ライフサイエンスコーパス: Tyr kinase

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1 tify selective peptide inhibitors of protein Tyr kinases.

2 ase, stk encodes a eukaryotic-like tyrosine (Tyr) kinase.

3 sion of the peptide inhibited ZAP-70 protein Tyr kinase activity by competing with protein substrates

4 The Ser/Thr/Tyr kinase activity of human biliverdin reductase (hBVR)

5 he Ser/Thr kinase activity of the MAP3K into Tyr kinase activity of the central dual specificity MAP2

6 rocessing through activation of its receptor Tyr kinase activity, and they suggest possible engagemen

7 ostin AG1478), a selective inhibitor of EGFR Tyr kinase activity, blocked EGFR and ERK activation by

8 Thr residues and to potentiate its intrinsic Tyr kinase activity.

9 ly transcribed RASSF1C isoform that promotes Tyr kinase activity.

10 Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase and intracellular scaffold/bridge/anchor, is

11 Data obtained with inhibitors of EGFR Tyr kinase and membrane metalloproteases support an inte

12 The simultaneous activation of all receptor Tyr kinases and nonreceptor Tyr kinases leads to complex

13 s kinase 3 (Jak3) is a cytoplasmic tyrosine (Tyr) kinase associated with the interleukin-2 (IL-2) rec

14 results in the stimulation of intracellular Tyr kinase-based signaling cascades and cellular activat

15 a(1)-integrin inhibited Abeta stimulation of Tyr kinase-based signaling cascades in both THP-1 monocy

16 The kinase domain is unlike Ser/Thr/Tyr kinases but resembles two ATPases, Gyrase B and Hsp9

17 toring the effects of chemical inhibition of Tyr kinase CK2 or by mutating the phosphorylation site.

18 dentified an IL-2-JAK-independent SRC family Tyr-kinase-controlled signaling network that regulates a

19 composed of a dual specificity (Ser/Thr and Tyr) kinase domain tethered to a calmodulin-like domain

20 Among the protein Tyr kinases expressed in neutrophils, only Fgr eluted ex

21 is mechanism is independent of Ror2 receptor Tyr kinase functions.

22 ERBB and other receptor Tyr kinases have been identified as immediate early resp

23 ctase (hBVR) is a recently described Ser/Thr/Tyr kinase in the MAPK insulin/insulin-like growth facto

24 Genistein, a known Tyr kinase inhibitor, was found to inhibit the activitie

25 Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase, inhibits apoptosis by reducing biliverdin-IX

26 ify specific inhibitors of ZAP-70, a protein Tyr kinase involved in T cell activation.

27 The related protein Tyr kinases, Lck and Syk, were not significantly inhibit

28 of all receptor Tyr kinases and nonreceptor Tyr kinases leads to complex cytoprotective responses in

29 d-binding domain, inhibition of the receptor Tyr kinase-mediating receptor activation, and overexpres

30 Cell lines dependent on the activation of Tyr kinase mitogen receptor targets of the resorcylic ac

31 tein that suppresses signaling from receptor Tyr kinases of the epidermal growth factor receptor/ErbB

32 mains, phosphorylated by protein Ser/Thr- or Tyr-kinases or mediate specific interactions with protei

33 alpha selectively mediates activation of the Tyr kinase Pyk2 and GTPase Rac1 to regulate barrier func

34 at acts as a positive transducer of receptor Tyr kinase (RTK) signaling, particularly the Ras-REK and

35 hBVR is a Ser/Thr/Tyr kinase/scaffold protein/transcription factor/intrace

36 pecificities of many families of Ser/Thr- or Tyr-kinases, SH2, SH3, PDZ, 14-3-3 and PTB domains, toge

37 nent systems versus the 'eukaryotic' Ser/Thr/Tyr kinases) to carry out signal transduction.

38 Thr/Tyr kinase (TTK)/monopolar spindle 1 kinase (Mps-1) is a

39 as receptor (IRK) and nonreceptor (Src, Abl) Tyr kinases with greatly enhanced selectivity.

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