ライフサイエンスコーパス: VGAT

1 VGAT and calcium binding protein-28K immunoreactivities

2 VGAT appeared more evenly distributed in the striatal pa

3 VGAT immunofluorescent puncta were first seen sparsely i

4 VGAT immunoreactivity in the OPL was predominantly local

5 VGAT immunostaining was present at P0 and older ages in

6 ridization revealed coexpression of SNAP-25, VGAT (vesicular GABA transporter), and GAD65/67 (glutami

7 Real-time imaging with a VGAT-pHluorin fusion provides a useful approach to explo

8 MAT2 (vesicular monoamine transporter 2) and VGAT (vesicular GABA transporter), consistent with vesic

9 utely dissociated retinas showed GAD(65) and VGAT immunoreactivity in both A-type and B-type horizont

10 Specific GABA, GAD(65), and VGAT immunostaining was localized to horizontal cell bod

11 monstrate the presence of GABA, GAD(65), and VGAT in horizontal cells of the guinea pig retina, and s

12 econd, the activity of SV-associated GAD and VGAT seems to be coupled because inhibition of GAD also

13 By P15, the GAT and VGAT immunostaining patterns appear similar to the adult

14 acid decarboxylase) 65 and 67 isoforms, and VGAT (vesicular GABA transporter) in interneurons from t

15 ar transporters so far identified (VAChT and VGAT) were first described and cloned in C. elegans; in

16 o quantify the density of labeled VGLUT2 and VGAT immunoreactivity onto GnRH neurons.

17 howed vesicular colocalization of VGLUT3 and VGAT.

18 Some double-labeled BDA/VGAT varicosities were seen apposed to small somata labe

19 of receptors within genetically defined BNST VGAT neurons that may serve as therapeutic targets for r

20 activation of Gq-mediated signaling in BNST VGAT neurons and saw increased activity within ventral m

21 highlight that Gq-mediated signaling in BNST VGAT neurons can drive downstream network activity that

22 d that activation of hM3Dq receptors in BNST VGAT neurons can induce a long-term depression-like stat

23 ch to profile the receptorome of single BNST VGAT neurons.

24 GAD(65), taken up into synaptic vesicles by VGAT, and likely released by a vesicular mechanism from

25 ctron microscopy by using well-characterized VGAT antibodies.

26 led because inhibition of GAD also decreases VGAT activity.

27 Taken together, these findings demonstrate VGAT immunoreactivity in both amacrine and horizontal ce

28 Developmentally, VGAT expression precedes VGLUT1.

29 al characterization of the newly established VGAT-ChR2(H134R)-EYFP, ChAT-ChR2(H134R)-EYFP, Tph2-ChR2(

30 medial ganglionic eminence and few expressed VGAT, found in GABAergic interneurons.

31 us and the neocortex, VGLUT3 was absent from VGAT-positive terminals in the striatum.

32 Furthermore, VGAT immunoreactivity overlapped or was immediately adja

33 (VGLUT1) and gamma-aminobutyric acid (GABA) (VGAT) transporter biosynthesis.

34 rst-order neurons are inhibitory (GABAergic, VGAT(+)) or excitatory (glutamatergic, VGLUT2(+)).

35 ubunit mRNAs and diminished levels of GAD65, VGAT, GluR1, and GABAAR alpha1 and alpha2 were observed

36 urons are inhibitory (GABAergic/glycinergic, VGAT-positive) in nature.

37 ons of a kainic acid-induced model of TLE in VGAT-ChR2 transgenic mice.

38 IPSCs and mIPSCs, correlating with increased VGAT (vesicular GABA transporter) puncta.

39 , while ATR associates only with inhibitory (VGAT(+)) vesicles.

40 MAT2 expression in GABAergic neurons lacking VGAT is sufficient to sustain GABA release.

41 tive and acute chemogenetic activation of LH VGAT(+) neurons was profoundly wake promoting, whereas a

42 Numerous VGAT and VGLUT2 labeled varicosities were observed appos

43 porter (VGAT) and NPY was found in 13-15% of VGAT-immunoreactive boutons in laminae I-II, and 5% of t

44 Only 6% of VGAT boutons presynaptic to large lamina I projection ne

45 The density of VGAT puncta increased with development, first within the

46 not control medium, increased the density of VGAT puncta.

47 Expression of VGAT, GAD67, and GAT-1 was not associated with working m

48 The localization of VGAT immunoreactivity to mouse and rat retina was evalua

49 The number of VGAT-ir terminals onto GnRH dendrites was reduced in the

50 in SPN local collaterals, down-regulation of VGAT expression in local processes of SPNs, and impaired

51 GluT2+) and GABA/glycine (known as VIAAT+ or VGAT+) vesicular transporters in the Mo5, Mo7, Amb, and

52 tained a single transporter, either VMAT2 or VGAT, we conclude that the secretory organelles of DAerg

53 psin 2-enhanced yellow fluorescence protein (VGAT-ChR2-YFP)-expressing mice and a novel fibreoptic 'l

54 of this atypical dileucine-like motif in rat VGAT indicates that the transporter recycles by interact

55 ransduction that transcriptionally regulates VGAT by NO.

56 In rat and mouse retina, VGAT occurred in the inner retina by postnatal day 1 (P1

57 In rat retina, VGAT-immunoreactive cell bodies also contained GABA, gly

58 Specific VGAT immunoreactivity was localized to numerous varicose

59 GnRH neurons, and at the time of the surge, VGAT-containing vesicles decrease and VGLUT2-containing

60 cells, and demonstrate optogenetically that VGAT neurons in the amygdala and bed nucleus of stria te

61 roscopy of mouse and rat retinae showed that VGAT immunoreactivity was localized to horizontal cell p

62 na II, we found that around one-third of the VGAT boutons that contacted them were NPY-immunoreactive

63 Third, VGAT and SV-associated Ca(2+)calmodulin-dependent kinase

64 Thus VGAT is the first of a new family of neurotransmitter tr

65 se varied with season in a manner similar to VGAT inputs.

66 ocalized with the vesicular GABA transporter VGAT in the CA1 region of the hippocampus.

67 expression of the vesicular GABA transporter VGAT was unchanged; however, there was a significant inc

68 AT (also known as vesicular GABA transporter VGAT) transports GABA or glycine into synaptic vesicles.

69 expression of the vesicular GABA transporter VGAT, drastically suppresses drinking, even in water-cra

70 ndependent of the vesicular GABA transporter VGAT.

71 presence of the vesicular GABA transporter (VGAT) and NPY was found in 13-15% of VGAT-immunoreactive

72 We used the vesicular GABA transporter (VGAT) as a marker for inhibitory presynaptic terminals t

73 ynaptophysin and vesicular GABA transporter (VGAT) revealed a group of small-sized ( approximately 0.

74 cid motif in the vesicular GABA transporter (VGAT) that controls its synaptic localization and activi

75 GAT-3), and the vesicular GABA transporter (VGAT) was evaluated by using immunohistochemistry with w

76 ression level of vesicular GABA transporter (VGAT) was upregulated, and no change in the synaptic ves

77 mparison of this vesicular GABA transporter (VGAT) with a vesicular transporter for monoamines shows

78 xpression of the vesicular GABA transporter (VGAT) within recurrent collaterals of SPNs.

79 nits, GAD65, the vesicular GABA transporter (VGAT), and the neuronal glutamate transporter (EAAC1) cD

80 ecarboxylase and vesicular GABA transporter (VGAT), markers of GABAergic neurons.

81 ties followed by vesicular GABA transporter (VGAT).

82 h VGLUT3 and the vesicular GABA transporter (VGAT).

83 VGLUT-2), or the vesicular GABA transporter (VGAT).

84 esicles (SVs) by vesicular GABA transporter (VGAT).

85 imately 27%) and vesicular GABA transporter (VGAT)/p38 IR (approximately 41%) was found, but not in v

86 MAT2)] and GABA [vesicular GABA transporter (VGAT)].

87 that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neurons).

88 gamma-aminobutyric acid (GABA) transporter (VGAT) in patch and matrix throughout the striatum.

89 gamma-aminobutyric acid (GABA) transporter (VGAT) to horizontal cell processes in primate and rodent

90 gamma-aminobutyric acid (GABA) transporter (VGAT), and vesicular acetylcholine transporter (VAChT) t

91 gamma-aminobutyric acid (GABA) transporter (VGAT), which transports the inhibitory amino acid transm

92 gamma-aminobutyric acid (GABA) transporter (VGAT)-expressing BNST neurons using hM3Dq, but neither h

93 and the vesicular GABA/glycine transporter (VGAT) were evaluated in the developing mouse retina by u

94 inergic [vesicular GABA/glycine transporter (VGAT)] vesicular transporters in postnatal retina.

95 yme (GAD(65)) and its vesicular transporter (VGAT).

96 sin and the vesicular GABAergic transporter, VGAT).

97 cular GABA and glutamate (Glu) transporters (VGAT and VGLUT1, respectively), and preCGG hippocampal a

98 A few varicose VGAT-immunoreactive processes entered the OPL from the I

99 lso found to receive dual-phenotype (VGLUT + VGAT) inputs; these varied with season in a manner simil

100 5-HT, and DbetaH expression, whereas VGLUT1, VGAT, and VAChT showed no change.

101 Amacrine cell somata characterized by weak VGAT immunoreactivity in the cytoplasm were located in t

102 At P5, weak VGAT immunostaining was also observed in horizontal cell