ライフサイエンスコーパス: UK

1 UK Biobank is the world's largest repository for phenoty

2 UK Biobank participants were more likely to be older, to

3 UK population-level data estimated the incidence of GBS-

4 UK Transplant Registry data were collected on deceased d

5 pulation-based cohort study including 119859 UK Biobank participants with complete phenotypic (medica

6 iratory acidemia, who were recruited from 13 UK centers between 2010 and 2015.

7 cholestasis of pregnancy (ICP) affects 1/140 UK pregnancies; with pruritus, hepatic impairment and el

8 54 patient eyes with diabetes mellitus at 19 UK hospital eye services were extracted at the initial a

9 age group and sex) were applied to the 2014 UK [corrected] population projections.

10 count below one cell per muL, whereas the 21 UK participants had a median absolute number of circulat

11 d, randomised controlled trial (OASIS) at 26 UK universities.

12 ve antibiotic therapy were recruited from 29 UK hospitals.

13 samples from 302 Ugandan volunteers and 302 UK individuals who were matched by age and sex to the Ug

14 Some agonists (e.g., 3cd; UK-432,097) but not others (e.g., 3ac; CGS-21680) demons

15 lanted, coupled with variation between the 7 UK liver transplant centers in risk appetite.

16 three (1%) Ugandan participants and 21 (7%) UK participants (p=0.00021); all three Ugandan participa

17 cT3N0/N1, or cT4N0/N1 were recruited from 72 UK hospitals.

18 t loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of these loci replicated at

19 dividuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone

20 able oesophagogastric adenocarcinoma from 87 UK hospitals and cancer centres.

21 ed multiple introductions of MRSA CC398 in a UK Equine Hospital, identifying an emerging zoonotic pat

22 Data analysis for this study in a UK general community was conducted from October to Decem

23 ldhood manifestations of this liability in a UK population-based cohort.

24 In a UK-representative sample (n = 6,710), we find widespread

25 This equates to a UK incidence of GBS-associated NE of 0.019 per 1000 live

26 mor data for 333 patients from Myeloma XI, a UK phase 3 trial and 434 patients from the CoMMpass stud

27 (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with indepe

28 By analyzing UK National Health Service drug prescription and sales d

29 um for Blood Pressure (ICBP; n = 69,396) and UK Biobank (UKB; n = 152,081) studies.

30 iagnosed AD but overall higher in UK 2/4 and UK 3/4.

31 t ages 6 years; n=50 at young adulthood) and UK controls (n=52 at age 6 years; n=39 at young adulthoo

32 n was studied in two independent (French and UK) cohorts representing a total of 959 cases and 1,043

33 Therefore, two separate cohorts (IL and UK) comprising mild, moderate, and severe asthma and hea

34 ovement metric in both the United States and UK.

35 ns between eDNA, community DNA, taxonomy and UK species abundance data further show significant relat

36 US and UK service members with acute watery diarrhea were rando

37 estry (2987 with AF) in the population-based UK Biobank.

38 s from a field that was largely dominated by UK and North American biologists to a much more internat

39 Wellcome Genome Campus, Hinxton, Cambridge, UK, 5-7 April, 2017.

40 rolled trial at the University of Cambridge, UK.

41 additional 39 sites in 11 countries (Canada, UK, Germany, Italy, Japan, South Korea, Taiwan).

42 nd Leukaemia Group (CCLG) treatment centres (UK), collaborating European institutions, and the UKCCSG

43 The UK Collaborative HIV Cohort (UK CHIC) Study is an ongoing multicentre cohort study th

44 INTERPRETATION: In a contemporary UK cohort, first transition into income poverty during e

45 This model is superior to the current UK PNF criteria and is based on statistical methods.

46 ted for follow-up in an independent dataset (UK Biobank, N = 134 251).

47 We compare self-declared UK practice in specialist perioperative allergy services

48 Analyzing data from 113 203 non-diabetic UK Biobank participants, we observed three (near TCF7L2,

49 their abscess, a rate unchanged from earlier UK series.

50 atients admitted to a hospital in Edinburgh, UK, after a suicide attempt were deemed eligible for the

51 controlled, phase 3 AZURE trial at eligible UK sites who had stage II or III breast cancer and who g

52 in children younger than 5 years in England (UK), a representative high-income temperate country, and

53 ars or older from 25 centres across England, UK.

54 epidemiology of cervical cancer in England, UK, will change: human papillomavirus (HPV) screening wi

55 Using three towns in southern England, UK, all with varying greenspace structures, we describe

56 nd estuarine samples from the Colne Estuary, UK, was investigated using DNA-Stable Isotope Probing (D

57 tter winters and more severe weather events, UK butterflies could come under severe pressure given th

58 retrospective cohort analysis, we extracted UK National Health Service general practice data that we

59 This is the first UK real-life study of a T&E treatment protocol with rani

60 rom secondary care and the community at five UK medical centres.

61 Financing of health care for UK citizens in the EU and vice versa is threatened, as i

62 ith mycobacterial growth in whole blood from UK/Asian adults and, to a lesser extent, in PBMC from So

63 imary medulloblastoma samples collected from UK Children's Cancer and Leukaemia Group (CCLG) treatmen

64 used cross-sectional observational data from UK Biobank.

65 gnitive function in 23 821 participants from UK Biobank.

66 centres in the UK and controls selected from UK Biobank (stage 1) matched for age, sex, and smoking s

67 rom 2013 and 2014 harvests were sourced from UK millers and wheat breeders, and individual kernels we

68 al of 110 fresh breast tissue specimens from UK patients for the presence of twelve HR-HPV types DNA

69 bTB) at Woodchester Park in Gloucestershire (UK) has produced a unique dataset, facilitating investig

70 ro growth of BCG in whole blood from healthy UK human volunteers.

71 facilities were associated with adiposity in UK adults.

72 Fasciolosis is common in UK beef cattle, but it is unclear at what levels liver f

73 ify individuals of white European descent in UK Biobank in the half of the population with high or lo

74 xtremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we incr

75 ls were determined in serum through ELISA in UK (cases n = 129; controls n = 39) and Dutch (cases n =

76 physician-diagnosed AD but overall higher in UK 2/4 and UK 3/4.

77 ompare the post-booster antibody response in UK infants given a reduced priming schedule of PCV13 (ie

78 rly for E. verrucosa, a protected species in UK waters and listed by the IUCN as 'Vulnerable', and fo

79 performed a genome-wide association study in UK Biobank testing approximately 9 million DNA sequence

80 These infections were widespread in UK black-grass populations and evidence was obtained for

81 In an independent UK cohort (171 NSCLP, 177 controls), we replicated 4 out

82 When combining data from an independent UK NAFLD cohort, in the overall cohort of non-cirrhotic

83 els using data and samples from the INTERMAP UK cohort (n=225) and a healthy-eating Danish cohort (n=

84 tabolic and dietary profiles in the INTERMAP UK cohort (p<0.0001) and the Danish cohort (p<0.0001).

85 Universities in the United Kingdom (UK) are required to incorporate values based recruitment

86 sum (XP), presenting via the United Kingdom (UK) XP service, and to analyze the correlations between

87 om animals and humans in the United Kingdom (UK), but the prevalence is unknown.

88 nd/or serum sampling (n = 148) in Lancaster, UK, over the winter of 2014-2015.

89 ys with acute kidney injury (AKI) in a large UK cohort.

90 department or acute medical unit of a large UK hospital with acute respiratory illness or fever high

91 icy on rates of physical assaults in a large UK mental health organisation.

92 Regional (Oxfordshire and Leeds, UK) and national data for the incidence of C difficile i

93 pulmonary arterial hypertension from London (UK; cohorts 1 and 2), Giessen (Germany; cohort 3), and P

94 ed controlled trial done in Hackney, London (UK), a borough with high HIV prevalence (>/=0.2% adult p

95 g fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets ar

96 tients from Moorfields Eye Hospital, London, UK.

97 l Health Service Foundation Trust in London, UK, 245 patients were followed up for 2 years from the o

98 from a tertiary neurology clinic in London, UK.

99 f injecting behaviour carried out in London, UK.

100 ased childhood CSE cohort from north London, UK (the north London convulsive status epilepticus surve

101 the South London and Maudsley Trust (London, UK).

102 nal Health Service Foundation Trust, London, UK.

103 terbody fed by the River Irwell, Manchester, UK.

104 ice clinics in Salford and South Manchester, UK.

105 n ongoing prospective cohort of >0.5 million UK adults aged 40-69 y.

106 About 5.5 million UK patients with no known cardiovascular or valve diseas

107 ntified as >1482 pg/ml (IL) and >1619 pg/ml (UK).

108 Nottingham University Hospitals (Nottingham, UK) in the development study and at University Hospital

109 (Cambridgeshire, Newcastle, and Nottingham; UK).

110 ion change in intact mixed-species blocks of UK salt marsh using six open-top chambers receiving CO2

111 practice was conducted across the network of UK Clinical Research Collaboration-registered trial unit

112 The first release of UK Biobank imaging data comprised participants with over

113 0 year period from 2005 to 2015 at a time of UK policy strategies and prioritisation of dementia.

114 nths and atopic eczema ascertained (based on UK Working Party Criteria for the Definition of Atopic D

115 ating the impact of liver fluke infection on UK beef cattle productivity and investigating the use of

116 e of a single strain (the so-called original UK strain) belonging to the hypervirulent sequence type-

117 harm to the John Radcliffe Hospital (Oxford, UK), between April 1, 2013, and March 31, 2014.

118 hool of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Meli

119 examined the impact of ECEs on the resident UK butterfly species (n = 41) over a 37-year period.

120 ved from eels collected in the Severn River (UK), approximately 50 km upstream of the estuary (i.e. n

121 Around Orkney, northern Scotland, UK, the harbour seal (Phoca vitulina) population has dec

122 nt evaluations, the National Health Service (UK) Economic Evaluation Database, and ISI Web of Science

123 Patients (aged 2-75 years) from six UK hospitals who were undergoing renal transplantation w

124 uperior to those seen following the standard UK 2 + 1 schedule.

125 erlands, New Zealand, Norway, Spain, Sweden, UK, and USA).

126 ungary, Ireland, Japan, South Korea, Taiwan, UK, and USA).

127 dulthood) had persistently higher rates than UK controls of symptoms of autism spectrum disorder, dis

128 The UK AML15 and AML17 trials are registered at www.isrctn.c

129 The UK Biobank is a unique resource for biomedical research,

130 The UK Biobank will allow unprecedented opportunities for an

131 The UK Collaborative HIV Cohort (UK CHIC) Study is an ongoin

132 The UK National Institute of Health and Care Excellence (NIC

133 The UK performs poorly relative to other economically develo

134 The UK Royal College of Psychiatrists offered a policy frame

135 The UK TACT2 trial used a 2x2 factorial design to test two h

136 In March, 2016, the UK Government proposed a tiered levy on sugar-sweetened

137 of Minnesota Medical Center, UMMC), and the UK (John Radcliffe Hospital, JRH).

138 reland (Growing up in Ireland [GUI]) and the UK (Millennium Cohort Study [MCS]).

139 Zealand [two], Switzerland [three], and the UK [83]) enrolled infants who had a clinical diagnosis o

140 from six independent GWAS consortia and the UK Biobank sample (N = 112 151).

141 dy contained two independent centres and the UK one independent centre.

142 the Netherlands, Spain, Switzerland, and the UK) and North and South America (Brazil, Canada, and the

143 a, Denmark, France, Germany, Sweden, and the UK).

144 TATION: MBL is common in both Uganda and the UK, but the substantial phenotypic differences might ref

145 ance, Germany, Israel, Italy, Spain, and the UK, to assess the safety and efficacy of an 8-week treat

146 over 2 weeks for patients in Canada and the UK.

147 s in Australia, Canada, New Zealand, and the UK.

148 , South Africa, Colombia, Australia, and the UK.

149 a, South Africa, Spain, Switzerland, and the UK.

150 people with HIV attending clinics around the UK.

151 ngs might mean that governments, such as the UK Government, who are attempting to prevent suburban de

152 oncerted regulatory and fiscal action by the UK Government is essential if the scale of the medical p

153 pediatric kidney transplants recorded by the UK Transplant Registry from 2000 to 2012, it was conclud

154 arge single sample of neuroimaging data; the UK Biobank Imaging study.

155 me a topical and controversial issue for the UK National Health Service.

156 r index, was developed and validated for the UK population of transplant recipients.

157 From the UK adult kidney transplant waiting list, we selected cro

158 sis of air quality measurement data from the UK and France, we demonstrate that road traffic exhaust

159 workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadi

160 We used prospective follow-up data from the UK Biobank cohort study to assess self-reported isolatio

161 ividual-level, cross-sectional data from the UK Biobank collected from 2007-2011, including 111986 in

162 orporating lung function using data from the UK Biobank prospective cohort study.

163 The study employed data from the UK Biobank resource and from the SUNLIGHT, GABRIEL and E

164 Data from the UK Biobank showed a positive association between the Asp

165 and diverse population sample drawn from the UK Biobank to identify healthy-weight-sustaining density

166 e with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were a

167 combined with individual-level data from the UK Biobank.

168 ), and a sample of European descent from the UK Biobank.

169 y using clinician-recorded findings from the UK National Neonatal Research Database between December

170 Data were obtained from the UK Small Area Health Statistics Unit and supplied by the

171 Data were collected from the UK Transplant Registry held by National Health Service B

172 urgically validated diagnosis of DD from the UK, with replication in British, Dutch, and German indiv

173 The study population was derived from the UK-based Clinical Practice Research Datalink (CPRD).

174 ine to 1,367 twin pairs (age 19-21) from the UK-representative Twins Early Development Study (TEDS).

175 inter 2013/14 a succession of storms hit the UK leading to record rainfall and flooding in many regio

176 mmunity-acquired pneumonia to 29 ICUs in the UK (second validation cohort).

177 y of Diplotaxis tenuifolia were grown in the UK (summer) and subjected to commercial growth, harvesti

178 e intermittent catheters are the norm in the UK although multi-use is common in some other countries.

179 Netherlands), and clinical data sets in the UK and Belgium.

180 recruited from nine different centres in the UK and controls selected from UK Biobank (stage 1) match

181 tries and from six non-MSBase centres in the UK and Germany between Nov 1, 2015, and June 30, 2016.

182 om 127 clinical centres and hospitals in the UK and Ireland, and randomly assigned (1:1) to one of tw

183 26 primary care centres and hospitals in the UK and Singapore.

184 ic cough recruited from seven centres in the UK and the Netherlands were randomly assigned (1:1, usin

185 adult progenitor cells in 33 centres in the UK and the USA.

186 patients awaiting a kidney transplant in the UK are sensitised with human leucocyte antigen (HLA) ant

187 group W disease has increased rapidly in the UK because of a single strain (the so-called original UK

188 r disease mortality increased by 400% in the UK between 1970 and 2010, resulting in rising pressures

189 MS done at three neuroscience centres in the UK between Jan 28, 2008, and Nov 4, 2011.

190 toms and excessive daytime sleepiness in the UK Biobank (n = 112,586).

191 sociation was independently confirmed in the UK Biobank (N=48,931) using heavy vs never smoking as a

192 ol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals.

193 -level data from 335 464 participants in the UK Biobank and summary association results from 7 large-

194 ee-structured routine healthcare data in the UK Biobank represents a new branch on a tree that is poi

195 In the UK Biobank sample (N=108 976), we carried out a genome-w

196 ese priors, for parental age of death in the UK Biobank study (n=116,279) revealed 16 independent SNP

197 075 women and 100,252 men taking part in the UK Biobank who had provided spirometry measurements and

198 In the UK Biobank, we investigated the associations between bod

199 n adults, aged 37-73 y, participating in the UK Biobank.

200 ticipants (42 [14%] individuals) than in the UK cohort (25 [8%]; p=0.038).

201 nt donation than is standard practice in the UK collected substantially more blood without having a m

202 ion of people diagnosed with dementia in the UK doubled from 0.42% (19 635 of 4 640 290 participants)

203 integrated phoma stem canker control in the UK due to their effectiveness on both Leptosphaeria spp.

204 hase 3 trial (TACE 2) in 20 hospitals in the UK for patients with unresectable, liver-confined hepato

205 ity National Health Service hospitals in the UK from Jan 1, 2006, to Dec 31, 2014.

206 odes used for electronic records used in the UK Health Improvement Network.

207 We predict it to be cost-effective in the UK in the medium term.

208 mber of prevalent heart failure cases in the UK increased even more, by 23% (from 750 127 to 920 616)

209 f sensitised patients undergoing HLAi in the UK is comparable with those on dialysis awaiting a compa

210 roduction of a PrEP programme for MSM in the UK is cost-effective and possibly cost-saving in the lon

211 ramme of fracture risk in older women in the UK is feasible, and could be effective in reducing hip f

212 mong Royal Marines and Army personnel in the UK military after deployment to Afghanistan.

213 omosynthesis with Digital Mammography in the UK National Health Service Breast Screening Program), an

214 ry Centre, a tertiary referral clinic in the UK National Health Service.

215 While recent policies in the UK offers scope to overcome some of these challenges the

216 our chemotherapy units/cancer centres in the UK Purposive sampling was used to select four cancer cen

217 rom deceased donors with ITP recorded in the UK Transplant Registry between 2000 and 2015 were review

218 quiring surgical intervention for NEC in the UK was conducted between 01/03/13 and 28/02/14.

219 f a July 2006 ozone pollution episode in the UK were made with input values for these variables plus

220 grain (WG) content of foods consumed in the UK which include ingredients that retain all three struc

221 with health care professionals based in the UK who prescribe catheters, teach intermittent catheteri

222 of a range of popular pet foods sold in the UK with EU guidelines (94% and 61% of wet and dry foods,

223 e included patients from 18 hospitals in the UK with newly diagnosed advanced or metastatic colorecta

224 We compared standard practice in the UK with shorter inter-donation intervals used in other c

225 ailability of free treatment and care in the UK, AIDS continues to account for the majority of deaths

226 treatment for COME from 35 hospitals in the UK, and their nuclear family.

227 ulticentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged

228 med to assess mortality by occupation in the UK, differences in rates between England and Wales and S

229 e 2 trial in two intensive care units in the UK, involving patients fulfilling the American-European

230 ty, affecting more than 60% of adults in the UK, is leading to an increasing liver disease burden.

231 , and Oct 27, 2010, and Sept 5, 2011, in the UK, we randomly assigned 414 women to the intervention g

232 surveys of > 900 trees from 60 sites in the UK, we tested for ecological or life history predictors

233 ergence of Verticillium stem striping in the UK, whereas in continental Europe Verticillium stem stri

234 Standing Commission on Liver Disease in the UK, which aim to reduce the unacceptable harmful consequ

235 in the UK-1 exploration contract area (eastern CCZ, 4,080 m wa

236 ons within this block were replicated in the UK-Ireland group of the most recent release of the Psych

237 ut metastatic disease from 59 centres in the UK.

238 attending a tertiary referral center in the UK.

239 ients undergoing mental health crises in the UK.

240 cture risk is not currently advocated in the UK.

241 and the National Health Service (NHS) in the UK.

242 the overall pattern of foods consumed in the UK.

243 90, and Dec 31, 2010, at 17 hospitals in the UK.

244 pecialist early intervention services in the UK.

245 rimary care electronic health records in the UK.

246 database of a clinical research unit in the UK.

247 dary and tertiary referral hospitals) in the UK.

248 omised, phase 2 trial at 20 hospitals in the UK.

249 has been the focus of policy debates in the UK.

250 ve survey, Natsal-3) on HIV among MSM in the UK.

251 gen so far only sporadically recorded in the UK.

252 from health and social care services in the UK.

253 ed patients from 34 general practices in the UK.

254 ief that was done at five study sites in the UK.

255 blood count and no history of cancer) in the UK.

256 re to calculate the number of infants in the UK/Ireland with surgical NEC and describe outcomes that

257 Other countries, including the UK, Canada, and Finland, however, have continued to reco

258 stigations in 214 patients enrolled into the UK National Prion Monitoring Cohort Study between Octobe

259 five countries- India, Denmark, Ireland, the UK and the USA).

260 ons between GS, adiposity, and mortality.The UK Biobank study is an ongoing prospective cohort of >0.

261 The representativeness of the UK Biobank cohort was investigated by comparing demograp

262 In participants of the UK Biobank of British ancestry, we found that variants t

263 he GERA cohort and among participants of the UK Biobank of non-British ancestry.

264 We used a subset of the UK Biobank Resource, a cross-sectional dataset including

265 is of dementia after the introduction of the UK National Dementia Strategy (p<0.0001).

266 physician-diagnosed AD and 2 versions of the UK Working Party Diagnostic Criteria.

267 itis by using the diagnostic criteria of the UK Working Party.

268 ter than that of fasciolosis in parts of the UK.

269 id theropod from the Early Cretaceous of the UK.

270 monthly rainfall totals in many parts of the UK.

271 onths old babies in a brand available on the UK market.

272 hold nursing qualifications from outside the UK are required to provide evidence of English language

273 care: 53% were female, 62% born outside the UK/Ireland, 75% black African.

274 , France, Germany, Israel, Italy, Spain, the UK, and the USA.

275 ok a 2-year national surveillance study (the UK Neonatal Collaborative Necrotising Enterocolitis [UKN

276 , South Korea, Singapore, Spain, Taiwan, the UK, and the USA).

277 eland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), wi

278 tter discrimination and calibration than the UK Prospective Diabetes Study Outcomes Model 2 (for micr

279 t lineages exist in isolation throughout the UK.

280 9.4%) and 226 (2.3%) had AD according to the UK Working Party Criteria when at least 2 and 3of 4 mino

281 his work, we apply percolation theory to the UK's road network using the relative angle between stree

282 This research has been conducted using the UK Biobank Resource and data from the SUNLIGHT, GABRIEL

283 This research has been conducted using the UK Biobank Resource.

284 While the UK has committed to reduce CO2 emissions to 80% of 1990

285 s in different geographical areas within the UK operating nurse-led chemotherapy clinics.

286 This UK study provides a contemporary reassessment in one of

287 Fifty-three UK controls consented and provided samples using the sam

288 ents with multiple myeloma enrolled in three UK clinical trials (Myeloma IX, Myeloma XI, and TEAMM) b

289 Focusing on three UK river catchments with contrasting bedrock and superfi

290 the quality of healthcare remains central to UK and international policy, practice and research.

291 age-specific, and sex-specific incidence to UK census mid-year population estimates.

292 important plant pathogens causing losses to UK potato harvests estimated at pound50 m/ year.

293 In this multicentre randomised trial (UK Flexible Sigmoidoscopy Screening Trial), done between

294 for variants in a cohort of 258 undiagnosed UK patients with developmental eye disorders, including

295 Unexposed UK controls were also recruited.

296 An urgent UK investigation was launched to assess risk of invasive

297 Industrialized countries (USA, UK, Germany, Japan, Italy, France and Canada) were the m

298 uence in the disproportionate roles the USA, UK, and the Bill & Melinda Gates Foundation have had in

299 To use UK Biobank data to report causal estimates of the associ

300 nset pattern with minimal differences versus UK controls at ages 11 years (p=0.0449) and 15 years (p=