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1 U2 snRNPs depleted of Rds3p fail to form stable presplic
2 leads to the demonstration that the core 17S U2 snRNP components, SF3b145 and SF3b49 bind directly to
3 ntribute to conversion of the 12S to the 17S U2 snRNP particle, which is essential for spliceosome as
4 ts intrinsic interaction with Caper alpha, a U2 snRNP auxiliary factor-related protein previously imp
6 of the adenine is critical in formation of a U2 snRNP-containing complex on a minimal branch-site oli
7 both minimal requirements for formation of a U2 snRNP-substrate RNA complex, here designated the Amin
8 y interacts with components of the activated U2 snRNP and enhances binding of U2 snRNP to the branch
11 ed for maximal binding of both U1 snRNPs and U2 snRNPs to the 5' and 3' splice site, respectively, su
12 SNF is a protein that is found in the U1 and U2 snRNPs (small nuclear ribonucleoproteins) of Drosophi
13 tion of NPL3 reduces the occupancy of U1 and U2 snRNPs at genes whose splicing is stimulated by Nbl3.
15 del for spliceosome assembly in which U1 and U2 snRNPs first associate with the spliceosome in the E
18 re required for communication between U1 and U2 snRNPs whether this interaction is across introns or
20 r (snf), which encodes a component of U1 and U2 snRNPs, participates in this RNA splicing control.
21 vivo, these proteins segregate to the U1 and U2 snRNPs, respectively, where they bind distinct RNA ha
22 the expression of core components of U1 and U2 snRNPs, splicing regulators and other post-transcript
26 each physically associated with both U1 and U2 snRNPs; Prp5 contains distinct U1- and U2-interacting
28 basis of ATP use for the interaction between U2 snRNP and the branchpoint is unclear, and, in particu
31 study interactions between the UACUAAC box, U2 snRNP, and Prp5p, a DEAD box protein necessary for pr
36 otein complex which can exchange with a core U2 snRNP and which is necessary for U2 snRNP function in
38 ddition to its established function in early U2 snRNP recruitment, SF3b plays a role in later maturat
42 tion involves binding of the splicing factor U2 snRNP auxiliary factor (U2AF or MUD2 in Saccharomyces
43 uctures of the heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) have revealed two unexp
44 m yeast stably associates with at least five U2 snRNP proteins, Cus1p, Hsh49p, Hsh155p, Rse1p, and Is
61 A.Z are especially dependent on a functional U2 snRNP (small nuclear RNA [snRNA] plus associated prot
62 idence that this complex contains functional U2 snRNP and that this snRNP is required for E complex a
67 s as a "decoy" acceptor site that engages in U2 snRNP-dependent but nonproductive splicing complexes
68 xes, implicate accessory splicing factors in U2 snRNP function, and support SF3b contribution from ea
69 In sharp contrast to its essential role in U2 snRNP recruitment in vitro, the RS domain on the Dros
70 A1, Pcbp1, and RBM39 stabilizes or increases U2 snRNP recruitment, enhances spliceosome A complex for
74 was detected by incubating human 32P-labeled U2 snRNP in micrococcal nuclease-treated HeLa nuclear ex
77 ns in spliceosome assembly within the mature U2 snRNP (small nuclear ribonucleoprotein particle), and
80 imidine tract binding protein (PTB), but not U2 snRNP auxiliary factor (U2AF), and that binding of PT
82 t sudemycin E interferes with the ability of U2 snRNP to maintain an H3K36me3 modification in activel
85 K4me3 levels by siRNA reduced association of U2 snRNP components with chromatin and, more importantly
88 tors are not necessary for stable binding of U2 snRNP per se, but rather are necessary for accessibil
90 Although U2 stem IIc inhibits binding of U2 snRNP to pre-mRNA during assembly, we found that weak
92 the presence of ATP, and supports binding of U2 snRNP to the 3' end of introns, yielding a weak ATP-i
94 e activated U2 snRNP and enhances binding of U2 snRNP to the branch site located upstream of the exon
95 complex followed by ATP-dependent binding of U2 snRNP to the branchpoint sequence (BPS) in the A comp
96 A splicing reaction is the stable binding of U2 snRNP to the branchpoint sequence (BPS) to form the A
98 istinguishable mechanisms for the binding of U2 snRNP to the pre-mRNA, including U2AF-dependent and -
102 d pre-mRNA, underscoring the conservation of U2 snRNP proteins that function in spliceosome assembly.
103 gion spanning from immediately downstream of U2 snRNP's binding site at the BPS to just beyond the 3'
105 prior data showing that loss of function of U2 snRNP components can interfere with cell growth and i
108 determined that U1 snRNP-directed loading of U2 snRNP onto the branch site as well as efficient trans
111 lex forms with stoichiometric association of U2 snRNPs and the U2 snRNA is base-paired to the pre-mRN
112 of nuclear export or targeted degradation of U2 snRNPs caused a marked decrease in the levels of U2 s
116 2 snRNP, as H2A.Z loss results in persistent U2 snRNP association and decreased recruitment of downst
117 ied role for phosphorylated SR proteins post-U2-snRNP addition coincides with the recruitment of the
118 dition, the antibody to PRPF40A precipitated U2 snRNPs from nuclear extracts, indicating that PRPF40A
123 nchpoint and the 3' splice site and recruits U2 snRNP to the branch site at an early step in spliceos
124 polypyrimidine tract of the intron, recruits U2 snRNP to the branch point sequence by interacting wit
130 -the hU2AF65 RS domain is required to target U2 snRNP to the branch site and the hU2AF35 RS domain is
131 anchpoint and the 3' splice site and targets U2 snRNP to the branch site at an early step in spliceos
138 reby Cus2p first helps Prp5p to activate the U2 snRNP for prespliceosome formation but then is displa
141 an interface between U4/U6 di-snRNP and the U2 snRNP SF3b-containing domain, which also transiently
143 tion, the proteins U2AF35 and U2AF65 and the U2 snRNP, are able to recognize alternative candidate si
144 ent in facilitating interactions between the U2 snRNP complex and ATP-dependent helicases, we examine
146 t are distinct from the binding site for the U2 snRNP protein p14, mapped to amino acids 396-424 of S
149 e U2B" counterpart, Sans-Fille (SNF), in the U2 snRNP is dispensable for viability, suggesting that S
152 nt spliceosomal rearrangements involving the U2 snRNP, as H2A.Z loss results in persistent U2 snRNP a
155 prevented from binding to the pre-mRNA, the U2 snRNP can no longer be recruited and the following ex
156 lso results in persistent association of the U2 snRNP and a severe defect in the association of downs
159 n (U1 70K) and with the small subunit of the U2 snRNP auxiliary factor (U2AF35) in live-cell nuclei.
161 11, and Prp21 influence the structure of the U2 snRNP in a manner that alters the accessibility of th
163 blish Rds3p as an essential component of the U2 snRNP SF3b complex and suggest a new link between the
164 and Prp21, are necessary for addition of the U2 snRNP to the pre-mRNA in an early step of spliceosome
168 a and human proteins suggest that two of the U2 snRNP-specific proteins, U2A' and U2B", function excl
178 oteins and the pre-mRNA, indicating that the U2 snRNP-intron interaction is Prp43's major target.
179 ng of the 2'-O-methyl oligonucleotide to the U2 snRNP in yeast cell extract was assayed by gel electr
181 linked to interactions of alphaCPs with the U2 snRNP complex and may be mediated by cooperative inte
183 Sudemycin E induces a dissociation of the U2 snRNPs and decreases their interaction with nucleosom
184 antisense morpholino oligonucleotide or the U2-snRNP-inactivating drug spliceostatin A unless U1 ant
188 bserved cross-linking of C hnRNP proteins to U2 snRNP was efficiently competed by excess U2 RNA and b
190 concurrently by two molecules of U2AF or two U2 snRNPs, so none of the components are restricted.
193 eterodimeric pre-mRNA splicing factor, U2AF (U2 snRNP auxiliary factor), plays a critical role in 3'
194 he splicing factor SF3b that associates with U2 snRNP and is recruited to prespliceosomal complexes.
195 by an interaction (direct or indirect) with U2 snRNP bound at the BPS and by a direct interaction wi
196 .Z shows extensive genetic interactions with U2 snRNP-associated proteins, and RNA sequencing (RNA-se
198 d spliceosomal complex A, is associated with U2 snRNPs, and colocalizes with splicing factors in nucl
200 east protein (YU2B") is a component of yeast U2 snRNP, and it is related to other members of the UIA-
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