ライフサイエンスコーパス: Thy

1 Thy-1 (-) and Thy-1 (+) fibroblast populations were trea

2 Thy-1 (-) fibroblasts responded to these stimuli with in

3 Thy-1 (-) lung fibroblasts transfected with Thy-1 also b

4 Thy-1 (CD90) is a 25-37 kDa glycosylphosphatidylinositol

5 Thy-1 (CD90) is a small GPI-anchored protein that is par

6 Thy-1 also affects numerous nonimmunologic biological pr

7 Thy-1 and alphavbeta3 integrin mediate bidirectional cel

8 Thy-1 and LAT clusters occur on membrane regions without

9 Thy-1 cross-linking, in the context of strong costimulat

10 Thy-1 in the retina is expressed predominantly in RGCs,

11 Thy-1 is a cell surface protein that is expressed during

12 Thy-1 is a marker of retinal ganglion cell (RGC) differe

13 Thy-1 is an important regulator of cell-cell and cell-ma

14 Thy-1 knockout mice had increased levels of both LTBP-4

15 Thy-1 low Sca-1+ Lineage- c-kit+ cells from old, reconst

16 Thy-1 physically couples to inactive alphavbeta3 integri

17 Thy-1 was expressed in some NS cells.

18 Thy-1(+) cells are also in rat fetal liver and exhibit p

19 Thy-1(+) cells in the OC niche are activated mesenchymal

20 Thy-1(+) fibroblasts displayed higher CD40 levels than d

21 Thy-1, a marker of hematopoietic progenitor cells, is al

22 Thy-1-integrin alpha(v)beta(5) interactions are RLD-depe

23 Thy-1/alphavbeta3 interactions stimulate astrocyte migra

24 molecule (EpCAM) and thymus cell antigen 1 (Thy-1)] were used for purification of freshly isolated c

25 Thymus cell antigen-1 (Thy-1)-expressing cells proliferate in the liver during

26 a primitive cell phenotype (c-kit+, SCA-1+, Thy-1+, CD31+, CD135neg, lineage neg), but only a minori

27 tic microbeads were enriched from 5.2%-87.2% Thy-1(+).

28 Whereas 1 (11%) of every 8.9 Thy(low)Sca-1(+)lineage(-)Mac-1(+) fetal liver cells gav

29 In a Thy-1 null environment, BM ATA B cells progress to a nor

30 anoma cells by mechanisms likely involving a Thy-1-mediated adhesion of melanoma cells to EC.

31 hen the identical ATA BCR was expressed on a Thy-1 low/null background.

32 fragmentation pattern as authentic Thy[ c,a]Thy.

33 athic pulmonary fibrosis demonstrated absent Thy-1 staining within fibroblastic foci.

34 Force exponentially accelerated Thy-1/alphavbeta3 dissociation, indicating slip bond beh

35 Activated Thy-1(+) cells do not express OC genes but they express

36 Activated Thy-1(+) cells produce predominantly latent transforming

37 Activated Thy-1.2(+) T lymphocytes from WT mice treated in vitro w

38 t DNA methylation in the minor groove at Ade/Thy- and/or Gua/Cyt-rich sequences.

39 Using adult Thy-1 GFP-M mice, we simultaneously recorded long-term s

40 have undergone T lineage specification after Thy-1 and CD25 up-regulation.

41 ce and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain (CD2

42 Although Thy-1 low Sca-1+ Lineage- c-kit+ cells from young bone m

43 Although Thy-1(+) cells proliferate moderately after carbon tetra

44 Thy-1 (-) and Thy-1 (+) fibroblast populations were treated with plate

45 Therefore, we isolated Thy-1(+) and Thy-1(-) cells from embryonic day (ED) 14 fetal liver an

46 CR4) axis for stem cell homing, Thy-1(+) and Thy-1(-) fetal hepatic epithelial cells equally expresse

47 additional distinction between Thy-1(+) and Thy-1(-) human fibroblast subtypes has important consequ

48 ession and that separation into Thy-1(+) and Thy-1(-) subsets resulted in functionally distinct subpo

49 ion is seen in rats after renal ablation and Thy-1 nephritis and in cultured murine podocytes in resp

50 y and for vimentin, smooth muscle actin, and Thy-1 immunoreactivity.

51 tion, as indicated by expression of B220 and Thy-1.2 on NK cells in chimeric mice at levels similar t

52 l expression of Sca-1, CD34, CD43, CD45, and Thy 1.2.

53 , suggesting an interaction between CD97 and Thy-1 that was further examined by adhesion and protein-

54 in binding was blocked partially by CD97 and Thy-1-blocking mAb.

55 We found that EpCAM(+) and Thy-1(+) cells represent two different populations of ce

56 l specific markers, neurofilament (NF-L) and Thy-1.

57 the mRNA level, we detected TEM1, TEM7, and Thy-1, specific markers of angiogenic endothelium.

58 meager increases in cells reactive with anti Thy-1, CXCR4 and CD133 in peripheral blood and allograft

59 enriched for SSCs by selection with an anti-Thy-1 antibody and cultured on STO (SIM mouse embryo-der

60 earing FDCs induced OVA-specific IgM in anti-Thy-1-pretreated nude mice and by purified murine and hu

61 m rats with resolving and proliferative anti-Thy-1 nephritis were examined for nitric oxide (NO) gene

62 RGCs were selected using anti-Thy 1.2-coated magnetic beads and plated onto a merosin

63 ment of CD8 cells from CD4 KO mice with anti-Thy 1.2 plus complement abolished their effector functio

64 lly to immobilized Thy-1 protein, as well as Thy-1(+)-activated EC and CHO cells.

65 ame MS/MS fragmentation pattern as authentic Thy[ c,a]Thy.

66 Because Thy-1 (CD90) marks CAFs that promote tumor cell invasion

67 This additional distinction between Thy-1(+) and Thy-1(-) human fibroblast subtypes has impo

68 Removal or blocking of Thy-1, or blocking Thy-1-beta integrin interactions, decreased mEV uptake a

69 f the gold particle-induced clusters of both Thy-1 and CD73, a 5' exonucleotidase, occurred for perio

70 null mouse, signaling pathways modulated by Thy-1, the role of the GPI anchor in Thy-1 localization

71 d this correlated with liver repopulation by Thy-1(+) cells.

72 s available concerning liver repopulation by Thy-1(+) fetal liver cells.

73 mbrane potential (DeltaPsim)(lo), Ep-CAM(+), Thy-1(+), beta3-integrin(+) stem cells in neonate rat te

74 es become SSc(lo), DeltaPsim(hi), Ep-CAM(+), Thy-1(lo), beta3-integrin(-) stem cells in pup rat teste

75 at possess initiation activity (CD19(+)CD5(+)Thy-1(int)IgM(high)IgD(high)) that we name "initiator B

76 e induced in mice receiving anti-CD4, -CD8, -Thy-1.2, and -NK1.1 monoclonal antibodies (mAbs) on Days

77 ss oval cell/stem cell markers such as CD90 (Thy-1), CD34, and OV-6 but do not stain with antibodies

78 fibroblasts with fibrogenic characteristics [Thy-1 (-) fibroblasts] responds to stimuli (bleomycin, i

79 CNT-Thy, simply recycled by centrifugation or filtration, ca

80 Thymine-modified CNTs (CNT-Thy) can be dispersed in solution in the presence of dia

81 by addition of DAT: the strong complementary Thy-DAT interaction inhibits crystallization of thymine

82 In conclusion, Thy-1 contributes to metastasis of melanoma cells by mec

83 d that human lung adenocarcinomas containing Thy-1(+) CAFs have a worse prognosis.

84 In contrast, Thy-1(-) fetal liver cells substantially repopulated nor

85 Here we report that compared to controls Thy-1-/- C57BL/6 mice displayed more severe histopatholo

86 d E-cadherin(+) cells were found in cultured Thy-1(-) cells, whereas nearly all CD45(+) cells were in

87 Orbital fibroblasts heterogeneously display Thy-1 and exhibit unique phenotypic attributes that may

88 cally to Thy-1(+)-activated human dermal EC, Thy-1(+) CHO cells, and immobilized Thy-1 protein.

89 Highly enriched Thy-1(+) ED14 fetal liver cells proliferate and repopula

90 Cells that co-express Thy-1 and alpha-smooth muscle actin (alphaSMA), a CAF ma

91 vated in vitro stellate cells do not express Thy-1.

92 ion of portal fibroblasts (PFs) that express Thy-1, fibulin 2, and the recently identified marker mes

93 The loss of RGCs expressing Thy-1 after optic nerve injury has an initial phase of r

94 essive loss in the number of RGCs expressing Thy-1.

95 on, whereas non-fibrogenic Thy-1-expressing [Thy-1 (+)] fibroblasts do not.

96 enic injury promotes loss of lung fibroblast Thy-1 expression, resulting in enhanced fibrogenesis.

97 osis factor-alpha induced loss of fibroblast Thy-1 surface expression in vitro, which was associated

98 We propose that fibroblast Thy-1 display pre-determines lineage to a contractile or

99 TGF)-beta activation, whereas non-fibrogenic Thy-1-expressing [Thy-1 (+)] fibroblasts do not.

100 ately estimating specific rupture forces for Thy-1-Fc/alphavbeta3-Fc dissociation and calculating the

101 induced reduction of retinal mRNA levels for Thy-1.

102 id cells, as a novel interacting partner for Thy-1.

103 RBPMS-positive cells were also positive for Thy-1, neurofilament H, and III beta-tubulin.

104 -linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation.

105 naling capacity suggests a possible role for Thy-1 in the maintenance of T cell homeostasis in the ab

106 This represents a novel role for Thy-1 in the regulation of fibroblast-matrix interaction

107 Fetal liver cells selected for Thy-1 expression using immunomagnetic microbeads were en

108 tic progenitor cell population distinct from Thy-1(-) stem/progenitor cells, which repopulate the nor

109 Furthermore, Thy-1 expression prevents fibroblast contraction-induced

110 The order of reaction determined was Gua>Thy>Cyt>Ade.

111 we describe a Lin(Neg) Sca-1(Pos) c-kit(Hi) Thy-1.1(Neg) L-selectin(Pos) adult mouse bone marrow pop

112 eceptor 4 (CXCR4) axis for stem cell homing, Thy-1(+) and Thy-1(-) fetal hepatic epithelial cells equ

113 However, how Thy-1 supports cell-cell adhesion in a dynamic mechanica

114 However, Thy-1 deletion did not affect subcutaneous primary tumor

115 at in vivo administration of IL-7 to SCID-hu Thy/Liv mice does not appear to enhance thymocyte surviv

116 d with human fetal thymus and liver (SCID-hu Thy/Liv mice), in which virus-mediated depletion of thym

117 In HIV-1-infected SCID-hu Thy/Liv mice, T-20 lost activity with infrequent dosing,

118 (low) T cells, we used the humanized SCID-hu Thy/Liv mouse model to show that HIV infection of the th

119 ity both in vitro and in vivo in the SCID-hu Thy/Liv mouse model.

120 n severe combined immunodeficient (SCID)-hu (Thy/Liv) mice.

121 tly infected cells generated in the SCID-hu (Thy/Liv) mouse demonstrated no functional viral RNA prod

122 ctivity was found in the MHC class I (MHC-I)-Thy-1+c-kit- cell fraction of the mouse cryptorchid test

123 heir surface phenotype was found to be MHC-I+Thy-1-Sca-1+, and the transplantation assay demonstrated

124 The antigenic phenotype of the MHC-I-Thy-1+c-kit- SSCs was alpha6-integrin+CD24+alphavintegri

125 Used as a probe to identify Thy-1(+) CAF-enriched tumors in a compendium of 1,586 lu

126 itation, 490 nm detection) was used to image Thy-1 CFP mice aged 6 to 9 months (n = 5) before optic n

127 rmal EC, Thy-1(+) CHO cells, and immobilized Thy-1 protein.

128 luble CD97 bound specifically to immobilized Thy-1 protein, as well as Thy-1(+)-activated EC and CHO

129 In Thy-1 nephritis in Lewis rats, IFN-beta started at induc

130 ated by Thy-1, the role of the GPI anchor in Thy-1 localization to lipid rafts and signaling, and reg

131 Changes in Thy-1 and NF-L immunoreactivities were also observed.

132 -4-bound large latent TGF-beta1 complexes in Thy-1 (-) fibroblasts to significantly higher levels tha

133 m the expression and localization of CTGF in Thy-1+ oval cells.

134 candidate genes differentially expressed in Thy-1+ oval cells, in this liver injury model.

135 ividual pial arterioles on motor function in Thy-1 line 18 channelrhodopsin-2 (ChR2) transgenic mice

136 ed in CA1 principal cells of Pin1(-/-) or in Thy-1GFP mice treated with the pharmacological inhibitor

137 regional lymph nodes was clearly reduced in Thy-1(-/-) mice.

138 induces transient phosphorylation of SFKs in Thy-1-expressing fibroblasts only.

139 lasts to significantly higher levels than in Thy-1 (+) fibroblasts.

140 impair thymocyte depletion in virus-infected Thy/Liv human thymus implants.

141 by disrupting the formation of an inhibitory Thy-1-TGFbetaRI complex.

142 ce Thy-1 expression and that separation into Thy-1(+) and Thy-1(-) subsets resulted in functionally d

143 Therefore, we isolated Thy-1(+) and Thy-1(-) cells from embryonic day (ED) 14 f

144 r the presence of Thy-1(+) CAFs, we isolated Thy-1(+) CAFs and normal lung fibroblasts (LFs) from the

145 mined by flow cytometric analysis of c-Kit(+)Thy-1.1(lo)Lin(-)Sca-1(+) (KTLS) cells.

146 Mice lacking Thy-1 showed markedly diminished experimental lung metas

147 At the single-molecule level, Thy-1 is capable of independently binding alpha5beta1 in

148 s expressing a stem cell phenotype (lineage-/Thy-1+) supported a productive HCMV infection.

149 In normal liver, Thy-1(+) cells are a heterogeneous population: those loc

150 lpha(+)Flt3(-) precursors that were c-kit(lo)Thy-1(hi) generated T lineage cells when cultured on OP9

151 center (GC) marker CXCR5, and is Vbeta5(low)Thy-1(low).

152 N2 colocalized with the ganglion cell marker Thy 1.2 and with the Muller cell marker vimentin, confir

153 sly reported hematopoietic stem cell markers Thy-1, c-kit, and CD34 or the neuroepithelial marker neu

154 tle or no colocalization of the raft markers Thy-1, GM1, and LAT with each other or with FcepsilonRI

155 levels of the ganglion cell-specific markers Thy-1 and neurofilament light (NF-L) in the retina at sp

156 -endothelial cell adhesion molecule, Megsin, Thy-1, PDGF receptor alpha, and vascular alpha-actin) an

157 The cell adhesion molecule Thy-1 (CD90) mediates the adhesion of melanoma cells to

158 Endothelial surface molecule Thy-1 (CD90) is implicated in the metastatic process thr

159 alpha-SMA), collagen, and adhesion molecules Thy-1/CD90 and alpha(v) beta(3) and beta(5) integrins.

160 gene (GFP), and the other encoding the mouse Thy-1 gene and GFP.

161 logical ligand or counterreceptor for murine Thy-1 in the lymphoid compartment has not yet been ident

162 The murine Thy-1 (mThy1)-alpha-syn transgenic (tg) model recapitula

163 teractions are RLD-dependent because mutated Thy-1, in which RLD is replaced by RLE, loses the abilit

164 Lineage-negative Thy-1+CXCR4+CD133+ stem cells were significantly increas

165 compartment can promote a relatively normal Thy-1(+) TCRalphabeta(+) T cell pool from the limited po

166 Interestingly, only Thy-1(-), but not Thy-1(+) subsets differentiated to lipofibroblasts, as d

167 /- 5.3%, 4.2% +/- 3.1%, and 3.3% +/- 2.1% of Thy-1-expressing RGCs remaining at weeks 1, 2, 3, 10, an

168 More than 95% of Thy-1 antigen-positive cells in the retina expressed the

169 Activation of Thy-1 can promote T cell activation, and this role of Th

170 e patches independently of each other and of Thy-1.

171 roblast populations selected on the basis of Thy-1 expression by cell sorting were examined for respo

172 Removal or blocking of Thy-1, or blocking Thy-1-beta integrin interactions, dec

173 ss-linking of Thy-1 promotes coclustering of Thy-1 with LAT, but not with GM1.

174 Colocalization of Thy-1 antigen and ctgf signals by in situ hybridization

175 caused a reduction in the retinal content of Thy-1 and NF-L mRNAs and immunoreactivities.

176 ls of mouse gamma-synuclein under control of Thy-1 promoter.

177 bit lamellar order and 2D crystallization of Thy in the bulk.

178 t, lack of Thy-1 expression or disruption of Thy-1-alpha(v)beta(5) interactions renders lung fibrobla

179 Disruption of Thy-1-alphavbeta3 coupling altered recruitment of Src fa

180 nisms underlying the anti-fibrotic effect of Thy-1 are not well understood.

181 Elimination of Thy-1.2(+) cells in mice given mAb to CD4 and CD8 transf

182 lls that gradually discontinue expression of Thy-1 and begin to express cytokeratins.

183 Despite its expression of Thy-1 and NMDA receptors, as found in primary RGCs, this

184 us with respect to the surface expression of Thy-1 differ markedly in morphology, cytoskeletal organi

185 broblasts lacking cell surface expression of Thy-1 glycoprotein, suggesting that Thy-1 modulates the

186 Here, we report a strong expression of Thy-1 on both blood vessel and lymphatic EC in melanoma

187 onstrated that lung fibroblast expression of Thy-1 prevents lung fibrosis.

188 s, Ki-67 staining and relative expression of Thy-1, alpha smooth muscle actin (alpha-SMA), and fibron

189 on also increased the relative expression of Thy-1, alpha-SMA, and fibronectin in anterior and poster

190 de in fibroblasts requires the expression of Thy-1, although it does not appear to function as a stab

191 Consistent with a known function of Thy-1 in regulating lipid raft-associated signaling, int

192 In reviewing the nonimmunologic functions of Thy-1, we discuss the phenotype of the Thy-1 null mouse,

193 factor-alpha were identified as inducers of Thy-1 expression on EC in vitro.

194 ruli immediately after a second injection of Thy-1 antibody generated NO spontaneously and were unres

195 After a single injection of Thy-1 antibody the cells generated large amounts of NO t

196 These data suggest that the interaction of Thy-1 with beta integrins mediates mEV uptake by lung fi

197 as implemented to analyze the interaction of Thy-1-Fc with nonpurified alphavbeta3-Fc integrin, where

198 In contrast, lack of Thy-1 expression or disruption of Thy-1-alpha(v)beta(5)

199 ed by measurement of total retinal levels of Thy-1 and NF-L mRNAs and NF-L protein.

200 effects were not seen after cross-linkage of Thy-1, another GPI-anchored protein, and were dependent

201 External cross-linking of Thy-1 promotes coclustering of Thy-1 with LAT, but not w

202 These included the localisation of Thy-1 and choline acetyltransferase, the a- and b-wave a

203 We first examined the location of Thy-1(+) CAFs within human lung adenocarcinomas.

204 brosis, previous work has shown that loss of Thy-1 (CD90) expression in fibroblasts correlates with r

205 derivative (OT-440) protects against loss of Thy-1 promoter activation following optic nerve crush an

206 Loss of Thy-1 was sufficient to induce myofibroblast differentia

207 The majority of Thy-1(+) cells located at the lobular interface and in t

208 plied to calculate the kinetic parameters of Thy-1/alphavbeta3 dissociation.

209 man lung cancer database for the presence of Thy-1(+) CAFs, we isolated Thy-1(+) CAFs and normal lung

210 Recruitment and proliferation of Thy-1+ oval cells is a hallmark of liver regeneration af

211 Optic nerve injury triggers reduction of Thy-1 promoter activation followed by retinal ganglion c

212 lipid rafts and signaling, and regulation of Thy-1 expression.

213 The physiological role of Thy-1 for lymphogenic and hematogenic metastasis of mela

214 promote T cell activation, and this role of Thy-1 is reviewed elsewhere.

215 (EGFP) fluorescence from the brain slices of Thy-1 EGFP transgenic mice, we show that there is an inh

216 Subcloning of Thy-1(+) cells from OC-activated livers yield Thy-1(+) f

217 The unresponsiveness of Thy-1 (+) cells is not because of defective TGF-beta sig

218 The self-complementary systems based on Thy exhibit lamellar order and 2D crystallization of Thy

219 Only Thy-1(+) human myometrial and orbital fibroblasts were c

220 Interestingly, only Thy-1(-), but not Thy-1(+) subsets differentiated to lip

221 port we investigated whether Thy-1(+) and/or Thy-1(-) fibroblasts were capable of differentiating int

222 Morphometric analyses of neurofilament- or Thy-1-positive cells, retinal ganglion cells (flat prepa

223 (3) The orphaned Thy residue displays structural flexibility by adopting

224 taining double-stranded base pairs, Cyt/Oxa, Thy/Oxa, Ade/Oxa, and Gua/Oxa, with no preference to bas

225 red amyloid through cranial windows in PDAPP;Thy-1:YFP double-transgenic mice using the in vivo amylo

226 es are relatively stable structures in PDAPP;Thy-1:YFP transgenic mice over several days.

227 uritic plaques in the brains of living PDAPP;Thy-1:YFP transgenic mice, a model that develops AD-like

228 defined as c-kit(pos)Lin(neg/low)Sca-1(pos)-Thy-1.1(neg)Flt3(pos), Sca-1 and CD62L resolved four pop

229 in both mice and humans, were predominantly Thy-1-positive.

230 the glycophosphatidylinositol-linked protein Thy-1 affects proliferation and myofibroblast differenti

231 glycosylphosphatidylinositol-linked protein Thy-1, the ganglioside GM1, palmitoylated LAT, and cross

232 Rather, Thy-1 (-) fibroblasts activate latent TGF-beta in respon

233 By defining how force regulates Thy-1/alphavbeta3 integrin binding, we provide an initia

234 Remarkably, Thy-1 cross-linking also results in the potent costimula

235 duced changes in the localisation of retinal Thy-1 and ChAT immunoreactivities.

236 autoreactive BCR knock-in mice lacking self-Thy-1 ligand, immunoglobulin light chain editing occurre

237 ptor (BCR) mouse line, specific for the self-Thy-1/CD90 glycoprotein, we demonstrate that BCR crossli

238 ssion but inhibited expression of alpha-SMA, Thy-1/CD90, and alphav beta(3) integrins.

239 tes, and diminished expression of alpha-SMA, Thy-1/CD90, and beta(3) integrins compared with control

240 Sorted Thy-1+ oval cells expressed a high level of CTGF gene in

241 , all under the control of a neuron-specific Thy-1 promoter.

242 6P) under the control of the neuron-specific Thy-1 promoter; referred to here as 'APPPS1').

243 ctionalized polymers, through supramolecular Thy/DAT association.

244 s were heterogeneous with respect to surface Thy-1 expression and that separation into Thy-1(+) and T

245 and LPL expressed a phenotype, TCRalphabeta+ Thy-1+ CD8+ similar to that expressed on reovirus 1/L-st

246 Therefore, we conclude that Thy-1 surface expression is required for thrombospondin-

247 in situ hybridization further confirmed that Thy-1+ oval cells were a source of CTGF.

248 t to fibrogenic stimulation, indicating that Thy-1 is a critical biological response modifier that pr

249 We now show that Thy-1 is a regulator of fibroblast rigidity sensing.

250 Here we show that Thy-1 supports beta1 integrin- and syndecan-4 (Syn4)-med

251 In this study, we showed that Thy-1 interacts with integrin alpha(v)beta(5), both in a

252 It is shown that Thy-1(+) cells are mesenchymal cells with characteristic

253 These data suggest that Thy-1-integrin alpha(v)beta(5) interactions inhibit cont

254 ssion of Thy-1 glycoprotein, suggesting that Thy-1 modulates the fibrogenic potential of fibroblasts.

255 inase-3 (GSK-3beta) transgene, driven by the Thy-1 promoter so limiting its localization predominantl

256 In the gut, the Thy-1(+)TCRalphabeta(+) intraepithelial lymphocyte (IEL)

257 Nonetheless, how the Thy-1/alphavbeta3 interactions respond to mechanical cue

258 whereas nearly all CD45(+) cells were in the Thy-1(+) fraction.

259 ns of Thy-1, we discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1,

260 yan fluorescent protein under control of the Thy-1 promoter (Thy1-CFP mice) to determine how the alph

261 yan fluorescent protein under control of the Thy-1 promoter (Thy1-CFP mice) was imaged using a blue-l

262 uorescent protein (CFP) under control of the Thy-1 promoter received MS-275 (subcutaneous) or vehicle

263 ets of a selective dissociating agent of the Thy/DAT association (DMSO).

264 1 in 8.5 for pup) enabled us to predict the Thy-1 and beta3-integrin status of stem cells in neonate

265 injected, yet a number of mice receiving the Thy/Liv implant alone, with no HSPC injection, were also

266 uantitative axonal loss, suggesting that the Thy-1 (CFP) transgenic mouse strain is appropriate for R

267 nt reporter protein (CFP) gene linked to the Thy-1 promoter, which expresses CFP in RGCs.

268 ice overexpressing alpha-synuclein under the Thy-1 promoter (ASO) show abnormal accumulation of alpha

269 partment is surprisingly intact, whereas the Thy-1(-)TCRalphabeta(+) subset is almost completely abse

270 displayed higher CD40 levels than did their Thy-1(-) counterparts and were largely responsible for t

271 Thus, Thy-1 marks a CAF population that adversely impacts clin

272 sed on poly(propylene oxide) (PPO), thymine (Thy), and diaminotriazine (DAT).

273 Increased anti-thymocyte/Thy-1 autoreactive (ATA) BCR cells in the B1 B cell subs

274 In anti-thymocyte/Thy-1 autoreactive BCR knock-in mice lacking self-Thy-1

275 tion of human fetal liver and thymus tissue (Thy/Liv) plus intravenous injection of autologous liver-

276 signals is governed, in part, by binding to Thy-1 (CD90) on activated endothelial cells (EC).

277 yn4, the two receptors bind cooperatively to Thy-1, to form a trimolecular complex.

278 mutations in the RpoB gene, 20% were Gua to Thy transversions.

279 ration and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for

280 overexpressing CD97 adhered specifically to Thy-1(+)-activated human dermal EC, Thy-1(+) CHO cells,

281 The transgenic Thy-1-YFP mouse line, in which a small number of RGCs ar

282 In normal rat liver, transplanted Thy-1(+) cells produced only rare, small DPPIV(+) cell c

283 In retrorsine-treated liver, transplanted Thy-1(+) fetal liver cells achieved a 4.6%-23.5% repopul

284 ct with cyan fluorescent protein (CFP) under Thy-1 promoter control, and a construct with beta-galact

285 tissue by a modified panning technique using Thy 1.1 antibody.

286 lustering of integrin and membrane rafts via Thy-1's glycophosphatidylinositol tether.

287 fty-five percent (SD 4.4%) of EOM-Fibro were Thy-1 positive compared with only 24% (SD 4.4%) of LM-Fi

288 rentiation in bleomycin-induced lesions were Thy-1-negative.

289 smooth muscle actin and fibronectin, whereas Thy-1 (+) fibroblasts resisted stimulation.

290 a in response to fibrogenic stimuli, whereas Thy-1 (+) cells fail to do so.

291 In this report we investigated whether Thy-1(+) and/or Thy-1(-) fibroblasts were capable of dif

292 pression in vitro, which was associated with Thy-1 shedding, Smad phosphorylation, and myofibroblast

293 ium mediated by the interaction of CD97 with Thy-1 is involved in firm adhesion of PMNC during inflam

294 ions, CD97(+) myeloid cells colocalized with Thy-1(+) EC of small vessels in microabscesses, suggesti

295 hematopoietic stem cells in conjunction with Thy-1+, CD34+, and lineage-specific markers.

296 nt of isolated cells were immunolabeled with Thy 1.1 antibody.

297 ested that CD97 interacts via its stalk with Thy-1 because mAb directed to the stalk of CD97 showed s

298 Thy-1 (-) lung fibroblasts transfected with Thy-1 also become resistant to fibrogenic stimulation, i

299 napses in somatosensory cortex of Line-H-YFP Thy-1 transgenic mice.

300 hy-1(+) cells from OC-activated livers yield Thy-1(+) fibroblastic cells and a population of E-cadher