ライフサイエンスコーパス: Tg mouse

1 D4(+) TCR transgenic mouse model system (ABM-tg mouse).

2 T cell deficiency observed in IkappaBDeltaN (tg) mouse.

3 eurons in the nigra of A53T transgenic (A53T-Tg) mouse.

4 a model of AD, the APPswe/PS1DE9 transgenic (Tg) mouse.

5 vivo, we generated an aP2-WISP2 transgenic (Tg) mouse.

6 b CD4 hybridoma were cloned to produce a TCR Tg mouse, 2-2-3.

7 A triple transgenic (Tg) mouse (3xTg-AD) was reported to develop Abeta plaque

8 surface expression of gp96 in a transgenic (Tg) mouse (96tm-Tg) conferred hyperresponsiveness to LPS

9 , oxidation, and covalently linked dimers in tg mouse Abeta provides an explanation for the differenc

10 cnn1b gene, betaENaC protein) in transgenic (Tg) mouse airways dehydrates mucosal surfaces, producing

11 Dystrophic neurites in plaques of PDAPP tg mouse and AD formed synapses and contained many dense

12 orm of nitric oxide synthase (iNOS) from VCP TG mouse and by pharmacological inhibition of iNOS in is

13 that repression of Spry2 expression in TCL1-tg mouse and human B-cell lymphomas and cell lines is as

14 We used the Scnn1b-Tg mouse as a model of CF lung disease and determined ef

15 as significantly increased in the db/db eNOS-Tg mouse, as serum alanine aminotransaminase (ALT) level

16 n isoforms in BASE strain-infected humanized Tg mouse brains are different from those from the origin

17 no-associated virus particles in mutant hAPP Tg mouse brains decreases synaptic Abeta levels and amel

18 Similar to AD, neuritic plaques in PDAPP tg mouse contained a dense amyloid core surrounded by an

19 physiological environment of the BDC-2.5 TCR-Tg mouse, despite being apparently "naive" in surface ph

20 The transgenic Myo-Tg mouse develops hypertrophy and HF as a result of over

21 In intact heart study, the P2X4 receptor TG mouse exhibited significantly elevated basal cardiac

22 To address this issue, we developed a Tg mouse expressing a single-chain, membrane-bound anti-

23 f basal autophagy, we generated an inducible Tg mouse expressing autophagy-related 7 (Atg7), a critic

24 A transgenic (Tg) mouse expressing human IL-15 was generated to define

25 ite of Ag deposition acts to protect the TCR-Tg mouse from EAE.

26 restoring the functional properties of LCAT-Tg mouse HDL and promoting the hepatic uptake of HDL-CE.

27 and regenerative pathways and found that the Tg mouse heart undergoes myocyte loss and regeneration,

28 The tamoxifen-treated TG mouse hearts also exhibited better functional recover

29 BC levels in the mitochondrial fractions of TG mouse hearts but no increase in alpha BC levels in an

30 t ischemia followed by reperfusion, the MKK6 TG mouse hearts exhibited significantly better functiona

31 muscles from the right ventricle of NTG and TG mouse hearts expressing ssTnI and measured isometric

32 age, tetracycline-transactivating factor/V1A-TG mouse hearts had reduced cardiac function, cardiac hy

33 n TG than non-transgenic (NTG) mouse hearts, TG mouse hearts were morphologically and functionally si

34 apillary muscle fibers from non-TG (NTG) and TG mouse hearts were used to measure tension, ATPase act

35 sible mechanisms of cardioprotection in MKK6 TG mouse hearts.

36 to their beta-TM counterparts in transgenic (TG) mouse hearts causes a depression in both +dP/dt and

37 cardiac fibre bundles from three transgenic (TG) mouse hearts in which 50, 92 and 6 % of the native c

38 were made in muscle fibers from transgenic (TG) mouse hearts that expressed a mutant alpha-Tm (Tm(H2

39 these roles, we have developed a transgenic (Tg) mouse in which all B lymphocytes produce only the me

40 cts, we generated Mecp2(WT_EGFP) transgenic (TG) mouse in which MeCP2 (endogenous plus TG) is mildly

41 issue, we generated a TGF-beta1-transgenic (Tg) mouse in which TGF-beta is linked to the IL-2 promot

42 nd beta-cell proliferation, were enhanced in TG mouse islets, without changes in Akt phosphorylation

43 iate their rapid degradation, was reduced in TG mouse islets.

44 We have generated a transgenic (Tg) mouse [keratin-14 (K14)-survivin] with skin expressi

45 Here, we developed a new TG mouse line in which the -800-base pair Rosa26 promote

46 A TG mouse line secreting high levels of hNGF protein in i

47 ed with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau misloca

48 Foxa proteins, we used the T-77 transgenic (TG) mouse line in which the -3-kb transthyretin (TTR) pr

49 We previously developed a transgenic (TG) mouse line in which the ubiquitous Rosa26 promoter w

50 and its function, we generated a transgenic (TG) mouse line that expressed a recombinant chimeric cTn

51 A-DRA-IE alpha was not detectable in several Tg mouse lines by flow cytometric analysis.

52 These 2 Tg mouse lines provide relatively rapid models to study

53 to tumorigenesis in vivo, we have generated Tg mouse lines that express human CR-1 under the transcr

54 anges were detected in the eyes of the other Tg mouse lines.

55 Transgenic (Tg) mouse lines (Dct-Survivin) were generated with melan

56 ission of human prions to 18 new transgenic (Tg) mouse lines expressing 8 unique chimeric human/mouse

57 Transgenic (Tg) mouse lines that express chimeric mouse-human prion

58 Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical

59 first intron construct, and four transgenic (TG) mouse lines were established.

60 Transgenic (TG) mouse lines were generated in which the luciferase r

61 thways relevant to the development of Scnn1b-Tg mouse lung pathology.

62 In this study, we used the MMTV-Neu-Tg mouse mammary tumor model to identify potential new s

63 is also observed in a number of transgenic (Tg) mouse mammary tumors.

64 gland-specific PELP1-expressing transgenic (Tg) mouse (MMTVrtTA-TetOPELP1).

65 isease manifestations in both the A53TalphaS Tg mouse model and the adeno-associated virus-transduced

66 Thus, myocytes from the alpha-MyHC TG mouse model display many morphological and functional

67 ments led to spatial memory improvement in a Tg mouse model of AD Alzheimer disease .

68 erved as early as 2 months of age in the 3 x Tg mouse model of AD, whereas no such induction of LRP1B

69 help explain the LV dysfunction seen in this TG mouse model of FHC.

70 ly in the disease pathogenesis in the YAC128 Tg mouse model strengthens the argument for a causative

71 In this study, we generated an AT-1 Tg mouse model that selectively overexpresses human AT-1

72 n maintaining CD8(+) T cell homeostasis in a Tg mouse model that specifically overexpresses a dominan

73 These results indicate that in a tg mouse model, overexpression of either wild-type hsp27

74 study, a constitutive TSC1 transgenic (Tsc1 (tg) ) mouse model was generated and characterized.

75 y roles of Ser282 we generated a transgenic (TG) mouse model expressing cardiac myosin binding protei

76 oncentration were performed in a transgenic (Tg) mouse model expressing human CETP.

77 igenesis in vivo using the established HPV16(tg) mouse model for cervical squamous cell carcinoma.

78 ically evaluated by generating a transgenic (TG) mouse model in which the SLN to sarco(endoplasmic)re

79 KT cell function, we generated a transgenic (Tg) mouse model in which thymocytes and peripheral T cel

80 idespread CNS delivery in an APP-transgenic (tg) mouse model of AD.

81 T mutant human alphaS transgenic (A53TalphaS Tg) mouse model of alpha-synucleinopathy, we show that d

82 y in tauopathies, we generated a transgenic (Tg) mouse model of astrocytic tau pathology by expressin

83 wing a tolerogenic signal, a TCR-transgenic (Tg) mouse model of collagen-induced arthritis was develo

84 human P301S tau-expressing transgenic (P301S-tg) mouse model of frontotemporal dementia/tauopathy.

85 We created a transgenic (Tg) mouse model of lifelong excess synaptic Glu release

86 The human TNF transgenic (hTNF-Tg) mouse model of RA displays a chronic, progressive di

87 h a knock-in (KI) and a myogenic transgenic (TG) mouse model of SBMA.

88 We recently generated a transgenic (Tg) mouse model of tau pathology in astrocytes by expres

89 pools in our new inducible rNLS8 transgenic (Tg) mouse model of TDP-43 proteinopathy and found striki

90 to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.

91 Using a transgenic (Tg) mouse model overexpressing Sulf1 (Sulf1-Tg), we asse

92 lymphocytes (iIELs) using the 2C transgenic (Tg) mouse model specific for a peptide antigen (Ag) pres

93 cytes (IELs), we utilized the 2C transgenic (Tg) mouse model specific for a peptide self Ag presented

94 demonstrate this, we developed a transgenic (TG) mouse model that exhibits an inappropriate overexpre

95 re regulated, we generated an Ig transgenic (Tg) mouse model that expresses an Ig that binds alpha3(I

96 ept was recently challenged by a transgenic (Tg) mouse model that lacks circulating antibody but stil

97 ed this question using a H chain transgenic (Tg) mouse model that lacks secreted Ig (mIg), and thus d

98 Recently, we developed a transgenic (Tg) mouse model that overexpress myotrophin (a 12-kDa pr

99 We used a Tlr7 transgenic (tg) mouse model to investigate the cellular and molecula

100 ific human CysLT2R (EC-hCysLT2R) transgenic (TG) mouse model using the Tie2 promoter/enhancer.

101 cific TCR/hLa neo-self-Ag double-transgenic (Tg) mouse model was developed and used to investigate ce

102 (T1D), we previously designed a transgenic (tg) mouse model where the viral nucleoprotein (NP) gene

103 ion (I/R) injury, we generated a transgenic (TG) mouse model with cardiac-specific overexpression of

104 We have generated a SALL4 transgenic (SALL4B Tg) mouse model with pre-leukemic MDS-like symptoms that

105 ts of ss-3 type HPV49 in a novel transgenic (Tg) mouse model, using a cytokeratin K14 promoter to dri

106 Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells fro

107 nditional mammary gland-specific transgenic (TG) mouse model, we show that miR-22 enhances mammary gl

108 alpha-syn in the mThy1-alpha-syn transgenic (tg) mouse model, which resembles the striato-nigral and

109 uced in cardiac myocytes using a transgenic (TG) mouse model.

110 of the HY-T-cell receptor (TCR) transgenic (Tg) mouse model.

111 nt diabetes mellitus (IDDM) in a transgenic (tg) mouse model.

112 took advantage of the OT-II TCR-transgenic (Tg) mouse model.

113 We generated a transgenic (Tg)-mouse model expressing a dominant negative-(DN)-RARa

114 c potential, with structural and transgenic (Tg) mouse modeling and cell-free prion amplification.

115 Using HCV Tg mouse models and patients with HCC, we isolated CD133

116 ctivity, and might be useful in the study of Tg mouse models for other neurodegenerative illnesses.

117 Rosa26-FoxM1b mice with both TRAMP and LADY TG mouse models of prostate cancer.

118 While several transgenic (Tg) mouse models have recapitulated aspects of AD-like A

119 Transgenic (Tg) mouse models of Alzheimer's disease have served as v

120 Transgenic (Tg) mouse models of autoimmunity have been used to expre

121 HTT) isolated from the brains of transgenic (Tg) mouse models of HD and humans with HD using an amylo

122 intraventricularly in newborn AD transgenic (tg) mouse models of SPs (PDAPP(+)/(-)), both SPs and NFT

123 Transgenic (Tg) mouse models overexpressing amyloid precursor protei

124 storically used first-generation transgenic (Tg) mouse models that overexpress proteins linked to fam

125 ifficulties with hapten-specific transgenic (Tg) mouse models that yield relatively large numbers of

126 T-cell receptor transgenic (TCR-tg) mouse models with direct CD4 alloreactivity will hel

127 (M83) and wild-type (M20) alphaS transgenic (Tg) mouse models.

128 Male TG mouse myocytes had higher [Ca(2+)](i) after 30 minute

129 d [Ca2+]i and [Na+]i in isolated transgenic (TG) mouse myocytes overexpressing the Na+-Ca2+ exchanger

130 This TCR-tg mouse, named 4C, was selected for reactivity against

131 amyloid precursor protein (hAPP) transgenic (Tg) mouse neurons.

132 previously characterized a novel transgenic (Tg) mouse on the IL-2Rbeta-/- genetic background (Tg-/-

133 and protein were detected in all transgenic (TG) mouse ovaries at levels far higher than in other tis

134 in solubility between human AD and the APP23 tg mouse plaques.

135 Thus, our double-Tg mouse provides a novel model in which to study epista

136 Thus double Tg mouse provides a novel model to study epistatic inter

137 This Tg mouse provides a valuable tool to study mechanisms by

138 the target tissue, which may explain the GAD-tg mouse's usual disease incidence.

139 human pregnancy, the mouse (including CYP3A4-tg mouse) seems to be an excellent animal model to deter

140 and clinical disease in the BAFF-Tg and non-Tg mouse sets.

141 , hypertrophic fibres from Mtn(-/-)/Errgamma(Tg/+) mouse showed satellite cell deficit which unexpect

142 of cystathionine gamma-lyase (alpha-MHC-CGL-Tg mouse) significantly limits the extent of injury.

143 ne diseases, we have generated a transgenic (Tg) mouse strain ectopically expressing DRAK2 via the lc

144 The transgenic (tg) mouse strain tg(Grm1)EPv develops spontaneous melano

145 gen stimulation by engineering a transgenic (Tg) mouse strain with CD8(+) T cells capable of augmente

146 ely used MHC class I-restricted TCRalphabeta Tg mouse strains and compared it with that in non-Tg mic

147 Both Tg mouse strains elicited, in an apparently Fas-independ

148 al tolerance, we established two transgenic (Tg) mouse strains expressing different levels of membran

149 ociated heart pathology in the P2X4 receptor TG mouse suggests a novel physiologic role of the P2X4 r

150 on-targeted Cav-1-overexpressing transgenic (Tg) mouse [synapsin-driven Cav-1 (SynCav1 Tg)] and subje

151 PG-TCR-Tg mouse T cells cultured with antigen-loaded DCs showed

152 Rapid evolution in transgenic (Tg) mouse technology now permits cell-specific and tempo

153 cell lines from the BDC-2.5 TCR transgenic (Tg) mouse that exhibit a Th2 cytokine phenotype in vitro

154 We developed a transgenic (Tg) mouse that expresses TGF-beta under control of the I

155 lished mouse model of EA2, the tottering (tg/tg) mouse, to examine the potential therapeutic utility

156 f the L-VDCC alpha(1) subunit in transgenic (Tg) mouse ventricles resulted in marked blunting of the

157 ng CaMKIIdeltac-overexpressing (CaMKIIdeltac-Tg) mouse ventricles.

158 (SS)) were significantly decreased in p90RSK-Tg mouse ventricular myocytes.

159 er report in which T cells obtained from the Tg mouse were cultured for 1 wk under Th2-promoting cond

160 ith cardiac-specific Gsalpha overexpression (TG mouse), which exhibits enhanced postsynaptic beta-adr

161 A TCR-tg mouse with direct CD4 specificity in the widely used

162 By crossing this TCR Tg mouse with mice expressing the kappa chain of mAb 36-

163 By using a transgenic (TG) mouse with cardiac-specific overexpression (3.5-fold

164 this problem by developing a TCR-transgenic (Tg) mouse with CD4 T cells that respond to a common Ag i