ライフサイエンスコーパス: Trypanosoma brucei

1 cal disease caused by the protozoan parasite Trypanosoma brucei .

2 nzamides (CNBs) against bloodstream forms of Trypanosoma brucei .

3 tozoa (Leishmania spp., Plasmodium spp., and Trypanosoma brucei).

4 ke and the modulation of drug sensitivity in Trypanosoma brucei.

5 generates functional mitochondrial mRNAs in Trypanosoma brucei.

6 telomeric ESs and VSG antigenic switching in Trypanosoma brucei.

7 characterize the non-snRNP PRP19 complex of Trypanosoma brucei.

8 and the early diverging parasitic protozoan, Trypanosoma brucei.

9 lar activity against the bloodstream form of Trypanosoma brucei.

10 all lysine residues for all core histones of Trypanosoma brucei.

11 ut not CD8(+), T cells in mice infected with Trypanosoma brucei.

12 . Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei.

13 ganisation of transcription in the genome of Trypanosoma brucei.

14 essential for retrograde cargo transport in Trypanosoma brucei.

15 ,3-d]pyrimidines are inhibitors of PTR1 from Trypanosoma brucei.

16 tion of 19 kinetochore proteins (KKT1-19) in Trypanosoma brucei.

17 cycle, and development in the model parasite Trypanosoma brucei.

18 glycoprotein (VSG) expression sites (ESs) of Trypanosoma brucei.

19 somiasis is caused by the eukaryotic microbe Trypanosoma brucei.

20 cytokinesis in the early-branching eukaryote Trypanosoma brucei.

21 were found to be essential for the growth of Trypanosoma brucei.

22 aused by a single-celled protozoan parasite, Trypanosoma brucei.

23 can trypanosomiasis caused by the protozoan, Trypanosoma brucei.

24 y diverged protist and significant pathogen, Trypanosoma brucei.

25 s (HAT) is caused by the parasitic protozoan Trypanosoma brucei.

26 All three proteins are essential for Trypanosoma brucei.

27 ugar nucleotide GDP-mannose is essential for Trypanosoma brucei.

28 in tRNAs from Bacillus subtilis, plants and Trypanosoma brucei.

29 death (PCD) in the human protozoan parasite Trypanosoma brucei.

30 ogue of SSNA1 in the kinetoplastid parasite, Trypanosoma brucei.

31 ), which is caused by the parasitic protozoa Trypanosoma brucei.

32 and brain infections caused by the parasite Trypanosoma brucei.

33 r of Procyclin surface antigen expression in Trypanosoma brucei.

34 orthologue, PNT1, in the parasitic protozoon Trypanosoma brucei.

35 by RNA polymerase I (Pol I) in the parasite Trypanosoma brucei.

36 diting in kinetoplastid protists typified by Trypanosoma brucei.

37 ents in the large ribosomal subunit (60S) of Trypanosoma brucei.

38 e boundaries of previously annotated CDSs in Trypanosoma brucei.

39 As and is unique for kinetoplastids, such as Trypanosoma brucei.

40 Trypanosoma brucei, a causative agent of African Sleepin

41 ng their function in the protozoan parasite, Trypanosoma brucei, a causative agent of African trypano

42 We examined BBSome functions in Trypanosoma brucei, a flagellated protozoan parasite tha

43 Trypanosoma brucei, a hemoflagellated parasitic protozoa

44 rganisms belonging to the phylum euglenozoa: Trypanosoma brucei, a lethal human parasite, and Euglena

45 Trypanosoma brucei, a lethal parasite living in the huma

46 and condition-specific metabolic network of Trypanosoma brucei, a parasitic protozoan responsible fo

47 Trypanosoma brucei, a protozoan parasite that causes hum

48 Trypanosoma brucei, a unicellular parasite, contains sev

49 Here we present evidence that Trypanosoma brucei acidocalcisomes possess an inositol 1

50 Bloodstream-form Trypanosoma brucei acquire iron by receptor-mediated end

51 sites such as the sleeping sickness pathogen Trypanosoma brucei adapt to different host environments,

52 er unexpected functional differences between Trypanosoma brucei ADAT2/3 (TbADAT2/3) and its bacterial

53 A Trypanosoma brucei adenosine transporter is well known f

54 In Trypanosoma brucei, AdoMetDC activity appears to be cont

55 rominent defence of the unicellular parasite Trypanosoma brucei against the host immune system is a d

56 We show that the Trypanosoma brucei AIR9-like protein, TbAIR9, is also cy

57 The Trypanosoma brucei aminopurine transporter P2/TbAT1 has

58 In Trypanosoma brucei, an ancient unicellular eukaryote, on

59 Trypanosoma brucei, an early branched microbial eukaryot

60 e biosynthesis pathway of the human parasite Trypanosoma brucei, an early branching eukaryote that la

61 otein localizing to the nuclear periphery of Trypanosoma brucei and a candidate nucleoskeletal compon

62 ct life cycle stages of two human parasites; Trypanosoma brucei and Leishmania mexicana.

63 el can be applied to the characterization of Trypanosoma brucei and Leishmania spp. ribosomes as well

64 wledge largely stems from the human pathogen Trypanosoma brucei and mouse experimental models.

65 zation of this channel to acidocalcisomes of Trypanosoma brucei and suggest that caution should be ex

66 The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for sign

67 roducts exhibit significant activity against Trypanosoma brucei and T. cruzi, featuring favorable dru

68 interference (RNAi) has been investigated in Trypanosoma brucei and to a lesser extent in Leishmania

69 o be essential for survival and virulence of Trypanosoma brucei and, in Trypanosoma cruzi, PDEC2 was

70 Mitochondrial ribosomes of Trypanosoma brucei are composed of 9S and 12S rRNAs, eub

71 an trypanosomiasis, caused by infection with Trypanosoma brucei are needed.

72 ological process for the bloodstream form of Trypanosoma brucei as the parasite would otherwise accum

73 y a pivotal role in life-cycle regulation of Trypanosoma brucei, as the translocation of a protein ph

74 Trypanosoma brucei belongs to a group of protists that s

75 Trypanosoma brucei BILBO1 (TbBILBO1) is an essential com

76 itional null mutant of PdxK was generated in Trypanosoma brucei bloodstream forms showing that this e

77 h a single-digit micromolar activity against Trypanosoma brucei brucei (EC50 = 2.97 muM), thus being

78 HAP) by triosephosphate isomerase (TIM) from Trypanosoma brucei brucei (Tbb) has been investigated.

79 Glu-167 of triosephosphate isomerase from Trypanosoma brucei brucei (TbbTIM) acts as the base to d

80 designed, synthesized, and evaluated against Trypanosoma brucei brucei .

81 ine transport activities in bloodstream form Trypanosoma brucei brucei found that these cells express

82 een of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promisi

83 eening of a focused protease library against Trypanosoma brucei brucei in culture.

84 responses in the penetration of T cells and Trypanosoma brucei brucei into the brain was studied in

85 ate immunity against the veterinary pathogen Trypanosoma brucei brucei is conferred by trypanosome ly

86 d low micromolar levels of inhibition of the Trypanosoma brucei brucei parasite grown in culture.

87 31-fold more active against bloodstream-form Trypanosoma brucei brucei trypomastigotes engineered to

88 ts: I172V, I172A, L232A, and P168A (TIM from Trypanosoma brucei brucei); a 208-TGAG for 208-YGGS loop

89 against the parasites Plasmodium falciparum, Trypanosoma brucei brucei, and Trypanosoma cruzi will be

90 everal African trypanosome species including Trypanosoma brucei brucei, but not the human-infective p

91 een of approximately 87000 compounds against Trypanosoma brucei brucei, we recently identified eight

92 omparable between Trypanosoma congolense and Trypanosoma brucei but is much lower in Trypanosoma viva

93 eotide-specific phosphodiesterases (PDEs) of Trypanosoma brucei, causative agent of the fatal human s

94 Trypanosoma brucei causes African sleeping sickness for

95 Trypanosoma brucei causes African sleeping sickness, a d

96 Trypanosoma brucei causes African trypanosomiasis and co

97 Trypanosoma brucei causes fatal human African trypanosom

98 Trypanosoma brucei causes human African trypanosomiasis

99 Trypanosoma brucei causes human African trypanosomiasis

100 The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis

101 Trypanosoma brucei causes human African trypanosomiasis

102 Trypanosoma brucei causes human African trypanosomiasis

103 The protist parasite Trypanosoma brucei causes Human African trypanosomiasis

104 The protozoan parasite Trypanosoma brucei causes the fatal illness human Africa

105 Labeling of Trypanosoma brucei cell cultures with 50% uniformly (13)

106 A defining feature of Trypanosoma brucei cell shape is the lateral attachment

107 red the transcriptomes of cultured procyclic Trypanosoma brucei cells in early and late logarithmic p

108 kinase system of the kinetoplastid parasite Trypanosoma brucei, consisting of three highly similar a

109 tids, such as the sleeping sickness parasite Trypanosoma brucei, contain a approximately 20S RNA-edit

110 The mitochondrial 45 S SSU* complex in Trypanosoma brucei contains the 9 S SSU ribosomal RNA, a

111 Trypanosoma brucei contains two target of rapamycin (TOR

112 also showed high inhibitory potency against Trypanosoma brucei cultures.

113 Trypanosoma brucei cyclic nucleotide phosphodiesterase B

114 n addition, the binding mode of 14t with the Trypanosoma brucei CYP51 (TbCYP51) orthologue has been c

115 The Trypanosoma brucei cysteine protease cathepsin B (TbCatB

116 e tsetse fly-transmitted African trypanosome Trypanosoma brucei depends on maintenance and expression

117 Survival of Trypanosoma brucei depends upon switches in its protecti

118 ishmania displays striking conservation with Trypanosoma brucei, despite the latter parasite replicat

119 However, in Trypanosoma brucei, disorganized arrays of microtubules

120 The mitochondrial genome of Trypanosoma brucei does not contain genes encoding tRNAs

121 The human parasite Trypanosoma brucei does not synthesize heme de novo and

122 generates functional mitochondrial mRNAs in Trypanosoma brucei Editing is catalyzed by three distinc

123 ential for growth of the parasitic protozoan Trypanosoma brucei, enabling the study of its function i

124 Trypanosoma brucei encodes three paralogue single-protei

125 Trypanosoma brucei encodes two deoxyhypusine synthase pa

126 ere, we report that TbVtc4 (Vtc4 ortholog of Trypanosoma brucei) encodes, in contrast, a short chain

127 Unlike other type II TKs, the Trypanosoma brucei enzyme (TbTK) is a tandem protein wit

128 Trypanosoma brucei evades the host immune system through

129 l-infecting bloodstream stages as well as in Trypanosoma brucei evansi, a form of the latter stage la

130 Bloodstream-form cells of Trypanosoma brucei exhibit massively increased endocytic

131 screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexa

132 Trypanosoma brucei expresses a diverse repertoire of N-g

133 Trypanosoma brucei expresses a large number of cyclins a

134 However, Trypanosoma brucei expresses an unusual CPC consisting o

135 The bloodstream form of the human pathogen Trypanosoma brucei expresses oligomannose, paucimannose,

136 Trypanosoma brucei faces relentless immune attack in the

137 We sought to develop inhibitors of Trypanosoma brucei FolD (TbFolD) as potential antiparasi

138 ine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification.

139 tivity against either human FPPS (HsFPPS) or Trypanosoma brucei FPPS (TbFPPS), the most active being

140 amides have been identified as inhibitors of Trypanosoma brucei from screening of a focused protease

141 ed by two subspecies of Trypanosoma brucei , Trypanosoma brucei gambiense , and Trypanosoma brucei rh

142 uman African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense can be diagnosed in the ear

143 NECT as first-line treatment in second-stage Trypanosoma brucei gambiense HAT.

144 Infection rates of Trypanosoma brucei gambiense in tsetse are extremely low

145 to replace the current treatment regimen for Trypanosoma brucei gambiense infections, following a pos

146 is (HAT), Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense, have developed independent

147 e of Human African Trypanosomiasis caused by Trypanosoma brucei gambiense.

148 this effect in an important human pathogen, Trypanosoma brucei gambiense.

149 on of both alleles of JGT from the genome of Trypanosoma brucei generates a cell line that completely

150 The Trypanosoma brucei genome contains more than 1,000 VSG g

151 However, the Trypanosoma brucei genome encodes only the last two step

152 MM and a PAGM enzymes have been found in the Trypanosoma brucei genome, there is, surprisingly, no ca

153 l evaluation of aminopyrazole derivatives as Trypanosoma brucei GSK3 short inhibitors.

154 In contrast to most other eukaryotes Trypanosoma brucei has a single mitochondrion whose sing

155 tive agent of human African trypanosomiasis, Trypanosoma brucei, has already shown the utility of thi

156 inactive mutant of metacaspase 2 (MCA2) from Trypanosoma brucei, has been determined to a resolution

157 microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a defined size, shape, and form

158 protists, such as the lethal human parasite Trypanosoma brucei, however, lack the heptad repeats and

159 context of the VSG layer, the dimensions of Trypanosoma brucei HpHbR and VSG have been determined by

160 In this study, we report the structure of Trypanosoma brucei HpHbR in complex with human haptoglob

161 ausative agent of African sleeping sickness, Trypanosoma brucei In mitochondria of this pathogen, mos

162 insect salivary glands for all subspecies of Trypanosoma brucei, including the human pathogens.

163 ed to TbKHC1, an orphan kinesin H chain from Trypanosoma brucei, inhibited T. musculi excreted/secret

164 ositol pyrophosphate biosynthetic pathway in Trypanosoma brucei: inositol polyphosphate multikinase (

165 The life cycle of Trypanosoma brucei involves developmental transitions th

166 Trypanosoma brucei is a kinetoplastid parasite of medica

167 del of glycolysis in the parasitic protozoan Trypanosoma brucei is a particularly well analysed examp

168 Trypanosoma brucei is a protozoan parasite that evades i

169 The African trypanosome Trypanosoma brucei is a single-celled eukaryote with a s

170 Trypanosoma brucei is a vector borne, lethal protistan p

171 Trypanosoma brucei is an extracellular parasite that cau

172 the current model for antigenic variation in Trypanosoma brucei is only one means by which these para

173 Trypanosoma brucei is the causative agent of African sle

174 Trypanosoma brucei is the causative agent of African sle

175 The parasite Trypanosoma brucei is the causative agent of African sle

176 The eukaryotic protozoan parasite Trypanosoma brucei is the causative agent of human Afric

177 Trypanosoma brucei is the causing agent of African trypa

178 acterized in kinetoplastid parasites such as Trypanosoma brucei is Tim17 (TbTim17), which is essentia

179 The African trypanosome, Trypanosoma brucei, is a parasitic protozoan that achiev

180 receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in

181 OM protein of the early diverging protozoan Trypanosoma brucei, is signal-anchored.

182 g sickness, caused by the protozoan parasite Trypanosoma brucei, is universally fatal if untreated, a

183 s and can functionally replace homologues in Trypanosoma brucei, its SufCB protein has similar bioche

184 y, it was shown that the parasitic protozoon Trypanosoma brucei lacks a conventional Tom40 and instea

185 The mitochondrion of the parasitic protozoan Trypanosoma brucei lacks tRNA genes, and thus imports al

186 tive agent of human African trypanosomiasis, Trypanosoma brucei, lacks de novo purine biosynthesis an

187 screen with 176 individual bloodstream form Trypanosoma brucei lines identified PKs required for pro

188 Here we present evidence that the Trypanosoma brucei mitochondrial calcium uniporter (TbMC

189 In Trypanosoma brucei, most mitochondrial mRNAs undergo int

190 Trypanosoma brucei N-myristoyltransferase (TbNMT) is an

191 In Trypanosoma brucei, PE synthesis has been shown to occur

192 The Polo-like kinase (PLK) in Trypanosoma brucei plays multiple roles in basal body se

193 Trypanosoma brucei PRMT7 (TbPRMT7) is a protein arginine

194 DNA (kDNA), we identified an uncharacterized Trypanosoma brucei protein, named TbLOK1, required for m

195 Trypanosoma brucei, protozoan parasites that cause human

196 on of the potentials of the redox centers in Trypanosoma brucei QSOX provides a context for understan

197 t that CRK1, a G1 cyclin-dependent kinase in Trypanosoma brucei, regulates anterograde protein traffi

198 The infectious metacyclic forms of Trypanosoma brucei result from a complex development in

199 ains of TR from the basal eukaryotic species Trypanosoma brucei, revealing the ancestry of TR compris

200 rence target sequencing (RIT-seq) screens in Trypanosoma brucei, revealing the transporters, organell

201 roove binders was evaluated in vitro against Trypanosoma brucei rhodesiense (8 compounds) and Plasmod

202 iprotozoal assays, ten of the oils inhibited Trypanosoma brucei rhodesiense (IC(50) 15.9-64.5 mug/mL)

203 ting against four other protozoan parasites: Trypanosoma brucei rhodesiense , Trypanosoma cruzi , Lei

204 ition of the cysteine proteases rhodesain of Trypanosoma brucei rhodesiense and falcipain-2 of Plasmo

205 .045 muM against the human pathogenic strain Trypanosoma brucei rhodesiense and is more than 4000 tim

206 brucei , Trypanosoma brucei gambiense , and Trypanosoma brucei rhodesiense and is one of Africa's ol

207 tent inhibitory effect against the parasites Trypanosoma brucei rhodesiense and Leishmania donovani w

208 t cause human African Trypanosomiasis (HAT), Trypanosoma brucei rhodesiense and Trypanosoma brucei ga

209 r proteins that contribute to virulence, and Trypanosoma brucei rhodesiense EVs contain the serum res

210 stance to most African trypanosomes, but not Trypanosoma brucei rhodesiense or T.b. gambiense, which

211 layed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with selectivity

212 ctive (0.5 muM </= IC(50) < 6.0 muM) against Trypanosoma brucei rhodesiense trypomastigotes were 5-31

213 ural product displayed high activity against Trypanosoma brucei rhodesiense, a recalcitrant parasite

214 ch as Plasmodium falciparum, Lassa Virus and Trypanosoma brucei rhodesiense, has resulted in elevated

215 -stage HAT, and the only drug for late-stage Trypanosoma brucei rhodesiense, is intravenous melarsopr

216 ave additional trypanolytic activity against Trypanosoma brucei rhodesiense, the cause of acute Afric

217 orrelation with the human infective parasite Trypanosoma brucei rhodesiense, the most potent compound

218 st important human trypanosomatid pathogens (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, and L

219 st important human trypanosomatid pathogens (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, and L

220 c markers in CSF from patients infected with Trypanosoma brucei rhodesiense, using 1H nuclear magneti

221 ite concentrations in patients infected with Trypanosoma brucei rhodesiense, using liquid chromatogra

222 We report X-ray structures of Trypanosoma brucei S-adenosylmethionine decarboxylase al

223 ved following RNAi-mediated silencing of the Trypanosoma brucei SODA ortholog suggests that SODA is e

224 Trypanosoma brucei sp. causes human African trypanosomia

225 The protozoan parasites Trypanosoma brucei spp. cause important human and livest

226 sites Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp., respectively.

227 e African ethnic groups with exposure to two Trypanosoma brucei subspecies that cause HAT.

228 Trypanosoma brucei survives in mammals through antigenic

229 The disease has two forms, Trypanosoma brucei (T b) rhodesiense and T b gambiense;

230 nst several wild type and resistant lines of Trypanosoma brucei (T. b. rhodesiense STIB900, T. b. bru

231 we have shown that depletion of centrin1 in Trypanosoma brucei (T. brucei) displayed arrested organe

232 Trypanosoma brucei (T. brucei) is responsible for the fa

233 ng drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the causative agent for

234 Here, we exploited Trypanosoma brucei (Tb), an early diverging eukaryote wh

235 e atomic structure of its close homolog from Trypanosoma brucei (TbASNA) at 2.2 A.

236 e SAS-4 homolog in the flagellated protozoan Trypanosoma brucei, TbSAS-4, plays an unusual role in co

237 Trypanosoma brucei TFIIH harbours all core complex compo

238 the procyclic and bloodstream form stages of Trypanosoma brucei that yields viable and proliferative

239 ing the cell cycle of the protozoan parasite Trypanosoma brucei The source of components required to

240 axoneme formation in the flagellate protist Trypanosoma brucei, the causal agent of African sleeping

241 ruzi, the causative agent of Chagas disease; Trypanosoma brucei, the causative agent of African sleep

242 Trypanosoma brucei, the causative agent of African sleep

243 Lipid metabolism in Trypanosoma brucei, the causative agent of African sleep

244 Here, we report that Trypanosoma brucei, the causative agent of African trypa

245 the trypanocidal activity of nicotinamide on Trypanosoma brucei, the causative agent of African trypa

246 Trypanosoma brucei, the causative agent of human African

247 , which had been identified as a hit against Trypanosoma brucei, the causative agent of human African

248 mpound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African

249 of polyamine metabolism in bloodstream-form Trypanosoma brucei, the causative agent of human African

250 es (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African

251 Here, we show that Trypanosoma brucei, the causative agent of human sleepin

252 The parasite Trypanosoma brucei, the causative agent of sleeping sick

253 Trypanosoma brucei, the causative agent of sleeping sick

254 play an important role in the life cycle of Trypanosoma brucei, the causative parasite of human Afri

255 We show that in Trypanosoma brucei, the causative pathogen of human Afri

256 In Trypanosoma brucei, the composition of the gamma-tubulin

257 Trypanosoma brucei, the etiologic agent of African Sleep

258 In the case of Trypanosoma brucei, the etiological agent of African try

259 A recent genome-wide analysis of Trypanosoma brucei, the etiological agent of sleeping si

260 tron microscopy structure of the ribosome of Trypanosoma brucei, the parasite that is transmitted by

261 nraveling the intricate interactions between Trypanosoma brucei, the protozoan parasite causing Afric

262 In Trypanosoma brucei, the single intron-containing tRNA (t

263 In the parasite Trypanosoma brucei, the single PLK homologue TbPLK is ne

264 In the protist parasite Trypanosoma brucei, the single Polo-like kinase (TbPLK)

265 In Trypanosoma brucei, the vast majority of gRNAs are trans

266 In Trypanosoma brucei, three of the five centrins associate

267 Unusually for a eukaryote, Trypanosoma brucei transcribes its variant surface glyco

268 ow that cytosine 32 in the anticodon loop of Trypanosoma brucei tRNA(Thr) is methylated to 3-methylcy

269 ping sickness is caused by two subspecies of Trypanosoma brucei , Trypanosoma brucei gambiense , and

270 e diseases caused by the protozoan parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania sp

271 nt parasites and include the human pathogens Trypanosoma brucei, Trypanosoma cruzi, and Leishmania sp

272 wth, and infectivity of the trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, and Leishmania.

273 pathway and its enzymes have been studied in Trypanosoma brucei, Trypanosoma cruzi, and various Leish

274 of evolution led to inactivation of PDEC in Trypanosoma brucei/Trypanosoma evansi/Trypanosoma congol

275 re we present a thorough kinetic analysis of Trypanosoma brucei TryS in a newly developed phosphate b

276 In the protist Trypanosoma brucei, two distinct genes encode fairly dif

277 Mitochondrial mRNAs in Trypanosoma brucei undergo extensive insertion and delet

278 ghly motile and versatile protozoan pathogen Trypanosoma brucei undergoes a complex life cycle in the

279 Trypanosoma brucei undergoes an essential process of mit

280 Trypanosoma brucei undergoes cytokinesis uni-directional

281 Trypanosoma brucei undergoes two clearly distinct develo

282 Trypanosoma brucei uses multiple mechanisms to evade det

283 nhibited J synthesis in Leishmania major and Trypanosoma brucei using DMOG.

284 its application to the pathogenic protozoan, Trypanosoma brucei, using hyperpolarized (13)C1 pyruvate

285 multiple ancestral VSG lineages, whereas in Trypanosoma brucei VSG have recent origins, and ancestra

286 re, in showing that the C-terminal domain of Trypanosoma brucei VSG plays a crucial role in facilitat

287 ve-site residues of PRMT7 from the protozoan Trypanosoma brucei We have designed 26 single and double

288 bitor of proliferation for the HAT pathogen (Trypanosoma brucei), we have now tested this class of an

289 e essentiality of pyrimidine biosynthesis in Trypanosoma brucei, we generated a umps double knockout

290 an and animal pathogenic protozoan parasite, Trypanosoma brucei, we generated conditional cardiolipin

291 ulation of glycosomes in live procyclic form Trypanosoma brucei When added to cells, this fluorescent

292 Compound 64 cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg.

293 component of approximately 20S editosomes in Trypanosoma brucei which contains a degenerate, noncatal

294 In the unicellular parasite Trypanosoma brucei, which causes African sleeping sickne

295 The protozoan parasite Trypanosoma brucei, which causes devastating diseases in

296 An example is Trypanosoma brucei, which causes human African trypanoso

297 idal activity against the protozoan parasite Trypanosoma brucei with IC50 < 5 muM, being each of thos

298 We compared the genome of Trypanosoma brucei with two closely related parasites Tr

299 more potent than nifurtimox against in vitro Trypanosoma brucei with very low cytotoxicity against hu

300 in the causative agent of sleeping sickness, Trypanosoma brucei, with that of human erythrocytes, and