ライフサイエンスコーパス: UPS

1 UPS characterization of the same FA-PVSK thin films prov

2 UPS function and relative activity was analyzed using a

3 UPS impacts transcriptional regulation by controlling th

4 UPS-indel identifies 15% redundant indels in dbSNP, 29%

5 UPS-indel is theoretically proven to find all equivalent

6 degradation of GL3 and EGL3 proteins is 26S UPS-dependent.

7 epeat expression triggered accumulation of a UPS reporter in a length-dependent fashion.

8 mouse model of tauopathy and in a cross to a UPS reporter mouse (line Ub-G76V-GFP).

9 n and relative activity was analyzed using a UPS reporter protein consisting of a short degron, CL1,

10 Accordingly, UPS substrates accumulate in prion-infected mouse brains

11 the synapse by dephosphorylation-induced and UPS-mediated degradation provides a mode to regulate pro

12 ndings reveal expression deficits in MT- and UPS-related genes specific to layer 3 and/or layer 5 pyr

13 le-crystal substrate of the other oxide, and UPS spectra are taken after each complete monolayer.

14 ptic density-95 mRNA, required both PP2A and UPS.

15 e patient group (P-values for MT-related and UPS-related pathways were <10(-7) and <10(-5), respectiv

16 o-ubiquitination, reduced ubiquitination and UPS-mediated degradation of myosin heavy chain 6, cardia

17 However, mixed-meal consumption attenuated UPS-mediated proteolysis, independent of energy status o

18 ile prevention of RAN translation attenuated UPS impairment in cells and suppressed the genetic inter

19 involving protein elimination via augmented UPS activity.

20 alth through mediating the interplay between UPS and autophagy/lysosome system and its alteration pro

21 udies, suggest that the relationship between UPS activity and memory retrieval depends on training pa

22 protein in cells, we observed that blocking UPS resulted in accumulation of GFP-HNF1alpha in cytopla

23 Simultaneously activating both UPS and autophagy might provide a powerful strategy for

24 USP14 may provide a strategy to promote both UPS and autophagy for developing novel therapeutics targ

25 ion of electronic structure determination by UPS with length- and work function-dependent transport m

26 nt, but it was dose-dependently increased by UPS inhibitors bortezomib and MG132.

27 did not tolerate structural perturbation by UPS when tested, indicating that structural integrity of

28 Understanding how cardiac UPS function is regulated will facilitate delineating th

29 Moreover, comparing UPS-indel to state-of-the-art approaches for indel call

30 y, knockdown of UBC9 significantly decreased UPS function in the model and resulted in increased aggr

31 s an essential role in cullin deneddylation, UPS-mediated degradation of a subset of proteins, and th

32 This paper describes UPS-indel, a utility tool that creates a universal posit

33 sis, but pharmacological agents that enhance UPS activity have been challenging to establish.

34 Overexpression of UBC9 enhanced UPS function in cardiomyocytes, whereas knockdown of UBC

35 cription of Atrogin-1 and MuRF1 and enhances UPS-mediated protein degradation in heart.

36 Here, we examined UPS activity after an extended-access cocaine self-admin

37 By comparing experimental UPS spectra with calculated spectra based on specific mo

38 3-ph isoform of C/EBPalpha and target it for UPS-mediated degradation.

39 ety of applications, including screening for UPS activating molecules and selecting for mammalian cel

40 In schizophrenia, studies have found UPS transcript abnormalities in both blood and brain, an

41 proteasome system positive inclusions (FTLD-UPS) that stained negatively for tau, TDP-43, and FUS.

42 a tumor suppressor protein and that the Gank-UPS-mediated reduction of CUGBP1 is a key event in the d

43 Using reporters for global UPS activity, protein aggregation, and oxidative stress,

44 terial effectors exploit or require the host UPS for their action, as currently best studied in Pseud

45 It has been suggested that the host UPS mediates this uncoating process, but there is no evi

46 es that pathogenic bacteria subvert the host UPS to facilitate infection.

47 acterial pathogens are known to use the host UPS, the first prokaryotic F-box protein, an essential c

48 These results show a novel role for BDNF in UPS regulation at the synapse, which is likely to act to

49 ne the role of CSN-mediated deneddylation in UPS function and postnatal cardiac development and funct

50 FD) complex are required for the increase in UPS activity observed in adults, and that animals that l

51 This rapid increase in UPS-mediated proteolysis continued for many hours and re

52 protein homoeostasis in adults by increasing UPS activity and polyubiquitination, while decreasing pr

53 ese findings suggest that CGG repeats induce UPS impairment at least in part through activation of RA

54 eubiquitination by USP14 is known to inhibit UPS.

55 uce cancer cell apoptosis through inhibiting UPS function.

56 By linking UPS activity to a simple and tunable fluorescence output

57 R into a fluorescent signal, thereby linking UPS activity to an easily detectable output, which can b

58 We have engineered Cre-lox UPS host acceptor vectors (pCR701- 705) with N-terminal

59 Whereas loss of Cuz1 alone causes only minor UPS degradation defects, its combination with mutations

60 t long-lived) cell proteins generally, model UPS substrates having different degrons, and aggregation

61 med to generate a mouse model for monitoring UPS function using a green fluorescent protein (GFP)-bas

62 To search for new UPS targets in the DNA damage signalling pathway, we hav

63 e various spectroscopic methods (UV-vis-NIR, UPS, pulse EPR), electrochemistry and spectroelectrochem

64 g diseases, and discuss the exciting area of UPS-targeting drug development for pulmonary disease.

65 In the assessment of UPS responses to varied protein intakes, ED, and feeding

66 In this article, we discuss the biology of UPS-targeting drugs, their use as therapy for neoplasia,

67 ctionally with Cdc48/p97/VCP, a component of UPS required for degradation of RNAPII.

68 tic F-box protein, an essential component of UPS, was identified in Agrobacterium.

69 ertility of plants through their delivery of UPS substrates to the 26S proteasome.

70 lar in nature suggesting that dysfunction of UPS is not specific to PD or to Lewy body formation.

71 folded protein revealed severe impairment of UPS function in CR-Csn8KO hearts.

72 expression of FMRpolyG enhanced induction of UPS impairment in cell models, while prevention of RAN t

73 ion of markers associated with inhibition of UPS and ERAD functions, which induces irresolvable prote

74 cogenic mutant p53 by targeted inhibition of UPS components, particularly key deubiquitinases (DUBs)

75 one leads to changes in expression levels of UPS-related proteins which has a knock-on effect on over

76 The mechanism of UPS-mediated elimination of C/EBPalpha during carcinogen

77 that this circuit responds to modulation of UPS activity in cell culture arising from the inhibitor

78 Comparing the performance of UPS-indel with existing variant normalization tools vt n

79 ED resulted in the up-regulation of UPS-associated gene expression, as mRNA expression of th

80 ating the pathophysiological significance of UPS dysfunction and developing new therapeutic strategie

81 riants, expanding the phenotypic spectrum of UPS-dependent disorders.

82 ing models posit that Cdc48 acts upstream of UPS receptors.

83 Subsequently, the effects of UBC9 on UPS function were tested in a proteotoxic model of desmi

84 hich specific UPS components are involved or UPS targets in neurons.

85 Manipulating K6a phosphorylation or UPS activity may provide opportunities to harness the in

86 onal design of inhibitors for DUBs and other UPS proteins.

87 adation by the ubiquitin-proteasome pathway (UPS) are determined by their rates of ubiquitination, we

88 lation between the gas phase and solid phase UPS measurements illustrated here provides a general app

89 ct type because of weak Fermi level pinning (UPS revealed E(F) - E(HOMO) varied only weakly with Phi)

90 provide support for the idea that the plant UPS uncoats synthetic T-complexes via the Skp1/Cullin/F-

91 thesis that early IPC preserves postischemic UPS function thus facilitating prosurvival signaling eve

92 IPC) may prevent dysregulation by preventing UPS dysfunction through inhibition of oxidative damage.

93 Ubiquitin/26S proteasome (UPS)-dependent proteolysis of a variety of cellular prot

94 51 in pH cooperativity for a representative UPS block copolymer, by far the largest reported in the

95 n and the impact of cardiomyocyte-restricted UPS dysfunction on the heart have not been reported.

96 Cardiomyocyte-restricted UPS malfunction can cause heart failure.

97 S) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes.

98 ed unstructured peptide-insertion screening (UPS) with electrophysiological and fluorescence recordin

99 -assembly of a series of ultra-pH sensitive (UPS) block copolymers.

100 orted the development of ultra-pH-sensitive (UPS) nanoprobes with sharp pH response using fluorophore

101 In the future, specific UPS proteins may serve as new biomarkers or therapeutic

102 The expression of specific UPS proteins in podocytes differentiated children with m

103 ay for future studies that focus on specific UPS enzymes or ubiquitinated substrates.

104 little is known about either which specific UPS components are involved or UPS targets in neurons.

105 hase ultraviolet photoelectron spectroscopy (UPS) measurements along with solution electrochemical me

106 ibit ultraviolet-photoelectron spectroscopy (UPS) signatures expected of metallic solids.

107 opy, ultraviolet photoelectron spectroscopy (UPS), cyclic voltammetry, and DFT computation.

108 with ultraviolet photoelectron spectroscopy (UPS).

109 d in ultraviolet photoemission spectroscopy (UPS) to determine the electronic density-of-states at th

110 The most clinically successful UPS-active agents (bortezomib and lenalidomide) are limi

111 discuss the experimental data which suggest UPS dysfunction is a common feature of cardiomyopathies,

112 ubiquitin-26S proteasome degradation system (UPS) in plants is involved in the signal transduction of

113 liana cDNAs in the universal plasmid system (UPS) donor vector pUNI51 should be applied broadly and e

114 proteins by the ubiquitin-proteasome system (UPS) accompanies the maternal-to-zygotic transition.

115 The ubiquitin-proteasome system (UPS) also plays an important role in protein homeostasis

116 The ubiquitin-proteasome system (UPS) and autophagy are two major intracellular degradati

117 onse (UPR), the ubiquitin-proteasome system (UPS) and autophagy, appear indispensable for longevity i

118 ively block the ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway, we show that HNF1a

119 mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome system and is fundamental fo

120 tive arm of the ubiquitin proteasome system (UPS) and is required for mouse embryonic development, in

121 ic systems, the ubiquitin proteasome system (UPS) and the autophagosomal/lysosomal system, in persist

122 degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors,

123 regulating the ubiquitin proteasome system (UPS) at synapses are poorly understood.

124 elicited by the ubiquitin proteasome system (UPS) but that it is orchestrated by the F-Box protein, F

125 The ubiquitin proteasome system (UPS) controls many cellular processes, including the ini

126 The ubiquitin-proteasome system (UPS) controls protein abundance and is essential for man

127 The ubiquitin proteasome system (UPS) degrades misfolded proteins including those implica

128 The ubiquitin proteasome system (UPS) directs programmed destruction of key cellular regu

129 The ubiquitin (Ub)/26S proteasome system (UPS) directs the turnover of numerous regulatory protein

130 The ubiquitin-proteasome system (UPS) for protein degradation has been under intensive st

131 n activates the ubiquitin-proteasome system (UPS) for widespread degradation of outer membrane protei

132 ondrial (MT) or ubiquitin-proteasome system (UPS) functions were markedly downregulated in the patien

133 The ubiquitin-proteasome system (UPS) has been implicated in the retrieval-induced destab

134 Ubiquitin-26S proteasome system (UPS) has been shown to play central roles in light and h

135 The ubiquitin proteasome system (UPS) has emerged as a drug target for diverse diseases c

136 The ubiquitin-proteasome system (UPS) has emerged as a therapeutic focus and target for t

137 In Drosophila, ubiquitin proteasome system (UPS) impairment led to enhancement of CGG-repeat-induced

138 egulated by the ubiquitin-proteasome system (UPS) in a process controlled by the envelope-localized u

139 the role of the ubiquitin-proteasome system (UPS) in human cytomegalovirus (HCMV) infection.

140 unction for the ubiquitin-proteasome system (UPS) in regulating the signalling network for DNA damage

141 ral role of the ubiquitin-proteasome system (UPS) in the degradation of cellular proteins, proteasome

142 ole of the host ubiquitin/proteasome system (UPS) in the infection process.

143 olvement of the ubiquitin-proteasome system (UPS) in the modulation of presynaptic function.

144 olvement of the ubiquitin proteasome system (UPS) in their pathogenesis.

145 The ubiquitin-proteasome system (UPS) influences gene transcription in multiple ways.

146 The ubiquitin-proteasome system (UPS) is a major mechanism of intracellular protein degra

147 The ubiquitin proteasome system (UPS) is a major regulator of protein processing, traffic

148 The ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquiti

149 proteins by the ubiquitin-proteasome system (UPS) is an essential biological process in the developme

150 The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular p

151 mediated by the ubiquitin-proteasome system (UPS) is critical to eukaryotic protein homeostasis.

152 ulation via the ubiquitin proteasome system (UPS) is crucial for normal HSC function; the loss of whi

153 The ubiquitin proteasome system (UPS) is known to regulate expression of many synaptic pr

154 The ubiquitin proteasome system (UPS) is primarily responsible for cellular protein degra

155 otic cells, the ubiquitin-proteasome system (UPS) is responsible for the regulated degradation of int

156 asis, including ubiquitin-proteasome system (UPS) mediated protein degradation, endoplasmic reticulum

157 function of the ubiquitin-proteasome system (UPS) occurs in dopaminergic neurones in the SN in PD and

158 erations in the ubiquitin-proteasome system (UPS) or the autophagy-lysosomal pathway (ALP).

159 adation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connectio

160 The ubiquitin-proteasome system (UPS) plays a central role in processing cellular protein

161 The ubiquitin-proteasome system (UPS) plays a critical role in removing unwanted intracel

162 The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integr

163 The ubiquitin proteasome system (UPS) plays a crucial role in modulating synaptic physiol

164 ase MDM2 by the ubiquitin-proteasome system (UPS) promotes carcinogenesis and malignant transformatio

165 The ubiquitin-proteasome system (UPS) regulates diverse cellular pathways by the timely r

166 The ubiquitin proteasome system (UPS) regulates many biological pathways by post-translat

167 The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation

168 bstrates to the ubiquitin-proteasome system (UPS) remains unclear.

169 haracterize the ubiquitin proteasome system (UPS) response to varied dietary protein intake, energy d

170 ocesses such as ubiquitin-proteasome system (UPS) to avoid a build-up of misfolded protein aggregates

171 nts utilize the ubiquitin-proteasome system (UPS) to modulate nearly every aspect of growth and devel

172 s, inhibits the ubiquitin-proteasome system (UPS) via targeting both 19S proteasome-specific DUBs and

173 ins through the ubiquitin-proteasome system (UPS) via the activities of E3 ubiquitin ligases regulate

174 tivation of the ubiquitin-proteasome system (UPS) was detected which resulted in a decreased expressi

175 of CIITA to the Ubiquitin Proteasome System (UPS), and we and others have demonstrated that mono-ubiq

176 omeostasis, the ubiquitin proteasome system (UPS), as it relates to lung disease.

177 -depends on the ubiquitin-proteasome system (UPS), but the specific processes regulated by the UPS du

178 involved in the ubiquitin proteasome system (UPS), including the Skp1-like protein SKR-5, while downr

179 Targeting the ubiquitin-proteasome system (UPS), therefore, is an attractive avenue to combat drug

180 teolysis by the ubiquitin proteasome system (UPS), which catalyzes most protein degradation in mammal

181 estrated by the ubiquitin proteasome system (UPS), which constitutes a cascade of enzymes that transf

182 trated that the ubiquitin-proteasome system (UPS), which is known to influence synaptic strength, dyn

183 translation and ubiquitin-proteasome system (UPS)-dependent proteolysis for the up- and downregulatio

184 quitination and ubiquitin proteasome system (UPS)-mediated degradation of FMRP in dendrites upon DHPG

185 and the rate of ubiquitin-proteasome system (UPS)-mediated proteolysis following heat stress.

186 n-regulation of ubiquitin proteasome system (UPS)-related genes, in particular, components of multime

187 (KAMPs) by the ubiquitin-proteasome system (UPS).

188 tophagy and the ubiquitin proteasome system (UPS).

189 egulated by the ubiquitin proteasome system (UPS).

190 is requires the ubiquitin-proteasome system (UPS).

191 ded through the ubiquitin proteasome system (UPS).

192 tivities of the ubiquitin-proteasome system (UPS).

193 radation by the ubiquitin-proteasome system (UPS).

194 ion through the Ubiquitin-Proteasome System (UPS).

195 tination by the ubiquitin-proteasome system (UPS).

196 aratus, and the ubiquitin-proteasome system (UPS).

197 to inhibit the ubiquitin-proteasome system (UPS).

198 e ATP-dependent ubiquitin-proteasome system (UPS).

199 ound within the ubiquitin-proteasome system (UPS).

200 erformed by the Ubiquitin-Proteasome System (UPS).

201 degraded by the ubiquitin-proteasome system (UPS).

202 I, Rpb1, by the ubiquitin proteasome system (UPS).

203 degraded by the ubiquitin-proteasome system (UPS).

204 ctivation of the ubiquitinproteasome system (UPS).

205 we hypothesize that UPS facilitates vascular BK-beta(1) degradation in diabe

206 Here we show that UPS-dependent proteolysis of two of these TFs, GLABROUS

207 and GATK LeftAlignAndTrimVariants shows that UPS-indel is able to identify 456,352 more redundant ind

208 The UPS catalyzes the destruction of many critical protein s

209 The UPS comprises a sequential series of enzymatic processes

210 The UPS effects selective degradation of ubiquitinated targe

211 The UPS is directed in part by a group of Ub-like/Ub-associa

212 The UPS library provides a useful toolkit to study pH regula

213 The UPS may function to suppress FDH mediated stress respons

214 The UPS prototypically recognizes specific protein substrate

215 , mTOR inhibition coordinately activates the UPS and autophagy, which provide essential amino acids a

216 Because the UPS is a crucial regulator of the cell cycle, and abnorm

217 In summary, the crosstalk between the UPS and autophagy highlight the pivotal and diverse role

218 re is a compensatory interaction between the UPS and autophagy in HIF2alpha degradation.

219 ophagy, and reveal a causal link between the UPS and autophagy, the major pathways for degradation of

220 ese results provide a novel link between the UPS, the ALP, and alpha-synuclein pathology and may have

221 Both the UPS and autophagy/lysosome system exhibit reduced effici

222 f mRNA from the nucleus-is influenced by the UPS and that all major arms of the system--from the firs

223 cyte-specific protein alpha-actinin-4 by the UPS depended on oxidative modification in membranous nep

224 but the specific processes regulated by the UPS during pruning have been largely elusive.

225 o unfold and be rapidly ubiquitinated by the UPS for degradation at the proteasome.

226 t protein kinase (PKA) on proteolysis by the UPS in several mammalian cell lines.

227 The degradation of proteins by the UPS occurs independently of the autophagy pathway, and i

228 nd damaged proteins are ubiquitinated by the UPS, their destruction by the proteasome is not always p

229 intracellular proteins to degradation by the UPS, we developed an unbiased method for large-scale ide

230 and native channels to downregulation by the UPS.

231 g of polyubiquitinated pQC substrates by the UPS.

232 In this study, we expand the UPS design to a library of nanoprobes with operator-pred

233 One of the challenges facing the UPS field is to delineate the complete cohort of substra

234 l as current and future therapeutics for the UPS will be examined.

235 uscle proteins to provide substrates for the UPS.

236 and selectivity efficiency inferred from the UPS data.

237 understanding the emerging field of how the UPS regulates HSC activity may lead to novel targets for

238 These findings directly implicate the UPS and actin cytoskeleton in regulating prions via a st

239 g activate muscle protein degradation in the UPS and caspase-3, a protease that disrupts the complex

240 Specific targets in the UPS may be more efficacious and less toxic.

241 candidates for therapeutic modulation in the UPS.

242 ow that Cuz1 modulates Cdc48 function in the UPS.

243 We report that inhibiting the UPS in developing Xenopus retinal ganglion cells (RGCs)

244 ithione complex (NiPT) potently inhibits the UPS via targeting the 19S proteasome-associated DUBs (UC

245 ization neuron dendrite pruning and link the UPS to the control of mRNA metabolism.

246 Notably, the UPS was overwhelmed in podocytes during experimental glo

247 ls, the targeting of other components of the UPS (e.g., the E3 ubiquitin ligases) can lead to an incr

248 activity confirmed similar activation of the UPS after retrieval of saline and cocaine memories.

249 sis it is not surprising that members of the UPS are frequently aberrantly expressed in a number of d

250 itself or specific proximal pathways of the UPS are in development as antiproliferatives or immunomo

251 This global characterization of the UPS as a key regulator of stem cell pluripotency opens t

252 hese studies highlight the importance of the UPS at all stages of the HCMV infection and support furt

253 es suggest that IPC protects function of the UPS by diminishing oxidative damage to 19S regulatory pa

254 These results suggest that modulation of the UPS by electrical activity contributes to persistent pre

255 ht a proteolysis-independent function of the UPS during class IV dendritic arborization neuron dendri

256 d proteins, small-molecule modulators of the UPS have the potential to significantly expand the drugg

257 c mice and age dependence to the role of the UPS in alpha-synuclein degradation.

258 Moreover, we report alterations of the UPS in alpha-synuclein transgenic mice and age dependenc

259 Here, the role of the UPS in plant defense and its exploitation by effectors a

260 and promising approach in regulation of the UPS involves targeting deubiquitinases (DUB).

261 which can be stimulated by components of the UPS that also trigger their destruction.

262 review article focuses on components of the UPS that have been demonstrated to be deregulated by a v

263 Furthermore, blockade of the UPS using E1-activating enzyme inhibitors also increases

264 of a general and reversible inhibitor of the UPS, bortezomib, in treating mantle cell lymphoma and mu

265 de an overall review of the mechanics of the UPS, describe aberrancies leading to cancer, and give an

266 This review will focus on one member of the UPS, the F-box protein, Fbw7 (also known as Sel-10, Ago,

267 vity that are perturbed by disruption of the UPS.

268 refore, they are essential regulators of the UPS.

269 However, whether BDNF acts on the UPS to mediate the effects on long-term synaptic potenti

270 mutant 9) signalosome (CSN) may regulate the UPS, but this has not been tested in a critical vertebra

271 highlight the pivotal and diverse roles the UPS plays in maintaining protein quality control and reg

272 evelopment of the cardiovascular system, the UPS regulates cell signaling by modifying transcription

273 myeloma has demonstrated that targeting the UPS has therapeutic potential.

274 ent drug therapies selectively targeting the UPS.

275 In addition, we provide evidence that the UPS and ALP might be functionally connected such that im

276 In summary, our results indicate that the UPS is likely to participate in tuning synaptic efficacy

277 We demonstrate that the UPS is the main degradation pathway for alpha-synuclein

278 Overall, these data suggest that the UPS not only orchestrates protein turnover, but also dyn

279 e last 10 years it has become clear that the UPS plays a prominent regulatory role in hormone biology

280 We also noted that the UPS regulates both Tomo-1 expression and functional outp

281 in regulating protein breakdown through the UPS in the heart is not known.

282 ry for AMPK-mediated proteolysis through the UPS in the heart.

283 t pathobiological mechanisms relating to the UPS and lung disease have been the focus of research, wi

284 uality control machinery and targeted to the UPS for degradation in mammalian cells.

285 hannel ubiquitination and sensitivity to the UPS, suggesting a role in pain processing.

286 ent density and increased sensitivity to the UPS.

287 Thus manipulation of DISC1 levels via the UPS may provide a novel method to explore DISC1 function

288 One way in which the UPS affects transcription centers on transcriptional act

289 lead to oncogenesis, aberrancies within the UPS pathway can result in a malignant cellular phenotype

290 uitin E3 ligase for HSF1 degradation through UPS.

291 In contrast to UPS-mediated, ER-associated degradation, few components

292 iquitin and ubiquitylated proteins is key to UPS function, the mechanisms that regulate ubiquitin hom

293 rbing switch from stable protein to unstable UPS substrate unlike other methods currently used to int

294 Moreover, using UPS-targeted RNAi screens, we identify additional regula

295 FMRP downregulation via UPS removes this brake enabling group I mGluR-mediated t

296 rominent in layer 3 pyramidal cells, whereas UPS-related gene alterations were more prominent in laye

297 Whether UPS participates in BK-beta(1) downregulation in diabeti

298 However, it is not clear whether UPS and autophagy can be controlled by a common regulato

299 x7 null genotype ERMS incidence drops, while UPS becomes the most frequent subtype.

300 and suppressed the genetic interaction with UPS manipulation in Drosophila.