ライフサイエンスコーパス: Toll-like receptor 7

1 ence of RNA, presumably for interaction with Toll-like receptor 7.

2 highly conserved cysteine residue (Cys98) on Toll-like receptor-7.

3 d RNA of HIV-1 encodes multiple uridine-rich Toll-like receptor 7/8 (TLR7/8) ligands that induce stro

4 cal intravital microscopy, we show that upon Toll-like receptor 7/8 (TLR7/8)-mediated inflammation of

5 -201 cells, can be activated by the specific Toll-like receptor 7/8 activator, R848, to release TNFal

6 application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely us

7 ammatory conditions, exposure of APCs to the Toll-like receptor 7/8 agonist R848 increases nanocluste

8 Activation of Toll-like receptor 7/8 by means of topical application o

9 We show that activation of pDCs through Toll-like receptor 7/8 suppresses ILC2-mediated AHR and

10 Administration of an agonist to toll-like receptor-7/8, a receptor expressed primarily o

11 patients, following in vitro stimulation of Toll-like receptors 7/8.

12 d produced significantly less IFN-alpha upon Toll-like receptor 7/9 (TLR7/9) engagement than controls

13 Nucleic acids from microbes are sensed by Toll-like receptors 7/9 (TLR7/9), which are selectively

14 On treatment with the toll-like receptor 7 agonist imquimod (IMQ), Trim32 knoc

15 Toll-like receptor agonists like the Toll-like receptor 7 agonist R848 induce DC maturation a

16 polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well

17 e isolated from whole blood, stimulated with Toll-like receptor 7 agonist, and analyzed by means of e

18 nal screening effort identified a pyrimidine Toll-like receptor 7 and 8 dual agonist.

19 rge amounts of type 1 interferon (IFN) after Toll-like receptor 7 and 9 engagements.

20 nterferon-alpha in response to SIV and other Toll-like receptor 7 and 9 ligands ex vivo.

21 Through pattern recognition receptors (Toll-like receptor 7 and retinoic acid-inducible gene 1)

22 ing recombinant Sm-p80 protein formulated in Toll-like receptor 7 and Toll-like receptor 9 agonists,

23 ce interferon alpha following stimulation of Toll-like receptor 7 and upregulation of interferon-stim

24 y to produce type I IFN after challenge with Toll-like receptor-7 and -9 ligands, or murine cytomegal

25 Toll-like receptors 7 and 8 (TLRs) have emerged as key t

26 re inhibited by ligation of Fc receptors and Toll-like receptors 7 and 8 in a PKCbeta-dependent manne

27 B cells and plasmacytoid dendritic cells via Toll-like receptors 7 and 9 suggested that agents that b

28 ferentiation and T cell activation, activate Toll-like receptor 7, and are linked to neurodegeneratio

29 ficiency in FcgammaRIIB or overexpression of Toll-like receptor 7 are protected from death caused by

30 We investigated Toll-like receptor 7-deficient (Tlr7(-/-)) and myeloid d

31 Furthermore, when formulated with a toll-like receptor 7-dependent (TLR7) agonist recently d

32 us sensing occurred in endosomes via a MyD88-Toll-like receptor 7-dependent mechanism and stimulated

33 spectively, retaining the ability to trigger Toll-like receptor 7 exclusively, and expanded human all

34 Toll-like receptor 7 expression in cortical neurons was

35 ce was associated with an increase in B cell Toll-like receptor 7 expression, increased serum levels

36 cells both in vivo and in vitro, leading to Toll-like receptor 7 hyporesponsiveness and impaired IFN

37 Ankara (MVA) boost) and stimulation of TLR7 (Toll-like receptor 7) improves virologic control and del

38 nt with the known neurodegenerative role for toll-like receptor 7 in neurons.

39 tive orally active small molecule agonist of Toll-like receptor 7--in chimpanzees with chronic HBV in

40 macytoid dendritic cell (pDC) activation via Toll-like receptor 7, inducing type I IFN and inflammato

41 ABCs and demonstrated that signaling through Toll-like receptor 7 is crucial for development of this

42 et al. used mouse models to demonstrate that Toll-like receptor 7 is required for the generation of a

43 Because a major function of Toll-like receptor 7 is to induce type I interferons (IF

44 However, despite large amounts of Toll-like receptor 7-mediated IFN-alpha, produced by pDC

45 it, colony stimulating factor 3 receptor and toll-like receptor 7 mRNA expression increases in the th

46 The small molecule GS-9620 activates Toll-like receptor 7 signaling in immune cells of chimpa

47 l replication, direct cell-cell contact, and Toll-like receptor 7 signaling, and we show that the act

48 , where the nucleic acid components activate Toll-like receptor 7 (TLR-7) or TLR-9.

49 otypes and clinical phenotypes, and assessed Toll-like receptor 7 (TLR-7)-stimulated MIF production i

50 so show that HIV-1-induced IKpDC depended on Toll-like receptor 7 (TLR7) activation.

51 Provision of CD40-specific antibody, Toll-like receptor 7 (TLR7) agonist and interleukin-2 (I

52 Imiquimod is a synthetic Toll-like receptor 7 (TLR7) agonist approved for the top

53 molecule immune response modifier that is a Toll-like receptor 7 (TLR7) agonist induces IL-12 and TN

54 od is a topical immune response modifier and Toll-like receptor 7 (TLR7) agonist that induces the imm

55 eport that intravenous administration of the Toll-like receptor 7 (TLR7) agonist, R848 in combination

56 Small molecule Toll-like receptor 7 (TLR7) agonists have been used as v

57 Pteridinone-based Toll-like receptor 7 (TLR7) agonists were identified as

58 use in plasmacytoid DC (pDC) stimulated with Toll-like receptor 7 (TLR7) agonists, Erk1/2 activation

59 This research examined the roles of Toll-like receptor 7 (TLR7) and autophagy in IFN-alpha p

60 ues report that platelets express functional TOLL-like receptor 7 (TLR7) and contribute to host survi

61 se include endosomal recognition through the Toll-like receptor 7 (TLR7) and cytosolic recognition th

62 e maturation of dendritic cells (DC) through Toll-like receptor 7 (TLR7) and its adaptor molecule MyD

63 e plasmacytoid dendritic cells (pDC) through Toll-like receptor 7 (TLR7) and its adaptor molecule, My

64 luenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88.

65 on pattern-recognition receptors, including Toll-like receptor 7 (TLR7) and retinoic acid inducible

66 acid-binding innate immune receptors such as Toll-like receptor 7 (TLR7) and TLR9 have been implicate

67 IRF-5 is activated by Toll-like receptor 7 (TLR7) and TLR9 via the MyD88 pathw

68 we present evidence showing that a ligand of Toll-like receptor 7 (TLR7) can induce anti-HCV immunity

69 Toll-like receptor 7 (TLR7) detects viral RNA, but can b

70 Toll-like receptor 7 (Tlr7) has been linked to systemic

71 Toll-like receptor 7 (TLR7) is expressed on multiple typ

72 Toll-like receptor 7 (TLR7) is required for promoting ge

73 shown that a moderate increase of the innate Toll-like receptor 7 (TLR7) is sufficient for the develo

74 pha (IFN-alpha) in response to HIV-1-encoded Toll-like receptor 7 (TLR7) ligands than pDCs derived fr

75 Toll-like receptor 7 (TLR7) mediates autoantigen and vir

76 s to viruses that are recognized through the Toll-like receptor 7 (TLR7) or TLR9 signaling pathway.

77 ne innate inflammatory responses mediated by Toll-like receptor 7 (TLR7) remain to be fully elucidate

78 Toll-like receptor 7 (TLR7) signaling predominantly regu

79 e the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling.

80 Toll-like receptor 7 (TLR7) signals to B cells are criti

81 Toll-like receptor 7 (TLR7) stimulation in the airways m

82 differentiation-associated gene 5 (MDA5) and Toll-like receptor 7 (TLR7) to induce transcription of t

83 Toll-like receptor 7 (TLR7) triggers antiviral immune re

84 Imiquimod (IQ) is an agonist of Toll-like receptor 7 (TLR7) used to treat various infect

85 We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber pri

86 endosomal uptake, and probably signaling via Toll-like receptor 7 (TLR7) were critical for sensing of

87 ic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), and IFNgamma receptors on B

88 ess pattern recognition receptors, including Toll-like receptor 7 (TLR7), which recognizes guanosine-

89 nity-purified anti-Ro60 antibody induces the Toll-like receptor 7 (TLR7)-dependent generation of supe

90 The induction of toll-like receptor 7 (TLR7)-dependent type I interferons

91 interferon (IFN-alpha/beta) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent

92 We investigated the hypothesis that reduced Toll-like receptor 7 (TLR7)-derived signaling drove the

93 cognition of intracellular Y. pestis by host Toll-like receptor 7 (TLR7).

94 and this response is attributed to platelet Toll-like receptor 7 (TLR7).

95 tion induced by compound CL097, a ligand for Toll-like receptor 7 (TLR7).

96 antibody production was largely dependent on Toll-like receptor 7 (TLR7).

97 port that several guanosine analogs activate Toll-like receptor 7 (TLR7).

98 a new systemic immunostimulatory agent, the Toll-like receptor-7 (TLR7) agonist R848, to augment rad

99 r rapid excitation of nociceptor neurons via toll-like receptor-7 (TLR7) and its coupling to TRPA1 io

100 Imiquimod is a small-molecule ligand of Toll-like receptor-7 (TLR7) that is licensed for the tre

101 A candidate gene on the X chromosome, toll-like receptor 7, was then examined.