ライフサイエンスコーパス: UDP-glucuronosyltransferase

1 chrome P450 or phase II conjugating enzymes (UDP-glucuronosyltransferase).

2 m deficiency of the hepatic enzyme bilirubin-UDP-glucuronosyltransferase.

3 otransferases, glutathione transferases, and UDP-glucuronosyltransferases.

4 ucuronic acid in the liver via the action of UDP-glucuronosyltransferases.

5 The human UDP-glucuronosyltransferase 1 (UGT1) locus spans nearly

6 A polymorphism in the promoter of the UDP-glucuronosyltransferase 1 (UGT1A1) gene has been sho

7 P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiat

8 In humanized UDP glucuronosyltransferase-1 (hUGT1) mice that express

9 nits (pfu) intravenously) in adult bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rat

10 olerance to adenoviral antigens in bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rat

11 via gastroduodenostomy tubes into bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient jaundice

12 tyltransferase (pSV2-CAT) or human bilirubin-UDP-glucuronosyltransferase-1 (pSVK3-hBUGT1) genes were

13 iplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at le

14 us result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inabili

15 UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the g

16 To study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and s

17 In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enz

18 UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an import

19 lpha), CAR, cytochrome P-450 2b10 (Cyp2b10), UDP-glucuronosyltransferase 1a1 (Ugt1a1), sulfotransfera

20 hich in turn is detoxified primarily through UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed glucu

21 tributed isozymes encoded at the UGT1 locus, UDP-glucuronosyltransferase 1A10 (UGT1A10) metabolizes a

22 nstitutive or ligand-induced CYP1A1; CYP1A2; UDP glucuronosyltransferase 1A2; NAD(P)H dehydrogenase,

23 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a major UGT

24 The UDP-glucuronosyltransferase 2 family, polypeptide B15 (U

25 Members of the human UDP-glucuronosyltransferase 2B family are located in a c

26 UDP-glucuronosyltransferase 2B17 (UGT2B17) is a key enzy

27 EPI is primarily inactivated by UDP-glucuronosyltransferase 2B7 (UGT2B7) in the liver.

28 Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in

29 obably due to interindividual differences in UDP-glucuronosyltransferase activity and/or excretion pa

30 This paralleled the hepatic bilirubin-UDP-glucuronosyltransferase activity, which was above 50

31 ecombinant adenovirus (Ad), adenovirus human UDP-glucuronosyltransferase (Ad-hBUGT1) carrying the hBU

32 Polymorphisms in UDP-glucuronosyltransferases and sulfotransferases may c

33 ss heme oxygenase, biliverdin reductase, and UDP-glucuronosyltransferases, and there was concordance

34 adenoviral antigens, we immunized bilirubin-UDP-glucuronosyltransferase (BUGT)-deficient jaundiced G

35 NA was injected intravenously into bilirubin-UDP-glucuronosyltransferase-deficient Gunn rats.

36 rlying developmental effects of a microsomal UDP-glucuronosyltransferase-encoding gene from pea (Pisu

37 Heterogeneity in uridine 5'-diphosphate (UDP) glucuronosyltransferase expression across the human

38 ion resulted in a reduced level of bilirubin UDP-glucuronosyltransferase expression in the liver.

39 observed across a 200 kb region spanning the UDP-glucuronosyltransferase family, including UGT1A1, an

40 ved hydrophobic region in the bilirubin-type UDP-glucuronosyltransferase isozyme was first uncovered

41 Consistent with the UDP-glucuronosyltransferase requirement for regulated ph

42 l as related detoxification enzymes, notably UDP-glucuronosyltransferases, suggesting a network of as

43 The human major bilirubin UDP glucuronosyltransferase (transferase), HUG-Brl, and

44 erone as substrate, we showed that LNCaP had UDP-glucuronosyltransferase (UDPGT) activity.

45 en is associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can

46 Microsomal uridine diphosphate (UDP)-glucuronosyltransferase (UGT) protein expression an

47 The human UDP-glucuronosyltransferase (UGT) 1A (UGT1A) locus is re

48 al recessive inherited deficiency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity.

49 e of constitutional genetic variation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast ca

50 etabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known t

51 ts induce the bilirubin-metabolizing enzyme--UDP-glucuronosyltransferase (UGT) 1A1--to prevent the on

52 of the rabbit liver dexamethasone-inducible UDP-glucuronosyltransferase (UGT) 2B13 RNA is related in

53 Because human prostate-distributed UDP-glucuronosyltransferase (UGT) 2B15 metabolizes 5alph

54 nvestigate the inhibitory effects of TKIs on UDP-glucuronosyltransferase (UGT) activities, and to qua

55 o indinavir-mediated impairment of bilirubin UDP-glucuronosyltransferase (UGT) activity and would be

56 drogen glucuronidation, catalyzed by the two UDP-glucuronosyltransferase (UGT) enzymes UGT2B15 and UG

57 ts of the UGT1A gene, encoding half of human UDP-glucuronosyltransferase (UGT) enzymes, undergo alter

58 and endoxifen, is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

59 AHA metabolism is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

60 protein-protein interactions between several UDP-glucuronosyltransferase (UGT) isoforms and cytochrom

61 The UDP-glucuronosyltransferase (UGT) isozyme system is crit

62 UDP-glucuronosyltransferase (UGT) isozymes catalyze deto

63 UDP-glucuronosyltransferase (UGT) isozymes detoxify meta

64 e 1 (NQO1), glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and phenol sulfotrans

65 and hepatic glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and sulfotransferase

66 UDP-glucuronosyltransferase (UGT)-mediated glucuronidati

67 explained at least partly by upregulation of UDP-glucuronosyltransferase (UGT).

68 ent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play ma

69 Human UDP-glucuronosyltransferases (UGT) are the dominant phas

70 UDP-glucuronosyltransferases (UGT) catalyze the conjugat

71 T), gamma-glutamylcysteine synthetase (GCS), UDP-glucuronosyltransferases (UGT),epoxide hydrolase, as

72 ence similarity to the rat CGT enzyme and to UDP-glucuronosyltransferases (UGT).

73 variable exons arrayed in tandem, including UDP glucuronosyltransferase (UGT1), plectin, neuronal ni

74 The human UDP-glucuronosyltransferase UGT1A locus encodes up to 12

75 r glioma-associated protein 1 (GLI1) and the UDP glucuronosyltransferase (UGT1A) family of enzymes ar

76 The UDP-glucuronosyltransferase, UGT1A1, is the critical enz

77 required for hepatic bilirubin elimination, UDP-glucuronosyltransferase, UGT1A1.

78 UDP-glucuronosyltransferase UGT1A7 catalyzes the glucuro

79 on of two androgen-inactivating enzymes, the UDP-glucuronosyltransferases UGT2B15 and UGT2B17, was as

80 The UDP-glucuronosyltransferase UGT2B7 is an important human

81 The UDP-glucuronosyltransferase UGT2B7 is an important human

82 Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded

83 e efficient in drug conjugation catalyzed by UDP-glucuronosyltransferases (UGTs) and now report on th

84 UDP-glucuronosyltransferases (UGTs) are critical to the

85 UDP-glucuronosyltransferases (UGTs) are highly expressed

86 UDP-glucuronosyltransferases (UGTs) are important enzyme

87 UDP-glucuronosyltransferases (UGTs) are membrane-bound p

88 Among the 19 functional UDP-glucuronosyltransferases (UGTs) in humans, UGT2B7 is

89 ffinity label [beta-32P]5-azido-UDP-GlcUA to UDP-glucuronosyltransferases (UGTs) in intact, but not i

90 g rapid, reversible down-regulation of human UDP-glucuronosyltransferases (UGTs) in LS180 cells follo

91 eta-D-glucopyranosides (glucuronides) by the UDP-glucuronosyltransferases (UGTs) is a significant met

92 ferator-activated receptor alpha (PPARalpha)-UDP-glucuronosyltransferases (UGTs) signalling is an imp

93 human liver microsomes and human recombinant UDP-glucuronosyltransferases (UGTs) was characterized an

94 The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate ce

95 nduction of cytoprotective genes such as the UDP-glucuronosyltransferases (UGTs).

96 probe to identify the phenol binding site of UDP-glucuronosyltransferases (UGTs).

97 ulatory patterns of the phase II superfamily UDP-glucuronosyltransferases (UGTs).

98 m is carried out by the Super gene family of UDP-glucuronosyltransferases (UGTs).

99 sion and catalytic activity of human hepatic UDP-glucuronosyltransferases (UGTs).

100 PsUGT1, which encodes a microsomal UDP-glucuronosyltransferase, was cloned from root tips o

101 tipraz both induce an unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a