ライフサイエンスコーパス: VDJ recombination

1 which is required for rejoining DSBs during VDJ recombination.

2 ements is essential for locus activation and VDJ recombination.

3 action with factors implicated in regulating VDJ recombination.

4 ighest potential CDR3 diversity generated by VDJ recombination.

5 strand breaks including those induced during VDJ recombination.

6 ensitive, but having only a modest defect in VDJ recombination.

7 H3 acetylation status was tightly linked to VDJ recombination.

8 pling enhancer activity to accessibility for VDJ recombination.

9 for example by ionizing radiation or during VDJ recombination.

10 or near a JH segment, suggesting an error in VDJ recombination.

11 RAG1 and RAG2 mediate VDJ recombination, a process necessary for the maturatio

12 ter immunization and assessed peripheral IgH VDJ recombination activities in C57BL/6 (B6) mice congen

13 data provide a window into the mechanisms of VDJ recombination and diversity creation and allow us to

14 Mutations impairing VDJ recombination and DNA repair were the most common un

15 This mechanism promotes VDJ recombination and effective selection of cells expre

16 ficant correlation between biases induced by VDJ recombination and our inferred selection factors tog

17 B ligation, resulting in failure to complete VDJ recombination and subsequent block of B-lymphocyte m

18 e to state in a hidden Markov model (HMM) of VDJ recombination, and assumed that mutations occur via

19 a process called variable-diversity-joining (VDJ) recombination] and, upon successful rearrangement,

20 ntroduced by somatic mutation or heavy chain VDJ recombination are necessary and sufficient for Dsg3

21 n of the TCR alpha joining gene segments for VDJ recombination at an early stage of T cell developmen

22 hat c-Myb plays a crucial role in activating VDJ recombination at the endogenous TCR-delta locus.

23 hancer, the inserted Vbeta segment underwent VDJ recombination at the same frequency as the natural c

24 Developmental activation of VDJ recombination at the T cell receptor (TCR) delta loc

25 elements in the developmental regulation of VDJ recombination at the TCR alpha/delta locus was exami

26 DN stage as observed in RAG-/- mice, DJ and VDJ recombination at the TCR beta locus was functional,

27 role in the ability of E(delta) to activate VDJ recombination by analyzing VDJ recombination in mice

28 ary, is not sufficient for the activation of VDJ recombination by E(delta).

29 been implicated in IgH locus transcription, VDJ recombination, class switch recombination, and somat

30 orting that E2A, PAX5, and the RAGs are in a VDJ recombination complex bound to key sequences on the

31 We show that pre-BCR activation releases the VDJ recombination complex through calmodulin binding to

32 includes overexpression of genes involved in VDJ recombination, CXCR4 pathway signaling, and BCL2 fam

33 expression vector significantly restores the VDJ recombination deficits in DNA-PKcs-deficient cells,

34 Although increased numbers of illegitimate VDJ recombination events do not directly portend leukemi

35 mline DH segment was expressed in functional VDJ recombination events involving different JH segments

36 n initial random DNA editing process, called VDJ recombination, followed by functional selection of c

37 es showed greatly enhanced expression of the VDJ recombination genes DNTT, RAG1, and RAG2, but not AI

38 ) to activate VDJ recombination by analyzing VDJ recombination in mice carrying a minilocus in which

39 signaling in B-cell development, we studied VDJ recombination in the pro-B cells of FLT3/ITD mice an

40 of TCR-delta gene rearrangement, we compared VDJ recombination in transgenic mice carrying two versio

41 agment of E(delta) is sufficient to activate VDJ recombination in vivo.

42 r (E(delta)) efficiently activates minilocus VDJ recombination in vivo.

43 ase with zebrafish maturity, suggesting that VDJ recombination involves a level of deterministic prog

44 Ordered assembly of Ag receptor genes by VDJ recombination is a key determinant of successful lym

45 VDJ recombination is developmentally regulated in vivo b

46 This process, known as "VDJ recombination", is implemented via a series of stoch

47 VDJ recombination of T cell receptor and immunoglobulin

48 In addition to its role in VDJ recombination, our study points out that the full-le

49 velopment of T and B cells by initiating the VDJ recombination process that leads to generation of a

50 fferent ages, we quantify the changes in the VDJ recombination process that occur from embryo to youn

51 nts can induce specific abnormalities of the VDJ recombination process.

52 cal impact of selection on the output of the VDJ recombination process.

53 DNA interstrand cross-links, involvement in VDJ recombination, repair of DNA double-strand breaks, a

54 was measured along versions of a transgenic VDJ recombination reporter and the endogenous T cell rec

55 enic mice containing variants of a minilocus VDJ recombination substrate.

56 ginates in a stochastic DNA editing process (VDJ recombination) that acts on the surface receptor gen

57 The first occurs during VDJ recombination, when inverted DH genes are usually av

58 the core-enhancer Emu element mainly affects VDJ recombination with minor effects on class switch rec

59 Despite a severe defect in VDJ recombination with partial blockade at the pro-B cel