ライフサイエンスコーパス: UCS

1 UCS and AMT, as an adjuvant to standard medical therapy

2 UCS has the advantage of faster improvement in corneal c

3 UCS predictability was varied on a trial-by-trial basis

4 UCS-evoked depolarization of amygdala neurons may instru

5 UCS-evoked responses in both amygdala and PAG were inhib

6 UCSs shared proteomic features with gynecologic carcinom

7 edator feces may also be less effective as a UCS because they are poorly predictive of the actual pre

8 Proteins containing a UCS (UNC-45/CRO1/She4p) domain are necessary for the inc

9 Sf9 cell expression system, which required a UCS (UNC-45/CRO1/She4p) family myosin chaperone from Pla

10 We propose that a UCS dimer links two myosins at their motor domains and t

11 10.2, and 22.9 +/- 10.1 days in MT, AMT, and UCS groups, respectively, with a significant difference

12 on every trial, whereas in others the CS and UCS are paired intermittently.

13 In many studies the CS and UCS are paired on every trial, whereas in others the CS

14 r or absent node condensation in myo2-E1 and UCS rng3-65 mutants.

15 how a dissociation between CR expression and UCS expectancy following differential delay conditioning

16 learning process mediates CR expression and UCS expectancy.

17 een MT and AMT (P = .001) and between MT and UCS (P = .001), but not between UCS and AMT (P = .9).

18 ed the identities of conditioned stimuli and UCS.

19 interval) elapses between CS termination and UCS onset.

20 The anti-UCS serum reacted with a P. carinii protein that migrate

21 kDa protein was immunoprecipitated with anti-UCS serum and shown to react with a monoclonal antibody

22 cological inactivation of the PAG attenuated UCS-evoked responses in the amygdala and impaired acquis

23 tween MT and UCS (P = .001), but not between UCS and AMT (P = .9).

24 de novo in the absence of UCS proteins, but UCS proteins promote myosin stability and interactions w

25 Only one locus, called UCS, supports the production of MSG mRNA.

26 Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with

27 haracterizations of uterine carcinosarcomas (UCSs).

28 % identical to the P. carinii f. sp. carinii UCS.

29 cells with proteins containing a conserved 'UCS' domain.

30 isoenergetic amounts of uncooked cornstarch (UCS; 1.76 +/- 0.41 g/kg) given in random order on consec

31 UCS presentations paired with the CS+ (CS + UCS) and CS- (CS - UCS), as well as presentations of the

32 paired with the CS+ (CS + UCS) and CS- (CS - UCS), as well as presentations of the UCS alone were inc

33 the uncertainty inherent in intermittent CS-UCS pairing procedures.

34 To better understand the influence of the CS-UCS pairing rate on brain activity, the experimenters pr

35 nd fusiform gyrus activity paralleled the CS-UCS pairing rate, whereas the insula and dorsolateral pr

36 yrus activity increased linearly with the CS-UCS pairing rate.

37 ing working memory processes maintain the CS-UCS representation during the trace interval.

38 Differential UCS expectancy (awareness) was observed only on perceive

39 as also observed independent of differential UCS expectancies.

40 romosomes, suggesting that the mechanism for UCS-MSG recombination is reciprocal exchange.

41 These VP units for UCS remained responsive to sucrose reward after learning

42 relevant, we show that miR-200 expression in UCS cells induces a robust mesenchymal-epithelial transi

43 The range of EMT scores in UCS was the largest among all tumor types studied via Th

44 ngent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decrea

45 Theory and evidence suggest that instructive UCS inputs to the amygdala will be inhibited when the UC

46 To gain more insight into UCS function, we determined the atomic structure of the

47 Moreover, by manipulating UCS aversiveness via reinforcer inflation, we showed tha

48 To distinguish between these two models, UCS/MSG junctions in the genome were compared with UCS/M

49 one (CS+) was paired with a loud white-noise UCS and a second tone (CS-) was presented alone.

50 st myosin can fold de novo in the absence of UCS proteins, but UCS proteins promote myosin stability

51 In addition, probe trials that consisted of UCS presentations paired with the CS+ (CS + UCS) and CS-

52 by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS inten

53 by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS inten

54 SCR and participants' expectations of UCS presentation were monitored during conditioning.

55 ons are proposed for the conserved family of UCS proteins: helping to fold myosin motor proteins and

56 A single dose (1.76 +/- 0.41 g/kg) of UCS at bedtime maintains plasma glucose concentrations >

57 t without generating the very high levels of UCS diversity previously seen.

58 ough both groups exhibited similar levels of UCS expectancy, the devaluation group had significantly

59 skin conductance and continuous measures of UCS expectancy were recorded concurrently with whole-bra

60 oned stimulus association, but the origin of UCS inputs to the amygdala is unknown.

61 lationship with the participants' ratings of UCS expectancy.

62 r, suggesting the need for a reevaluation of UCS functions in aversive conditioning.

63 t a CS+ retains access to representations of UCS value in distinct regions of ventral prefrontal cort

64 Finally, by treatment of UCS-xenografted mice with miR-200c incorporated in DOPC

65 The T. gondii genome contains one UCS family myosin co-chaperone (TgUNC).

66 and aggressiveness of miR-200-overexpressing UCS cell lines.

67 ned response (UCR) produced by a predictable UCS can also develop.

68 nitude related to the accuracy of predicting UCS presentations.

69 the DNA encoding the P. carinii f. sp. ratti UCS was not unique in the genome.

70 Groups 1, 2, and 3 received UCS with medical therapy (MT), AMT with MT, and MT alone

71 Unc45-/Cro1p-/She4p-related (UCS) protein Rng3p restored the full motility and actin-

72 ite, termed the upstream conserved sequence (UCS), through two related but distinct mechanisms.

73 nce, called the upstream conserved sequence (UCS), which is encoded by a single locus.

74 nce, called the Upstream Conserved Sequence (UCS), which is in frame with the contiguous MSG sequence

75 UNC-45/CRO1/She4p (UCS) proteins have variously been proposed to affect the

76 In budding yeast the single UCS protein (She4p) acts on both myosin-I isoforms (Myo3

77 ward cues in reward learning and uses stable UCS population and firing codes to encode sucrose reward

78 unpleasant odors [the unconditioned stimuli (UCS)] in a partial reinforcement schedule.

79 g revaluation of the unconditional stimulus (UCS) in human fear conditioning.

80 tioning, an aversive unconditional stimulus (UCS) is repeatedly paired with a neutral conditional sti

81 ed stimulus (CS) and unconditioned stimulus (UCS) coterminate.

82 e response (SCR) and unconditioned stimulus (UCS) expectancy were measured concurrently as participan

83 stimulus (CS) and an unconditioned stimulus (UCS) has been learned.

84 e conditioning as an unconditioned stimulus (UCS) when presented in large amounts.

85 red with an aversive unconditioned stimulus (UCS).

86 red with an aversive unconditioned stimulus (UCS).

87 reward was received [unconditioned stimulus (UCS)].

88 salient reinforcer (unconditioned stimulus, UCS).

89 Previous work identified a sequence termed UCS, which is present at the beginning of nearly all MSG

90 domain of unknown function, and a C-terminal UCS domain known to interact with the myosin head.

91 The COOH-terminal UCS domain of Rng3p alone restored motility to pure Myo2

92 oth the N-terminal (central) and C-terminal (UCS) domains of Rng3p can concentrate independently in c

93 Test performance revealed that UCS inflation did not alter expectancy ratings, but the

94 MSG genes linked to the UCS, suggesting that UCS-MSG junctions are formed by recombination during pop

95 Our data suggest that UCSs do not develop from EACs via EMT.

96 The UCS contains several potential start sites for translati

97 The UCS memory retrieval-extinction procedure has superior r

98 The UCS/MSG junctions in the mRNA matched those in the genom

99 al pathways that relay information about the UCS to the amygdala by recording neurons in the amygdala

100 ression site model is that mRNAs acquire the UCS by RNA splicing.

101 n which a single MSG sequence resided at the UCS locus in 80 to 90% of the organisms, showing that P.

102 rom a population highly heterogeneous at the UCS locus reproduced this heterogeneity.

103 organisms that were already different at the UCS locus.

104 lack the UCS, the correspondence between the UCS/MSG junctions in transcripts and those in the genome

105 Both the UCS and MSG genes were shown to be located at the ends o

106 We conclude that while both the UCS and the Central domains bind the myosin head with hi

107 We found that both the UCS and the Central domains bind to the myosin motor dom

108 st the 123-amino-acid peptide encoded by the UCS.

109 cialis carinii has a unique locus called the UCS, which controls surface antigen variation by acting

110 of MSG, the nucleotide sequence encoding the UCS peptide was ligated to the 5' end of an MSG gene and

111 . carinii, it was of interest to examine the UCS locus in the related P. carinii f. sp. ratti.

112 To investigate this issue, we examined the UCS locus in P. carinii from rats that had been exposed

113 begins with 380 nucleotides copied from the UCS locus.

114 Given the UCS's importance in P. carinii f. sp. carinii, it was of

115 Corneal clarity was better in the UCS group at 21 (P = .008) and 30 days (P = .002), but n

116 hat in P. carinii, translation begins in the UCS to produce a pre-MSG protein, which is subsequently

117 ne if translation of MSG mRNAs begins in the UCS, polyclonal antiserum was raised against the 123-ami

118 Given that few if any MSG mRNAs lack the UCS, the correspondence between the UCS/MSG junctions in

119 baculovirus carrying an MSG gene lacking the UCS expressed a nonglycosylated 130-kDa protein.

120 (CS - UCS), as well as presentations of the UCS alone were included to assess UCR diminution.

121 techniques to study the interactions of the UCS and Central domains with the myosin motor domain.

122 To determine the chaperone activity of the UCS and Central domains, we used two different methods:

123 To explore the functional role of the UCS in the trafficking of MSG, the nucleotide sequence e

124 The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced re

125 did not contribute to the attachment of the UCS to the 5' ends of MSG mRNAs.

126 In Experiment 1, the intensity of the UCS was decreased after acquisition for one group (deval

127 In Experiment 2, the value of the UCS was increased after acquisition for one group (infla

128 is modified by conscious expectations of the UCS, conditioned diminution of the UCR can be expressed

129 the myosin head with high affinity, only the UCS domain displays chaperone activity.

130 d memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and

131 In the current study, the UCS of the MSG from human-derived P. carinii was obtaine

132 ication of the second method showed that the UCS domain but not the Central domain prevents the therm

133 Using the first method, we found that the UCS domain is sufficient to prevent misfolding of a titi

134 S probability or explicit knowledge that the UCS intensity had changed.

135 S probability or explicit knowledge that the UCS intensity had changed.

136 Southern blot analysis demonstrated that the UCS was present in a single copy per genome, whereas mul

137 Here we show that the UCS was present in one copy per haploid genome, but that

138 the genome indicates that attachment to the UCS is both necessary and sufficient for transcription o

139 One possibility is that attachment to the UCS locus is required for the transcription of an MSG ge

140 ith respect to the MSG genes attached to the UCS locus.

141 er diminution of the UCR was observed to the UCS when it followed the CS+ compared to when it followe

142 d a different set of MSG genes linked to the UCS, suggesting that UCS-MSG junctions are formed by rec

143 s to the amygdala will be inhibited when the UCS is expected, but this has not been found during fear

144 The mechanism by which the UCS becomes part of different MSG mRNAs is not obvious b

145 Insect cells infected with the UCS-MSG hybrid gene expressed a 160-kDa protein which wa

146 This UCS leader sequence is necessary for initiation of trans

147 le common mechanism for the function of this UCS (UNC-45/CRO1/She4p) protein family.

148 side the cleft binding epitope accessible to UCS binding.

149 ng, whereas the population that responded to UCS did not change.

150 ifferent MSG genes were linked to the unique UCS locus in different members of a P. c. carinii popula

151 Improvement in pain score was better with UCS than AMT (P value: .012, .002, and .012 on days 7, 1

152 G junctions in the genome were compared with UCS/MSG junctions in mRNA.

153 tential treatment approach for patients with UCS.

154 The fission yeast UCS protein (Rng3p) concentrates in nodes containing myo

155 determined the atomic structure of the yeast UCS protein, She4p, at 2.9 A resolution.