detect the treatment-in

219 significantly decreased in fat-1 transgenic (TG) mice (P < 0.001), which exhibited decreased cyclooxy

220 f CD4(+) T cells occurred in H-2(k/k) double-Tg mice presenting high levels of the I-E(k)-restricted

221 letion was less extensive in H-2(k/b) double-Tg mice presenting lower levels of the epitope, and some

222 de cells from L. major-infected BALB/c-CXCR3(Tg) mice produced more interleukin-4 (IL-4) and IL-10 an

223 Fecal microbiota from REG3A-TG mice protect non-TG mice from induction of colitis.

224 Wild-type (WT) and TG mice received vehicle or BACE inhibitor (60 mg/kg) st

225 The Tg mice receiving AngII exhibited more advanced cardiac

226 Following ischemic stroke, ubqln Tg mice recovered motor function more rapidly than did t

227 Long term oral FTY720 in Tg mice reduced ENS aSyn aggregation and constipation, e

228 (2+) channels, known to be upregulated in tg/tg mice, reduces the high-power state.

229 Obese Tg mice remained insulin sensitive, had increased glucos

230 In contrast, Gata3-tg mice remained resistant, while Gata3-tg mice had lowe

231 The data from young and old Tg mice revealed FTY720-associated neuroprotection and r

232 Depletion of NK cells from IL-15 TG mice revealed that these cells were important for pro

233 Sulf1-Tg mice show a higher incidence of large and multifocal

234 let-7 transgenic (let-7-Tg) mice show features of nonproliferative DR, including

235 Although hPER3-P415A/H417R-Tg mice showed a mild depression-like phenotype, Per3 kn

236 C57/BL6J-betaENaC-Tg mice showed higher survival rates and key pulmonary a

237 Likewise, in vivo studies in GFAP-Tat tg mice showed increased autophagosome accumulation in n

238 In contrast, the GAPDH Tg mice showed resistance to all of these injury-induced

239 art-specific phosphodiesterase 2-transgenic (TG) mice showed a marked reduction in resting and in max

240 ls in draining lymph nodes from BALB/c-CXCR3(Tg) mice showed enhanced Th2 and reduced Th1 cell accumu

241 n level of transgenes, while the D-Tg+ and D-Tg++ mice showed minor to mild enamel defects, indicatin

242 were attenuated in db/dbhnRNP F-transgenic (Tg) mice specifically overexpressing hnRNP F in their RP

243 Moreover, the male Tg mice spontaneously developed myocardial hypertrophy (

244 LB/c Rag2(-/-)Il2rg(-/-)Sirpa(NOD)Alb-uPA(tg/tg) mice, stably engrafted with human hepatocytes (HUHEP

245 In M20 Tg mice, starting at 4 mo after IM injection, we observe

246 f filtered air (FA)-exposed Scnn1b-Tg(+) (FA-Tg(+)) mice successfully cleared spontaneous bacterial i

247 kinase B (Akt) and H3K36me3 in bones of NO66-TG mice, suggesting an inverse correlation between NO66

248 an the hindbrain across the life span of the Tg mice, suggesting that sortilin, at least in part, inh

249 ehydrogenase activity were increased in UCP3 Tg mice, suggestive of a shift in tissue NADH/NAD(+) rat

250 ults demonstrate that expression of GPPrP in Tg mice supports the rapid propagation of BSE and vCJD p

251 Increased ApoA-I in ApoA-I(tg) mice suppressed CD4(+) T and B cell activation witho

252 production became significantly less in the Tg mice than in WT mice.

253 nificantly higher in the lungs of CC10-IL-13 Tg mice than wild-type animals.

254 is article, we show that tau-transgenic (tau-tg) mice that develop neurodegenerative disease characte

255 atment inhibits cognitive decline in APP/PS1 Tg mice, the critical molecules for amyloid precursor pr

256 However, in Tg mice, the magnitudes of LTP and LTD stayed constant a

257 However, in contrast with FA-Tg(+) mice, the SHS-Tg(+) mice had pronounced epithelial

258 Here, we utilized betaENaC-transgenic (Tg) mice, the previously established mouse model of seve

259 146a-deficient mice with 2D2 T cell receptor-Tg mice to generate 2D2 CD4 T cells that are deficient i

260 stions, we exposed Scnn1b transgenic (Scnn1b-Tg(+)) mice to SHS from postnatal day (PND) 3-21 and lun

261 Accordingly, Tg-C73A mice and non-Tg mice treated with dasatinib exhibited improved behavi

262 hTNF-Tg mice treated with infliximab demonstrated significant

263 havioral characterization of our transgenic (Tg) mice uncovered that the Pvalb/Gad1 Tg mice have pron

264 ns and some primates, we created transgenic (Tg) mice using the promoter of nephrin-encoding Nphs1 to

265 ve elimination of KCs from the liver in CETP Tg mice virtually abolished hepatic CETP expression and

266 s into different brain regions of female non-Tg mice, we demonstrated the induction and propagation o

267 ng Trps1-Tg and Col1a1-Dspp transgenic (Dspp-Tg) mice, we generated Col1a1-Trps1;Col1a1-Dspp double t

268 urthermore, fasting acyl carnitines in obese TG mice were decreased, indicating that increased GLUT4-

269 When the Tg mice were fed chow containing IC3, plasma prolactin c

270 When the Tg mice were fed normal chow (NC), plasma prolactin conc

271 However, we found that K14 HPV49 E6/E7-Tg mice were highly susceptible to upper digestive tract

272 Wild-type (WT) and APRIL Tg mice were infected with Helicobacter felis and Helico

273 fore AF onset) and old (TGo, after AF onset) TG mice were investigated by mRNA microarray profiling i

274 Females from both wt and AhRR Tg mice were less sensitive than male mice to acute toxi

275 Furthermore we found that male AhRR Tg mice were protected from high-dose TCDD-induced letha

276 n in response to ATII, whereas PGC-1alpha EC TG mice were protected.

277 he plasminogen-deficient background and Lp(a)tg mice were resistant to inhibition of macrophage recru

278 in house dust mite-driven asthma, CD2-Gata3 Tg mice were significantly more susceptible to AAI than

279 The Tg mice were viable and did not show any developmental o

280 A-transgenic (A-Tg) mice were assessed for A-antigen expression by histo

281 nd that T cell numbers in Grb2(fl/fl) CD4cre(tg) mice were normal in the thymus and were only slightl

282 Human TNF transgenic (hTNF-Tg) mice were treated with infliximab after development

283 d when CTF expression was suppressed in aged Tg mice, which ameliorated neuron loss in the DG despite

284 beta2M(-/-) Sur-TCR-Tg mice, which cannot effectively present survivin pepti

285 ng the VE-cadherin promoter to create ECIRS1 TG mice, which elevated pAkt activation and expressions

286 ed hepatocyte-specific apoM transgenic (APOM Tg) mice, which had an approximately 3-5-fold increase i

287 In MMTV-cNeu(Tg/Tg) mice, which model HER2/Neu-amplified breast cancer,

288 mice deficient for 5LO and administering 3 x Tg mice with a 5LO inhibitor.

289 Treatment of PELP1 Tg mice with a KDM1 inhibitor significantly reduced PELP

290 Treatments of C57/BL6J-betaENaC-Tg mice with a serine protease inhibitor ONO-3403, a der

291 TG mice with Hap -6A and -6G were treated with and witho

292 ncreased blood pressure and redox markers in TG mice with Hap-6A of the hAGT gene.

293 Treatment of adult Scnn1b-Tg mice with the IL-1R antagonist anakinra had protectiv

294 Using transgenic (Tg) mice with a neuronal promoter driving expression of

295 tor defect, but not homozygous tottering (tg/tg) mice with a P/Q type calcium channel mutation.

296 ardiac performance, we generated transgenic (TG) mice with cardiomyocyte-directed overexpression of B

297 ic inflammation in Scnn1b-transgenic (Scnn1b-Tg) mice with CF-like lung disease.

298 We used CD2-Gata3 transgenic (Tg) mice with enforced Gata3 expression driven by the CD

299 Here, we developed transgenic (Tg) mice with forebrain Camk2a-controlled doxycycline-su

300 let transcriptome was greatly altered in hep-tg mice, with >2,000 genes differentially expressed vers