ライフサイエンスコーパス: Tr1 cell

1 xpansion and/or maintenance of IL-27-induced Tr1 cells.

2 ta promote the generation of IL-10-producing Tr1 cells.

3 ls induced the generation of IL-10-producing Tr1 cells.

4 tic activity in HNSCC abrogated outgrowth of Tr1 cells.

5 ay is required for functional development of Tr1 cells.

6 e function of differentiated IL-10-producing Tr1 cells.

7 27 activates Egr-2 to induce IL-10 producing Tr1 cells.

8 -10, and promoting development of regulatory Tr1 cells.

9 dicinal product containing an average of 10% Tr1 cells.

10 controls the early metabolic reprograming of Tr1 cells.

11 a significant change in the frequency of TH1/TR1 cells.

12 Finally, we confirmed these data using human TR1 cells.

13 rgy with c-Maf to promote the development of Tr1 cells.

14 7-induced differentiation of IL-10-producing Tr1 cells.

15 ICOS further promotes IL-27-driven Tr1 cells.

16 cluding differentiation into IL-10-secreting Tr1 cells.

17 N-gamma/IL-10-secreting T regulatory type 1 (Tr1) cells.

18 istent with the phenotype of T regulatory-1 (Tr1) cells.

19 xp3(+) Tregs and Foxp3(-) type 1 regulatory (Tr1) cells.

20 differentiation of type 1 regulatory T cell (Tr1) cells.

21 he first evidence for a differential role of Tr1 cells and Foxp3(+) Tregs in regulating innate immune

22 n human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a

23 omoters, which resulted in the generation of Tr1 cells and the amelioration of experimental autoimmun

24 CD4+Foxp3(-) IL-10-producing (Tr1) cells and CD4+Foxp3+ regulatory (Treg) cells were a

25 rcinomas (HNSCC) induce type 1 regulatory T (Tr1) cells and contribute to carcinogenesis by creating

26 estinal IL-10-producing type 1 regulatory T (Tr1) cells and decrease diabetes incidence.

27 pressing regulatory T cells, IL-10-secreting Tr1 cells) and Th17 cells in rodents have been defined,

28 s in the differentiation of FoxP3(+) T(reg), Tr1 cells, and IL-17-producing T cells (Th17).

29 y responses, expansion of type 1 regulatory (Tr1) cells, and restriction of humoral immunity during m

30 9b(+) lymphocyte-activation gene 3 (LAG3)(+) TR1 cells, antigen-specific proliferative responses, and

31 y, we show that granzyme B-expressing CD4(+) Tr1 cells are capable of killing target cells in a perfo

32 Tr1 cells are CD4+ T lymphocytes that are defined by the

33 Th2 cells revealed that only the regulatory Tr1 cells are characterized by both LIF and IL10 release

34 e that CD4(+) T cells with the properties of Tr1 cells are present in the intestinal lamina propria a

35 The human PSA-induced Tr1 cells are profoundly anergic and exhibit nonspecific

36 atory (Treg) cells, and T regulatory type 1 (Tr1) cells are essential for ensuring peripheral immune

37 Regulatory T type 1 (TR1) cells are potent suppressors of immune responses an

38 Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and hav

39 This loss of Tr1 cell-associated IL-10 secretion was specific to CD46

40 eneration of CD4(+) T cells that express the Tr1-cell-associated molecules IL-10, inducible T-Cell co

41 These data suggest that to optimize TR1 cell-based therapy, IL-10 receptor expression has to

42 eriodic syndrome patients, was suppressed by Tr1 cells but not Foxp3(+) Tregs.

43 Surprisingly, Tr1 cells, but not Foxp3(+) Tregs, inhibited the transcr

44 f is essential for the induction of IL-10 by Tr1 cells, but the molecular mechanisms that lead to the

45 a amplified the generation of induced IL-10+ Tr1 cells by IL-27.

46 nd differentiation of IL-10-producing murine Tr1 cells by inducing three key elements: the transcript

47 sought to determine whether peanut-specific TR1 cells can be generated in vitro from peripheral bloo

48 Peanut-specific TR1 cells can be induced from HC subjects and patients w

49 tes in NOD mice required IL-10 signaling, as Tr1 cells could not suppress CD4(+) T cells with a domin

50 Finally, we used human TR1 cells, currently employed for cell therapy, to confi

51 Accordingly, Tr1 cells derived from MT-deficient mice showed an incre

52 Tr1 cell development and suppressive function of Itk def

53 metallothioneins (MTs) that in turn prevent Tr1 cell development.

54 Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging

55 Conversely, CD39 promotes Tr1 cell differentiation by depleting eATP.

56 vely active HRas rescues IRF4 expression and Tr1 cell differentiation in Itk(-/-) cells.

57 molecular pathways for negatively regulating Tr1 cell differentiation remain elusive.

58 e factors serve a pioneering function during Tr1 cell differentiation.

59 ase activity is required for mouse and human Tr1 cell differentiation.

60 r AHR inactivation by HIF1-alpha and inhibit Tr1 cell differentiation.

61 een STATs and MTs in regulating IL-10 during Tr1 cell differentiation.

62 ligands responsible for T regulatory type 1 (Tr1) cell differentiation remain undefined.

63 model, we found a direct correlation between Tr1 cell engraftment and protection from weight loss in

64 sting the ability to generate donor-specific Tr1 cell-enriched lymphocytes from patients on dialysis

65 The Tr1 cell-enriched lymphocytes were generated by cocultur

66 The Tr1 cell-enriched medicinal products can be efficiently

67 The Tr1 cell-enriched medicinal products generated from PBMC

68 The ability to generate clinical-grade Tr1 cell-enriched products was defined by testing the re

69 rized T cell subsets including Th1, Th2, and Tr1 cells express functional Bonzo, suggesting expressio

70 We found that murine TR1 cells expressed functional IL-10Ralpha.

71 esponses and promotes the differentiation of Tr1 cells expressing interferon-gamma and IL-10 and lack

72 inhibited the generation of IL-10-producing Tr1 cells from naive and memory CD4(+) T cells induced b

73 -producing cells of several types, including Tr1 cells, from naturally tolerant patients suggests an

74 ity and expression of the genes required for Tr1 cell function.

75 , Th17, T follicular helper (Tfh), Treg, and Tr1 cells has helped to define unique surface molecules,

76 However, how IL-27 induces the expansion of Tr1 cells has not been elucidated.

77 rance, active suppression by T-regulatory 1 (Tr1) cells has emerged as an essential factor in the con

78 ressive properties, and IL-10-producing CD4+ Tr1 cells have been characterized as regulators of Th1-m

79 vely regulate the generation and function of Tr1 cells have been elusive.

80 These intestinal antigen-specific Tr1 cells have the ability to migrate to the periphery v

81 ratio is discussed as a possible cause of PA TR1 cell impairment.

82 Th2/Tc2, Th9/Tc9, Th17/Tc17, Th22/Tc22, and Tr1 cells in 26 filariae-infected individuals stimulated

83 signaling were used to test the activity of TR1 cells in a murine inflammatory bowel disease model,

84 e investigated the intra-hepatic presence of Tr1 cells in biopsies from a genotype 1b infected patien

85 roinflammation with an emphasis on Tregs and Tr1 cells in MS.

86 ICOShigh Treg induced Tr1 cells in nonactivated RC and Th2 cells in preactivat

87 Here, we examined the role of Tr1 cells in patients with multiple sclerosis (MS) by st

88 ther, our data show a key role of intestinal Tr1 cells in the control of effector T cells and develop

89 HNSCC plays a major role in the induction of Tr1 cells in the tumor microenvironment.

90 required for the TCR-induced development of Tr1 cells in various organs, and in the mucosal system d

91 ired for the differentiation and function of Tr1 cells in vitro and in vivo.

92 igated the role of IL-10 signaling in mature TR1 cells in vivo.

93 of a regulatory subset of CD4(+) cells, the Tr1 cells, in an IL-27-dependent manner in vitro and in

94 Several cytokines derived from Th3 and Tr1 cells, including IL-10, are believed to regulate ora

95 on factors that promote IL-10 secretion from Tr1 cells induced by IL-27.

96 inhibited the generation of IL-10-producing Tr1 cells induced by two physiologic stimuli, the induci

97 are functional compared with peanut-specific TR1 cells induced from healthy control (HC) subjects.

98 thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to a

99 /CD28 or CD3/CD46 (to generate T regulatory [Tr1] cells), induced substantial expression of granzyme

100 mmunotherapy (OIT) leads to antigen-specific TR1 cell induction has not been established.

101 ream of ITK, Ras activity is responsible for Tr1 cell induction, as expression of constitutively acti

102 Bir Tr1 cells inhibited proliferation and IFN-gamma producti

103 Transfer of Bir Tr1 cells into SCID mice did not result in colitis, and

104 ting gut-associated lymphoid tissue to boost Tr1 cells may be important in type 1 diabetes management

105 r capacity to produce high amounts of IL-10, Tr1 cells may have unique therapeutic effects in disease

106 Consistent with the role for IL-10 in Tr1 cell-mediated suppression, inhibition of inflammasom

107 T regulatory type 1 (Tr1) cell-mediated induction of tolerance in preclinical

108 HIF1-alpha degradation and takes control of Tr1 cell metabolism.

109 cy of malaria-specific adaptive regulatory T/Tr1 cells (p = 0.024), and the addition of neutralizing

110 e target cell proliferation, suggesting that Tr1 cells play an important role.

111 IL-10-producing CD4(+) type 1 regulatory T (Tr1) cells play a critical role in the maintenance of pe

112 Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-ce

113 characterize the CD3(+)CD4(+) Th, Treg, and Tr1 cell populations simultaneously across 23 memory T c

114 e already defined CD3(+)CD4(+) Th, Treg, and Tr1 cell populations, for a total of 11 Th cell, 4 Treg,

115 ells from unmanipulated mice are enriched in Tr1 cell precursors, enabling differentiation of cells t

116 CD4(+) T regulatory type 1 (TR1) cells produce large amounts of this cytokine and ar

117 Bir Tr1 cells proliferated poorly, but their proliferation w

118 In conclusion, TR1 cell regulatory activity is dependent on IL-10 recep

119 er, factors and molecular signals sustaining TR1 cell regulatory activity still need to be identified

120 TR1 cells required IL-10 receptor signaling to activate

121 olerance, but the diversity of Th, Treg, and Tr1 cell subsets has not been fully characterized.

122 ns, for a total of 11 Th cell, 4 Treg, and 1 Tr1 cell subsets.

123 IL-27-induced type 1 regulatory T (Tr1) cells suppress autoimmunity by producing IL-10.

124 l network, which generates suppressive human Tr1 cells that may be harnessed for the control of aller

125 wever, distinct induced T regulatory type 1 (Tr1) cells that lack Foxp3 expression also regulate T ce

126 Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are inst

127 tic cells are implicated in the induction of Tr1 cells, the signals that negatively regulate the gene

128 The ability of Tr1 cells to cure diabetes in NOD mice required IL-10 si

129 The ability of Foxp3(+) Tregs and Tr1 cells to suppress adaptive immune responses is well

130 We compared the ability of Tr1 cells versus Foxp3(+) Tregs to suppress IL-1beta pro

131 ells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-1

132 f IL-27 in cDC and through the generation of Tr1 cells, we propose that the PGE2-induced inhibition o

133 Human Tr1 cells were generated from peripheral blood mononucle

134 CD49b(+)LAG3(+) TR1 cells were induced in pea-T10 cells at comparable pe

135 motes the differentiation of IL-10-secreting Tr1 cells while inhibiting Th17 generation and molecules

136 re were striking defects in the induction of Tr1 cells with CD46 costimulation as measured by IL-10 b

137 TR1 cells with impaired IL-10 receptor signaling lost th

138 SCC or exogenous PGE(2) induced outgrowth of Tr1 cells with the CD3(+)CD4(+)CD25(-)IL2Rbeta(+)IL2Rgam