ライフサイエンスコーパス: USV

1 USVs and locomotion were measured for 6 min, with antino

2 ocked or severely impaired both freezing and USV elicited as CRs but had no effect on either behavior

3 hock paired training, postshock freezing and USV responses were significantly impaired in BLA-lesione

4 nance, or expression, then both freezing and USV should be blocked or impaired when elicited as CRs d

5 both postshock and conditioned freezing and USV.

6 significantly impaired conditioning to both USV conditional stimuli and to the training context but

7 ed fear in rats of both sexes as assessed by USVs.

8 e present study is the first to characterize USV responses to the same aversive event throughout deve

9 This study attempted to deconstruct USVs into simpler stimulus features that cause fear cond

10 -day-old pups; higher doses of MOR decreased USV but produced motor deficits as well.

11 Thus, pups' differential USV responses to contact with passive adults in isolatio

12 ations (USVs) and newborn pups emit distress USVs when separated from their dam, thereby facilitating

13 r, the conditions classically used to elicit USV vary greatly with the animal's age (isolation from t

14 return by itself is not sufficient to elicit USV.

15 uperior vena cava or carotid artery elicited USV from pups in their home cage.

16 g) attenuated BAT metabolism while enhancing USV production, and norepinephrine (NE, 800 microg/kg) e

17 gainst the two leading hypotheses explaining USV production: superficial vocal fold vibrations [2], a

18 r venous return is a necessary mechanism for USV production, 5% dextrose in water or blood was infuse

19 MUPET thus serves as a new tool for USV repertoire analyses, with the capability to be adapt

20 es during training, as measured by freezing, USV, and defecation.

21 that the expression of conditioned freezing, USV, defecation, and analgesia were significantly impair

22 Although play deprivation enhanced high USVs, an arousing but aversive stimulus (bright light) r

23 characterized eliciting conditions for high USVs.

24 n together, these findings suggest that high USVs may index an appetitive motivation to play in juven

25 This findings suggested that high USVs were linked to a motivational state rather than spe

26 igh-frequency ultrasonic vocalizations (high USVs, approximately 55 kHz) during rough-and-tumble play

27 perthermia, and adults showed alterations in USV observed as aftereffects of intoxication, despite gr

28 This indicates a specific deficit in USV calling rate in Fmr1 KO mice.

29 2 by siRNA eliminated the sex differences in USVs and altered the order of pup retrieval.

30 in fine sensorimotor function that includes USV production and complexity.

31 After removal of the dam, pups increased USV rates over baseline (potentiation).

32 stimulation produced analgesia and increased USVs and locomotion.

33 potentiated by NPA, whereas U-50,488-induced USVs were attenuated by both DA agonists.

34 should have inverse effects on cold-induced USVs.

35 Next, we questioned if these infant USV were also emitted in a more naturalistic context by

36 he hypothesis that BAT metabolism influences USVs during cold challenge by affecting cardiac rate and

37 ned to one of three cues: a multicall 19-kHz USV, a 19-kHz discontinuous tone, and a 19-kHz continuou

38 d in rat PR by a 22 kHz tone cue or a 22 kHz USV cue.

39 This treatment enhanced 40-kHz USV while leaving 66-kHz USV unchanged suggesting that t

40 ition, but led to increased prosocial 50-kHz USV emission rates and enhanced social approach behavior

41 ent enhanced 40-kHz USV while leaving 66-kHz USV unchanged suggesting that the use of USV goes far be

42 duces social approach behavior, while 22 kHz USVs lead to freezing behavior.

43 ns, rats produce 50 kHz USVs, whereas 22 kHz USVs occur in aversive situations.

44 (USV) conditional stimuli (10 sec of "22 kHz USVs").

45 in random order: (1) 50 kHz USVs, (2) 22 kHz USVs, (3) time- and amplitude-matched white noise, and (

46 n patterns, with 50 kHz USVs, but not 22 kHz USVs, activating neurons in the nucleus accumbens (NAcc)

47 ypothesized that 50 kHz USVs, but not 22 kHz USVs, elicit NAcc dopamine release.

48 -social 50 kHz USVs, but not alarming 22 kHz USVs.

49 d in a nor-BNI reversible increase in 22-kHz USVs (mimicking an alcohol-dependent state).

50 onism blocked the increased number of 22-kHz USVs observed during acute alcohol withdrawal and a KOR

51 Only presentation of 50 kHz USVs induced phasic dopamine release and elicited approa

52 Reception of 50 kHz USVs induces social approach behavior, while 22 kHz USVs

53 trasonic speaker in random order: (1) 50 kHz USVs, (2) 22 kHz USVs, (3) time- and amplitude-matched w

54 tinct brain activation patterns, with 50 kHz USVs, but not 22 kHz USVs, activating neurons in the nuc

55 Therefore, we hypothesized that 50 kHz USVs, but not 22 kHz USVs, elicit NAcc dopamine release.

56 c dopamine release encodes pro-social 50 kHz USVs, but not alarming 22 kHz USVs.

57 n appetitive situations, rats produce 50 kHz USVs, whereas 22 kHz USVs occur in aversive situations.

58 iments 1 and 2, rats showed increased 50-kHz USVs before receiving experimenter-delivered ventral teg

59 MPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevat

60 3 and 4, rats increased their rate of 50-kHz USVs in response to cues that predicted the opportunity

61 ngs support the hypothesis that short 50-kHz USVs may selectively index a state of reward anticipatio

62 daily 1-hr feeding sessions increased 50-kHz USVs, whereas a cue that predicted footshock decreased 5

63 d robust, dose-dependent increases in 50-kHz USVs, which could not be accounted for by concomitant in

64 n LA without significant increases in 50-kHz USVs.

65 ue that predicted footshock decreased 50-kHz USVs.

66 pe of ESB evoked 20-kHz, rather than 50-kHz, USVs.

67 teract with kappa opioid systems to modulate USVs, antinociception, and locomotion in preweanling rat

68 ted male rat pups emitted substantially more USV calls and these were characterized by a significantl

69 d EMG responses and displayed practically no USV behavior.

70 nditioned EMG responses but exhibited normal USV behavior, whereas animals with lesions to the amygda

71 n juvenile and adult rats, a single class of USV is observed with an age-dependent main frequency and

72 e mother, accounting for the greater rate of USV production during the second isolation period.

73 of venous return did not affect the rate of USV.

74 All pups reduced rates of USV in contact with anesthetized adults.

75 nalyses characterizing the bout structure of USV production indicated that the average bout size (i.e

76 kHz USV unchanged suggesting that the use of USV goes far beyond a signal studied in terms of amount

77 The average amplitude of USVs was also greater following maternal reunion.

78 des data-driven, high-throughput analyses of USVs.

79 Consistent with prior studies, the number of USVs emitted was significantly increased in the period f

80 d that the average bout size (i.e. number of USVs/bout) was increased severalfold following the reuni

81 In 10-day-olds, USV has been shown to be reduced by either the administr

82 f NAcc amphetamine (AMPH) microinjections on USVs.

83 One USV CS was a continuous sequence of eight calls, and the

84 nt firing changes in response to the tone or USV conditional stimulus (CS) after it had been paired s

85 Pups reared with aunts potentiated USV after contact with adult females but suppressed USV

86 Pups reared with sires potentiated USV after contact with sires or strange males.

87 ously into isolated pups that were producing USV.

88 Pups' USV rates after the adult's removal depended on their re

89 performance, the alterations in their pups' USVs and maternal potentiation do not appear to result f

90 In contrast, infant rat USV were split into two classes with specific relationsh

91 nhanced proximal orientation toward recorded USVs, however, if a silent pup was positioned below the

92 When presented with recorded USVs, mothers of 6- to 8-day-old pups and nulliparous vi

93 kg dose of MOR is less effective in reducing USV in 3- and 7-day-olds; calling rates declined by no m

94 These data suggest that mating-related USVs are robust and relevant biomarkers of FXS, and that

95 reared with castrated males did not suppress USV after contact with castrates but did after contact w

96 er contact with adult females but suppressed USV after contact with males.

97 adult male mice during mating, we show that USV calling rate (number of calls/second) is reduced in

98 etween single-unit responses elicited by the USV cue and those elicited by the tone cue.

99 he units (14 of 123 units) recorded from the USV-conditioned group displayed a precisely timed increa

100 n/off pattern of the individual calls in the USV, but it lacked the characteristic frequency modulati

101 firing was approximately 30 ms longer in the USV-conditioned group than in the tone-conditioned group

102 The presence of a companion also lowered the USV of 3- and 7-day-olds by a lesser amount (55-57%) tha

103 early anxiety state, and potentiation of the USV response after brief maternal encounters is a newly

104 oxic PR lesions impaired conditioning to the USV, the discontinuous tone, and the training context.

105 This US-timed response was unique to the USV-conditioned group.

106 on of conditioned EMG responses, whereas the USV behavior was unaffected.

107 re presented with mild foot-shocks and their USV frequency, duration, and relationship with respirati

108 The two USV conditional stimuli were multi-call segments that we

109 Using USV data from a large mouse genetic reference panel and

110 hy (EMG) and 22 kHz ultrasonic vocalization (USV) activities were measured concurrently from the same

111 freezing and 22 kHz ultrasonic vocalization (USV) as dependent measures of fear in rats.

112 d two different rat ultrasonic vocalization (USV) conditional stimuli (10 sec of "22 kHz USVs").

113 tioning to a 22 kHz ultrasonic vocalization (USV) cue.

114 f isolation-induced ultrasonic vocalization (USV) of infant rats (Rattus norvegicus) were measured on

115 The ultrasonic vocalization (USV) response of the isolated infant rat is a promising

116 f social rearing on ultrasonic vocalization (USV) responses of 11- to 12-day-old rat (Rattus norvegic

117 g analgesia, 22 kHz ultrasonic vocalization (USV), defecation, and freezing.

118 rtle reactivity and ultrasonic vocalization (USV).

119 freezing and 22 kHz ultrasonic vocalization (USV)] elicited under three conditions (during context co

120 mice, we recorded ultrasonic vocalizations (USV) and found that although both wild-type (WT) and het

121 f prosocial 50-kHz ultrasonic vocalizations (USV) paralleled by a lack of social approach in response

122 By recording ultrasonic vocalizations (USV) produced by adult male mice during mating, we show

123 ut life, rats emit ultrasonic vocalizations (USV) when confronted with an aversive situation.

124 ts communicate via ultrasonic vocalizations (USVs) and newborn pups emit distress USVs when separated

125 Rodent ultrasonic vocalizations (USVs) are a vital tool for linking gene mutations to beh

126 increase in 22-kHz ultrasonic vocalizations (USVs) associated with alcohol withdrawal and KOR activat

127 ed rates of 50-kHz ultrasonic vocalizations (USVs) before receiving social and pharmacological reward

128 ar conditioning to ultrasonic vocalizations (USVs) but have no effect on conditioning to continuous t

129 Rat pups emit ultrasonic vocalizations (USVs) during cold challenge.

130 p that is emitting ultrasonic vocalizations (USVs) far more than do virgin females.

131 proposed that all ultrasonic vocalizations (USVs) in young rats are by-products of a cardiovascular

132 adult rats, 50-kHz ultrasonic vocalizations (USVs) index a state characterized by high arousal and ex

133 Rats emit ultrasonic vocalizations (USVs) that are thought to serve as situation-dependent a

134 Rat pups emit ultrasonic vocalizations (USVs) when isolated in a novel environment.

135 pa opioid-mediated ultrasonic vocalizations (USVs), antinociception, and locomotion in young rats.

136 Like ultrasonic vocalizations (USVs), DA signals were modulated by delivery of reward t

137 Ultrasonic vocalizations (USVs), freezing, and corticosterone responses were quant

138 easures to compare ultrasonic vocalizations (USVs), which limits the ability to address repertoire co

139 cited freezing and ultrasonic vocalizations (USVs; 22 kHz) were measured after 10 tone-shock training

140 elicited under all three conditions, whereas USV should be spared.

141 increased across training sessions, whereas USV responses were initially robust but decreased across

142 us return was decreased in infant rats while USV and cardiovascular measures were monitored.