ライフサイエンスコーパス: U

1 ual yield losses worth more than 100 billion US$.

2 g public health threat in the United States (US).

3 (>= 2 m diameter) Porites colonies around Ta'u.

4 -year period at a site in the upper Midwest, US.

5 of newly reported chronic infections in the US.

6 OC and p53 signature lesions at transvaginal US.

7 tecture and human nature that impacts all of us.

8 d or probable COVID-19-related deaths in the US.

9 What do these reflections tell us?

10 Equivalent annual cost varied between US$1.2 (95% CI $1.1-$1.4) and US$1.5 (95% CI $1.3-$1.7),

11 varied between US$1.2 (95% CI $1.1-$1.4) and US$1.5 (95% CI $1.3-$1.7), assuming that each net was pr

12 incubated with increasing concentrations of [U-(13)C] glucose under conditions where GSIS was not aff

13 The enrolled patients underwent 215 US, 167 CT, and 69 MRI examinations, and 67% of them had

14 n, with a median cost of illness per case of US $196.37 (IQR, US $72.89-496.40).

15 A significant proportion of the total U (20-57%) was released from these three shales after re

16 The possibility of measuring low (236)U/(238)U isotope ratios can offer a large variety of geo

17 s) and an accurate determination of low (236)U/(238)U isotope ratios.

18 1 in Vero cells and human glioblastoma cells U-251 MG.

19 ming that each net was priced identically at US$3.

20 medical cost per case was US $58.64 (range: US $37.25 at Hospital B, US $73.27 at Hospital A).

21 uns, using a cost-effectiveness threshold of US$500 per disability-adjusted life-year (DALY) averted

22 the average direct medical cost per case was US $58.64 (range: US $37.25 at Hospital B, US $73.27 at

23 nce interval [CI] $776-927) for FLU+5FC, and US $628 (95% CI $557-709) for FLU.

24 cost of illness per case of US $196.37 (IQR, US $72.89-496.40).

25 s US $58.64 (range: US $37.25 at Hospital B, US $73.27 at Hospital A).

26 year with extraction costs of approximately US$80-180 per tonne of CO(2).

27 The mean costs per patient were US $847 (95% confidence interval [CI] $776-927) for FLU+

28 roteins or in coordination complexes affords us a better understanding of the assembly and function o

29 approach to population health science teach us about COVID-19?

30 This was a study of faculty at 113 US academic programs.

31 was an outpatient study conducted across six US academic sites.

32 U accumulation was limited in these wild populations due

33 presentative database of all discharges from US acute care hospitals.

34 the COVID-19 pandemic, fewer than 10% of the US adult population formed antibodies against SARS-CoV-2

35 , AND PARTICIPANTS: Representative sample of US adults aged at least 40 years in the National Health

36 9 emergency medical services agencies in the US and Canada from May 2015 to November 2017.

37 trial at 39 DRCR Retina Network sites in the US and Canada including 205 adults with vison loss due t

38 re risk were developed using eligible female US and Canadian participants in the Childhood Cancer Sur

39 Nanoliposomes prepared by US and MF were characterized based on particle size, str

40 have in 20 scientific societies based in the US and UK, and provides guidelines on how societies can

41 United States (US) and European Union 5 ([EU5]; i.e., France, Germany,

42 tiffness of the diaphragm, using ultrasound (US) and strain elastography (SE) in patients with hyperk

43 acebo after two nights of undisturbed sleep (US) and two nights of forced awakening (FA) sleep disrup

44 CH were assessed by chi-square, Mann-Whitney U, and ANOVA testing.

45 More than half of procedures in the US are performed in outpatient settings, yet little is k

46 ility of this plant-mediated mobilization of U as a function of the presence of various essential pla

47 XAS and EDX) and diffraction indicated that U-As-Ca- and U-Ca-bearing solids resemble uranospinite [

48 ife, and reduce illness and disability," the US biomedical research enterprise must directly confront

49 rdial amino acids: Valine (coded by GUX [X = U, C, A or G]), alanine (coded by GCX), aspartic acid (c

50 The short U-C distances and obtuse U-C-E angles suggest significan

51 The short U-C distances and obtuse U-C-E angles suggest significant U=C double bond charact

52 and obtuse U-C-E angles suggest significant U=C double bond character.

53 and diffraction indicated that U-As-Ca- and U-Ca-bearing solids resemble uranospinite [Ca(UO(2))(2)(

54 Low Mg/Ca, and high U/Ca, Mo/Ca, and V/Ca potentially suggest a decreased ab

55 th anterior vitrectomy +/- IOL implantation (US-Cat: 98.65%; BS-Cat: 95.24%; BT-Cat: 100%; P = .08).

56 In April 2015, in collaboration with the US Centers for Disease Control and Prevention and Gilead

57 As of 1st June 2020, the US Centres for Disease Control and Prevention reported 1

58 In total, this corpus spans five US cities and consists of 19.8 h of audio matched on the

59 for the general adult population across 477 US cities and for the Medicare population aged 65 years

60 t drugs were recruited and interviewed in 20 US cities for 2015 National HIV Behavioral Surveillance.

61 US citizens/residents) was associated with a similar ris

62 with an intact uterus were carried out at 40 US clinical centers (1993-2016).

63 Using patient-level claims data from US commercial and Medicare payers, we implemented inclus

64 to describe primary care services offered by US community health centers in March through May 2020, i

65 ccepted Ni(0) -> Ni(II) route was refuted by us, confirming the generality of the Ni(II) -> N(IV) pro

66 balance across irrigated maize fields in the US Corn Belt was explained by persistent factors and ide

67 ulation aged 65 years and older across 3,113 US counties, respectively.

68 The US Department of Agriculture (USDA) Supplemental Nutriti

69 for Advancement of Military Medicine and the US Department of Defense, Ragon Institute of MGH, MIT, &

70 The US Dietary Guidelines for Americans provide dietary reco

71 We developed a straightforward U-DNA sequencing method (U-DNA-Seq) that was combined wi

72 d a straightforward U-DNA sequencing method (U-DNA-Seq) that was combined with in situ super-resoluti

73 ade is valued between eight and 26.5 billion US dollars annually [3,4].

74 ively excited by the unconditioned stimulus (US) during fear conditioning.

75 ies, slow U uptake rates from food, and fast U elimination.

76 Deceptive claims surround us, embedded in fake news, advertisements, political pro

77 ostic testing for pulmonary embolism (PE) in US emergency departments (EDs), and no data have examine

78 harmaceutical, nanoparticles and ultrasound (US) enhanced delivery to develop a clinically viable the

79 t of detection of 1.93 uM, below that of the US environmental protection agency guidelines (5.37 uM),

80 We jointly model the US epidemic at the state-level, using publicly available

81 tivity up to 11.09 dB for PA and 6.69 dB for US flow.

82 tics have been developed and approved by the US Food and Drug Administration (FDA) for human use.

83 cal suppression at 48 weeks according to the US Food and Drug Administration (FDA) snapshot analysis.

84 ts at 1-hour posttransplant with Anakinra, a US Food and Drug Administration (FDA)-approved IL-1R ant

85 sure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA).

86 In 2015, the US Food and Drug Administration published revised guidan

87 European medical device regulatory agencies, US Food and Drug Administration, as well as payers, that

88 ingly and in combination with other existing US Food and Drug Administration-approved anti-cancer mod

89 ors, collectively termed JAK inhibitors, are US Food and Drug Administration-approved in a few autoim

90 A US Food and Drug Administration-led environmental assess

91 ation of the ENDO trial (NCT01728116) by the US Food and Drug Administration.

92 s abdominal pain response, as defined by the US Food and Drug Administration: at least a 30% decrease

93 ranone, and 4-methyl-2(5H)-furanone, allowed us for the first time to fully elucidate the isomeric st

94 d, reflecting the desorption of weakly bound U from the insect's integument.

95 In this analysis of branded drugs in the US from 2007 to 2018, mean increases in list and net pri

96 with diverse case studies in the Roman Army, US Government, and a healthcare organisation.

97 th stereotactic guidance in 29 studies; with US guidance in nine, with MRI guidance in nine, and with

98 Transvaginal US had 20% sensitivity (one of five), 93% specificity (1

99 est that pathogenesis of FXII-, ANGPT1-, and U-HAE moves through an unbalanced control of kallikrein

100 (KNG1-HAE), or angioedema of unknown origin (U-HAE).

101 ween January 1, 2020 and April 22, 2020 at a US high-volume transplant center.

102 MS on WGS somatic mutational profiles enable us identify more comprehensive context-based mutational

103 ancestral-sequence reconstruction could help us identify protein sequences that are more amenable to

104 peckers enabled rhinos to evade detection by us in 40% to 50% of encounters.

105 Occurrences of As, and to a lesser extent U, increased with pH, likely reflecting desorption, whil

106 equire extensive uridine insertion/deletion (U-indel) editing for their maturation.

107 ramework combined with multiscale data gives us insight into the relative roles of variation from dif

108 ral during person perception, to better help us interact in differing situations with a variety of pe

109 lpha,alpha-dicyanoolefines under ultrasound (US) irradiation.

110 eaction with fracture fluid, indicating that U is readily leachable.

111 fected by fear extinction learning (where no US is presented), and how fear and extinction memory und

112 The possibility of measuring low (236)U/(238)U isotope ratios can offer a large variety of geochemica

113 an accurate determination of low (236)U/(238)U isotope ratios.

114 ne (18)F-FDG PET/CT scans were selected from U.K. and Dutch studies on DLBCL to provide a balance bet

115 r the management of PCB contamination in the U.K. and reinforce the need to prevent PCBs entering the

116 Mutagenesis of U-loop residues reveals its contribution to enzyme kinet

117 s achieved after 4 h, at E/S ratios of 1/150 U/mg, regardless the initial protein concentration.

118 Seroconversion (IgA >= 20 U/mL) conferred substantial protection against any and s

119 trospective cohort study was conducted using US National Center for Health Statistics natality files

120 US National Institutes of Health, Royal Society, Wellcom

121 tnership, UK Multiple Sclerosis Society, and US National Multiple Sclerosis Society.

122 red with those from a three-dimensional (3D) U-Net and a coarse-to-fine deep learning method.

123 ams (CTA) was compared against a generic 3-D U-Net and displayed superior results.

124 The performance of our Attention-based U-Net in extracting both the inner (blood flow) lumen an

125 A generic three-dimensional (3D) U-Net was trained on four different databases to generat

126 network (FCN), SegNet, Dilated-Net, original U-Net, and Faster R-CNN models and the conventional regi

127 to the problem of image segmentation using a U-Net.

128 The mesityl imido compound [U(NMes)(NP(pip)(3))(4)], 2-U(PN)NMes, exhibits a unique

129 nce Program (SNAP) is the cornerstone of the US nutrition safety net.

130 nal bipyramidal geometry of the oxo complex [U(O)(NP(pip)(3))(4)], 2-U(PN)O.

131 US of the left breast (Fig 1), bilateral breast MRI (Fig

132 nvolved in a cortical computation can inform us on the sources and targets of these signals.

133 This approach takes us one step closer to mass production of macroscopic mon

134 's role as a novel fibrotic-switch, bringing us one step closer to understanding the complex biologic

135 iggered by classic opioids-in particular the u-opioid receptor (MOR).

136 which we confirm by locally eliminating the u-Opioid receptor.

137 Here, we hypothesized that the u-opioid system-extensively implicated in placebo effect

138 ed by GCX), aspartic acid (coded by GAY [Y = U or C]), glutamic acid (coded by GAZ [Z = A or G]), gly

139 Medical graduate status outside of the US (OR: 0.58; 99% CI: 0.36-0.93; P < .001) was associate

140 n addition to designing prospective studies, U-PASS enables researchers to retrospectively assess the

141 U-PASS is an open-source R Shiny application.

142 Here we present U-Pb ages for impact-driven shock-recrystallised accesso

143 This pharmacoepidemiology study uses US pharmacy data to compare prescriptions for hydroxychl

144 l imido compound [U(NMes)(NP(pip)(3))(4)], 2-U(PN)NMes, exhibits a unique square pyramidal geometry i

145 of the oxo complex [U(O)(NP(pip)(3))(4)], 2-U(PN)O.

146 Importantly, in the context of US politics, greater inaccuracy was associated with incr

147 ding alcohol use and its consequences in the US population remain.

148 s-sectional representative study of an adult US population revealed a statistically significant assoc

149 orted impaired HRQoL compared to the general US population.

150 s a major source of isoprene exposure in the US population.

151 cHL, respectively, compared with the general US population.

152 emiology and End Results Program sites and a US prostate cancer registry, with surveys through Septem

153 econdary) in children and adolescents in the US ranges from 3% to 4%.

154 They reveal postdepositional U redistribution explained by major U speciation changes

155 -invariant optical flow algorithm that helps us reduce error in blood perfusion estimate below 10% in

156 At steady-state U release, kinetic and spectroscopic results suggest det

157 In a case-control study nested within the US Renal Data System, we identified all hip fracture eve

158 Using U(S)3 deletion and U(S)3 kinase-dead recombinant MDV, we

159 Using U(S)3 deletion and U(S)3 kinase-dead recombinant MDV, we identified U(S)3-r

160 ing infection and found that the majority of U(S)3-responsive genes were located in the MDV repeat re

161 3 kinase-dead recombinant MDV, we identified U(S)3-responsive MDV genes during infection and found th

162 stimated by 150% in Canada and by 20% in the U.S.

163 l inter-region transfer distances across the U.S.

164 5 billion in damages across the southeastern U.S.

165 We examined 1,254 U.S. adolescents (12-17 years) self-reported sleep durat

166 In U.S. adolescents, use of an electronic vapor product was

167 d advanced practice providers of established U.S. and Canadian critical care organizations and provid

168 economic, and demographic data from ~65,000 U.S. census tracts.

169 s Diseases, Johns Hopkins Health System, and U.S. Centers for Disease Control and Prevention.

170 and Biokinetic (IEUBK) model was applied for U.S. children aged 0 to <6 years.

171 ible for outbreaks of urethritis in multiple U.S. cities since 2015, other mucosal infections, and ca

172 Undergraduate students and faculty at U.S. colleges.

173 The U.S. Federal Emergency Management Agency (FEMA) recommen

174 nstitute (CLSI) LC-MS C62-A document and the U.S. Food and Drug Administration (FDA) Bioanalytical Me

175 ltrials.gov, MEDLINE, and publicly available U.S. Food and Drug Administration (FDA) drug reviews, al

176 On August 16, 2019, the U.S. Food and Drug Administration approved expanding the

177 Initial implementation of the U.S. Food and Drug Administration EFS program has been s

178 either the European Medicines Agency or the U.S. Food and Drug Administration for the management of

179 tion treatment that has been approved by the U.S. Food and Drug Administration for treatment-resistan

180 In October 2018, the U.S. heart allocation system expanded the number of prio

181 S) scenarios with process emissions from the U.S. industrial sector by analyzing the variabilities in

182 acteristics and adverse clinical outcomes of U.S. invasive Hia cases detected through multi-state sur

183 global industrial greenhouse gases, and the U.S. is the world's second-largest steel consumer.

184 ly 12 000 sites across the United States and U.S. jurisdictions.

185 COVID-19-related public health mandates in 3 U.S. locations.

186 LRT in patients with beyond-MC HCC from the U.S. Multicenter HCC Transplant Consortium (20 centers,

187 of the largest protected areas on earth are U.S. National Monuments in the Pacific Ocean.

188 According to the U.S. National Osteoporosis Foundation guidelines, postme

189 Interventions to address the U.S. opioid crisis primarily target opioid use, misuse,

190 who meet the age and smoking criteria of the U.S. Preventive Services Task Force (USPSTF) for annual

191 Expert groups, including the U.S. Preventive Services Task Force (USPSTF), recommend

192 pparently reflects the inefficiencies of the U.S. private insurance-based, multipayer system.

193 wly expanded program to an assessment of the U.S. Regional Greenhouse Gas Initiative (RGGI), the Unit

194 r 11, 2017, and May 4, 2018 (n = 79) from 29 U.S. sites.

195 seasons in central Amazonia and Southeastern U.S. summer.

196 The rapid growth in U.S. unconventional oil and gas has made energy more ava

197 testing and treatment intervention among non-U.S.-born residents was projected to produce sustained r

198 llions of live animals are imported into the U.S.A. alone every year.

199 d that TSHR activation exhibits an "inverted U-shaped dose-response curve" with increasing cAMP produ

200 capture RAG engaged with transposon ends and U-shaped target DNA prior to integration (the target cap

201 were reduced by >90% relative to Pb RBA for U soils, which is substantially more effective than othe

202 sitional U redistribution explained by major U speciation changes due to redox cycling in the wetland

203 low concentrations of bioavailable dissolved U species, slow U uptake rates from food, and fast U eli

204 Estimates of US spending on health care showed substantial increases

205 ithin a global human-earth system model with US state-level energy systems, in scenarios to 2050, to

206 Thirty-one facilities in 11 US states had SEOV infection, and among those with >=10

207 We sought to conduct a nationwide US survey to assess Guidelines implementation among alle

208 ntion, decision-making, and learning to help us survive in an uncertain world.

209 The Cancer Genome Atlas consortium brought us terabytes of information about genetic alterations in

210 The Mann-Whitney U test was used to check that the proposed super-resolut

211 Mean safe-reporting scores were lower in the US than other English-speaking nations and variation exi

212 It was found by us that the P-C coupling reaction of >P(O)H reagents wit

213 ly normal human T cell responses have taught us that there is still much to be discovered about this

214 This gives us the ability to tune the anomalous phase, and opens ne

215 ay to think about alkali metal halides, show us the way to integrate simulation with theory.

216 ragments by Escherichia coli PBP1B, allowing us to (a) identify recognition elements of transpeptidas

217 epair constituting from 40% of TEVARs in the US to 72% in the UK (p < 0.001).Mean intact TAA (iTAA) d

218 important, it may not be sufficient to carry us to a place of truly new insight regarding consciousne

219 High-resolution confocal images allowed us to analyze AL innervations of the various reported ne

220 es' responses to climate dynamics will allow us to anticipate and manage future range shifts driven b

221 efrogs and developed a pipeline that allowed us to assemble their complete amino acid and nucleotide

222 mediated through other drivers, would allow us to better predict population fates and design mitigat

223 These models allow us to characterize each TF's specificity, activity and i

224 erforms other existing predictors and allows us to classify 1,760 genes-which are currently unascerta

225 man 3D skin constructs (HSCs), which enabled us to closely monitor and quantitate T cell responses.

226 This discovery prompted us to collect data from nine additional patients with de

227 utants in parallel to FUS knockout, allowing us to compare mutation-induced changes to genuine loss o

228 in the Bass diffusion framework that enables us to compare the differential equation version with an

229 ta stereoselective cellular uptake, allowing us to decouple aggregation from cellular, receptor-media

230 e low concentration of nanoparticles allowed us to demonstrate the capability of TOF-SIMS to spatiall

231 in structure and sulfation pattern, allowing us to determine how heparanase recognizes HS substrate a

232 lts, based on longitudinal GPS data, allowed us to determine ideal habitat ratios (grassland:open woo

233 (HS-AFM) and kinetic modeling which allowed us to determine that septin filament assembly was a diff

234 e temporally chimeric male mice thus enabled us to determine the contribution of VPAC2-expressing cel

235 This mutant chimera enabled us to determine the cryoelectron microscopy (cryo-EM) st

236 These observations prompted us to develop a high-throughput screening platform of ca

237 This prompted us to develop such a tool, the Angioedema Control Test (

238 ingle-cell RNA-sequencing (scRNA-seq) allows us to dissect transcriptional heterogeneity arising from

239 ion needs to be appropriately integrated for us to effectively engage with and learn from our world.

240 nomes from available patient samples enabled us to estimate that SARS-CoV-2 was introduced to Scotlan

241 sure compartmentalized cAMP, and this allows us to estimate the range of effector activation.

242 ntents of theobromine and flavanols prompted us to examine the cocoa varieties to seek correlations b

243 h the proinflammatory host response prompted us to examine the role of early corticosteroid therapy i

244 ecting two images simultaneously that allows us to excite water with stimulated Raman scattering and

245 enantiomerically pure amino acids, enabling us to explore structural diversity.

246 l time via an NMR-based approach that allows us to follow the steps that couple ATP turnover to mecha

247 al transport through disordered media allows us to formulate precise links between the statistics of

248 The data and spectra obtained allowed us to gain further insight into accurate identification,

249 This finding leads us to hypothesize that the therapeutic effects of CoQ10,

250 s was applied to 290 isolates, which allowed us to identify 25 additional cases related to the outbre

251 rounds of site-directed mutagenesis allowed us to identify 4 of 413 residues from TrpB that are cruc

252 Solving the V2F challenge requires us to identify causative genetic variants, relevant cell

253 those of suitable reference compounds allows us to identify their specific isomeric form, including t

254 only used R packages nlme and MASS, allowing us to incorporate the well-developed analytic procedures

255 duced peptidoglycan cross-linking, prompting us to investigate synergism between beta-lactams and DCS

256 urden of JAK2-mutated clones(6,7), prompting us to investigate the mechanism underlying disease persi

257 injection of HoxB8 progenitors also allowed us to maintain stable circulating HoxB8 neutrophil count

258 These data have allowed us to map the electronic structures of this metallocenat

259 ane extract hydrogels (Matrigel) that allows us to measure contractile force from the shape of the re

260 n any previous simulation of 5-HT(3A), allow us to observe the dynamic binding and unbinding of 5-hyd

261 ss spectrometry (MS)-based proteomics allows us to obtain snapshots of molecular microenvironments wi

262 is powerful combination of techniques allows us to obtain valuable insights into structural, electron

263 metal dichalcogenide heterostructures allow us to optically create and investigate low-energy excite

264 nce is sensitive to viscosity, Coupa allowed us to precisely localize sites of mitochondria-lysosome

265 strongly for a specific word, they do allow us to predict some upcoming information.

266 is established based on Tempel that enables us to predict the mutations at any specific residue site

267 the time the vaccine is introduced, enables us to predict whether the strain increases or decreases

268 cs-based informatics framework, which allows us to probe for the contribution of equilibrium fluctuat

269 However, approaches that allow us to probe G4s in living cells without perturbing their

270 Taken together, our results not only allow us to propose a revised model of how CDK8 activity is re

271 cert with in situ (19)F NMR monitoring allow us to propose that the pyridone ligand plays a role in e

272 Single-molecule spectroscopy allows us to quantify the effects of crowding on a comprehensiv

273 performed in a Bayesian framework, allowing us to quantify uncertainty in the allocation of proteins

274 This allows us to realize a regime of nearly ideal QD doping when in

275 spondo, whose spine is dysmorphic, prompted us to reconstruct paleontological evidence, highlighting

276 However, the neural mechanisms that enable us to respond to target stimuli while ignoring distracto

277 e by leveraging IM separation, which enabled us to separate and analyze CID and ECD fragmentation sim

278 These findings led us to separate the two chiral species and test their eff

279 This paradigm allowed us to simultaneously measure amputee subject and prosthe

280 roves micrograph interpretability and allows us to solve 3D single particle structures of clustered p

281 The enhanced CIU capabilities enable us to study the gas phase stability of the GroEL 7-mer a

282 of diamond nanoparticles in phantoms allowed us to tune the T1 value of the phantoms which open the w

283 r, but the novel coronavirus pandemic allows us to understand how partisan animus contributes to opin

284 we show that having so many materials allows us to use big-data methods as a powerful technique to st

285 n intact TAA (iTAA) diameter varied from 59 (US) to 69 mm (Nancy, France) (p < 0.001), 25.3% of patie

286 resenting more than 70% of the assays in the US Tox21 research consortium.

287 nactivation processes, including N-, C-, and U-types.

288 explain how these remarkable birds can help us uncover the basic biological processes driving techno

289 These results help us understand the mechanisms underlying the psychedelic

290 ns of bioavailable dissolved U species, slow U uptake rates from food, and fast U elimination.

291 Among US veterans 75 years and older and free of ASCVD at base

292 copic results suggest detachment of oxidized U(VI) from the UO(2)(s) surface as the rate-determining

293 Acidic solutions containing U(VI), Sr(II), Eu(III), and Ce(III) were used to determi

294 ta overall and excess mortality rates in the US vs that of 18 OECD countries and the timing of any in

295 Nearly 90% of the accumulated U was eliminated within 24 h after the waterborne exposu

296 High-resolution ultrasonic spectroscopy (HR-US) was applied for real-time monitoring of beta-casein

297 classified as clustered microcysts at breast US were retrospectively identified in women at two hospi

298 Both PMI(Prot) and PMI(UD) were associated with 5-year cardiovascular mortality

299 uts to demonstrate that current N removal by US wetlands (about 860 +/- 160 kilotonnes of nitrogen pe

300 CT deletions and mutagenesis analyses helped us zoom in on three residues in the CT, namely Glu-719,