ライフサイエンスコーパス: UDP

1 UDP and UDP-glucose activate the P2Y14 receptor (P2Y14R)

2 UDP exerted a similar effect, but higher concentrations

3 UDP-4-N3-GlcNAc served as a chain termination substrate

4 UDP-4FGlcNAc was transferred onto an acceptor by Pastuer

5 UDP-apiose (UDP-Api) together with UDP-xylose is formed

6 UDP-D-galacturonic acid, the key building block of pecti

7 UDP-galactopyranose mutase (UGM) catalyzes the conversio

8 UDP-Galactopyranose mutase (UGM) is a flavin-containing

9 UDP-galactose transporter (UGT; SLC35A2) and UDP-N-acety

10 UDP-GlcNAc is the donor substrate used in multiple glyco

11 UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase

12 UDP-glucose pyrophosphorylase (UGP) alternatively makes

13 UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) is

14 UDP-glucuronic acid (UDP-GlcA) is the precursor of many

15 UDP-glucuronosyltransferase 2B17 (UGT2B17) is a key enzy

16 UDP-glucuronosyltransferases (UGTs) are highly expressed

17 UDP-glycosyltransferase (UGT) plays a major role in the

18 UDP-sugars, which are indispensable for protein glycosyl

19 UDP-xylose (UDP-Xyl) is the Xyl donor used in the synthe

20 ction was hypothesized to involve a family 1 UDP-sugar dependent glycosyltransferase (UGT) to facilit

21 nes, an acetyl-CoA transporter (pfact) and a UDP-galactose transporter (pfugt).

22 utant alleles of RGP2, a gene that encodes a UDP-arabinose mutase that interconverts UDP-arabinopyran

23 RHM1 encodes a UDP-L-rhamnose synthase, and rhm1 mutations affect synth

24 s D and D' contain an intact gene encoding a UDP-galactose epimerase (galE1) and a truncated remnant

25 st, key catalytic domain residues and even a UDP-GlcNAc oxygen important for Ser/Thr glycosylation ar

26 recently shown, unexpectedly, to occur in a UDP-GlcNAc-dependent fashion within the transferase acti

27 SVEN_3027 is a UDP-glucose pyrophosphorylase, SVEN_3972 is an unusual I

28 TMEM5 is a UDP-xylosyl transferase that elaborates the structure.

29 t loss of another P2Y subtype called P2Y6, a UDP receptor, was associated with a macrocardia phenotyp

30 nase (Pam), a 4-N-acetyltransferase (Pdi), a UDP-hydrolase (Phy), an enzyme (Ppa) that adds phosphoen

31 ferase motif with alanine residues abolished UDP-GlcNAc binding and lymphostatin activity, although o

32 (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc) transport in Arabidopsis thaliana.

33 ized facilitator of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc) t

34 nds uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) but not UDP-glucose (UDP-Glc).

35 the HBP metabolite UDP-N-acetylglucosamine (UDP-GlcNAc) to CRPC-like cells significantly decreases c

36 of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a substrate for cellular glycosyltransferas

37 ith the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc transferase (OGT) catalyzes

38 ase uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc).

39 the [uridine diphosphate N-acetylhexosamine (UDP-HexNAc)]/[uridine diphosphate hexose (UDP-hexose)] r

40 re it is converted to UDP-galacturonic acid (UDP-GalA), UDP-arabinose, and UDP-xylose.

41 P-xylose is formed from UDP-glucuronic acid (UDP-GlcA) by UDP-Api synthase (UAS).

42 nthesis of UDP-Xyl from UDP-glucuronic acid (UDP-GlcA) is irreversibly catalyzed by UDP-glucuronic ac

43 UDP-glucuronic acid (UDP-GlcA) is the precursor of many plant cell wall polys

44 transfer of the sugar moiety from activated UDP-sugars to various acceptors.

45 ingle protein with key enzymatic activities, UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosam

46 xpression did not respond to P2Y14 R agonist UDP-glucose (UDP-Glu) while hCPCs with higher P2Y14 R ex

47 In addition, CTP, UTP and nearly all UDP-activated sugars that serve as donors for glycosylat

48 l studies, the non-hydrolyzable donor analog UDP-phosphono-galactose (UDP-C-Gal).

49 ng of a polymeric acceptor substrate analog, UDP from a hydrolyzed donor, and an alpha-glyceryl-GlcNA

50 -4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), w

51 se, as well as UDP-N-acetylgalactosamine and UDP-N-acetylglucosamine.

52 ilding blocks of HA, UDP-Glucuronic acid and UDP-N-Acetyl-Glucosamine, as well as hyaluronic acid syn

53 e that interconverts UDP-arabinopyranose and UDP-arabinofuranose, exhibited the low cell wall arabino

54 cturonic acid (UDP-GalA), UDP-arabinose, and UDP-xylose.

55 s found to activate glutamine catabolism and UDP-GlcNAc-associated modules.

56 ors activated by adenosine 5-diphosphate and UDP-sugars, respectively-were upregulated after allergen

57 ntrolled by the availability of fructose and UDP, depending on the metabolic status of a tissue.

58 uridine diphosphate (UDP) into fructose and UDP-glucose, is a key enzyme in sucrose metabolism in hi

59 We show that PGE2-G and UDP are both agonists at P2Y6, but they activate the rec

60 , or bi-functional, synthesising UDP-Gal and UDP-galactosamine (UDP-GalNAc).

61 GALE), which interconverts UDP-galactose and UDP-glucose, as well as UDP-N-acetylgalactosamine and UD

62 it strongly reduced cellular UDP-GalNAc and UDP-GlcNAc pools.

63 analogues of both UDP-Galp (UDP-F4-Galp) and UDP-Galf (UDP-F4-Galf)), which represent the first compl

64 calized protein that transports UDP-GlcA and UDP-GalA in vitro.

65 dified nucleotide sugars UDP-4-N3-GlcNAc and UDP-4-N3-GalNAc were chemically synthesized for the firs

66 tOGT and OGT(C917A) with both UDP-GlcNAc and UDP-GlcNDAz.

67 of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc) transport in Arab

68 on is the metabolic source of UDP-GlcNGc and UDP-GalNGc and the latter allows an unexpectedly selecti

69 aining cell wall precursors, UDP-Glucose and UDP-N-acetylglucosamine are efficiently used to initiate

70 rm from C24 can utilize both UDP-glucose and UDP-xylose but with a higher affinity to the glucose don

71 nsferase (UGT91L1) that uses isoorientin and UDP-rhamnose as substrates and converts them to rhamnosy

72 ons, are located within the Golgi lumen, and UDP-Arap, synthesized within the Golgi, is not their pre

73 including cytochrome P450 monooxygenases and UDP-glycosyltransferases, was shared between both treatm

74 We show that the affinity to NAD+ and UDP-containing factors during initiation is much lower t

75 s, epoxide hydrolases, cytochrome P450s, and UDP-glucosyltransferases.

76 ortance of the cytosolic UDP-xylose pool and UDP-xylose transporters in cell wall biosynthesis.

77 e (ADPG), kaempferol and UDPG, quercetin and UDP-galactose, isoliquiritigenin and UDPG, and luteolin

78 UDP-galactose transporter (UGT; SLC35A2) and UDP-N-acetylglucosamine transporter (NGT; SLC35A3) form

79 e identify an interaction between TAPBPR and UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1), a

80 UDP and UDP-glucose activate the P2Y14 receptor (P2Y14R) to modu

81 UDP-apiose (UDP-Api) together with UDP-xylose is formed from UDP-glu

82 redominant Ara form found in plants is Araf, UDP-Arap must exit the Golgi to be interconverted into U

83 ospira bacteria carry two genes annotated as UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransfera

84 nction of these NSTs confirmed their role as UDP-Araf transporters in vivo.

85 ts UDP-galactose and UDP-glucose, as well as UDP-N-acetylgalactosamine and UDP-N-acetylglucosamine.

86 a slight conformational change when binding UDP-MurNAc-pentapeptide.

87 Like glycosyltransferases, H3 binds UDP-glucose, as shown by saturation transfer difference

88 e dideoxy-tetrafluorinated analogues of both UDP-Galp (UDP-F4-Galp) and UDP-Galf (UDP-F4-Galf)), whic

89 showed that the concomitant binding of both UDP-MurNAc-pentapeptide-DNS and C35-P to the enzyme is r

90 r, and the isoform from C24 can utilize both UDP-glucose and UDP-xylose but with a higher affinity to

91 e activity of wtOGT and OGT(C917A) with both UDP-GlcNAc and UDP-GlcNDAz.

92 ck of the phosphate moiety of C35-P on bound UDP-MurNAc-pentapeptide.

93 Golgi to be interconverted into UDP-Araf by UDP-Ara mutases that are located outside on the cytosoli

94 acid (UDP-GlcA) is irreversibly catalyzed by UDP-glucuronic acid decarboxylase (UXS).

95 ormed from UDP-glucuronic acid (UDP-GlcA) by UDP-Api synthase (UAS).

96 etabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known t

97 s blood group criteria and is synthesized by UDP-N-acetylgalactosamine: globotriaosylceramide 3-beta-

98 Rather, it strongly reduced cellular UDP-GalNAc and UDP-GlcNAc pools.

99 precursor has a pyranose ring configuration (UDP-Arap).

100 Subsequent C5aR1 activation controlled UDP-glucose ceramide glucosyltransferase production, the

101 even different enzymes that together convert UDP-GlcNAc to CMP-pseudaminic acid.

102 second enzyme, which we named Pal, converts UDP-6-deoxy-D-GlcNAc-5,6-ene to UDP-4-keto-6-deoxy-L-Alt

103 e first enzyme, which we named Pen, converts UDP-d-GlcNAc to an uncommon UDP-sugar, UDP-6-deoxy-D-Glc

104 n UDP-rhamnose synthase (RHS1) that converts UDP-glucose into UDP-l-rhamnose.

105 pocket closure as seen for the corresponding UDP-Gal derivative.

106 In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc tra

107 oduced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3)

108 ings support the importance of the cytosolic UDP-xylose pool and UDP-xylose transporters in cell wall

109 by fluorescence enhancement using dansylated UDP-MurNAc-pentapeptide and heptaprenyl phosphate (C35-P

110 /specificity effector-pairs bound (CDP/dATP, UDP/dATP, ADP/dGTP, GDP/TTP) that reveal the conformatio

111 NAc-transferase (MGAT1) and GSLs by deleting UDP-glucose ceramide glucosyltransferase (UGCG).

112 ed in cells into the uridine 5'-diphosphate (UDP)-activated form, it was not incorporated into GAGs.

113 P) and P2Y6 [ADP/UTP/uridine 5'-diphosphate (UDP)] have been shown to have profibrotic effects, as we

114 nversion of sucrose and uridine diphosphate (UDP) into fructose and UDP-glucose, is a key enzyme in s

115 alyzes the synthesis of uridine diphosphate (UDP)-MurNAc, a crucial precursor of the bacterial peptid

116 Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosam

117 Pal is NAD(+)-dependent and has distinct UDP-6-deoxy-d-GlcNAc-5,6-ene 4-oxidase, 5,6-reductase, a

118 ains strongly bound NADP(+) and has distinct UDP-GlcNAc 4-oxidase, 5,6-dehydratase, and 4-reductase a

119 A resolution in complex with natural donors UDP-Gal, UDP-Glc and, in an attempt to overcome one of t

120 ural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and

121 epression of the key GSL biosynthetic enzyme UDP-glucose ceramide glucosyltransferase (UGCG).

122 The Golgi enzyme UDP-GlcNAc:lysosomal enzymeN-acetylglucosamine-1-phospho

123 (UDP-Galf), which is generated by the enzyme UDP-galactopyranose mutase (UGM or Glf).

124 Y14 R), a crucial detector for extracellular UDP-sugars released during injury/stress.

125 e p97 and the luminal quality control factor UDP-glucose:glycoprotein glucosyltransferase (UGGT1) in

126 A cis-QTL for UDP-glucose pyrophosphorylase activity in the UGP1 promo

127 roup E which has a synthetic requirement for UDP-GalNAc.

128 The recombinant UAS homologs all form UDP-Api from UDP-glucuronic acid albeit in different amo

129 All four UDP-sugars are essential donors for glycoprotein biosynt

130 combinant UAS homologs all form UDP-Api from UDP-glucuronic acid albeit in different amounts.

131 Api) together with UDP-xylose is formed from UDP-glucuronic acid (UDP-GlcA) by UDP-Api synthase (UAS)

132 transfer GalNAc from UDP-GalNAc or Gal from UDP-Gal to the H-antigen acceptor.

133 ine whether the enzymes transfer GalNAc from UDP-GalNAc or Gal from UDP-Gal to the H-antigen acceptor

134 cts catalyzed transfer of [(3)H]glucose from UDP-[(3)H]glucose to the trisaccharide form of Skp1 in a

135 74F1 and UGT74F2) that transfer glucose from UDP-glucose to SA.

136 acNAc) units within N-glycans initiated from UDP-GlcNAc by the medial-Golgi branching enzymes as well

137 The biosynthesis of UDP-Xyl from UDP-glucuronic acid (UDP-GlcA) is irreversibly catalyzed

138 tion in complex with natural donors UDP-Gal, UDP-Glc and, in an attempt to overcome one of the common

139 mster ovary ldl-D cells defective in UDP-Gal/UDP-GalNAc 4-epimerase in which N- and O-linked glycosyl

140 nverted to UDP-galacturonic acid (UDP-GalA), UDP-arabinose, and UDP-xylose.

141 dine 5'-diphosphate-alpha-d-galactofuranose (UDP-Galf), which is generated by the enzyme UDP-galactop

142 opyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf) and plays a key role in the biosynthesis of th

143 lyzes the conversion of UDP-galactofuranose (UDP-Galf) to UDP-galactopyranose (UDP-Galp) and is an im

144 ofuranose (UDP-Galf) to UDP-galactopyranose (UDP-Galp) and is an important virulence factor.

145 eversible conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf) and plays a

146 synthesising UDP-Gal and UDP-galactosamine (UDP-GalNAc).

147 yzable donor analog UDP-phosphono-galactose (UDP-C-Gal).

148 mono-functional, synthesising UDP-galactose (UDP-Gal), or bi-functional, synthesising UDP-Gal and UDP

149 of both UDP-Galp (UDP-F4-Galp) and UDP-Galf (UDP-F4-Galf)), which represent the first complex structu

150 tetrafluorinated analogues of both UDP-Galp (UDP-F4-Galp) and UDP-Galf (UDP-F4-Galf)), which represen

151 he reduction of the anthocyanin-related gene UDP glucose:flavonoid 3-O-glucosyl transferase (UFGT), w

152 ene encoding sucrose synthase that generates UDP-glucose from sucrose for cell wall biosynthesis.

153 mately 2-5% of the total glucose, generating UDP-GlcNAc as the end product.

154 ed to produce diazirine-modified UDP-GlcNAc (UDP-GlcNDAz), and the diazirine-modified GlcNAc analog (

155 lucosamine (UDP-GlcNAc) but not UDP-glucose (UDP-Glc).

156 not respond to P2Y14 R agonist UDP-glucose (UDP-Glu) while hCPCs with higher P2Y14 R expression show

157 GNE (UDP-GlcNAc 2-epimerase/ManNAc kinase) myopathy is a rare

158 s that synthesize the building blocks of HA, UDP-Glucuronic acid and UDP-N-Acetyl-Glucosamine, as wel

159 The data indicate that lymphostatin has UDP-sugar binding potential that is critical for activit

160 e (UDP-HexNAc)]/[uridine diphosphate hexose (UDP-hexose)] ratio exhibited dramatic tailing to higher

161 o-opt the host transporter SLC35D2 to import UDP-glucose into the vacuole, where it serves as substra

162 inese hamster ovary ldl-D cells defective in UDP-Gal/UDP-GalNAc 4-epimerase in which N- and O-linked

163 Taken together, these findings indicate UDP-sugar balance is a key modifier of neurological outc

164 action in CHS, rs686237, strongly influenced UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polyp

165 complex structures of MtUGM with inhibitors (UDP and the dideoxy-tetrafluorinated analogues of both U

166 es a UDP-arabinose mutase that interconverts UDP-arabinopyranose and UDP-arabinofuranose, exhibited t

167 ose 4'-epimerase (GALE), which interconverts UDP-galactose and UDP-glucose, as well as UDP-N-acetylga

168 nthase (RHS1) that converts UDP-glucose into UDP-l-rhamnose.

169 ust exit the Golgi to be interconverted into UDP-Araf by UDP-Ara mutases that are located outside on

170 rt to its ability to sequester intracellular UDP-glucuronic acid and inhibition of hyaluronan synthas

171 An exception is UDP-xylose, which is biosynthesized in both the cytosol

172 ere their folding is surveyed by the 170-kDa UDP-glucose:glycoprotein glucosyltransferase (UGGT).

173 The EBD binds to the suppressor ligand UDP-N-acetyl-beta-d-muramyl-l-Ala-gamma-d-Glu-meso-DAP-d

174 racterization of a family of Golgi-localized UDP-Araf transporters in Arabidopsis The application of

175 To identify the Golgi-localized UDP-GlcA transporter, we screened Arabidopsis thaliana m

176 pyrophosphorylase (UGP) alternatively makes UDP-galactose from uridine triphosphate and galactose-1-

177 Mechanistically, UDP-Glu stimulation enhanced the activation of canonical

178 l-3-O-glucose (D3G), by secondary metabolism UDP-glucosyltransferases (UGTs).

179 Strikingly, addition of the HBP metabolite UDP-N-acetylglucosamine (UDP-GlcNAc) to CRPC-like cells

180 uated for their tolerance for azide-modified UDP-sugar substrates, including derivatives of 2,4-diace

181 are engineered to produce diazirine-modified UDP-GlcNAc (UDP-GlcNDAz), and the diazirine-modified Glc

182 Sm1 encodes a multidomain UDP-rhamnose synthase (RHS1) that converts UDP-glucose i

183 ate-N-acetylglucosamine (UDP-GlcNAc) but not UDP-glucose (UDP-Glc).

184 the pentose phosphate pathway, nucleobases, UDP-sugars, glycogen, lipids, and proteins in mouse tiss

185 monstrate that H3 binds the sugar nucleotide UDP-glucose, as do glycosyltransferases.

186 The biosynthesis of UDP-Arap mainly occurs via the epimerization of UDP-xylo

187 se enzyme, PglD, involved in biosynthesis of UDP-diNAcBac in Campylobacter jejuni.

188 bypasses the general de novo biosynthesis of UDP-MurNAc and contributes to high intrinsic resistance

189 The biosynthesis of UDP-Xyl from UDP-glucuronic acid (UDP-GlcA) is irreversi

190 d T cells contained higher concentrations of UDP-GlcNAc and increased intracellular protein O-GlcNAcy

191 ose mutase (UGM) catalyzes the conversion of UDP-galactofuranose (UDP-Galf) to UDP-galactopyranose (U

192 that catalyzes the reversible conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (U

193 o investigate the structural determinants of UDP-galactose selectivity.

194 We identified an inhibitory effect of UDP on in vitro isoproterenol-induced cardiomyocyte hype

195 -Arap mainly occurs via the epimerization of UDP-xylose (UDP-Xyl) in the Golgi lumen.

196 us result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inabili

197 At5g65000) as an ER-localized facilitator of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgal

198 cosylation is initiated by a large family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

199 e cytosol and the Golgi lumen by a family of UDP-xylose synthases.

200 ty from acetyl-CoA to the C-4 amino group of UDP-d-viosamine.

201 t Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A

202 ugh the enzyme facilitated the hydrolysis of UDP-GlcNAc.

203 ed compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deace

204 nst the UTP receptor P2Y2, and inhibitors of UDP receptors P2Y6 and P2Y14, indicated that the respons

205 Similarly, knockdown of UDP-glucose 6-dehydrogenase (UGDH) using lentiviral shRN

206 GNE deficiency may affect levels of UDP-GlcNAc, a key metabolite in the nutrient-sensing hex

207 Galactosemia III results from the loss of UDP-galactose 4'-epimerase (GALE), which interconverts U

208 RNAs specifically reacted with the lysine of UDP-MurNAc-pentapeptide, a peptidoglycan precursor used

209 affected the binding of fructose, but not of UDP.

210 eu5Gc degradation is the metabolic source of UDP-GlcNGc and UDP-GalNGc and the latter allows an unexp

211 cted by the lack of ROCK1-mediated supply of UDP-GlcNAc.

212 ucose and glutamine for de novo synthesis of UDP-GlcNAc, a sugar-nucleotide that inhibits receptor en

213 Mur (A-F) enzymes, involve the synthesis of UDP-n-acetylmuramyl pentapeptide, a key precursor molecu

214 Thus, the transport of UDP-Araf into the Golgi is a prerequisite.

215 s and studied the mitochondrial transport of UDP-GlcNAc.

216 The NST-based transport of UDP-xylose into the Golgi lumen would appear to be redun

217 nvestigate the inhibitory effects of TKIs on UDP-glucuronosyltransferase (UGT) activities, and to qua

218 with a >15-fold preference for TDP-Glc over UDP-Glc.

219 ensis, the enzymatic product of Pen and Pal, UDP-4-keto-6-deoxy-L-AltNAc, is converted to CMP-pseudam

220 ent sensing hexosamine biosynthetic pathway, UDP-GlcNAc, as its substrate donor.

221 phate + UDP-glucose to glucose-1-phosphate + UDP-galactose.

222 ALT), which converts galactose-1-phosphate + UDP-glucose to glucose-1-phosphate + UDP-galactose.

223 , S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Delta(2)-isopentenyl-PP play similar ro

224 or hexose-, pentose-, and triose-phosphates, UDP-glucose, and adenosine monophosphate (AMP).

225 cessive glycosyltransferases that polymerize UDP-activated glucose and secrete the nascent polymer th

226 The recombinant enzyme polymerizes UDP-activated glucose to cellulose, as determined by enz

227 pC transcription by binding the PG precursor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide.

228 k of pectins, is produced from the precursor UDP-D-glucuronic acid by the action of glucuronate 4-epi

229 incorporation of mature cell wall precursor, UDP-MurNAc-pentapeptide, is inhibited by region 3.2 of s

230 ant uridine-containing cell wall precursors, UDP-Glucose and UDP-N-acetylglucosamine are efficiently

231 ne biosynthetic pathway (HBSP) that produces UDP-N-acetylglucosamine for O-linked N-acetylglucosamine

232 extracellular UTP or its breakdown products UDP and UMP act as mediators for hyaluronan synthase (HA

233 ORC1v2 interact with calnexin cycle proteins UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1),

234 sis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse

235 r freundii), its DNA operator, and repressor UDP-MurNAc-pentapeptide.

236 Subsequently, UDP-Araf must be transported back into the lumen.

237 lex structures of MtUGM with bound substrate UDP-Galp (both oxidized flavin and reduced flavin).

238 of the enzyme in complex with its substrate UDP-GlcNAc at 2.8 A resolution.

239 l aligned near the entrance of the substrate UDP-glucose into the active site.

240 nzyme (wtOGT) prefers the natural substrate, UDP-GlcNAc, over the unnatural UDP-GlcNDAz.

241 but is distinct from, its natural substrate, UDP-MurNAc-pentapeptide.

242 verts UDP-d-GlcNAc to an uncommon UDP-sugar, UDP-6-deoxy-D-GlcNAc-5,6-ene.

243 atural chemically modified nucleotide sugars UDP-4-N3-GlcNAc and UDP-4-N3-GalNAc were chemically synt

244 se (UDP-Gal), or bi-functional, synthesising UDP-Gal and UDP-galactosamine (UDP-GalNAc).

245 n to be either mono-functional, synthesising UDP-galactose (UDP-Gal), or bi-functional, synthesising

246 cosyltransferase in complex with a synthetic UDP-GalNAc derivative.

247 ationally predicted putative miR-185 targets UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltran

248 to the antibiotic fosfomycin, which targets UDP-MurNAc de novo biosynthesis.

249 Substrate binding assays indicated that UDP and fructose, respectively, were the leading substra

250 in uxs3 xus5 uxs6 declined, indicating that UDP-Xyl from cytosol AtUXS participates in xylan synthes

251 nduction of cytoprotective genes such as the UDP-glucuronosyltransferases (UGTs).

252 n PBP genes but carried murEUo5 encoding the UDP-N-acetylmuramyl tripeptide synthetase.

253 on of two androgen-inactivating enzymes, the UDP-glucuronosyltransferases UGT2B15 and UGT2B17, was as

254 er" conformation previously observed for the UDP-Gal donor.

255 genous expression systems, we identified the UDP receptor P2Y6 as the specific target of PGE2-G.

256 s thaliana) lines carrying insertions in the UDP-Glc:sterol glucosyltransferase genes, UGT80A2 and UG

257 es I and II but not, or only marginally, the UDP-MurNAc pentapeptide nucleotide precursor as acceptor

258 s study unveil novel biological roles of the UDP-sugar receptor P2Y14 in hCPCs and suggest purinergic

259 ween UGT89A2 from Col-0 and C24 reversed the UDP-sugar preferences, indicating that residue 153 plays

260 observed across a 200 kb region spanning the UDP-glucuronosyltransferase family, including UGT1A1, an

261 to UDP-MurNAc-pentapeptide predicts that the UDP-MurNAc moiety of the repressor participates in modul

262 t shares twin Rossmann-like domains with the UDP-glucose-specific OtsA from Escherichia coli However,

263 psis thaliana NST family and designated them UDP-XYLOSE TRANSPORTER1 (UXT1) to UXT3.

264 In addition, we show that this UDP-GalNAc derivative in complex with the H-antigen acce

265 sed in uuat1 These results suggest that this UDP-GlcA transporter plays a key role defining the seed

266 ntly developed approach, we identified three UDP-xylose transporters in the Arabidopsis thaliana NST

267 otif in H3 greatly diminished its binding to UDP-glucose.

268 Modeling the AmpR.DNA tetramer bound to UDP-MurNAc-pentapeptide predicts that the UDP-MurNAc moi

269 of the AmpR effector-binding domain bound to UDP-MurNAc-pentapeptide revealed that the terminal D-Ala

270 he Golgi apparatus, where it is converted to UDP-galacturonic acid (UDP-GalA), UDP-arabinose, and UDP

271 al, converts UDP-6-deoxy-D-GlcNAc-5,6-ene to UDP-4-keto-6-deoxy-L-AltNAc.

272 version of UDP-galactofuranose (UDP-Galf) to UDP-galactopyranose (UDP-Galp) and is an important virul

273 version of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf) and plays a key role in t

274 Genes linked to UDP-sugar biosynthesis and cellulose synthesis were also

275 showed enhanced proliferation in response to UDP-Glu stimulation.

276 GT89A2 from Col-0 is highly selective toward UDP-xylose as the sugar donor, and the isoform from C24

277 prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NA

278 orter (NST) family can efficiently transport UDP-Araf in vitro.

279 r, pyrimidine nucleotide carrier, transports UDP-GlcNAc from the cytosol to the inside of the mitocho

280 es a Golgi-localized protein that transports UDP-GlcA and UDP-GalA in vitro.

281 Predictions for the function of two UDP-glycosyltransferases in flavonoid metabolism were co

282 the subsequent 4-HPAA reductase and tyrosol:UDP-glucose 8-O-glucosyltransferase, respectively, to co

283 lly characterize nine ripening-related UGTs (UDP-glucosyltransferases) in Fragaria that function in t

284 ed Pen, converts UDP-d-GlcNAc to an uncommon UDP-sugar, UDP-6-deoxy-D-GlcNAc-5,6-ene.

285 The resulting unnatural UDP-sugar donors were then tested as substrates in glyco

286 al substrate, UDP-GlcNAc, over the unnatural UDP-GlcNDAz.

287 These unnatural UDP sugar products were then tested for incorporation in

288 obtained with squaramate-RNA and unprotected UDP-MurNAc-pentapeptide efficiently inhibited FemXWv .

289 ion is triggered by redistribution of unused UDP-GlcNAc from the medial to trans-Golgi via inter-cist

290 substrate rather than the more commonly used UDP-glucose.

291 UGT8 uses UDP galactose to galactosidate ceramide, a key step in t

292 on of successive coupled enzyme assays using UDP-n-acetylglucosamine as the initial sugar substrate.

293 ose-containing glycans are synthesized using UDP-apiose as the donor.

294 inly through P2Y2 and to a lesser extent via UDP receptors.

295 ddition, the complex structure of MtUGM with UDP-F4-Galf reveals the first detailed insight into how

296 ciency of initiation with NAD+, but not with UDP-containing factors, is affected by amino acids of th

297 and catalytic domains, which, together with UDP-GlcNAc, are required for both glycosylation and prot

298 UDP-apiose (UDP-Api) together with UDP-xylose is formed from UDP-glucuronic acid (UDP-GlcA)

299 occurs via the epimerization of UDP-xylose (UDP-Xyl) in the Golgi lumen.

300 UDP-xylose (UDP-Xyl) is the Xyl donor used in the synthesis of major