ライフサイエンスコーパス: Topo III

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1 -catalyzed relaxation of supercoiled DNA and Topo III-catalyzed resolution of DNA replication interme

2 r results demonstrate that RecQ helicase and Topo III function together to comprise a potent and conc

3 ated DNA species formed by RecQ helicase and Topo III using atomic force microscopy.

4 strand passage activity of RecQ helicase and Topo III.

5 RecQ DNA helicases and Topo III topoisomerases have conserved genetic, physical

6 ia coli topoisomerases I and III (Topo I and Topo III) relax negatively supercoiled DNA and also cate

7 . cerevisiae, consistent with other RecQ and Topo III homologs acting together in a similar capacity.

8 BLM is a RecQ helicase component of the BLM-Topo III alpha-RMI1-RMI2 (BTR) complex, which maintains

9 tion-dependent substrate that is resolved by Topo III.

10 In addition, similar to E. coli Topo III, the TraE protein is a potent decatenase and ca

11 The gene encoding Topo III (topB) can be deleted without affecting cell vi

12 In yeast, mutation of the TOP3 gene encoding Topo III causes pleiotropic defects that are suppressed

13 omerase III (Topo III) that is essential for Topo III-mediated resolution of DNA replication intermed

14 though the relaxation rate during a run for Topo III is much faster.

15 s a potent decatenase and can substitute for Topo III activity in vivo.

16 a RecQ helicase-DNA fork, is the target for Topo III action.

17 deletion strains grow normally; however, if Topo III activity is repressed in these cells, they fila

18 a coli DNA topoisomerase I (Topo I) and III (Topo III) play in catalysis was examined by comparing th

19 ities, DNA topoisomerase I (Topo I) and III (Topo III).

20 gether, RecQ helicase and topoisomerase III (Topo III) of Escherichia coli comprise a potent DNA stra

21 d in Escherichia coli DNA topoisomerase III (Topo III) that is essential for Topo III-mediated resolu

22 ically stimulates E. coli topoisomerase III (Topo III) to fully catenate dsDNA molecules.

23 pB, the gene encoding DNA topoisomerase III (Topo III).

24 a level comparable with that of full-length Topo III.

25 aining the amino-terminal 605 amino acids of Topo III and the putative generalized DNA binding domain

26 n of the carboxyl-terminal 49 amino acids of Topo III decreases the affinity of the enzyme for its su

27 timulated both the topoisomerase activity of Topo III alone and the DNA strand passage activity of Re

28 strand passage ("supercoiling") activity of Topo III, as revealed by changes in the linking number o

29 acking the generalized DNA binding domain of Topo III, Topo I, and a hybrid topoisomerase polypeptide

30 Putative homologues of Topo III have been found to be encoded by other broad ho

31 and dif, whereas rescue by overproduction of Topo III, which bypasses Topo IV function, did not.

32 was examined by comparing the properties of Topo III with those of a truncated enzyme lacking the ge

33 ts topoisomerase activity similar to that of Topo III.

34 Overall, Topo III relaxes DNA efficiently in fast processive runs

35 Deletion of this domain reduced Topo III-catalysed resolution of DNA replication interme

36 roximately 2 orders of magnitude and reduces Topo III-catalyzed relaxation of supercoiled DNA and Top

37 y four orders of magnitude, whereas reducing Topo III-catalysed relaxation of negatively supercoiled

38 and Gram-positive organisms, suggesting that Topo III-like polypeptides may have an essential role in

39 RecQ helicase has a comparable effect on the Topo III homolog of S. cerevisiae, consistent with other

40 is more efficient at DNA relaxation, whereas Topo III is more efficient at catenation/decatenation, p

41 The phenotype associated with Topo III loss suggests that accumulation of a RecQ-creat

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