ライフサイエンスコーパス: Trp

1 Trp analogues are also valuable as building blocks for m

2 Trp-Pro was shown to have high 2,2'-azino-bis (3-ethylbe

3 uenching of the photoexcited tryptophan 14 (*Trp(14)) residue is in part due to an electron transfer

4 is largely abolished when residues Lys(17), Trp(20), Tyr(24), or Arg(26) are mutated resulting in di

5 ical thioredoxin-fold with a Cys(19)-Pro(20)-Trp(21)-Cys(22) motif, and an insertion consisting of a

6 at this structural motif, a minimal Pro(314)-Trp(316) turn, is essential for HCV RNA replication, and

7 a well-conserved tryptophan at position 375 (Trp 375) in HIV-2/SIVsmm.

8 ptor primarily by the residues Tyr-35(1.39), Trp-84(2.60), and Arg-167(ECL2), similar to the antagoni

9 site, including residues Tyr-37(I:07/1.39), Trp-86(II:20/2.60), and Phe-109(III:09/3.33) The small m

10 itrated other active-site residues (Trp(52), Trp(396), and Tyr(393)).

11 -375, and Leu-378 with ZapD residues Leu-74, Trp-77, Leu-91, and Leu-174.

12 re induced by the C-terminal residues Asp-78-Trp-82 of EcMazE, which are also responsible for strong

13 A Trp guest-host peptide was studied by manipulating its s

14 A Trp-73 mutant (W73V) bound weakly to mRNAs and failed to

15 issing from Chlamydia Thus, how Chlamydia, a Trp auxotroph, responds to Trp starvation in the absence

16 f sensor via the simultaneous inclusion of a Trp residue but also as a turn-on sensor via the competi

17 en bond, but preserves other properties of a Trp residue.

18 of highly conserved neighboring amino acids (Trp-68 and Lys-170) that control the rate of channel ope

19 nstream transcripts were less abundant after Trp codon-rich sequences.

20 obic core comprising tryptophans Trp(21) and Trp(25) and two adjacent leucines.

21 al points of the left (harboring Trp(21) and Trp(25)) and right (harboring Trp(29)) anchor arms.

22 irmed the critical importance of Tyr-362 and Trp-385 in mediating the ING3PHD-H3K4me3 interaction.

23 matic cage composed of Tyr-362, Ser-369, and Trp-385 that accommodate the tri-methylated side chain o

24 ur Trp residues with two of them, Trp-40 and Trp-38, in the substrate binding sites near the tunnel e

25 bic platform defined by residues Trp-711 and Trp-106, located in a highly mobile loop, appears able t

26 was completely symmetrical, rich in Arg and Trp residues, and able to adopt a native RTD-1-like stru

27 However, Gln and Trp substitution at Arg-1150 significantly decreased gli

28 Kyn and Trp concentrations were measured using ultraperformance

29 it of detection (0.5nM and 120nM for Kyn and Trp detection, respectively) and a broad linear range of

30 auxotrophic for Arg, Gln/Glu, His, Leu, and Trp in chemically defined medium.

31 This compensation between CBM-linker and Trp-38 indicates synergism between CBM-linker and CD in

32 re we studied the role of the CBM-linker and Trp-38 of TrCel7A with respect to binding affinity, on-

33 th the exception of two amino acids (Met and Trp), all other amino acid residues are each encoded by

34 otropic receptor (IR), Pickpocket (Ppk), and Trp families.

35 lyzing GAL4 driver lines of Ir, Gr, Ppk, and Trp receptor genes.

36 mely Gln, Lys, or Tyr at UAA or UAG PTCs and Trp, Arg, or Cys at UGA PTCs.

37 Tyr and Trp residues served as donor and acceptor at the ends of

38 LNAA supplementation should include Tyr and Trp together with LNAAs that effectively reduce brain Ph

39 find that the cytoplasmic domain of Vpu and Trp-76 specifically interact with lipids.

40 histidines containing tripeptides His(2-Ar)-Trp-His(2-Ar) exhibit potent antifungal activity against

41 n approach on Ac-Nle-c[Asp-His-D-Nal(2')-Arg-Trp-Lys]-NH2 (Ac-Nle(4)-c[Asp(5),D-Nal(2')(7),Lys(10)]-N

42 The tetrapeptide His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe

43 tide His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe sequence in the AGRP active

44 ist potency at the mMC4R, c[Pro-His-DPhe-Arg-Trp-Asn-Ala-Phe-DPro] and c[Pro-His-DPhe-Arg-Trp-Dap-Ala

45 Trp-Asn-Ala-Phe-DPro] and c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro], and may be further developed to gener

46 he melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2.

47 sections of hydrophilic residues (Ser, Asn, Trp) tend to stay on or fall below the isotropic model t

48 ved emission spectral variations of (2,7-aza)Trp between AnsA and AnsB.

49 In AnsA, (2,7-aza)Trp exhibits prominent green N(7)-H emission resulting f

50 analog probe 2,7-diaza-tryptophan ((2,7-aza)Trp), which exhibits unique water-catalyzed proton-trans

51 t measurable rates and that the analog 7-aza-Trp, which is expected to temper the nucleophilicity of

52 49), Tyr(189), Cys(192), and Tyr(196); beta2-Trp(57), Arg(81), and Phe(119)) may form the molecular b

53 ar dynamics studies revealed that ET between Trp(233) and Cys(222) is possible and likely to particip

54 acid with a spacer-free C-C linkage between Trp and a BODIPY fluorogen, which shows remarkable fluor

55 The most potent peptide 12f [His(2-biphenyl)-Trp-His(2-biphenyl)] displayed high in vitro activity ag

56 Both Trp fluorescence and neutron reflectometry results sugge

57 )-cryptophane interactions were evidenced by Trp fluorescence quenching.

58 ere both the Sa and Si sites are occupied by Trp.

59 generation of a tryptophanyl radical-cation (Trp(233*+)).

60 C-terminal catalytic domain (CAT), a central Trp-Gly-Arg (WGR) domain and an N-terminal region (NTR).

61 -lipid transfer for the aromatic side chains Trp, Tyr, and Phe as a function of depth in the membrane

62 exception of Glu-126 (helix IV), side chains Trp-151 (helix V), Glu-269 (helix VIII), Arg-144 (helix

63 NQ2-5 channels, interacting with a conserved Trp residue in the channel pore domain.

64 he R-spine of RAF interacts with a conserved Trp residue in the vicinity of the NtA motif, connecting

65 trans isomerization about a highly conserved Trp-Pro imide bond in a region of the TAD that is requir

66 beta-turn but instead required two conserved Trp(1)-Cys(2) residues at the N terminus.

67 greatest increases in antibodies containing Trp or Val motifs.

68 The long loop containing Trp-308 creates a platform that possibly contributes to

69 We also showed that beta-cyclopropyl-Trp undergoes C2 methylation in the absence of cycloprop

70 es quenching with three pairs of cytoplasmic Trp/fluorophore probes, indicating closing of cytoplasmi

71 hway-selective parathyroid hormone analog [d-Trp(12), Tyr(34)]bovine PTH(7-34) in six different murin

72 We find that [d-Trp(12), Tyr(34)]bovine PTH(7-34) elicits a distinctive

73 ion process was developed to nitrate 4-Me-DL-Trp.

74 ichia coli lactose permease (the LacY double-Trp mutant Gly-46-->Trp/Gly-262-->Trp) with bound p-nitr

75 is enhanced) and can synthesize enantiopure Trp analogues substituted at the 4-, 5-, 6-, and 7-posit

76 We found that aromatic residues, especially Trp, and sulfur-containing residues at the i-2 position

77 We have developed a fluorogenic Trp-BODIPY amino acid with a spacer-free C-C linkage bet

78 Fmoc-Trp(C2-BODIPY)-OH contains a BODIPY (4,4-difluoro-4-bora

79 synthesis of the fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH (3-4 d), the preparation of the labele

80 phan (Trp)-based fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH and its incorporation into peptides fo

81 d 1-100microM for Kyn, and 0.1-300microM for Trp detection).

82 human macrophages, which are auxotrophic for Trp and Phe, but is dispensable for growth within the Ac

83 oped on the basis of a Negishi coupling (for Trp-2-CO2 H) and Blaise reaction (for Pyrr).

84 c gradient in the transfer free energies for Trp and Tyr, where transfer was most favorable to the me

85 Tyr supplementation is higher than it is for Trp, and the relative effect of brain Phe reduction is h

86 is especially attractive because it can form Trp analogues directly from serine (Ser) and the corresp

87 he active site of TrCel7A is lined with four Trp residues with two of them, Trp-40 and Trp-38, in the

88 ces between fluorescence lifetimes of "free" Trp derivatives hydroxytryptophan (OH-Trp), N-formylkynu

89 Furthermore, Trp-110 is a critical site for urate transport.

90 between some key hydrophobic residues (e.g. Trp-64) and MoS2 surface also help to accelerate the pro

91 ctive peptides, Ile-Asn-Tyr-Trp, Leu-Asp-Gln-Trp, and Leu-Gln-Lys-Trp, and different bile salts in th

92 -aminomethylaniline-diglycolic acid-DPhe-Gln-Trp-Ala-Val-Gly-His-Leu-NHEt), showing excellent tumor l

93 Glu-Xaa8-Glu (double E) loop and the Met-Gln-Trp sequence of the canonical Thr-His-Trp (THW) loop kno

94 4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 ((68)Ga-RM2) is a synthe

95 4-amino-1-carboxymethyl-piperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 ((68)Ga-RM2) is a synthe

96 With respect to Arg-395 --> Trp, using protein docking and structure analyses, we pr

97 or Trp in the X2 position, and Pro >> Ala > Trp in the X3 position.

98 acY double-Trp mutant Gly-46-->Trp/Gly-262-->Trp) with bound p-nitrophenyl-alpha-d-galactopyranoside

99 ermease (the LacY double-Trp mutant Gly-46-->Trp/Gly-262-->Trp) with bound p-nitrophenyl-alpha-d-gala

100 rving as focal points of the left (harboring Trp(21) and Trp(25)) and right (harboring Trp(29)) ancho

101 ng Trp(21) and Trp(25)) and right (harboring Trp(29)) anchor arms.

102 spot residue Phe(279) Mutation of this HCDR3 Trp residue into any other residue except Tyr or Phe sig

103 down mainly into two fragments from Glp-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (LHRHa) to Trp-Ser-Ty

104 et-Gln-Trp sequence of the canonical Thr-His-Trp (THW) loop known to interact with the methyl-accepti

105 olved in Trp and Arg catabolism (IDO1, IDO2, Trp 2,3-dioxygenase [TDO], arginase [ARG] 1, ARG2, induc

106 can almost exclusively be attributed to Ile-Trp, the ACE inhibition by plant protein hydrolysates is

107 ected to temper the nucleophilicity of C2 in Trp, is a very poor substrate.

108 hat upregulated transcripts were enriched in Trp codons, thus supporting our hypothesis.

109 We demonstrate an increase in Trp degradation in the serum of patients during acute EH

110 pression and activity of enzymes involved in Trp and Arg catabolism (IDO1, IDO2, Trp 2,3-dioxygenase

111 pression and activity of enzymes involved in Trp and Arg catabolism, as well as to investigate amino

112 ires deprotonation of the indole nitrogen in Trp during its attack on methylcobalamin.

113 oniae genes that were either rich or poor in Trp codons and found that Trp codon-rich transcripts wer

114 The dynamical transition in Trp-cage is a collective phenomenon, with every residue

115 computationally the dynamical transitions in Trp-cage miniprotein powders, at three levels of hydrati

116 es Bta from canonical amino acids, including Trp.

117 An increased Trp degradation is detected in the supernatants of circu

118 ft is accompanied by intrusion of water into Trp-cage's interior and the hydration of buried hydropho

119 for the synthesis of previously intractable Trp analogues.

120 Kyn/Trp (IDO activity) was significantly lower in subjects w

121 Kyn/Trp ratio, regulatory T-cells (Tregs) frequency, T-cell

122 Kyn/Trp was decreased from healthy through completely tolera

123 gnificant association with Trp, Kyn, and Kyn/Trp in healthy and food-allergic cases.

124 ase of infection presented with elevated Kyn/Trp ratios, which further increased in untreated patient

125 The Kyn/Trp ratio was positively associated with CD8(+) T-cell a

126 n mechanism with selectivity toward D- and L-Trp as shown in voltammetric, photoluminescence and mole

127 139 and could be specifically displaced by L-Trp and L-Phe.

128 omenon that occurs between photoexcited D-/L-Trp enantiomers and rGO/gamma-CD giving rise to an enant

129 cal mode for of tryptophan enantiomers (D-/L-Trp).

130 cture also reveals an exo binding site for L-Trp, located ~42 A from the active site and formed by re

131 a)-l-tryptophanamide (FDTA), prepared from l-Trp, followed by LCMS analysis; all amino acids were fou

132 ecies, during oxidation of L-Trp, 1-methyl-L-Trp, and a number of other substrate analogues.

133 The production of both 4-Me-5-NO2-L-Trp and 4-Me-7-NO2-L-Trp uncovered remarkable regio-prom

134 on of both 4-Me-5-NO2-L-Trp and 4-Me-7-NO2-L-Trp uncovered remarkable regio-promiscuity of nitration

135 his exo site may therefore provide a novel L-Trp-mediated regulation mechanism for cellular degradati

136 ent with the physiologic concentrations of L-Trp and L-Phe in tissues.

137 which corresponded to the elution peaks of L-Trp and L-Phe.

138 d II (ferryl) species, during oxidation of L-Trp, 1-methyl-L-Trp, and a number of other substrate ana

139 ) in a ternary complex with the substrates L-Trp and O2 and in a binary complex with the product N-fo

140 direct attack of O2 on the C2 atom of the L-Trp indole ring.

141 l RNAs, activate PKR in TRAP-free and TRAP/l-Trp-bound forms.

142 Amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) activated GPR139, with

143 athway is the major route of L-tryptophan (L-Trp) catabolism in biology, leading ultimately to the fo

144 ts were increased, whereas those that lacked Trp codons were unchanged or even decreased.

145 (ligand 5: H-Dmt-d-Ala-Gly-Phe(4-F)-Pro-Leu-Trp-NH-Bn(3',5'-(CF3)2)) exhibits balanced binding affin

146 , 5, and 7 (H-Tyr-d-Ala-Gly-Phe(4-F)-Pro-Leu-Trp-NH-Bn(3',5'-(CF3)2)) showed that their stability dep

147 ric interface within the dodecamer and a Lys-Trp-Lys triad at the center of the ring are important fo

148 sn-Tyr-Trp, Leu-Asp-Gln-Trp, and Leu-Gln-Lys-Trp, and different bile salts in the submicellar or mice

149 ered immunosensor was examined in monitoring Trp consumption and Kyn production in metastatic (Calu-6

150 nvolved operons or large genes with multiple Trp codons: downstream transcripts were less abundant af

151 mutagenesis of selected residues neighboring Trp-164 resulted in improved apparent second-order rate

152 alculated absorption spectra for the neutral Trp radical.

153 e chemical nature of the non-tryptophan (non-Trp) fluorescence of porcine and human eye lens proteins

154 rexpressed and was shown to prenylate C-3 of Trp residues in both linear and cyclic peptides in vitro

155 wed robust growth in the complete absence of Trp.

156 that all other indole-substituted analogs of Trp undergo methylation at varying but measurable rates

157 ught to involve the sequential conversion of Trp to indole-3-pyruvic acid to IAA However, the pathway

158 tric immunosensor for in vitro evaluation of Trp consumption and Kyn production controlled by cancer

159 Fluorescence of Trp, its derivatives and argpyrimidine (ArgP) can be exc

160 a highly promising PET probe for imaging of Trp metabolism.

161 The impact of Trp-248 was further confirmed by ZnClTerp, a chloro-subs

162 these PTMs to the fluorescence intensity of Trp, to determine semi-quantitatively their concentratio

163 netic data that confirmed the interaction of Trp(21) with the active site shielding C-terminal arm, s

164 that can mimic the molecular interactions of Trp, enabling wash-free imaging.

165 the previous suggestion of an involvement of Trp-244, Tyr-248, and Pro-252 in proline binding is furt

166 Mutation of Trp(233) to phenylalanine (W233F) completely abolishes t

167 Trp or any molecule within a tested panel of Trp analogs.

168 we showed that the unmodified N1 position of Trp is important for turnover and that 1-thia-Trp and 1-

169 use of off-mechanism oxidation, primarily of Trp-321, and PxEDs stimulate KatG catalase activity by p

170 rpB is a powerful platform for production of Trp analogs and for further directed evolution to expand

171 water-scant environment in the proximity of Trp for AnsA and AnsB, respectively.

172 as post-translational modifications (PTM) of Trp and Arg amino acid residues.

173 Replacement of Trp 185 by an Arg residue caused displacement of TM2 tow

174 The residues of Trp-354, Arg-359, Glu-355, Leu-363, and Glu-367 in DR5 d

175 The stability of Trp-cage's alpha-helix at low temperatures suggests a po

176 ZnClTerp blocks the conformational switch of Trp-248 required for receptor activation, thereby explai

177 While the enantioselective synthesis of Trp analogues is often lengthy and requires the use of p

178 Using the technique of Trp-Cys contact quenching, we investigate the effects of

179 e energetics of low-temperature unfolding of Trp-cage comes from the hydration of hydrophilic residue

180 y profiles corresponding to the unfolding of Trp-cage miniprotein in the presence and absence of urea

181 the hydrogen-bond network in the vicinity of Trp for the two Ans.

182 However, the invariance of *Trp decay times in ferric and ferrous Mbs raises the que

183 "free" Trp derivatives hydroxytryptophan (OH-Trp), N-formylkynurenine (NFK), kynurenine (Kyn), hydrox

184 We show that the cumulative fraction of OH-Trp, NFK and ArgP emission dominates the total fluoresce

185 These data suggest that ribosome stalling on Trp codons causes a negative polar effect on downstream

186 ecular collapse of Tyr(93) in kringle-1 onto Trp(547) in the protease domain that obliterates access

187 > Ala in the X1 position, basic residues or Trp in the X2 position, and Pro >> Ala > Trp in the X3 p

188 termediate chorismate into either Phe/Tyr or Trp biosynthesis.

189 ollowing electrochemical oxidation of Tyr or Trp results in a spirolactone moiety at the newly formed

190 u, Pro, Phe, or Tyr) and Asp-1028 (to Tyr or Trp) with larger side chains showed reduced degrees of b

191 t for turnover and that 1-thia-Trp and 1-oxa-Trp serve as competitive inhibitors.

192 One residue in particular, Trp-271, is essential for cleavage of MKK3, MKK4, and MK

193 that generates the aromatic amino acids Phe, Trp, and Tyr.

194 of various planar (including aromatic (Phe, Trp, Tyr, and His)/amide (Asn and Gln)/Guanidine (Arg))

195 nsin II (UII, 1, H-Glu-Thr-Pro-Asp-c[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) fragment 4-11 were synthesized

196 urring mixed kappa/mu-ligand c[Phe-d-Pro-Phe-Trp] 1 (CJ-15,208).

197 ticular, the mu-agonist c[beta-Ala-d-Pro-Phe-Trp] 9 was shown to elicit potent antinociception in a m

198 acid substitutions (including His, Phe, Pro, Trp, and Tyr) support an enhanced viability during oxida

199 We demonstrate that this Pro-Trp turn is required for proper interaction with the hos

200 s are obtained for three different proteins (Trp-cage, myoglobin, and cytochrome c) with folding time

201 CLR selectivity for CGRP/AM in part by RAMP1 Trp-84 or RAMP2 Glu-101 contacting the distinct CGRP/AM

202 FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689

203 Lys(8) residues in the biologically relevant Trp-Lys-Tyr triad.

204 nce of a solvent-exposed tryptophan residue (Trp-164).

205 evolutionarily conserved tryptophan residue (Trp-73) of Y14 is critical for its binding to the mRNA c

206 a strong enrichment of the aromatic residues Trp, Tyr, and Phe in rcSso7d-based binders.

207 A hydrophobic platform defined by residues Trp-711 and Trp-106, located in a highly mobile loop, ap

208 ne scanning of GpTx-1 revealed that residues Trp(29), Lys(31), and Phe(34) near the C-terminus are cr

209 ted and nitrated other active-site residues (Trp(52), Trp(396), and Tyr(393)).

210 crystal structure of an MTM analogue MTM SA-Trp bound to a DNA oligomer containing a site GGCC, and

211 Serum Trp and Kyn concentrations were analyzed by high-pressur

212 first time, a FRET assay in PCa cells shows Trp-quenching due to Trp-NAD(P)H interactions, correlati

213 al water environments surrounding the single Trp.

214 HBS stapled Trp peptide exhibited signs of steric hindrance and diff

215 an alpha-helical protein, the widely studied Trp-cage miniprotein.

216 hat only three key amino acid substitutions (Trp --> Pro, Gly --> Ser and Arg --> Leu) are responsibl

217 ures of hIDO1 in complex with its substrate, Trp, an inhibitor, epacadostat, and/or an effector, indo

218 the evolution of cells capable of surviving Trp-->[3,2]Tpa substitutions in their proteomes in respo

219 g strong interactions with the toggle switch Trp 246(6.48), and delineated the structural response to

220 f the folded structure at high temperatures, Trp-cage cold denatures at 210 K into a compact, partial

221 e effects of residues adjacent to N-terminal Trp, Phe, or Tyr.

222 The N-terminal Trp-Trp (WW) domain of PLEKHA7 interacts directly with t

223 t the earliest reaction time points and that Trp-321 is the preferred site of off-catalase protein ox

224 d biochemical approaches to demonstrate that Trp(136), located at the mouth of the VhChiP pore, plays

225 We demonstrate that Trp(334) in the TPbeta C-terminus is critical for the CC

226 We find that Trp-76 is critical for the ability of Vpu to displace BS

227 er rich or poor in Trp codons and found that Trp codon-rich transcripts were increased, whereas those

228 ochemical and cellular studies indicate that Trp binding at this exo site does not affect enzyme cata

229 ved residues within WRDPLVDID indicated that Trp-637 plays a crucial role in Pah1 function.

230 in cell culture media, and could reveal that Trp consumption and Kyn production by highly metastatic

231 tic relaxation enhancement studies show that Trp-76 inserts into the lipid.

232 The Trp peptide synthesized with L-amino acids translocated

233 The Trp-38 to Ala substitution resulted in increased off-rat

234 (III:16/3.40), a residue that constrains the Trp-248 microswitch in its inactive conformation.

235 To probe this model, we developed the Trp(21) reporter and collected crystallographic, spectro

236 (ArgP) can be excited at the red edge of the Trp absorption band which allows normalisation of the em

237 rk suggests that coordinate targeting of the Trp catabolic enzymes tryptophan 2,3-dioxygenase (TDO) a

238 r molecules revealed in the proximity of the Trp residue have semiquantitative correlation with the o

239 ulfamides were inserted as surrogates of the Trp(7) and Lys(8) residues in the biologically relevant

240 The effect of the Trp-38 to Ala substitution on on-rates was strongly depe

241 variant was found to be more active than the Trp-325 form following induced expression in HEK293 cell

242 to understand this and hypothesized that the Trp codon content of a given gene would determine its tr

243 Liposome swelling assays confirmed that the Trp(136) mutations decreased the rate of bulk chitohexao

244 single channel recordings indicated that the Trp(136) mutations W136A, W136D, W136R, and W136F consid

245 this cofactor donates a methyl moiety to the Trp substrate is unknown.

246 celerated zinc transport kinetics versus the Trp-form.

247 fects of anionic lipids are mediated via the Trp(67)-Glu(71)-Asp(80) inactivation triad within the ch

248 ntrast to ZnBip, interacts directly with the Trp-248(VI:13/6.48) microswitch, contributing to its 8-f

249 ned with four Trp residues with two of them, Trp-40 and Trp-38, in the substrate binding sites near t

250 rp is important for turnover and that 1-thia-Trp and 1-oxa-Trp serve as competitive inhibitors.

251 is, we subtly altered the properties of this Trp to reveal specific chemical interactions required fo

252 lying preparation and separation steps, this Trp-Kyn immunosensor offers an improved limit of detecti

253 ers for Tyr(187) in TMIV (Phe(171)) and TMV (Trp(194)).

254 In addition to Trp(233*+), a Cys(222)-derived radical was identified by

255 It is attached to Trp via a spacer-free C-C linkage, resulting in a labele

256 ssay in PCa cells shows Trp-quenching due to Trp-NAD(P)H interactions, correlating energy transfer ef

257 activity, as measured by the ratio of Kyn to Trp, could be used to diagnose or predict active tubercu

258 rp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (LHRHa) to Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (fragment 1) and Ser-

259 how Chlamydia, a Trp auxotroph, responds to Trp starvation in the absence of a stringent response is

260 rates are accommodated mainly by stacking to Trp-105, explaining the production of neokestose and the

261 d conditions, its position is shifted toward Trp-cage's C-terminus.

262 alyses revealed that tRNA(Met(CAU)) and tRNA(Trp(CCA)) are substrates for Cm formation, tRNA(Gln(UUG)

263 Tryptophan (Trp) catabolism into kynurenine (Kyn) contributes to imm

264 Tryptophan (Trp) was substituted at the N terminus, central hydropho

265 ma (IFN-gamma), which leads to a tryptophan (Trp)-limiting environment via induction of the enzyme in

266 Derivatives of the amino acid tryptophan (Trp) serve as precursors for the chemical and biological

267 uto-fluorescent NAD(P)H, FAD and tryptophan (Trp) lifetimes and their enzyme-bound fractions as marke

268 C-terminal to tyrosine (Tyr) and tryptophan (Trp) residues provides a potential alternative to enzyma

269 ar cation-pi interaction between tryptophan (Trp) and an amine cation are shown to absorb and fluores

270 ioxygenase (IDO), which degrades tryptophan (Trp) to kynurenine (Kyn), has been demonstrated to contr

271 gulatory enzyme that breaks down tryptophan (Trp) to metabolites known as kynurenines (Kyns).

272 lyzes the methylation of C2 in l-tryptophan (Trp).

273 ne (Kyn) as a main catabolite of tryptophan (Trp) degradation is involved in the immuno-editing proce

274 One such amino acid is the tryptophan (Trp) analog 3-benzothienyl-l-alanine (Bta) with an imino

275 By use of the tryptophan (Trp) analog probe 2,7-diaza-tryptophan ((2,7-aza)Trp), w

276 he intrinsic fluorescence of the tryptophan (Trp) and tyrosine (Tyr) amino acid residues present in t

277 small-molecule inhibitors of the tryptophan (Trp) catabolic enzyme indoleamine 2,3-dioxygenase (IDO)

278 describes the preparation of the tryptophan (Trp)-based fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH

279 itoring the distance between the tryptophan (Trp-59)-heme donor-acceptor (D-A) pair.

280 We also show that an active-site tryptophan, Trp-321, participates in off-pathway electron transfer.

281 cise hydrophobic core comprising tryptophans Trp(21) and Trp(25) and two adjacent leucines.

282 Two Trp residues play pivotal roles for stabilizing MTHF by

283 w during FAD photoreduction proceeds via two Trp triads.

284 mplex is inhibited upon binding of Ala, Tyr, Trp and Asp to the protein.

285 n of oxidizable amino acids (i.e., Met, Tyr, Trp, His, Lys) and structure were observed during HOCl,

286 logues of the aromatic amino acids Phe, Tyr, Trp, and His within peptide medicinal chemistry are show

287 between milk bioactive peptides, Ile-Asn-Tyr-Trp, Leu-Asp-Gln-Trp, and Leu-Gln-Lys-Trp, and different

288 ith the most hydrophobic peptide Ile-Asn-Tyr-Trp.

289 e difference in steric hindrance between Tyr/Trp(604) and the trifluoromethoxy moiety of NMS-P715, th

290 the dioxygen-using oxidoreductases have Tyr/Trp chain lengths >/=3 residues.

291 Among the hydrolases, long Tyr/Trp chains appear almost exclusively in the glycoside hy

292 Unlike Trp, Bta is not capable of forming a hydrogen bond, but

293 rg-325 with that of a low risk ZnT8 variant (Trp-325).

294 The rank order according to AA was: Trp > norleucine > Phe, Leu > Ile > His >3,4-dihydroxyph

295 When Trp is replaced by Phe, protons can be transferred to H3

296 pH 7.5 vs delta = 67.6 ppm at pH 5.5, where Trp(peptide)-cryptophane interactions were evidenced by

297 of Gln, Tyr, and Lys at UAA and UAG, whereas Trp, Arg, and Cys were inserted at UGA, and the frequenc

298 ese data are consistent with a model whereby Trp-76 anchors the C terminus of the cytoplasmic tail of

299 id not reveal a significant association with Trp, Kyn, and Kyn/Trp in healthy and food-allergic cases

300 dicals was observed during the reaction with Trp or any molecule within a tested panel of Trp analogs