ライフサイエンスコーパス: USP

1 USP <797> standards, radiation safety concerns, and work

2 USP and HD-OCT showed better agreement in CCT readings a

3 USP NaInS(2) films are used as a new photoanode material

4 USP thus establishes the precedent that invertebrate orp

5 ial of chronic pancreatitis patients, 90 000 USP U of pancreatin with meals decreased fat malabsorpti

6 eatment of fat malabsorption requires 90,000 USP U of lipase with meals.

7 ne receptor B1 (EcR-B1) and Ultraspiracle 1 (USP-1) were expressed at high levels under the control o

8 ating enzyme ubiquitin-specific protease-46 (USP-46) regulates the abundance of the glutamate recepto

9 0 and 6.0 in subjects treated with 55 IU (68 USP) and 75 IU (93 USP) of hyaluronidase respectively, v

10 We here study the role of the MHV-68 USP, encoded by ORF64.

11 ts treated with 55 IU (68 USP) and 75 IU (93 USP) of hyaluronidase respectively, versus 2.0 in saline

12 the maturation of MC3T3 pre-osteoblasts in a USP-dependent and Arf6-independent manner.

13 stable cell lines overexpressing TRE17, in a USP-dependent manner.

14 al. provide a counterintuitive example of a USP residing in an E3 complex, and establish Usp37 as a

15 Through cell-based screening of a USP siRNA library, we discovered that knockdown of USP2a

16 The test utilized a USP-apparatus II with rotations of 50, 75 and 100rpm in

17 (anticoagulant citrate dextrose, solution A, USP mixed with 0.9% NaCl, v/v) was added to the tube and

18 lity shift assays showed no binding of EcR-A/USP-1 to EcRE1.

19 squito Aedes aegypti receptor complex (AaEcR-USP), significantly enhancing DNA binding and transactiv

20 SP-encoding genes, but little is known about USP tissue distribution, pattern of expression, activity

21 a ligand that can transcriptionally activate USP would provide heuristic leads to the structure of po

22 ional proteomics approach to identify active USPs in normal, virus-infected, and tumor-derived human

23 catalysis and developing inhibitors against USPs.

24 loenzyme DUB families and highlight that all USPs tested display low linkage selectivity.

25 y ubiquitylation occurs more generally among USP-family enzymes.

26 t, in vitro-transcribed-translated USP-1 and USP-2 both formed heterodimeric complexes with EcR-B1 th

27 jugates, suggesting that WDR-20, WDR-48, and USP-46 function together to deubiquitinate and stabilize

28 Two USP isoforms, USP-A and USP-B, with distinct N-termini, occur in the mosquito Ae

29 d the normal activation caused by EcR-B1 and USP-1 by 50%.

30 was expressed together with both EcR-B1 and USP-1, it reduced the normal activation caused by EcR-B1

31 In contrast, high expression of EcR-B1 and USP-2 caused little increase in CAT levels in response t

32 EcR and USP are expressed, activated and autonomously required i

33 teins that co-immunoprecipitate with EcR and USP identified multiple Mediator subunits, including CDK

34 K8 protein positively correlate with EcR and USP levels, but inversely correlate with the activity of

35 heteromeric receptor composed of the EcR and USP nuclear receptor proteins.

36 ough a heterodimer consisting of the EcR and USP nuclear receptors.

37 s transduced by a heterodimer of the EcR and USP nuclear receptors.

38 heteromeric receptor composed of the EcR and USP proteins.

39 EcR and USP use similar surfaces, and rely on the deformed minor

40 tein(s) in the cell extract, but not EcR and USP, and so are not EcREs in this cellular context.

41 iously increases the levels of CDK8, EcR and USP, yet down-regulates SREBP activity.

42 can Medical Association Drug Evaluations and USP-DI subsequently ceased publication, and the Medicare

43 RING domain ubiquitin ligases, of JAMM- and USP-domain-deubiquitinating enzymes, and of numerous ubi

44 lower than those obtained by both HD-OCT and USP at all follow-up visits.

45 The patients CCTs were measured with OCT and USP by three different examiners.

46 The differences between OCT and USP were not significant (t-test, p = 0.32).

47 The mean CCT measurements by the HD-OCT and USP were similar to baseline readings except for the thi

48 ing methods (such as sample-and-separate and USP apparatus 4).

49 In fluorescence-based binding assays, USP protein binds JH III and JH III acid with specificit

50 the three putative EcREs to bind the EcR-B1-USP-1 complex in gel mobility shift assays and was respo

51 sponsible for the silencing action of EcR-B1-USP-1 in the absence of hormone.

52 excess USP-2 prevented the binding of EcR-B1-USP-1 to this element.

53 sion of USP-2 prevented activation by EcR-B1-USP-1.

54 When cell extracts were used, the EcR-B1-USP-2 heterodimer showed no binding to EcRE1, and the pr

55 Previous studies showed that EcR-B1/USP-1 bound only to EcRE1 and high levels of this comple

56 cR-A, however, reduced the binding of EcR-B1/USP-1 by about 50%.

57 mistry, the microdroplet reactors created by USP facilitate the formation of a wide range of nanocomp

58 urities were below the limits established by USP.

59 the proteasomal system or be reactivated by USP-33/20-mediated deubiquitination.

60 ubiquitin-like domain, whereas its catalytic USP domain is positioned variably.

61 Additionally, putative CF1/USP and Broad Complex Z2 transcription factor elements w

62 In contrast to other characterized USP deubiquitinases, our results indicate that USP28 has

63 the United States Pharmacopeial Convention (USP) and international stakeholders collaborated to rede

64 AD in combination with Neoral (cyclosporine, USP MODIFIED) and corticosteroids.

65 l PUB domain, which binds the catalytic CYLD USP domain in a CYLD B-box-dependent manner.

66 e describe the crystal structure of the CYLD USP domain, revealing a distinctive architecture that pr

67 The results demonstrated that the developed USP 4 method was capable of detecting manufacturing proc

68 These results showed that the developed USP apparatus 4 method was capable of discriminating PLG

69 age of activation/differentiation, different USP activity profiles were revealed.

70 sophila melanogaster receptor complex (DmEcR-USP).

71 memory after extinction training by low-dose USP methylene blue (MB).

72 We found previously that the DUB USP-46 deubiquitinates the Caenorhabditis elegans glutam

73 in GST pull-down experiments, including EcR, USP, DHR3, SVP and betaFTZ-F1.

74 nockdown of the expression of Met, SRC, EcR, USP, BR-C (Broad-Complex), TOR (target of rapamycin), an

75 of the EcR subunit of the heterodimeric EcR-USP ecdysone receptor.

76 ement for a heterodimeric arrangement of EcR-USP subunits to bind to a symmetric DNA is unusual withi

77 ding interfaces to be the same as in the EcR-USP complex.

78 We describe the 2.24 A structure of the EcR-USP DNA-binding domain (DBD) heterodimer bound to an ide

79 We show that the EcR-USP ecdysone receptor is first activated in the extraemb

80 The EcR-USP heterodimer preferentially mediates transcription th

81 endly insecticides, the evolution of the EcR-USP heterodimer, and indeed Ashburner's classical bioche

82 CMI associates with TRR, as well as the EcR-USP receptor, and is required for hormone-dependent tran

83 Consistently, CDK8-CycC interacts with EcR-USP in vivo; in particular, CDK8 and Med14 can directly

84 Although EcR.USP-A recognizes the same ecdysteroid-responsive element

85 he same ecdysteroid-responsive elements, EcR.USP-B binds them with an affinity twofold higher than th

86 Likewise, EcR.USP-B transactivates a reporter gene in CV-1 cells twofo

87 V-1 cells demonstrated that the mosquito EcR.USP heterodimer is capable of transactivating reporter c

88 an affinity twofold higher than that of EcR.USP-A.

89 in CV-1 cells twofold more strongly than EcR.USP-A.

90 yellow fever mosquito, Aedes aegypti, by EcR/USP and E74 in response to an elevation of 20E titers.

91 y demonstrates cell-autonomous roles for EcR/USP in controlling neuronal remodeling, potentially thro

92 other retinoid X receptor heterodimers, EcR/USP affects gene transcription in a ligand-modulated man

93 We found 502 significant regions of ECR/USP binding throughout the genome.

94 y, we found that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular d

95 Surprisingly, most identified primary EcR/USP targets are dispensable for MB neuronal remodeling.

96 controlled by the ecdysteroid receptor (EcR/USP) and products of ecdysteroid early responsive genes

97 at least three quarters of the remaining ECR/USP regions are near 20-HE-regulated genes in other tiss

98 We conclude that EcR/USP activation by the systemic ecdysteroid signal may be

99 We show that EcR/USP DNA binding activity requires activation by a chaper

100 ate third instar larvae, suggesting that EcR/USP loses its ability to function as an efficient activa

101 r activity in vivo, demonstrate that the EcR/USP heterodimer functions in a stage-specific manner dur

102 dicted for ecdysteroid activation of the EcR/USP heterodimer.

103 The ecdysone signal is transduced by the EcR/USP nuclear receptor heterodimer that binds to specific

104 that 20E mediates secretion through the EcR/USP receptor, and two early-gene products, the rbp(+) fu

105 ximal region containing binding sites to EcR/USP, GATA, C/EBP and HNF3/fkh is required for the correc

106 dimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormone receptor complex throughout the ent

107 st that in imaginal discs the unliganded EcR/USP complex acts as a ligand-sensitive ;gate' that can b

108 tion is also repressed by the unliganded EcR/USP complex but the block occurs after senseless express

109 l stage but suppressed by the unliganded EcR/USP complex.

110 suggest that silencing by the unliganded EcR/USP receptor and the subsequent release of silencing by

111 0-hydroxyecdysone (20E), consistent with EcR/USP acting as a 20E receptor.

112 Analysis of large gene families encoding USPs, nitroreductases, and DGATs demonstrates a mosaic d

113 binding to EcRE1, and the presence of excess USP-2 prevented the binding of EcR-B1-USP-1 to this elem

114 constitutively bound endogenously expressed USPs 20 and 33 from the beta(2)AR immediately after agon

115 nfidence interval (CI): 0.98-0.996], and for USP, 0.97 (CI: 0.95-0.98).

116 adigms of USP action that do not include for USP a ligand-binding activity.

117 logic intervention, and future prospects for USP inhibitors to treat diverse cancers.

118 ated from one another in a liquid, while for USP it is hot droplets isolated from one another in a ga

119 Our results point to a novel function for USPs in the regulation and function of Polycomb complexe

120 show that the patterns of GAL4-EcR and GAL4-USP activation at the onset of metamorphosis reflect wha

121 In addition, both GAL4-EcR and GAL4-USP are activated in larval organs cultured with 20-hydr

122 -third instar imaginal discs results in GAL4-USP activation, but this response is not seen in imagina

123 We also show that GAL4-USP activation depends on EcR, suggesting that USP requi

124 es Pharmacopeia (USP) General Chapter <797> (USP <797>), "Pharmaceutical Compounding-Sterile Preparat

125 As reported here, USP activity is conserved in Marek's disease virus (MDV)

126 The herpesvirus USP thus appears to be required not only to maintain a f

127 ced activation, whereas the presence of high USP-2 prevented this increased activation.

128 de useful insights into the mechanism of how USP recognizes ubiquitin moieties in a chain structure,

129 cts residues that are conserved in the human USP family, and thus it is likely important for the inte

130 e expression ceases, AaSvp replaces AaEcR in USP heterodimers.

131 SPs featuring an N-terminal tandem domain in USP (DUSP) and ubiquitin-like (UBL) domain.

132 al cultures were more frequently negative in USP compared to NALC specimen aliquots (58% versus 43%;

133 mation of a protein-DNA complex, and induces USP-dependent transcription in a reporter assay.

134 in vitro to EcR and DHR38, both known insect USP partners.

135 Two USP isoforms, USP-A and USP-B, with distinct N-termini, occur in the m

136 s to tumor pathogenesis, and the role of its USP and TBC domains, are unknown.

137 MMP-9 and MMP-10, in a manner requiring its USP activity, but not its ability to bind Arf6.

138 alphaherpesvirus Marek's disease virus, its USP is involved in T-cell lymphoma formation.

139 Puf containing point mutations within its USP enzymatic domain failed to alter dMyc levels and dis

140 eight core gene groups (regulators, kinases, USPs, DGATs, nitroreductases, ferredoxins, heat shock pr

141 f Saccharomyces cerevisiae expressing a LexA-USP fusion protein stabilizes an oligomeric association

142 Like, USP, it activates transcription in Drosophila Schneider

143 M48(USP) adopts a papain-like fold, with the active-site cys

144 se domain of murine cytomegalovirus M48 (M48(USP)) in a complex with a ubiquitin (Ub)-based suicide s

145 ion with an exposed beta hairpin loop of M48(USP).

146 led each nuclear pharmacy laboratory to meet USP <797> requirements for facility design and environme

147 T-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications.

148 ver, development of selective small-molecule USP inhibitors has been challenging, partly due to the h

149 Mean CCT values were 555.11 +/- 35.83 mum (USP), 535.82 +/- 41.10 mum (SP-2000P) and 552.57 +/- 36.

150 c of Drosophila shows that in the absence of USP, early hormone responsive genes such as EcR, DHR3 an

151 t promote the gastrointestinal absorption of USP heparin in rats and primates has been discovered.

152 In contrast, 20E inhibits activation of USP-A transcription.

153 that repression involves the association of USP with DNA.

154 at EcR-A competes with EcR-B1 for binding of USP-1, leading to a decline in activity of the promoter.

155 ation here of these functional capacities of USP in a transcriptional activation pathway has signific

156 ffect is further enhanced by coexpression of USP-46.

157 rough a nuclear receptor complex composed of USP (ultraspiracle) and EcRB1 (ecdysone receptor B1) to

158 Moreover, expression of USP-2 prevented activation by EcR-B1-USP-1.

159 X receptor (RXR) is the mammalian homolog of USP, we also solved the 2.60 A crystal structure of the

160 sence is required to sustain a high level of USP-B expression.

161 Ligand-binding pocket point mutants of USP that do not bind methyl epoxyfarnesoate act as domin

162 ficant implications for current paradigms of USP action that do not include for USP a ligand-binding

163 These newly revealed properties of USP might implicate similar properties for retinoid X re

164 in different cancers, the current status of USP inhibitor-mediated pharmacologic intervention, and f

165 anistic example for allosteric activation of USPs by their regulatory partners.

166 This family of USPs is conserved in all mycobacteria, and we suggest th

167 (USPs) USP15 and USP4 belong to a subset of USPs featuring an N-terminal tandem domain in USP (DUSP)

168 pulate transcriptional pathways dependent on USP or other orphan receptors.

169 ydroxyecdysone (20E) has opposite effects on USP isoform transcripts in in vitro fat body culture.

170 Hs) from six different manufacturers and one USP standard sample.

171 t binding of ecdysteroids to either DHR38 or USP.

172 nd the ligand binding domain (LBD) of EcR or USP, combined with a GAL4-dependent lacZ reporter gene.

173 ement among the three observers using OCT or USP for pachymetry measurements was good.

174 d apo form of USP7, which differs from other USP deubiquitinases.

175 ty than ATP, an established ligand for other USPs.

176 In the fat body and ovary, USP-A mRNA is highly expressed during the pre- and late

177 tomography (HD-OCT), ultrasound pachymetry (USP), and dual Scheimpflug tomography.

178 both with the OCT and ultrasound pachymetry (USP), in patients suffering from glaucoma.

179 inherent precision of ultrasound pachymetry (USP), noncontact specular microscopy (SP-2000P) and the

180 hibitor of the ubiquitin specific peptidase (USP) 14/ubiquitin carboxyl-terminal hydrolase (UCH) L5 d

181 ymes, such as ubiquitin-specific peptidases (USPs).

182 U.S. Pharmacopeia (USP) chapter <797> calls for tryptic soy agar with polys

183 ) injection listed in the U.S. Pharmacopeia (USP); the draft Chemistry, Manufacturing, and Controls (

184 According to the United States Pharmacopeia (USP) General Chapter <797> (USP <797>), "Pharmaceutical

185 The novel universal sample processing (USP) method has been reported to improve conventional di

186 rug Information for the Health Professional (USP-DI), and American Hospital Formulary Service Drug In

187 a ubiquitin (Ub)-specific cysteine protease (USP) domain embedded within the large tegument protein O

188 fy a human DUB, ubiquitin-specific protease (USP) 13, whose expression modulates the antiviral activi

189 rolase 6 [Ubp6; ubiquitin-specific protease (USP) 14 in mammals] is the most abundant proteasome-inte

190 TRE17 encodes a ubiquitin-specific protease (USP) and a TBC (TRE2-Bub2-Cdc16) domain that promotes ac

191 s (DUBs) of the ubiquitin-specific protease (USP) class.

192 binding to the ubiquitin-specific protease (USP) family of deubiquitinases.

193 The herpesvirus ubiquitin-specific protease (USP) family, whose founding member was discovered as a p

194 TRE17 encodes a ubiquitin-specific protease (USP), and a TBC domain that mediates binding to the Arf6

195 characterized a ubiquitin-specific protease (USP), Puffyeye (Puf), as a novel regulator of dMyc level

196 lso showed that ubiquitin-specific protease (USP)15 interacted with RORgammat, removed ubiquitin from

197 ated and stabilized by Ub-specific protease (USP)7 and USP10.

198 Ubiquitin-specific proteases (USP) are one class of DUBs that have drawn special atten

199 family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a varie

200 alled ubiquitin-specific cysteine proteases (USPs).

201 ating enzymes, ubiquitin-specific proteases (USPs) 20 and 33, thus, inhibiting lysosomal trafficking

202 tightly to particular Ub-specific proteases (USPs) and used phage display and saturation scanning mut

203 Ubiquitin-specific proteases (USPs) constitute the largest family of deubiquitinating

204 ases (E3s) and ubiquitin-specific proteases (USPs) dynamically oppose each other during ubiquitinatio

205 ; however, the ubiquitin-specific proteases (USPs) that carry out deubiquitination of cellular substr

206 Ubiquitin-specific proteases (USPs) USP15 and USP4 belong to a subset of USPs featurin

207 identify specific universal stress proteins (USP) as abundantly expressed cAMP-binding proteins in sl

208 v3130c), and many universal stress proteins (USPs).

209 The human genome contains many putative USP-encoding genes, but little is known about USP tissue

210 t synthesis with ultrasonic spray pyrolysis (USP) for the first time.

211 is the basis for ultrasonic spray pyrolysis (USP) with subsequent reactions occurring in the heated d

212 technique called ultrasonic spray pyrolysis (USP).

213 is activated by the orphan nuclear receptor USP.

214 eptor, EcR, and the Drosophila RXR receptor, USP.

215 Isolated, recombinant USP from Drosophila melanogaster specifically binds meth

216 a model in which ubiquitin adducts regulate USP enzyme interactions and functions.

217 es of C. sapidus and other arthropod EcR/RXR/USP analyzed by in silico indicates a plausible, strong

218 The activity of specific USPs, including USP5, -7, -9, -13, -15, and -22, was up-

219 ans WDR-20 and WDR-48 can bind and stimulate USP-46 catalytic activity in vitro.

220 Moreover, one ICP0 ubiquitination target, USP-7, was also more stable after infection with these t

221 Consistent with the notion that USP forms a heterodimer with the ecdysone receptor (EcR)

222 We observed that USP is able to activate as well as repress the Z1 isofor

223 These results suggest that USP-B functions as a major heterodimerization partner fo

224 P activation depends on EcR, suggesting that USP requires its heterodimer partner to function as an a

225 The USP domain binds to Rpt1 in the immediate vicinity of th

226 e amino acid substitution that abolishes the USP activity of the MDV large tegument protein diminishe

227 domly numbered specimen was processed by the USP method and the other by the NALC method.

228 Overall, the mean CCT obtained by the USP was similar to that obtained by the HD-OCT throughou

229 phic skin tumor cylindromatosis, disrupt the USP domain, accounting for loss of CYLD catalytic activi

230 ore, we provide biochemical evidence for the USP domain of CYLD and the PUB domain of the SPATA2 comp

231 cularization, with an essential role for the USP domain.

232 cleared by day 7, indicating a role for the USP in the persistence of MHV-68 infection or efficient

233 and specificity of smear microscopy for the USP method were 52% and 86%, respectively, and were not

234 However, the USP activity in MHV-68 is unlikely to be involved in the

235 d cons of each of the QA tests stated in the USP, CMC, and EP and to propose a practical testing meth

236 ards and official monographs included in the USP.

237 the properties of EcR: one that involves the USP DNA-binding domain and one that can be achieved sole

238 dth was >/=0.6mm deemed critical to meet the USP criteria of immediate release products.

239 ents indicated that the EcR protein, not the USP protein, was responsible for ligand specificity.

240 79 mum, and 466.66 mum using the HD-OCT, the USP, and dual Scheimpflug tomography, respectively (P =

241 Here we show that many DUBs of the USP and UCH subfamilies can be reversibly inactivated up

242 uitin aldehyde stabilizes the binding of the USP domain in a position where it bridges the proteasome

243 We identify regions of the USP domain responsible for this specificity and demonstr

244 -is inserted within the globular core of the USP domain.

245 is study, we compared the performance of the USP method to that of the standard N-acetyl-L-cysteine-N

246 We determined the structure of the USP MSMEG_3811 bound to cAMP, and we confirmed through s

247 Expression of the USP transcripts in MDV-transformed cell lines further su

248 ctive site of ORF64, we demonstrate that the USP activity of ORF64 is abolished.

249 These results suggest that the USP method did not provide any significant advantage ove

250 These data establish a paradigm in which the USP ligand-binding pocket can productively bind ligand w

251 This review attempts to summarize the USPs implicated in different cancers, the current status

252 for binding of cAMP, and we show that these USPs bind cAMP with a higher affinity than ATP, an estab

253 Up-regulation of this USP was a late event in the establishment of Epstein-Bar

254 Thus, USPs 20 and 33 serve as novel regulators that dictate bo

255 olves binding of JH or JH-like structures to USP.

256 In contrast, in vitro-transcribed-translated USP-1 and USP-2 both formed heterodimeric complexes with

257 Two USP isoforms, USP-A and USP-B, with distinct N-termini,

258 modulate the differential actions of the two USP isoforms.

259 reporter promoter, and addition of wild-type USP rescues this activation.

260 Ultraspiracle (USP), the insect homologue of the vertebrate retinoid X

261 EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).

262 ) ecdysone receptor (EcR) and ultraspiracle (USP), USP being the insect orthologue of the vertebrate

263 e ecdysone receptor (EcR) and ultraspiracle (USP).

264 e ecdysone receptor (EcR) and ultraspiracle (USP).

265 : Ecdysone Receptor (EcR) and Ultraspiracle (USP)/Retinoid-X Receptor (RXR).

266 phila ecdysone receptor (EcR)/ultraspiracle (USP) heterodimer is a key regulator in molting and metam

267 ndeed, the ability of the EcR-Ultraspiracle (USP) heterodimer to bind to polytene chromosomes and the

268 retinoid X receptor homologue Ultraspiracle (USP), the obligatory functional ecdysteroid receptor (Ec

269 retinoid X receptor homologue Ultraspiracle (USP).

270 he ecdysone receptor (EcR) or Ultraspiracle (USP), the two components of the ecdysone receptor, cause

271 and its heterodimeric partner Ultraspiracle (USP).

272 eceptor (EcR) or its partner, ultraspiracle (USP) are required for expression of Vg genes.

273 nhancer to which the receptor ultraspiracle (USP) binds.

274 bind to the nuclear receptor ultraspiracle (USP).

275 nvertebrate nuclear receptor, ultraspiracle (USP), an ortholog of the vertebrate RXR, is typically mo

276 g of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) t

277 noxycarb as activators of the Ultraspiracle (USP) ligand-binding domain.

278 ucture, which is important for understanding USP catalysis and developing inhibitors against USPs.

279 Unlike USP porcine heparin, bovine intestinal heparin (BIH) has

280 This steroid hormone upregulates USP-B transcription and its presence is required to sust

281 f the naltrexone microspheres obtained using USP apparatus 4.

282 on the in vitro release data obtained using USP apparatus 4.

283 ypills were evaluated for drug release using USP dissolution testing.

284 sone receptor (EcR) and ultraspiracle (USP), USP being the insect orthologue of the vertebrate RXR.

285 results distinguish two mechanisms by which USP modulates the properties of EcR: one that involves t

286 These data support a model in which USP-46 promotes GLR-1 abundance at synapses by deubiquit

287 to a period of low ecdysteroid titer, while USP-B mRNA exhibits its highest levels during the vitell

288 expressed EcR-A alone or in combination with USP-1 under the control of Autographa californica baculo

289 e that WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabi

290 DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ec

291 +/- 29 mum, and the average pachymetry with USP was 532 +/- 32 mum.

292 ing the activity of the subset of the UAF1 x USP complexes.