ライフサイエンスコーパス: VCD

1 VCD amide I data for the 22mer (n = 4) in D2O indicate t

2 VCD analysis provided a clear explanation for these expe

3 VCD analysis with respect to hypothetical localized mode

4 VCD and absorption IR spectra in methanol solutions can

5 VCD and FTIR spectra over the amide I and II bands of 23

6 VCD chiroptical analysis of a SynOxA derivative with thr

7 VCD experiments associated with DFT calculations confirm

8 VCD is shown to selectively destroy small ovarian follic

9 VCD spectroscopy itself is found to have the ability to

10 the per-protocol population, there were 176 VCD cases (with 11,793 person-years at risk) in the vacc

11 -years at risk) in the vaccine group and 221 VCD cases (with 5809 person-years at risk) in the contro

12 at better predictors than amide I' (in 2H2O) VCD alone and, for helix, worse than ECD alone.

13 ch cohort were confirmed to be VCD, with 319 VCD episodes (4.6 episodes per 100 person-years) occurri

14 years) occurring in the Asian cohort and 389 VCD episodes (2.9 episodes per 100 person-years) occurri

15 in 208 patients (6.9%) assigned to receive a VCD and 119 patients (7.9%) assigned to manual compressi

16 d patients, 3015 were randomly assigned to a VCD group (1509 received intravascular VCD and 1506 rece

17 This active VCD segment contains residues that are conserved in Pcdh

18 D-TDV dengue vaccine was efficacious against VCD and severe VCD and led to fewer hospitalizations for

19 In propensity score-matched analysis, VCDs were associated with reductions in vascular complic

20 In addition, the amide I absorption and VCD bands of protein films are found to be independent o

21 The vibrational absorption and VCD spectra are predicted for these two conformers using

22 the ab initio predictions of absorption and VCD spectra obtained with density functional theory usin

23 Experimental absorption and VCD spectra of (+)-2,5-dimethylthiolane and (-)-2,5-dime

24 significantly shorter AL, shallower ACD and VCD, than did men (P < or = 0.01).

25 between age and strain for AL, CT, ACD, and VCD.

26 0.001, p < 0.05), mean difference in AL and VCD between the affected and control eyes was 0.56 +/- 0

27 Shorter AL and VCD might be a potential anatomical predisposing factor

28 In eyes with CRVO mean AL and VCD of affected eyes were significantly shorter than tho

29 ber depth (ACD), lens thickness (LT), AL and VCD of eyes with RVO were compared with those of fellow

30 o hemostasis, repeat manual compression, and VCD failure.

31 e biaryls was determined using TDDFT ECD and VCD calculations, the combination of which however did n

32 Comparison of the experimental ECD and VCD spectra with the density functional theory simulated

33 methodology consisting of concerted ECD and VCD spectroscopy.

34 FTIR, electronic and vibrational CD (ECD and VCD) spectra for these small peptides are comparable to

35 and vibrational circular dichroism (ECD and VCD), as well as NMR spectroscopy have been utilized to

36 Combining FTIR and VCD data did not dramatically change the prediction resu

37 Both methods (FTIR and VCD) using data for proteins in H2O are somewhat better

38 ance of the media causing the low growth and VCD in the cell culture process.

39 level theoretical simulations of the IR and VCD band shapes are used to analyze the spectra and to c

40 The IR and VCD difference spectra further confirm the assignment of

41 Theoretical IR and VCD simulations were performed for correspondingly isoto

42 IR and VCD spectra are in qualitative agreement with theoretica

43 Analysis of the experimental IR and VCD spectra has been carried out using ab initio density

44 ment of the conformationally averaged IR and VCD spectra of 1 and 2, predicted using DFT, provides un

45 DFT calculations of the IR and VCD spectra of 2a-d show unambiguously that the experime

46 ies and to simulate the corresponding IR and VCD spectra of the dimers.

47 for some distinguishing modes in both IR and VCD spectra.

48 We have used IR and VCD spectroscopies to identify the structure of this pro

49 ce (NMR), ECD, Raman, ROA, infrared (IR) and VCD spectral parameters are computed for the eight possi

50 eous solution, we used isotopic labeling and VCD to demonstrate that the alpha-helix noncooperatively

51 were verified experimentally through NMR and VCD spectroscopy and allowed rationalization of the ster

52 on of severe seizures among control, OVX and VCD-treated mice, OVX+E mice exhibited seizures of a sig

53 IR, isotropic Raman, anisotropic Raman, and VCD spectra in terms of a mixture of three conformations

54 ifs, we combined vibrational (IR, Raman, and VCD) with NMR spectroscopy.

55 %, and 47%) of patients (VDCR, VDR, VCD, and VCD-mod, respectively); the corresponding 1-year progres

56 reated MM, and, based on this trial, VDR and VCD-mod are preferred for clinical practice and further

57 significant differences between the VTD and VCD arms.

58 ndergoing transfemoral coronary angiography, VCDs were noninferior to manual compression in terms of

59 Applying VCD to pharmaceutically relevant compounds has been hand

60 Acute febrile episodes were determined to be VCD by means of a nonstructural protein 1 antigen immuno

61 episodes in each cohort were confirmed to be VCD, with 319 VCD episodes (4.6 episodes per 100 person-

62 Strong characteristic bisignate VCD signatures in the carbonyl stretching region have be

63 However, both VCD-induced ovarian failure and OVX led to a dramatic re

64 C and the absolute configuration assigned by VCD technique in combination with ab initio Hartree-Fock

65 ress in cells that is further exacerbated by VCD.

66 pathway in untreated cells and is induced by VCD via both Nrf2-dependent transcription and protein st

67 heir supramolecular chirality as revealed by VCD.

68 ign, thus leading to a reversal of the (13)C VCD pattern and explaining the large shift in the (13)C

69 The C3 VCD competes with Dishevelled for binding to the DIX dom

70 on the use of the DeVoe theory to calculate VCD, oriented VCD, IR absorption, and IR linear dichrois

71 Calculated VCD band shapes for 3(10)-helices showed more significan

72 previously reported measured and calculated VCD and IR spectral results.

73 perior, to the existing methods, such as CD, VCD, and absorption spectroscopy.

74 e light-scattering artifacts that plague CD, VCD, and IR absorption measurements.

75 bited shorter than normal vitreous chambers (VCDs) and thickened choroids, while BMP2 was down-regula

76 Furthermore, characteristic VCD patterns have been observed for protein films whose

77 in 31 patients with endoscopically confirmed VCD (+/- asthma), 29 asthmatics with no history of VCD a

78 ptoms and response to treatment in confirmed VCD.

79 illness and virologically confirmed dengue (VCD) in 3424 healthy children, 2 to 16 years of age, in

80 symptomatic, virologically confirmed dengue (VCD), regardless of disease severity or serotype, occurr

81 NO2 tropospheric vertical column densities (VCDs) are seen to be increasing by as much as 10%/year,

82 ailure to meet required viable cell density (VCD).

83 nvestigated using vibronic coupling density (VCD) analysis.

84 r axial length (AL), vitreous chamber depth (VCD) and both central (CRVO) and branch retinal vein occ

85 iameters of the eye, vitreous chamber depth (VCD) and dilated pupil diameter was performed on 111 occ

86 lens thickness (LT), vitreous chamber depth (VCD), and retinal thickness (RT) were measured in the op

87 l corneal thickness, vitreous chamber depth (VCD), anterior chamber depth (ACD), lens thickness (LT),

88 f axial length (AL), vitreous chamber depth (VCD), anterior chamber depth (ACD), lens thickness (LT),

89 The role of vascular closure devices (VCD) for the achievement of hemostasis in patients under

90 The role of vascular closure devices (VCDs) in patients having percutaneous coronary intervent

91 Vascular closure devices (VCDs) introduce a novel means for improving patient comf

92 The impact of vascular closure devices (VCDs) via the femoral arterial access site on short-term

93 h bortezomib-cyclophosphamide-dexamethasone (VCD) as induction before high-dose therapy and autologou

94 nsitivity of vibrational circular dichroism (VCD) allow determination of the segment sequence of unfo

95 d calculated vibrational circular dichroism (VCD) and electronic circular dichroism (ECD) spectra.

96 Vibrational circular dichroism (VCD) and Fourier transform IR (FTIR) methods for predict

97 Vibrational circular dichroism (VCD) and Fourier transform IR (FTIR) were measured for a

98 to calculate vibrational circular dichroism (VCD) and infrared (IR) absorption spectra of four polyri

99 an enhanced vibrational circular dichroism (VCD) couplet in the amide I' band region that is nearly

100 m (ECD), and vibrational circular dichroism (VCD) experiments and were compared to those of cryptopha

101 etermined by vibrational circular dichroism (VCD) in combination with density functional theory (DFT)

102 form-IR, and vibrational circular dichroism (VCD) spectra by means of a novel algorithm which utilize

103 (FT-IR), and vibrational circular dichroism (VCD) spectra by means of recently developed algorithms.

104 sm (ECD) and vibrational circular dichroism (VCD) spectra for 23 proteins, matrix descriptors encompa

105 red (IR) and vibrational circular dichroism (VCD) spectra for Ac-(Ala)(4)-NH(2), Ac-(Aib-Ala)(2)-NH(2

106 Vibrational circular dichroism (VCD) spectra have been measured for 23 globular proteins

107 Vibrational circular dichroism (VCD) spectra in the 1800-1400 cm(-)(1) region have been

108 on of IR and vibrational circular dichroism (VCD) spectra of 1 and 3-5, calculated using DFT, to expe

109 c Raman, and vibrational circular dichroism (VCD) spectra of Ac-Ala-Ala-Aib-OMe, Ac-Ala-Aib-Ala-OMe,

110 alculate the vibrational circular dichroism (VCD) spectra of the R and S enantiomers of CClHDT adsorb

111 red (IR) and vibrational circular dichroism (VCD) spectra were measured for a series of isotopically

112 ctive IR and vibrational circular dichroism (VCD) spectra were simulated.

113 ite signs of vibrational circular dichroism (VCD) spectra.

114 red (IR) and vibrational circular dichroism (VCD) spectroscopies.

115 igated using vibrational circular dichroism (VCD) spectroscopy, electronic circular dichroism (ECD) s

116 merin, using vibrational circular dichroism (VCD) spectroscopy.

117 alysis using vibrational circular dichroism (VCD) spectroscopy; (3) reinterpretation of the ECD exper

118 tions of its vibrational circular dichroism (VCD) spectrum, electronic circular dichroism (ECD) spect

119 nsitivity of vibrational circular dichroism (VCD) to the formation and development of amyloid fibrils

120 sm (ECD) and vibrational circular dichroism (VCD), are highly sensitive techniques to probe molecular

121 rmined using vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and optical r

122 lculation of vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and transpare

123 plication of vibrational circular dichroism (VCD).

124 igated using vibrational circular dichroism (VCD).

125 cal methods (vibrational circular dichroism, VCD, and Raman optical activity, ROA) provide more relia

126 ration using vibrational circular dichrosim (VCD) and simplify its usage will advance this technique

127 an toxicity of 4-vinylcyclohexene diepoxide (VCD) in mice.

128 oxic chemical, 4-vinylcyclohexene diepoxide (VCD), selective for primary and primordial follicles, is

129 the ovotoxin, 4-vinylcyclohexene diepoxide (VCD, n=8) to deplete ovarian follicles.

130 t test-retest reliability and differentiated VCD vs. healthy (Mann-Whitney U-test: z = -5.390, P < 0.

131 e show that the variable cytoplasmic domain (VCD) is required for trafficking and organelle tubulatio

132 that its unique variable cytoplasmic domain (VCD) is the critical one for Wnt pathway inhibition.

133 VopL consists of a VopL C-terminal domain (VCD) and an array of three WASP homology 2 (WH2) motifs.

134 Administered at low doses, VCD specifically causes apoptotic cell death of primordi

135 Vocal cord dysfunction (VCD) typically involves abnormal adduction of the vocal

136 h severe obesity and vocal cord dysfunction (VCD).

137 In this study, the ECD, VCD, and ROA chiroptical spectroscopies are evaluated fo

138 Employing VCD spectroscopy, we demonstrate that the structural beh

139 aring -10 D lenses, which developed enlarged VCDs.

140 individual components of AL were evaluated, VCD had the greatest contributing effect (SRC = -0.99; S

141 es of vascular complications were evaluated, VCDs were associated with fewer hematomas (OR, 0.69 [CI,

142 Although the experimental VCD is weak and restricted by the limited amount of samp

143 e VCD spectra of 1 and 2 to the experimental VCD spectra of the natural products, (+)-1 and (+)-2, le

144 m, and optical rotation (OR) to experimental VCD, ECD, and OR data.

145 vascular VCD and 1506 received extravascular VCD) and 1509 patients were randomly assigned to the man

146 sis with an intravascular VCD, extravascular VCD, or manual compression in a 1:1:1 ratio.

147 0.5 minute [IQR, 0.2-1.0]), vs extravascular VCD (2.0 minutes [IQR, 1.0-2.0]; P <.001) and closure de

148 ng those with intravascular vs extravascular VCD (80 patients [5.3%], vs 184 patients [12.2%]; P < .0

149 here it is shown that the sign of the fibril VCD pattern correlates with the sense of supramolecular

150 study shows that the combination of the film VCD and ECD techniques is a relatively straightforward m

151 re VCD and led to fewer hospitalizations for VCD in five Latin American countries where dengue is end

152 These findings demonstrate the potential for VCD to be used for real-time monitoring of the compositi

153 the amounts of protein samples required for VCD measurements on films are approximately 2 orders of

154 te somewhat lower reliability than those for VCD.

155 FT-VCD, as opposed to dispersive scanning VCD, eliminates t

156 transform vibrational circular dichroism (FT-VCD) to follow changes in the percent enantiomeric exces

157 We have used a combination of FTIR, VCD, ECD, Raman, and NMR spectroscopies to probe the sol

158 dual methods for AC determination as AXRD >> VCD > ECD, while the synergy of all three methods provid

159 more than a decade of development, however, VCD utilization has neither been routine in the U.S. nor

160 increasing Aib content, the overall amide I VCD intensity becomes weaker and the amide I couplet bec

161 nt, but they have very weak negative amide I VCD, both reflecting experimental patterns seen in aggre

162 ecomes more conservative, while the amide II VCD is less affected.

163 rger variation was predicted in the amide II VCD, which had added complications due to non-hydrogen-b

164 pectral analyses and the mixed amide I' + II VCD plus ECD analysis are comparable for the helix and s

165 FA/ RMR approach for analysis with amide III VCD.

166 No sex differences were found in VCD, LT, and NOP after height adjustment.

167 structure leads to a significant increase in VCD intensity, while the parallel structure was not as d

168 h, with slightly greater effects observed in VCD-treated mice.

169 microscopy (SEM), we demonstrate that indeed VCD supramolecular chirality is correlated not only by t

170 ndomized to hemostasis with an intravascular VCD, extravascular VCD, or manual compression in a 1:1:1

171 to a VCD group (1509 received intravascular VCD and 1506 received extravascular VCD) and 1509 patien

172 ly shorter among patients with intravascular VCD (0.5 minute [IQR, 0.2-1.0]), vs extravascular VCD (2

173 species were studied using EPR, UV-vis, IR, VCD, UHR-ESI-MS, and XANES/XAFS measurements.

174 away from the fragment approach when making VCD assignments.

175 Application of the third chiroptical method, VCD, indicates unique spectral features for all eight Sy

176 VCD for highly helical proteins and negative VCD for highly sheet-containing proteins.

177 pectroscopic techniques (IR absorption, NMR, VCD, and EPR) we gained clear evidence that both compoun

178 and their structures were determined by NMR, VCD, ECD, and X-ray diffraction.

179 icroscopic examination indicates that normal VCD fibrils have a left-handed twist, whereas reversed V

180 In the case of Boc-L-Phe-L-Oxd-OBn, VCD spectra in CCl(4) and detailed DFT computational ana

181 l calculations we conclude that the observed VCD amplification finds its origin in vibronic coupling

182 By comparing experimentally obtained VCD spectra to computationally simulated ones, the absol

183 d, strengthening the case for application of VCD in the study of complex natural products.

184 A more pronounced association of VCD with a reduction in 30-day mortality was evident in

185 systematic approach for rapid calculation of VCD/IR spectra and comparison with corresponding measure

186 concerted application of DFT calculations of VCD, ECD, and OR to the determination of the AC of a nat

187 Challenges in the second decade of VCD experience will include performing definitive random

188 olase, a key enzyme in the detoxification of VCD, and increases the oxidative stress in cells that is

189 /- asthma), 29 asthmatics with no history of VCD and 14 healthy controls.

190 The percentage of VCD episodes requiring hospitalization was 19.1% in the

191 o determine % EE values from kinetic sets of VCD spectral data is also reported.

192 We collated symptoms of VCD from focus groups comprising patients and healthcare

193 4, is analyzed using the Stephens theory of VCD and density functional theory (DFT).

194 jective was the comparison of the 2 types of VCD.

195 ork provides the first example of the use of VCD spectroscopy to discriminate between structural isom

196 applications and highlight the usefulness of VCD as a tool for probing amyloid fibril formation.

197 IIb/IIIa inhibitors, in whom the benefit of VCDs over manual closure was attenuated.

198 entrally randomly assigned to receive VTD or VCD.

199 the DeVoe theory to calculate VCD, oriented VCD, IR absorption, and IR linear dichroism (LD) spectra

200 ides in this report of site-specific peptide VCD conformational analysis.

201 conclusions from measured polyribonucleotide VCD and IR spectra.

202 (-1), with the extreme forms having positive VCD for highly helical proteins and negative VCD for hig

203 The overall predicted VCD intensity is quite weak but predominantly negative (

204 When compared with manual pressure, VCD was associated with a minor short-term (30-day) prog

205 nants of refractive error were AL (primarily VCD) and CP.

206 the basic pattern of amide I and II relative VCD intensities still differs between alpha- and 3(10)-h

207 ddition to enabling faster and more reliable VCD assignments of absolute configuration, the ability t

208 s have a left-handed twist, whereas reversed VCD fibrils are flat-like aggregates with no obvious hel

209 FT-VCD, as opposed to dispersive scanning VCD, eliminates the need to scan the VCD spectrum in tim

210 ation of chiral preparative HPLC separation, VCD measurements, and theoretical calculations allows th

211 ccine was efficacious against VCD and severe VCD and led to fewer hospitalizations for VCD in five La

212 Among the severe VCD cases, 1 of 12 was in the vaccine group, for an inte

213 SO2 VCDs in the oil sands have remained approximately consta

214 port the preferential use of VTD rather than VCD in preparation for ASCT.

215 These results demonstrate that VCD can be used to study the structure of proteins in th

216 eory simulated counterparts establishes that VCD is the more reliable technique to assign absolute co

217 Recent data, however, suggest that VCD are improving, complication rates associated with th

218 The VCD data do not support the 310-helix as a dominant cont

219 The VCD illustrates the origin of the interaction between th

220 The VCD injection procedure can be applied to studies using

221 The VCD organizes three actin monomers in a spatial arrangem

222 The VCD signals associated with the labeled residues are amp

223 The VCD spectrum of the acetate derivative of 3, 4, is analy

224 The VCD with respect to the effective mode could provide a p

225 ence of 0.57 +/- 0.15 mm (p < 0.001) and the VCD was significantly shorter with a mean difference of

226 omponents were required to describe both the VCD and FTIR data for the n = 4 peptide in D2O.

227 s filament-like structures, organized by the VCD with monomers delivered by the WH2 array, that can t

228 with the results for Au40, we calculate the VCD spectra of the R and S enantiomers of CClHDT adsorbe

229 changed from paramagnetic to diamagnetic the VCD amplification vanishes completely.

230 or each spectral data set as well as for the VCD and FTIR sets grouped together and with similarly ob

231 y of the best PC/FA RMR to near that for the VCD.

232 d (+)-2, confirming the ACs derived from the VCD spectra.

233 response (primary end point) vs 56.2% in the VCD arm (P = .05).

234 Hematologic toxicity was higher in the VCD arm, with significantly increased rates of grade 3 a

235 higher in the VTD arm (92.3% vs 83.4% in the VCD arm; P = .01).

236 We show that, for each adsorption mode, the VCD spectra are distinctly different for the Au40(R)-ClH

237 we show that, for each adsorption mode, the VCD spectra are mirror symmetric but otherwise essential

238 This localized character of the VCD amplification provides a unique tool to specifically

239 t has been demonstrated that the sign of the VCD band pattern from filament chirality can be controll

240 Here, we report the crystal structure of the VCD dimer bound to actin.

241 olecule, whereas deletion or excision of the VCD or replacement of the Pcdh-gammaA3 cytoplasmic domai

242 Comparison of DFT calculations of the VCD spectra of 1 and 2 to the experimental VCD spectra o

243 Comparison of DFT calculations of the VCD, ECD, and OR of schizozygine to experimental data le

244 canning VCD, eliminates the need to scan the VCD spectrum in time to monitor the % EE at more than on

245 ric aggregate is discussed; in solution, the VCD spectra strongly suggest only monomeric species are

246 j] were significantly more accurate than the VCD ones, which may result from the longer range length

247 We show that the VCD signal intensities of amino acids and oligopeptides

248 Truncations or internal deletions within the VCD defined a 26-amino acid segment required for traffic

249 Thus the VCDs of Pcdh-gammas mediate interactions critical for Pc

250 was that femoral hemostasis achieved through VCD is noninferior to manual compression in terms of vas

251 The ratio of dilated pupil area to VCD(2) was highly variable.

252 Nrf2-/- female mice exposed to VCD exhibit an age-dependent decline in reproduction lea

253 usion criteria, 28 528 (37%) procedures used VCDs.

254 ounds have been unambiguously assigned using VCD and ECD spectroscopy.

255 iridoid plumericin, 1, also determined using VCD spectroscopy.

256 s consistent with our earlier findings using VCD measured for proteins in 2H2O and ECD data.

257 al and a relatively unusual example of using VCD carbonyl multiplets, the absolute configuration coul

258 , 24%, 22%, and 47%) of patients (VDCR, VDR, VCD, and VCD-mod, respectively); the corresponding 1-yea

259 l pressure [including external clamp] versus VCD) and 30-day mortality was examined in a national rea

260 e fire ant alkaloids could be determined via VCD spectroscopy.

261 This intrinsically weak VCD can explain the high variation seen experimentally i

262 While VCD, requiring milligram quantities, allowed the determi

263 h manual pressure and 59.9% (n=162 844) with VCD.

264 s was significantly shorter in patients with VCD (1 minute [interquartile range {IQR}, 0.5-2.0]), vs

265 asuring changes in symptoms in patients with VCD.

266 ortality was lower in the group treated with VCD compared with manual pressure (hazard ratio [HR], 0.

267 Subjects treated with VCD had fewer comorbidities and were less likely to pres

268 Treatment with VCD induces apoptotic death in cultured cells and in ova