ライフサイエンスコーパス: UTR

1 UTR-seq provides a general strategy to uncover the rules

2 UTR-seq revealed two temporal degradation programs: a ma

3 in, CPEB1, and its binding elements in the 3 UTR.

4 androgen response elements in the Nkx3.1 3' UTR.

5 ated region (UTR) lengthening in head and 3' UTR shortening in testis, and characterize new tissue an

6 lrn1-UTR (Clrn1 cDNA including its 5' and 3' UTR) under the control of regulatory elements (Atoh1 3'

7 bility, cytoplasmic compartmentalization, 3' UTR length and translational efficacy.

8 characterize new tissue and developmental 3' UTR patterns.

9 a subset of stress-related genes exhibits 3' UTR extensions of their mRNAs during dehydration stress.

10 d to display APA, S. pombe showed greater 3' UTR size differences among APA isoforms than did S. cere

11 t (DSE) motifs drive broad alterations in 3' UTR isoform expression across the Drosophila phylogeny.

12 a novel function for these stress-induced 3' UTR extensions as long noncoding RNAs in the regulation

13 f one mouse in vivo can also regulate its 3' UTR reporter in the liver of another mouse through serum

14 sses VEGF-C expression via binding to its 3' UTR.

15 al PASs lead to higher abundances of long 3' UTR isoforms than short ones, a feature that is opposite

16 In contrast, the translocation of longer 3' UTR mRNAs from RNPs to polysomes correlated with the pro

17 Increasing METTL16 occupancy on the MAT2A 3' UTR is sufficient to induce efficient splicing.

18 rate conserved hairpin (hp1) in the MAT2A 3' UTR.

19 wnstream targets, transcriptome-wide mRNA 3' UTR interaction sites were experimentally determined at

20 e from mice carrying genomic deletions of 3' UTR selenocysteine-insertion-sequences (SECIS1 and SECIS

21 rvey the dynamics of tens of thousands of 3' UTR sequences during early zebrafish embryogenesis.

22 ic compartmentalization of mRNAs based on 3' UTR length.

23 In both species, short 3' UTR isoforms are more likely to be expressed when cells

24 Significantly, 3' UTR shortening in S. pombe coordinates with up-regulatio

25 ex control of alternative tissue-specific 3' UTR formation and its consequences for post-transcriptio

26 emoves the last two exons and part of the 3' UTR of DSTYK.

27 d microRNA, miR-204, directly targets the 3' UTR of GLP1R and thereby downregulates its expression in

28 We found that miR-128 targets the 3' UTR of nuclear import factor transportin 1 (TNPO1) mRNA.

29 xpression through AU-rich elements in the 3' UTR of PD-L1 mRNA.

30 nce binding sites for these miRNAs on the 3' UTR of protein coding genes.

31 ssion through their direct binding to the 3' UTR of TrxR1 mRNA.

32 not show AEI and were homozygous for the 3' UTR variant.

33 me accumulation at stop codons and in the 3' UTR, suggesting a global defect in termination in the ab

34 ptional control of gene expression at the 3' UTR.

35 , and mixed patterns of enrichment in the 3' UTR.

36 This 3' UTR heterogeneity directs distinct temporal patterns of

37 Our thorough 3' UTR annotations permit reassessment of post-transcriptio

38 ehydration stress could induce transcript 3' UTR extensions and elucidate a novel function for these

39 r analysis suggests that transcripts with 3' UTR extensions have weaker poly(A) signals than those wi

40 gene expression through interaction with 3' UTR-binding sites.

41 weaker poly(A) signals than those without 3' UTR extensions.

42 ed to the successful design of artificial 3' UTRs that conferred specific mRNA dynamics.

43 tion (APA) generates mRNAs with different 3' UTRs, but the involvement of this process in stress resp

44 These extended 3' UTRs have characteristics of long noncoding RNAs and lik

45 map HuR and miRNA binding sites on human 3' UTRs and assess their co-occurrence.

46 data suggest that transcripts with longer 3' UTRs tend to contain distal miRNA binding sites and are

47 iferase assays with wild-type and mutated 3' UTRs for six miRNA families.

48 observed a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to o

49 The 3' untranslated regions (3' UTRs) of mRNAs play important roles in the regulation of

50 In contrast, those with shorter 3' UTRs only possess proximal miRNA binding sites, which, t

51 rget site utilization localizes mainly to 3' UTRs, in Chlamydomonas utilized target sites lie predomi

52 hrough sequence-specific association with 3' UTRs before ZGA.

53 ression of two distinct forms of the HLA-A 3'UTR based on use of either the proximal or the distal PA

54 urvey the entire regulatory landscape of a 3'UTR, and apply it in a multiplex fashion to analyse comb

55 ound an enrichment of eccDNAs at exons and 3'UTR (enrichment folds from 1.36 to 3.1) as well as the D

56 ranslated region (UTR) hypomethylation and 3'UTR hypermethylation of the cellular epitranscriptome, r

57 e CACNA1A gene, including the promoter and 3'UTR regions, in 49 unrelated patients diagnosed with epi

58 -GWAS identified the associated exonic and 3'UTR variants within the FGF5 and RSPO2 genes, respective

59 ristics and features of the 5'UTR, CDS and 3'UTR.

60 ads us to suggest a novel relation between 3'UTR length and sensitivity to CPA factor expression.

61 lls, C/EBPbeta activation is suppressed by 3'UTR-mediated localization of Cebpb transcripts to a peri

62 clin levels and describe a recurrent CCND1 3'UTR mutation associated with increased expression in end

63 sum, our study unveils that the extensive 3'UTR editing of METTL7A is merely a footprint of ADAR bin

64 ssion of target genes undergoing extensive 3'UTR editing.

65 transfected with a plasmid containing FXI-3'UTR.These results should open the door to new therapeuti

66 with known functions during LTP, including 3'UTR APA of Notch1 and intronic APA of Creb1.

67 binding, translation enhancer (TSS) in its 3'UTR that serves as a hub for interactions throughout the

68 or gene with multiple editing sites at its 3'UTR, we demonstrate that its expression could be repress

69 anos/Pumilio response element (PRE) in its 3'UTR.

70 nally independent target sites in the KRas 3'UTR and clinically significant correlation between miR-1

71 Rescue experiments with mutated KRas 3'UTR showed very significantly that the anti-tumour effec

72 However, the long 3'UTR conferred lower luciferase activity as compared with

73 anisms: local synthesis requiring the long 3'UTR form of CaMKII mRNA and a process that requires zygo

74 The selective loss of the long 3'UTR mRNA in CaMKII-null larvae allows us to test its rol

75 We show that the short and the long 3'UTR produced similar mRNA expression levels.

76 LA-A allotype that uses primarily the long 3'UTR, whereas an allotype expressing only the short form

77 icating translation inhibition of the long 3'UTR.

78 escued by genomic fosmids lacking the long 3'UTR.

79 enriched HuR binding to mRNAs with longer 3'UTR and with higher density of U/AU-rich elements, sugge

80 uently, mature miR-27a targets the METTL7A 3'UTR to repress its expression level.

81 and that HuR binds directly to GM-CSF mRNA 3'UTR.

82 APA changes, including a general trend of 3'UTR shortening and activation of intronic APA isoforms.

83 ding on the target location site (5'UTR or 3'UTR), LIN41 triggers repression of translation or mRNA d

84 truct, but only in the presence of the p21 3'UTR.

85 hermore, specific blocking of the proximal 3'UTR reduced surface expression without decreasing mRNA e

86 ry neurons and the 3' untranslated region (3'UTR) landscapes after unilateral sciatic nerve entrapmen

87 importance of 3 prime untranslated region (3'UTR) non-coding regulatory variants across neurodevelopm

88 ch elements of the 3' untranslated region (3'UTR) of numerous pro-inflammatory cytokines including IL

89 inding of Syncrip to the long versus short 3'UTR.

90 The model uncovered that 3'UTR methylation has much less impact on transcriptional

91 Changes in the 3'UTR composition of mRNAs can alter gene expression by re

92 We found that changing the 3'UTR of a miRNA-targeted reporter modulates translational

93 Interestingly, the 3'UTR of AhAI varied in these species.

94 The 3'UTR of CDK4/6 mRNAs are targeted by a family of miRNAs,

95 Sequencing of the 3'UTR of common HLA-A alleles indicated the presence of tw

96 ls through canonical RNAi by targeting the 3'UTR of critical survival genes in a unique form of off-t

97 hat miR-140-5p directly interacts with the 3'UTR of Pin1 and inhibits Pin1 translation.

98 f editing events alter the sequence of the 3'UTR of targeted transcripts, and we focus on one cell ty

99 also found that MSI1 directly binds to the 3'UTR of Tensin 3 (TNS3) mRNA, a negative regulator of cel

100 ed the interaction between miR-122 and the 3'UTR of the CYP1A2 and CYP3A4.

101 revealed that miR-1 directly regulates the 3'UTR of the E3 ubiquitin ligase Nedd4 Analysis of embryon

102 entified a novel miR-SNP (rs713065) in the 3'UTR region of FZD4 gene linked with decreased risk of de

103 ns eliminated one-site RdRp binding to the 3'UTR, suggesting that RdRp binding to the adenylates disr

104 by post-transcriptional regulation by the 3'UTR.

105 This 3'UTR dependent modulation can be further altered by chang

106 confirmed expression regulation via three 3'UTR binding sites.

107 I-transcribed ES, as well as conserved VSG 3'UTR 16-mer sequences for the generation of functional le

108 mRNA enrichment in the affected axons with 3'UTR alterations potentially contributing to the mechanis

109 Furthermore, analysis of genes with 3'UTR extensions of different length leads us to suggest a

110 s suggest that further development of ZIKV-3'UTR-LAV is warranted for humans.Zika virus infection can

111 Furthermore, the ZIKV-3'UTR-LAV vaccine candidates have a desirable safety profi

112 ated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and

113 ncovered an important role for variants in 3'UTRs, especially those affecting binding of the PUF fami

114 ssues produce mRNAs with particularly long 3'UTRs, suggesting that such extensions might be important

115 These mRNAs' 3'UTRs have enriched binding motifs for several RNA-bindin

116 Lengthening of 3'UTRs was more prevalent in the injured axons, including

117 ms with different 3' untranslated regions (3'UTRs) and/or coding sequences.

118 dominantly in the 3' untranslated regions (3'UTRs) of spliced mRNA.

119 e found that miR-495 directly targeted the 3'UTRs of Bdnf, Camk2a and Arc.

120 Putative miRNA binding sites on the 3'UTRs of the CYPs were identified in-silico.

121 s (TSS1500 and TSS200), 1st exons, 5'UTRs, 3'UTRs, CpG islands, shores, shelves, open seas and FANTOM

122 th 5'-UUUAA-3' originating from the COX-2 3'-UTR.

123 de an increased generation of alternative 3'-UTR isoforms.

124 s were less stable than mRNAs that end at 3'-UTR poly(A) sites.

125 ion, demonstrating an unexpected role for 3'-UTR sequences in transcriptional regulation.

126 The PD-L1 3'-UTR contains two functional miR-155-binding sites.

127 Compared to yeast, in humans, median 3'-UTR length has expanded approximately tenfold alongside

128 ion through its interaction with the MyoD 3'-UTR.

129 emonstrates the duality and complexity of 3'-UTR sequences in regulation of gene expression and provi

130 1 by type I and II interferons depends on 3'-UTR post-transcriptional regulation, whereas the promote

131 teracted with the 3' untranslated region (3'-UTR) of Igf2r mRNA, and the association of CUGBP1 with I

132 regulated by its 3'-untranslated region (3'-UTR).

133 target the SNAI2 3'-untranslated region (3'-UTR).

134 letion within the 3' untranslated region (3'-UTR).

135 its mRNA three prime untranslated region (3'-UTR).

136 de signal within the APOE region (rs6857, 3'-UTR=PVRL2, p=2.21x10(-12)), and a suggestive signal for

137 -181a, miR-30a, and miR-155 in the SAMHD1 3'-UTR.

138 atively polyadenylated, producing a short 3'-UTR isoform that excludes regulatory elements, including

139 k gene for LAS with an association in the 3'-UTR (rs2023938; P = 7.76E-7, OR = 1.28).

140 hough these effects were augmented by the 3'-UTR deletion.

141 gh PRDM1 mRNA in CD38(-) cells lacked the 3'-UTR harboring miRNA binding sites regulating mRNA stabil

142 Analysis of the 3'-UTR of NRT1.1 showed that the pattern of polyadenylation

143 miR-21 directly targeted the 3'-UTR of PTEN and SMAD7, and negatively regulated their ex

144 is caused by expanded CTG repeats in the 3'-UTR of the dystrophia myotonica protein kinase (DMPK) ge

145 hinery to the AU-rich elements within the 3'-UTR of the target transcripts.

146 achment protein and a deletion within the 3'-UTR of the viral genome.

147 oblast cells, whereas miR-30c targets the 3'-UTR of Tnrc6a mRNA to weaken its function.

148 SNP rs2072920 is located in the 3'-UTR of WNT4 and SNP rs11918967 is located in the intron

149 ed that bta-miR-23a directly targeted the 3'-UTR of ZNF423.

150 Removal of the 3'-UTR stabilizes PpCSP1 transcripts, results in accumulati

151 and SmyD1b expression by targeting their 3'-UTR.

152 All of these 3'-UTR functions are accomplished by effector proteins that

153 ited by RNA-binding proteins that bind to 3'-UTR cis-elements.

154 The risk T allele was linked to 3'-UTR variation in MBOAT7 and to reduced MBOAT7 expression

155 by EBV miR-BHRF1-2-5p was confirmed using 3'-UTR luciferase reporter assays and Western blot assays.

156 SNPs in protein-coding regions and within 3'-UTR regions of genes.

157 3'-UTRs are best known to regulate diverse fates of mRNAs,

158 Targeting six chemokine 3'-UTRs increased chemokine mRNA levels as expected.

159 A regions corresponding to nine chemokine 3'-UTRs that destabilized mRNA in a reporter assay.

160 However, targeting CXCL1, CXCL6 and CXCL8 3'-UTRs unexpectedly led to substantial mRNA decreases.

161 x formation, which establishes a role for 3'-UTRs as evolved eukaryotic operons.

162 This suggests an important role for 3'-UTRs in the biology of higher organisms.

163 Furthermore, 3'-UTRs determine the fate of proteins through the regulati

164 pression and for functional annotation of 3'-UTRs in the native context.

165 to investigate the regulatory activity of 3'-UTRs in their native context.

166 3'-untranslated regions (3'-UTRs) are the noncoding parts of mRNAs.

167 emonstrated that 3' untranslated regions (3'-UTRs) regulate gene expression by controlling mRNA stabi

168 promote the interaction of two subunits, 3'-UTRs enable the formation of protein complexes with dive

169 In summary, 3'-UTRs seem to be major players in gene regulation that en

170 cted interactions between miR-153 and the 3'-UTRs of Cltc, Lamp1 (in a prior study), Clcn4 and Slc4a4

171 assays showed that targeting these three 3'-UTRs increased mRNA stability, as predicted by the repor

172 r small RNAs, as has been shown for whole 3'-UTRs as well as for cleaved fragments.

173 e UG repeats of its 3-untranslated region (3-UTR).

174 Spinach II, 2-MS2 binding domain and glgC 5 UTR.

175 Here, we demonstrate that the full-length 5 UTR of the zorO type I toxin hinders its own translation

176 ndependent of the sRNA whereas a processed 5 UTR (zorO Delta28) promotes translation.

177 ive effects on translation imparted by the 5 UTR can be transferred onto a reporter gene, indicative

178 onto a reporter gene, indicative that the 5 UTR can solely drive regulation.

179 Processing of the 5 UTR does not alter the RBS structure, but opens a large

180 The full-length zorO 5 UTR folds into an extensive secondary structure sequeste

181 oxin base pairs to the 174-nucleotide zorO 5 UTR.

182 , these results indicated that both HIV-1 5' UTR and the 5' gag sequence are required for efficient p

183 t antisense lncRNAs interact first with a 5' UTR-containing promoter-spanning transcript, which is th

184 ely inhibits translation of mRNAs bearing 5' UTR methylation, but not mRNAs with 5' terminal oligopyr

185 e of the presence of G4 in human P1-HNF4A-5' UTR in vitro, and establishes a novel working model of s

186 nslational suppressing effect of P1-HNF4A-5' UTR.

187 egative correlations being more common in 5' UTR and positive correlations in the gene 'Body' region.

188 m(1)A in 5' UTR, particularly those at the mRNA cap, associate with

189 a reporter mRNA harboring the viral mRNA 5' UTR.

190 tro with the assistance of the viral mRNA 5' UTR.

191 raction with the G-quadruplex in the NRF2 5' UTR during oxidative stress.

192 nated H2O2-induced activation of the NRF2 5' UTR.

193 SL1 encompasses a portion of RNA1 5' UTR but extends into the coding sequence for nine nucleo

194 t with chemically modified ASOs targeting 5' UTR inhibitory regions in the mRNAs encoding these prote

195 vel variants (<5%) distributed across the 5' UTR and P1 genomic region in all three Sabin serotypes,

196 Insertion of the 5' UTR and the first 32-nt of gag into two different report

197 Nucleotide substitutions at the 5' UTR of acrA mRNA that could potentially weaken the inhib

198 , we showed that a genetic variant in the 5' UTR of DDX39B reduces translation of DDX39B mRNAs and in

199 a limited expansion of CGG repeats in the 5' UTR of FMR1.

200 These two sRNAs base pair with the 5' UTR of oprD leading to increase in resistance of the bac

201 ndary structure, G-quadruplex (G4) in the 5' UTR of P1-HNF4A, the predominant HNF4alpha isoform(s) in

202 tutions in miR-122 binding regions in the 5' UTR of the HCV genome.

203 rved across mammals and overlaps with the 5' UTR of the interleukin 1 receptor-associated kinase (IRA

204 adding the 5' half of the gag gene to the 5' UTR strongly facilitates the packaging of two reporter R

205 ractions of RBPs with the G4 motif in the 5' UTR to promote cell proliferation during liver developme

206 putative protein-binding sites within the 5' UTR was necessary and sufficient to mediate a strong tra

207 function and identified rs34481144 in the 5' UTR.

208 d to computationally evolve highly active 5' UTRs.

209 m 5' UTRs as well as native S. cerevisiae 5' UTRs.

210 quence coding region of NA into different 5' UTRs confirmed that NS1 can promote the translation of s

211 other translation inhibitory elements in 5' UTRs.

212 s (uORFs), located in transcript leaders (5' UTRs), are potent cis-acting regulators of translation a

213 half a million 50-nucleotide-long random 5' UTRs and assayed their activity in a massively parallel

214 sion of both a held-out set of the random 5' UTRs as well as native S. cerevisiae 5' UTRs.

215 l results indicated that G4 motifs in the 5' UTRs of other liver-enriched transcription factors also

216 gative regulatory elements present in the 5' UTRs of some mRNAs.

217 134 mimic repressed translation of Sabin-1 5'UTR driven luciferase validating the mechanism of miR-13

218 In-solution, HIV-1 5'UTR forms two interchangeable long-range nucleotide (nt)

219 HIV(NL4-3) 5'UTR substitutions were designed to individually stabiliz

220 pression is controlled by RBPs through its 5'UTR.

221 vely regulates MICB expression through its 5'UTR.

222 The effect of 5'UTR conformation on ribosome loading to HIV unspliced RN

223 ltered by changing the codon-optimality or 5'UTR of the luciferase reporter.

224 nctional genome annotations (e.g., exon or 5'UTR), total linkage disequilibrium (LD) scores and heter

225 Sabin-3 via direct interaction with the PV 5'UTR.

226 nslation, the SIN1 5' untranslated region (5'UTR) was fused with luciferase reporter and named as 5'S

227 The induced Pabp isoform has shorter 5'UTR removing an auto-inhibitory element.

228 thout the SIN1 5'UTR, suggesting that Sin1 5'UTR is necessary for Pdcd4 to inhibit Sin1 translation.

229 ot the control luciferase without the SIN1 5'UTR, suggesting that Sin1 5'UTR is necessary for Pdcd4 t

230 at, depending on the target location site (5'UTR or 3'UTR), LIN41 triggers repression of translation

231 ppressed by a lox-stop-lox sequence in the 5'UTR (Mc3r(TB/TB)).

232 ion by characteristics and features of the 5'UTR, CDS and 3'UTR.

233 ory single-nucleotide polymorphisms in the 5'UTR.

234 dently of monomer:dimer equilibrium of the 5'UTR.

235 conserved genome regions of all EV types (5'UTR, 2 C, 3Dpol) were employed.

236 s an antigen-presenting gene (CD1A), where 5'UTR mutations correlate significantly with decreased sur

237 promoters (TSS1500 and TSS200), 1st exons, 5'UTRs, 3'UTRs, CpG islands, shores, shelves, open seas an

238 by mTORC1 and Akt/S6K1 dissociates it from 5'UTRs and relieves its inhibitory activity on RP mRNA tra

239 nal regulation, and the importance of HAdV 5'UTRs for precisely coordinated viral protein expression

240 cid deprivation and predicts novel ORFs in 5'UTRs, long noncoding RNAs, and introns.

241 s supported by analysis of deleted/mutated 5'UTRs and two native regulatory single-nucleotide polymor

242 Monomer- and dimer-prone 5'UTRs displayed equivalent, basal rate of translation.

243 HAdV 5' untranslated regions (5'UTRs) are crucial for cap-independent initiation, and in

244 ents cause the fusion of the promoter and 5'-UTR of the androgen-regulated TMPRSS2 (transmembrane pro

245 The viral envelope and 5'-UTR sequences of the lymphotropic HCV strain were respon

246 Such a structure is important for 5'-UTR activity, since its removal by sequence mutation eli

247 show that splicing yields distinct local 5'-UTR secondary structures in SERPINA1 transcripts.

248 e splicing in the 5'-untranslated region (5'-UTR).

249 e human KRAS transcript contains a G-rich 5'-UTR sequence (77% GC) harboring several G4 motifs capabl

250 Splicing in the 5'-UTR also changes the inclusion of long upstream ORFs (uO

251 wn TSSs and all but 18 nucleotides of the 5'-UTR had virtually no effect on the level of gene express

252 of small molecules binding to RG4s in the 5'-UTR of mRNA.

253 3' coding portion of the EGFR gene to the 5'-UTR of the SEC61G, yielding products lacking the entire

254 nd plays important roles beyond unwinding 5'-UTR structure is consistent with a recent proposal that

255 ms with 3' ends that lie within annotated 5'-UTRs were overrepresented in polysomes and were as stabl

256 latory program governed by their distinct 5'-UTRs and that this regulation ultimately determines alph

257 permethylated CpG loci included promoter, 5'-UTRs, upstream and exonic regions.

258 protein for Mss116 action on the COX1 mRNA 5-UTR to promote efficient Cox1 synthesis.

259 s granules correlates with longer coding and UTR regions and poor translatability.

260 EV-enclosed mRNAs are mostly fragmented, and UTRs enriched; nevertheless, some full-length mRNAs are

261 hin RNA sequences, mostly in the introns and UTRs (un-translated regions).

262 Gene promoters and UTRs harbor more OG-enriched sites than expected if the

263 ring a transgene, TgAC1, consisting of Clrn1-UTR (Clrn1 cDNA including its 5' and 3' UTR) under the c

264 Here we introduce UTR-seq, a combination of massively parallel reporter as

265 uated, revealing the potential importance of UTR in gene therapy.

266 n critical regions of the genome (promoters, UTRs, and introns), while being depleted in coding and i

267 tissue expression of UII and UII receptors (UTR) are increased in diabetic nephropathy, it remains u

268 method targeting the 5' untranslated region (UTR) and P1 genomic region to characterize vaccine-relat

269 lements in the NLRP3 3'-untranslated region (UTR) and represses NLRP3 expression.

270 (SLB) located in the 5' untranslated region (UTR) are critical for binding the viral polymerase NS5 t

271 Targeting the IL1R1 3' untranslated region (UTR) by EBV miR-BHRF1-2-5p was confirmed using 3'-UTR lu

272 ral complexity of the 5'untranslated region (UTR) derives from bacterial and other riboswitches.

273 consists of a short 3'-untranslated region (UTR) form lacking regulatory elements that guide local t

274 enomic variation in the untranslated region (UTR) has been shown to influence HLA class I expression

275 nt infection induces 5' untranslated region (UTR) hypomethylation and 3'UTR hypermethylation of the c

276 pecific APA, such as 3' untranslated region (UTR) lengthening in head and 3' UTR shortening in testis

277 in expression of the 5' untranslated region (UTR) of mRNAs in the yeast Saccharomyces cerevisiae.

278 The 3' untranslated region (UTR) of mRNAs is the primary regulatory region that medi

279 lex structure in the 5' untranslated region (UTR) of NRF2 mRNA, as measured by circular dichroism, nu

280 region, the 5'- and 3'-untranslated region (UTR) of SAMHD1, and the mechanism responsible for the ce

281 Although the 5' untranslated region (UTR) of the HIV-1 RNA is known to be important for RNA p

282 quent variant in the 3' untranslated region (UTR) of the mutant allele, which disrupts the most dista

283 The 5' untranslated region (UTR) plays dual roles in CDC20 mRNA nuclear localization

284 mechanism involving a 3 untranslated region (UTR) selenocysteine insertion sequence (SECIS) and the S

285 mRNAs possess a long 5 untranslated region (UTR) that serves as the target site of the corresponding

286 ds to the viral mRNA 5' untranslated region (UTR) with high affinity.

287 8-bp deletion in its 5'-untranslated region (UTR), conferring the spontaneous brown midrib trait and

288 a part of the viral 5' untranslated region (UTR), is critical for the initiation of dengue virus rep

289 otif within the mutS 5' untranslated region (UTR), repressing translation in the absence of sRNA part

290 n was located in the 5'-untranslated region (UTR), suggesting that the intron affects transcription i

291 NAs within the egl-1 3' untranslated region (UTR), which affect both mRNA copy number and translation

292 present in the FOXP1-3' untranslated region (UTR).

293 s preferentially to 3' untranslated regions (UTRs) of developmental targets.

294 ames (uORFs) across 5'-untranslated regions (UTRs) of key signalling components.

295 Thus far, only the 3' untranslated regions (UTRs) of MICA, MICB, and UL16-binding protein 2 were sho

296 ry structure in the 5'-untranslated regions (UTRs) of mRNAs to promote their recruitment to the eukar

297 3' ends that map to 5'-untranslated regions (UTRs), introns, and protein-coding regions.

298 ipts with different 3' untranslated regions (UTRs).

299 challenged GMCs were attenuated by selective UTR antagonist, TRPC4 channel blocker, and CaMKII and CR

300 ation of rare variants in the coding and the UTR sequences within the genes of suicide victims.