ライフサイエンスコーパス: Toll-like receptor 4

1 dapter molecule 1, toll-like receptor 2, and toll-like receptor 4.

2 nflammation in ALD through activation of the Toll-like receptor 4.

3 s blunted by incubation with an inhibitor of Toll-like receptor 4.

4 nism remarkably similar to that of mammalian Toll-like Receptor 4.

5 nd to enhance fibroblast CCN2 expression via Toll-like receptor 4.

6 ted for lppA had reduced ability to activate Toll-like receptor 4.

7 CD14, myeloid differentiation protein 2, and Toll-like receptor 4.

8 eta1 integrin and the innate immune receptor toll-like receptor 4.

9 ury triggering the macrophage activation via Toll-like receptor 4.

10 s, an event triggered by the innate receptor Toll-like receptor 4.

11 lowing binding of growth factor receptors or Toll-like receptor 4.

12 ccharides through Toll-like receptors, e.g., Toll-like receptor 4.

13 The levels of mRNA for Toll-like receptors 4, 5, and 9 also largely decreased i

14 60 adjuvanted with nanoparticle-encapsulated Toll-like receptor 4/7/8 (TLR4/7/8) agonists, administer

15 Chemical inhibition or genetic deletion of Toll-like receptor 4, a pattern recognition receptor res

16 t PTX sensitizes mice to HA independently of Toll-like receptor 4, a purported receptor for PTX, and

17 hanisms, such as innate immune responses via Toll-like receptor-4, accumulation of diacylglycerols (D

18 otein (CRP) at baseline and months 4 and 16; toll-like receptor-4 activated monocyte production of pr

19 anscriptional rate of CXCL8 and TNF-alpha to Toll-like receptor 4-activating signals.

20 investigates the mechanisms linking CFTR to toll-like receptor 4 activity.

21 ts demonstrate that the use of the synthetic Toll-like receptor 4 agonist glucopyranosyl lipid A in s

22 otective immunity was also induced using the Toll-like receptor 4 agonist glucopyranosyl lipid adjuva

23 Our data suggest that the Toll-like receptor 4 agonist MPL may be a treatment for

24 nophosphoryl lipid A (MPL) is an LPS-derived Toll-like receptor 4 agonist that exhibits unique immuno

25 ated the immune response elicited by a novel Toll-like receptor 4 agonist vaccine adjuvant, glucopyra

26 engineered liposomes carrying the synthetic Toll-like receptor-4 agonist, CRX-601.

27 Additionally, we found a significant toll-like receptor 4/alpha4beta1-dependent enrichment in

28 NA encoding CD40 ligand, constitutive active Toll-like receptor 4 and CD70, results in the in situ mo

29 reduced lipopolysaccharide activation of the toll-like receptor 4 and increased survival times compar

30 n, c-Jun phosphorylation, inflammatory gene (toll-like receptor 4 and monocyte chemotactic protein 1)

31 astrocytic GAP43 expression was mediated by Toll-like receptor 4 and nuclear factor-kappaB (NF-kappa

32 at induction of IP-10 by MRP8/MRP14 required Toll-like receptor 4 and TRIF but not MyD88.

33 identified two innate immune cell receptors, Toll-like receptor 4 and type 1 interferon receptor (IFN

34 innate immune signaling components including Toll-like receptor-4 and type I IFNs.

35 y and apoptosis, surface expression of CD16, Toll-like receptors () 4 and TLR2, CD14, MD-2, HLA-DP,-D

36 Cell-surface expression of Toll-like receptors 4 and 2 were significantly enhanced

37 Intracellular adhesion molecule 1, Toll-like receptor 4, and macrophage inflammatory protei

38 on of IL-33 in DCs is dependent on FcRgamma, Toll-like receptor 4, and phosphoinositide 3-kinase.

39 so improved the level of HA receptors (CD44, Toll-like receptor-4, and receptor for HA-mediated motil

40 In particular, aged neutrophils engage Toll-like receptor-4- and p38 MAPK-dependent pathways to

41 f immune inhibitory receptors on T cells via Toll-like receptor 4 binding to CD14(+) monocytes.

42 ube and network formation in the presence of Toll-like receptor 4 blockade but not in the presence of

43 Information on gene expression of toll-like receptor 4, catalase, and tumor necrosis facto

44 ood monocytes and 30% lower monocyte surface Toll-like receptor 4, compared with those with high expr

45 ts a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of

46 failed to induce depressive-like behavior in Toll-like receptor 4-deficient mice and in mice harborin

47 ia coli both in vitro and in vivo, through a Toll-like receptor 4-dependent mechanism.

48 he granules and new CXCL1/CXCL2 synthesis is Toll-like receptor 4-dependent.

49 were mediated through its extra domain A and Toll-like receptor 4 expressed in mesenchymal cells.

50 ll-derived Fn-EDA exacerbates stroke through Toll-like receptor-4 expressed on hematopoietic cells.

51 r level, HR reduced innate immunoreactivity (toll-like receptor 4 expression and high mobility group

52 ciated with increased basal inflammation and Toll-like receptor 4 expression and lack of the p65/beta

53 with healthy controls (p = 0.0002), whereas Toll-like receptor 4 expression was decreased compared w

54 evated hepatic stellate cell-derived TnC and Toll-like receptor 4 expression was observed in the diet

55 Dectin-1, Toll-like receptor 2, and Toll-like receptor 4 expression; regulatory T cell (Treg

56 In the brain, levels of RAGE and Toll-like receptor 4, glial fibrillary acidic protein an

57 n end products (RAGE) messenger RNA, but not toll-like receptor 4 in hippocampal microglia.

58 amplified platelet response to the agonists; Toll-like receptor 4 inhibitor blunted this effect.

59 ockdown of beta-catenin increased PTEN/TLR4 (Toll-like receptor 4), interferon regulatory factor-3 (I

60 ity to inhibit lipopolysaccharide binding to toll-like receptor-4, leading to reductions in mitogen-a

61 f mice with either protein formulated with a Toll-like receptor 4 ligand (TLR4L)-containing adjuvant

62 effect of liver inflammation induced by the Toll-like receptor 4 ligand lipopolysaccharide (LPS) wit

63 lipopolysaccharide (LPS), a proinflammatory Toll-Like Receptor 4 ligand.

64 primes the cell for an enhanced response to toll-like receptor 4 ligands.

65 mature phenotype, greater responsiveness to Toll-like receptor 4 ligation, and stronger proinflammat

66 They share regulatory function downstream of Toll-like receptor 4/LPS in mast cells, through regulati

67 ibitor of LPS, blocking the formation of the Toll-like receptor 4/MD-2/LPS complex.

68 and subsequent sustained bacteremia leads to Toll-like receptor 4-mediated hyperinflammation and leth

69 rass pollen or mite allergens to enhance the Toll-like receptor 4-mediated proallergic properties of

70 lls (NFkappaB) DNA binding without affecting Toll-like receptor 4 mRNA in liver.

71 s) of this new class of small-molecule mouse Toll-like receptor 4 (mTLR4) agonists.

72 Moreover, Toll-like receptor 4 mutant mice (C3H/HeJ) with high-fat

73 esults in increased recognition by the human Toll-like receptor 4-myeloid differentiation factor 2 (h

74 iv) both LPS forms mainly signal through the Toll-like receptor 4/myeloid differentiation primary res

75 ediated by the cluster of differentiation 14/Toll-like receptor 4/myeloid differentiation protein 2 (

76 ly inhibited lipopolysaccharide binding to a toll-like receptor-4/myeloid differentiation factor 2 fu

77 ation by the innate immune system, including Toll-like receptor 4, nuclear factor kappa-light-chain-e

78 and bicarbonate secretion, up-regulation of toll-like receptor 4/nuclear factor kappa light-chain-en

79 T cells and Toll-like receptor 4 on B cells were important in the ge

80 Inhibition of PKR or NE or neutralization of Toll-like receptor 4 or 2(TLR4 or TLR2) prevented the de

81 nd SseK3 suppress TNF-alpha-induced, but not Toll-like receptor 4- or interleukin-induced, NF-kappaB

82 tion of MMP-1 and COX-2 was mediated through Toll-like receptor-4, possibly through thrombin-induced

83 ation-approved immunostimulatory agonist for Toll-like receptor-4, promoted high-titer, high-avidity

84 e release via its interaction with the TLR4 (Toll-like receptor 4) receptor and cell migration via an

85 l a novel function of CFTR as a regulator of toll-like receptor 4 responses and cell polarity in bili

86 ine kinase self-activates and phosphorylates toll-like receptor 4, resulting in activation of nuclear

87 In vitro studies found enhanced Toll-like receptor 4 signaling activated by TnC, promoti

88 Overall, these studies suggest TnC/Toll-like receptor 4 signaling as an important regulator

89 The penta-acylated LOS exhibits reduced toll-like receptor 4 signaling but does not affect N. go

90 arly postnatal inflammatory stimuli activate toll-like receptor 4 signaling in astrocytes and promote

91 ng low-status-associated polarization of the Toll-like receptor 4 signaling pathway toward a proinfla

92 gen species production and activation of the Toll-like receptor 4 signaling pathway.

93 nown that lipopolysaccharide (LPS)-activated toll-like receptor 4 signaling pathways play a crucial r

94 lls, relied on innate immune sensing through toll-like receptor 4 signaling, and ultimately depended

95 gram-negative bacterial products in situ via Toll-like receptor 4 signaling, contributing to genital

96 ipopolysaccharide (LPS) stimuli through CD14/Toll-like receptor 4 signaling.

97 tive bacterial lipopolysaccharide-stimulated Toll-like receptor-4 signaling.

98 nced proinflammatory immune response against Toll-like receptor 4 stimulation, whereas ER-stressed he

99 flammatory cytokine secretion in response to Toll-like receptor-4 stimulation.

100 es of TAK-242, a small molecule inhibitor of Toll-like receptor 4, that primarily reacted with a sing

101 Interestingly, a direct activator of toll-like receptor 4, the bacterial cell wall component

102 fter infection with Y. pestis, influenced by Toll-like receptor 4-TIR-domain-containing adapter-induc

103 NA levels were assessed by real-time PCR and Toll like receptor 4 (TLR-4) protein expression by Weste

104 t into atherosclerotic lesions and inhibited toll-like receptor 4 (TLR 4)-initiated proinflammatory m

105 This can occur through toll-like receptor 4 (TLR-4) in stroke models.

106 insulin resistance through activation of the toll-like receptor 4 (TLR-4) receptor in the liver, whic

107 the present study is to examine the level of Toll-like receptor 4 (TLR-4), interleukin-18 (IL-18), an

108 ytokine expression involved at least in part Toll-like receptor 4 (TLR-4).

109 increase in TJ permeability was mediated by toll-like receptor 4 (TLR-4)/MyD88 signal-transduction p

110 livery system, and simultaneously, activated Toll-Like Receptor-4 (TLR-4) on APCs to release chemokin

111 present study aimed to elucidate whether the toll-like receptor-4 (TLR-4) signaling pathway is activa

112 In this work, human Toll-Like Receptor-4 (TLR-4), a protein responsible for

113 different human-compatible adjuvants (alum, Toll-like receptor 4 [TLR-4] agonist glucopyranosal lipi

114 Additionally, the activation of toll like receptor 4 (TLR4) induced by LPS showed no alt

115 This activation is through the toll like receptor 4 (TLR4)/myeloid differentiation prim

116 mor necrosis factor alpha (TNFA) (n = 6) and toll-like receptor 4 (TLR4) (n = 3).

117 evere disease subcategory, downregulation of Toll-like receptor 4 (TLR4) (P = .003).

118 ng number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, th

119 In this study we hypothesized that Toll-like receptor 4 (TLR4) activation and subsequent in

120 Toll-like receptor 4 (TLR4) activation by bacterial infe

121 ponses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopo

122 as a MEK-1/2 kinase, which is essential for Toll-like receptor 4 (TLR4) activation of extracellular

123 cell (DC) response to C. jejuni LOS through Toll-like receptor 4 (TLR4) activation.

124 and synthesize cytokines in response to the Toll-like receptor 4 (TLR4) agonist lipopolysaccharide (

125 immune stimulation, such as treatment with a Toll-like receptor 4 (TLR4) agonist, enhanced bacterial

126 In primary rat cardiomyocyte cultures Toll-like receptor 4 (TLR4) agonist- or PKCepsilon/CN-de

127 g stimulation by lipopolysaccharide (LPS) of Toll-like receptor 4 (TLR4) and by poly(I.C) of TLR3 but

128 iated mainly by leukocytes that express both Toll-like receptor 4 (TLR4) and Fc gamma receptors (Fcga

129 e microbiota, hematopoietic cell deletion of Toll-like receptor 4 (TLR4) and inactivation of the IL-1

130 with a decrease in the expression of mucosal toll-like receptor 4 (TLR4) and its adaptor myeloid diff

131 LPS-induced ACSL1 expression is dependent on Toll-like receptor 4 (TLR4) and its adaptor protein TRIF

132 ession of the innate immune recognition gene toll-like receptor 4 (Tlr4) and its downstream effector,

133 ring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic pro

134 The levels of Toll-like receptor 4 (TLR4) and proinflammatory cytokine

135 hat expression of the innate immune receptor Toll-like receptor 4 (TLR4) and the extracellular matrix

136 Here we identify endothelial Toll-like receptor 4 (TLR4) and the gut microbiome as cr

137 f innate immune signaling systems, including toll-like receptor 4 (TLR4) and the interleukin-1beta (I

138 In addition, reduced levels of Toll-like receptor 4 (TLR4) and TLR2 activation were obs

139 lular Leishmania donovani infection enhanced Toll-like receptor 4 (TLR4) and TLR2 gene expression.

140 show here that the combination of synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent

141 the combination of synthetic small-molecule Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent

142 uvant comprised of two synthetic ligands for Toll-like receptor 4 (TLR4) and TLR7.

143 ntigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in p

144 MyD88/Toll-like receptor 4 (TLR4) and TRIF/TLR4 signaling path

145 (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been show

146 Proteinases and the innate immune receptor Toll-like receptor 4 (TLR4) are essential for expression

147 The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for

148 further implicate the innate immune receptor toll-like receptor 4 (TLR4) as an underlying mechanism m

149 Identification of Toll-like receptor 4 (TLR4) as one of the most abundant

150 Recognition of lipopolysaccharides (LPS) by Toll-like receptor 4 (TLR4) at the plasma membrane trigg

151 Upon activation, Toll-like receptor 4 (TLR4) binds adapter proteins, incl

152 Surprisingly, disruption of the Toll-like receptor 4 (TLR4) but not TLR2 signaling resto

153 oxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by approximately 1000-fold o

154 Stimulation of Toll-like receptor 4 (TLR4) by bacterial lipopolysacchar

155 evels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic f

156 action of the lipid A region of LPS with the Toll-like receptor 4 (TLR4) complex causes dimerization

157 microbial ligands, immune receptors such as toll-like receptor 4 (TLR4) could play a role.

158 Our results show that Toll-like receptor 4 (TLR4) drives breast cancer cell gr

159 testinal mucosa is characterized by elevated Toll-like receptor 4 (TLR4) expression, which can lead t

160 totic function, and downregulation of innate Toll-like receptor 4 (TLR4) expression.

161 Toll-like receptor 4 (TLR4) has a key role in the initia

162 Toll-like receptor 4 (Tlr4) has a pivotal role in innate

163 Similarly, Toll-like receptor 4 (TLR4) has been implicated in breas

164 Ps) induced NF-kappaB activation mediated by Toll-like receptor 4 (TLR4) in a glycoprotein (GP)-depen

165 MA with wild-type lipid A to stimulate human Toll-like receptor 4 (TLR4) in a reporter cell line.

166 Increasing evidence points to a key role for toll-like receptor 4 (TLR4) in chronic pain states of so

167 LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-bi

168 in frequency and expressed higher levels of Toll-like receptor 4 (TLR4) in HIV-1-infected individual

169 t potent hit compound selectively stimulated Toll-like receptor 4 (TLR4) in human and mouse cells.

170 m gene knockout studies supports the role of Toll-like receptor 4 (TLR4) in intestinal inflammation a

171 LPS-mediated activation of Toll-like receptor 4 (TLR4) in macrophages results in th

172 e 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species.

173 cal role for the lipopolysaccharide receptor toll-like receptor 4 (TLR4) in NEC development through i

174 Recent evidence implicates toll-like receptor 4 (TLR4) in opioid analgesia, toleran

175 Polymorphisms in toll-like receptor 4 (TLR4) induce an aberrant immune re

176 Our findings demonstrate that LPS induces Toll-like receptor 4 (TLR4) internalization in corneal e

177 Toll-like receptor 4 (TLR4) is a critical component of i

178 SIGNIFICANCE STATEMENT: Toll-like receptor 4 (TLR4) is a key mediator of innate

179 Toll-like receptor 4 (TLR4) is a key mediator of innate

180 Toll-like receptor 4 (Tlr4) is a key mediator of pro-inf

181 Toll-like receptor 4 (TLR4) is a pattern recognition mol

182 Toll-like receptor 4 (TLR4) is an important lipo-polysac

183 Toll-like receptor 4 (TLR4) is an innate immune receptor

184 While Toll-like receptor 4 (TLR4) is responsible for all the h

185 Toll-like receptor 4 (TLR4) is unique among the TLRs in

186 Innate immune system activation via Toll-like receptor 4 (TLR4) leads to inflammation and ox

187 The Toll-like receptor 4 (TLR4) ligand endotoxin triggers ro

188 n enhanced sensitivity of macrophages to the Toll-like receptor 4 (TLR4) ligand lipopolysaccharide (L

189 morphine binds to the innate immune receptor toll-like receptor 4 (TLR4) localized primarily on micro

190 Here, we show that Toll-like receptor 4 (TLR4) mediates cancer-induced musc

191 To test the hypothesis that toll-like receptor 4 (TLR4) mediates proinflammatory pol

192 ng adolescence had a significant increase in Toll-like receptor 4 (TLR4) mRNA and protein expression

193 nsplantation procedure between wild-type and Toll-like receptor 4 (TLR4) mutant mice, we demonstrated

194 eria activates plasma membrane signaling via Toll-like receptor 4 (TLR4) on host cells and triggers i

195 rs of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells.

196 rs of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells.

197 ow that GOS is recognized by and upregulates Toll-like receptor 4 (TLR4) on RAW264.7 macrophages, fol

198 either bacterial lipopolysaccharide through Toll-like receptor 4 (TLR4) or leukocyte cytokine IFN-ga

199 The toll-like receptor 4 (TLR4) pathway is known to be invol

200 interacts with rapid kinetics to engage the Toll-like receptor 4 (TLR4) pathway, leading to the prod

201 tumor necrosis factor alpha (TNF-alpha) and Toll-like receptor 4 (TLR4) pathways, and resulted in co

202 entiation revealed that binding of S100A9 to Toll-like receptor 4 (TLR4) promotes activation of p38 m

203 Toll-like receptor 4 (TLR4) promotes vascular inflammato

204 Hsp70 exerts endotoxin-like effects through Toll-like receptor 4 (TLR4) receptors.

205 As part of the innate immune system, Toll-like receptor 4 (TLR4) recognizes bacterial cell su

206 Using Toll-like receptor 4 (TLR4) signaling in macrophages as

207 recently discovered the presence of multiple Toll-like receptor 4 (TLR4) signaling intermediates in l

208 In the liver, IRF3 is activated via Toll-like receptor 4 (TLR4) signaling or the endoplasmic

209 RF3) is an important transcription factor in Toll-like receptor 4 (TLR4) signaling, a pathway that is

210 otential vanilloid subtype 1 (TRPV1) through Toll-like receptor 4 (TLR4) signaling.

211 rating that 3SL induces inflammation through Toll-like receptor 4 (TLR4) signaling.

212 During bacterial infections, Toll-like receptor 4 (TLR4) signals through the MyD88- a

213 re, we provide evidence that immune receptor toll-like receptor 4 (TLR4) supports OL lineage cell spa

214 sion checkpoint that restricts expression of toll-like receptor 4 (TLR4) target genes in macrophages.

215 emonstrate that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4) through its N terminal and m

216 Conversely, the ability of Toll-like Receptor 4 (TLR4) to activate NFkappaB in resp

217 flammatory endocytosis pathway that delivers Toll-like receptor 4 (TLR4) to endosomes.

218 that ragweed pollen extract (RWPE) requires Toll-like receptor 4 (TLR4) to stimulate CXCL-mediated i

219 ced by reduced proinflammatory responses via Toll-like receptor 4 (TLR4) to the hypoacylated LPS.

220 ent of Gram-negative bacteria that activates Toll-like receptor 4 (TLR4) to trigger proinflammatory r

221 300b, and its adaptor DAP12, associated with Toll-like receptor 4 (TLR4) upon LPS binding, thereby en

222 Binding of MfP to Toll-like receptor 4 (TLR4) was determined by co-immunop

223 WD-fed Toll-like receptor 4 (TLR4)(-/-) mice did not exhibit my

224 osis factor alpha (TNF-alpha) or blocking of Toll-like receptor 4 (TLR4), (v) was absent in TLR4-knoc

225 as a consequence of sequential activation of toll-like receptor 4 (TLR4), a receptor for endotoxin, a

226 data suggest that the innate immune receptor Toll-like receptor 4 (TLR4), along with its coreceptor m

227 -NS5A in liver up-regulate the expression of Toll-like receptor 4 (TLR4), and develop liver tumors co

228 hat can lyse bacteria, suppress signaling by Toll-like receptor 4 (TLR4), and enhance signaling to do

229 of normal human monocytes, primarily through Toll-like receptor 4 (TLR4), and suppressed phytohemaggl

230 o found to bind TRAM, an adaptor protein for Toll-like receptor 4 (TLR4), and thereby impact both vir

231 ningothelial cells expressed a high level of Toll-like receptor 4 (TLR4), and, using a gene silencing

232 nses invoked by IL-1beta, TNF-alpha, and LPS/Toll-like receptor 4 (TLR4), but not TRIF-dependent poly

233 In the ALHS, we tested for a gene [Toll-like Receptor 4 (TLR4), encoding the endotoxin rece

234 d not require T-cell-intrinsic expression of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-

235 ith the immunosurveillance receptor complex, Toll-like receptor 4 (TLR4), on microglial cells to init

236 on and regulation of the known ENV receptor, Toll-like receptor 4 (TLR4), on oligodendroglial precurs

237 ytoplasm and downregulated the expression of toll-like receptor 4 (TLR4), receptor for advanced glyca

238 with lipopolysaccharide (LPS), the ligand of Toll-like receptor 4 (TLR4), reveals previously unobserv

239 ssociated lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4), stimulating production of t

240 We have previously demonstrated that toll-like receptor 4 (TLR4), the receptor for bacterial

241 gle study revealed a new complex composed of Toll-like receptor 4 (TLR4), TLR6, and CD36 induced by f

242 Toll-like receptor 4 (TLR4), together with MD-2, binds b

243 ends on liver X receptor (LXR) and partly on Toll-like receptor 4 (TLR4), whereas C3 secretion is inc

244 ediated activation of TRPC1 was dependent on Toll-like receptor 4 (TLR4), which induced endoplasmic r

245 olecules and innate immune receptors such as Toll-like receptor 4 (TLR4), which recognizes the lipid

246 sma G-CSF levels and neutrophil numbers in a Toll-like receptor 4 (TLR4)- and myeloid differentiation

247 del of PHH, we demonstrate that IVH causes a Toll-like receptor 4 (TLR4)- and NF-kappaB-dependent inf

248 Although Toll-like receptor 4 (TLR4)- and nucleotide-binding olig

249 In PRR analyses, whereas Toll-like receptor 4 (TLR4)- and SIGNR1-deficient vagina

250 one was sufficient to induce meningitis in a Toll-like receptor 4 (TLR4)-CXCL2-dependent manner.

251 Toll-like receptor 4 (TLR4)-dependent and TIR-domain-con

252 idized phospholipid that potently stimulates Toll-like receptor 4 (TLR4)-dependent inflammation.

253 Disease was linked to a Toll-like receptor 4 (TLR4)-dependent mechanism of IAP d

254 EL induced PTX3 expression by activating the Toll-like receptor 4 (TLR4)-dependent pathway via nuclea

255 high mobility group box 1 (HMGB1)-mediated, toll-like receptor 4 (TLR4)-driven inflammation.

256 ct ligations or sham surgeries on C57BL/6 or toll-like receptor 4 (TLR4)-knockout mice to induce live

257 in LPS activates innate immunity through the Toll-like receptor 4 (TLR4)-MD-2 complex on host cells.

258 Single inhibition of the Toll-like receptor 4 (TLR4)-MD2 complex failed in treatm

259 stimulates proinflammatory responses via the Toll-like receptor 4 (TLR4)-MD2-CD14 pathway.

260 ages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX)

261 f opioids, and we recently demonstrated that Toll-like receptor 4 (TLR4)-mediated neuroinflammation i

262 Toll-like receptor 4 (TLR4)-mediated signaling was asses

263 ue damage and expressed by tumors, activates toll-like receptor 4 (TLR4)-mediated sterile inflammatio

264 pid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)-myeloid differentiation fact

265 f extracellular CIRP is mediated through the Toll-like receptor 4 (TLR4)-myeloid differentiation fact

266 ll understood, FNIII EDA is known to agonize Toll-like receptor 4 (TLR4).

267 antimicrobial peptides and signaling through Toll-like receptor 4 (TLR4).

268 amaged epidermal keratinocytes and driven by Toll-like receptor 4 (TLR4).

269 age-associated molecular pattern to activate Toll-like receptor 4 (TLR4).

270 eceptor, but the lipopolysaccharide receptor Toll-like receptor 4 (TLR4).

271 ated predominantly via the membrane receptor Toll-like receptor 4 (TLR4).

272 caspase-11 independently of the LPS receptor Toll-like receptor 4 (TLR4).

273 or 2 (TLR2) and an antagonist or agonist for Toll-like receptor 4 (TLR4).

274 ndothelial toxicity via interaction with the toll-like receptor 4 (TLR4).

275 triggered by an interaction of S100A12 with Toll-like receptor 4 (TLR4).

276 mary human monocytes following activation of Toll-like receptor 4 (TLR4).

277 s in cultured myenteric neurons that express Toll-like receptor 4 (TLR4).

278 Dimerization of Toll-like receptor 4 (TLR4)/myeloid differentiation fact

279 Palmitate activated the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-ka

280 A3 are transcriptional targets of S100A4 via Toll-like receptor 4 (TLR4)/nuclear factor-kappaB signal

281 To study the role of Toll-like receptor 4 (TLR4)/stem cell antigen-1 (Sca-1)

282 tor cluster-of-differentiation 14 (CD14) and Toll-like receptor 4 (TLR4; essential for the LPS respon

283 In mechanistic experiments, inhibition of toll-like receptor-4 (TLR4) and the receptor for advance

284 Toll-like receptor-4 (TLR4) and type 1 interferon recept

285 the present study was to assess the role of Toll-like receptor-4 (TLR4) in mediating the inflammator

286 Toll-like receptor-4 (TLR4) pathway induced nuclear fact

287 of this process, inducing the activation of toll-like receptor-4 (TLR4) signaling and endoplasmic re

288 Toll-like receptor-4 (TLR4) was recently found to be exp

289 vate the host repair program orchestrated by Toll-like receptor-4 (TLR4).

290 ir of UVB-induced DNA damage is regulated by Toll-like receptor-4 (TLR4).

291 botic activity and is known to interact with Toll-like-receptor 4 (TLR4).

292 resistant to Fas-mediated apoptosis ex vivo, Toll-like receptor 4(TLR4)-ligation restored Fas-sensiti

293 Thus, TRIF signaling (likely downstream of Toll-like receptor 4, TLR4) serves as one of the microbi

294 Activation of ERK signaling, downstream of toll-like receptor 4, was essential to the mitogenic eff

295 The NMDA-R and Toll-like receptor-4 were not required for proinflammato

296 also attenuated proinflammatory signaling by Toll-like receptor 4, which has a central role in Ad pat

297 A member of the toll-like receptor family, toll-like receptor 4, which is known to contribute to di

298 d macrophages (BMDM) upon stimulation of the Toll-like receptor 4 with Kdo2-Lipid A (KLA) and stimula

299 Novel associations of CNVs in toll-like receptor-4 with apolipoprotein AI were replica

300 through Toll-like receptor pathways (notably Toll-like receptor 4), with downstream effects on the ri