ライフサイエンスコーパス: VH

1 VH replacement provides a unique RAG-mediated recombinat

2 VH replacement represents a RAG-mediated secondary rearr

3 VH was purified using ultrafiltration, ion exchange and

4 stigate in vivo targets of human mAb 24.3.1, VH/VL genes were expressed in B cells of transgenic (Tg)

5 Local observers classified 100 VH-IVUS-defined coronary plaques to determine single cen

6 A total of 4429 VH intravascular ultrasound frames from 53 patients were

7 tral B cell deletion in 4E10, but not in 48d VH KI mice.

8 e Maps against coregistered histology in 72 (VH-IVUS) and 87 (CT) segments from 8 postmortem coronary

9 gene is rearranged to a D gene followed by a VH gene rearranging to the DJH rearrangement.

10 he engrafted B-1 cell population expressed a VH-DH-JH composition similar to cord blood B-1 cells, in

11 We observe similar behavior for a VH domain grafted with a large hydrophobic peptide from

12 with high probability, DHJH elements reach a VH element within minutes.

13 Patients with a VH from a single-center hernia clinic were prospectively

14 Moreover, Abeta VH domains with negatively charged CDR3 mutations show s

15 eletion (core or full length) did not affect VH gene usage.

16 somatic mutations in the VH CDR and altered VH CDR3 physicochemical properties.

17 However, although VH-IVUS could identify thin-cap fibroatheromas (TCFA) wi

18 sdAbs in the sera from immunized animals and VH H antibody domains isolated from the library show spe

19 ount simultaneous CDR loops conformation and VH/VL orientation optimisation upon antibody sequence ch

20 ntogeny into two types: CDR H3-dominated and VH-gene-restricted.

21 ts caused intestinal barrier dysfunction and VH, which were blocked by the LPS antagonist LPS-RS or b

22 ues for VH gene mutation, H-CDR3-length, and VH/JH usage, comparing these different characteristics w

23 ntextual information through the VH-mPFC and VH-amygdala pathways.

24 Time to progression of PDR and VH were calculated with Cox regression after stratifying

25 model, despite an unexpected CDRH3 tilt and VH/VL interface deviation, which indicates that the mode

26 A single domain antibody VH-9.7 showed selectivity for five distinct patient-deri

27 f epitopic tagged, heavy chain-only antibody VH domains (VHHs) specific for the ricin enzymatic (RTA)

28 ion-based technology for sequencing antibody VH-VL repertoires from >2 x 10(6) B cells per experiment

29 We also assessed VH-IVUS and CT Plaque Maps against coregistered histolog

30 affinity maturation to derive an autonomous VH domain (VH-V1a) that recognized both human and mouse

31 lts suggest that VH-B1a and other autonomous VH domains may be useful scaffolds to support both conve

32 However, direct comparisons between VH-IVUS and OCT are lacking and it remains unknown wheth

33 urther demonstrate that the distance between VH, D, and JH gene segments influence their ability to r

34 nd to reside in a deep pocket formed between VH and VL domains of the Fab fragments.

35 Selective and biased VH:VL pairing was particularly evident among expanded cl

36 e immunogen but nonetheless exhibited biased VH use, V(D)J mutation, and clonal expansion comparable

37 to constitutively express the LEDGF-binding VH and these cells showed interference with HIV viral re

38 Both VH-IVUS and OCT can reliably identify TCFA, although OCT

39 d distinct gene segment usage biases in both VH and VL sequences within the naive and memory compartm

40 CDR H3 ontogenies and the other achieved by VH-gene-restricted ontogenies.

41 The lead candidate VH H clones (designated B11 and H10) bound to C. reinhar

42 ctions at the population level; (ii) certain VH:VL gene pairs were significantly enriched or depleted

43 W33T of the associated variable heavy chain (VH) allele were identified and confirmed by gene sequenc

44 nature and human immunoglobulin heavy chain (VH) repertoire that was relatively uncoupled from other

45 eas variable gene segment of the H Ig chain (VH) gene usage in asthma reflected germline distribution

46 e sequencing of both immune receptor chains (VH+VL or TCRbeta/delta+TCRalpha/gamma) at the single-cel

47 Combined VH-IVUS/OCT imaging markedly improved TCFA identificatio

48 Combining VH-defined fibroatheroma and fibrous cap thickness </=85

49 Common VH gene usage indicates common humoral immune responses,

50 cally mutated antibodies encoded by a common VH gene, but each binding to a different antigen, were c

51 Such high-complexity VH H antibody libraries for algae will be valuable tools

52 s conventional TCRalpha/delta locus contains VH genes that are expressed with the conventional Cdelta

53 formational specificity of the corresponding VH domains.

54 v hybrid libraries of allergic donor-derived VH epsilon and synthetic VL were established from 107 mo

55 5.60, and 7.29 times more likely to develop VH, respectively.

56 es (4Q DBH) had 3.84 higher HR of developing VH (95% CI 1.39-10.62, P = .0095).

57 mmon after initial 23-gauge PPV for diabetic VH and was associated with incomplete scatter photocoagu

58 nty-three-gauge PPV for nonclearing diabetic VH.

59 over 100 candidates encoded by 11 different VH genes.

60 unctional diversity rather than differential VH gene use.

61 ted intergenic repeat elements and 5' distal VH genes were compromised by the Setd1a-cKO.

62 ents and a corresponding reduction in distal VH gene segment use.

63 Bcl2 expression overcomes defects in distal VH-DJH and secondary Vkappa-Jkappa rearrangement associa

64 Here, we have marked the distal VH and DH-JH-Emu regions with Tet-operator binding sites

65 determining regions (CDRs) of single-domain (VH) antibodies.

66 pecifically label VHHs [the variable domain (VH) of a camelid heavy-chain only antibody] with (18)F o

67 pacos) heavy chain-only variable VH domain (VH H) libraries against antigens in total cell lysates f

68 aturation to derive an autonomous VH domain (VH-V1a) that recognized both human and mouse VEGF with h

69 autonomous heavy chain variable (VH) domain (VH-B1a) to support diversity within its antigen-binding

70 elative orientation of the variable domains, VH and VL.

71 and predominantly included germline-encoded VH and VL regions commonly found in either the conventio

72 cation of pharmaceutical agents that enhance VH and use these agents to examine the contribution of r

73 influences on the distribution of expressed VH and VL genes and by influencing the amino acid compos

74 l response composed of most of the expressed VH gene segments, illustrating the considerable genetic

75 hen egg white lysozyme revealed an extended VH binding interface, with complementarity-determining r

76 entification was 63.6%, 78.1%, and 76.5% for VH-IVUS and 72.7%, 79.8%, and 79.0% for OCT.

77 y using live C. reinhardtii cells to pan for VH H clones with specific recognition of cell-surface ep

78 Management patterns for VH are heterogeneous, often with little supporting evide

79 Management patterns for VH are heterogeneous, often with little supporting evide

80 Surgery for VH and ERM generally results in favorable outcomes, but

81 uences from different subsets or tissues for VH gene mutation, H-CDR3-length, and VH/JH usage, compar

82 increased the positive predictive value for VH intravascular ultrasound to identify clinical present

83 usion and the secondary complications of FP, VH, and TRD.

84 Two prototype bnAbs were derived from VH-germlines that were 99% identical and used a common g

85 The purified peptides (F37) from VH, which had the highest specific antioxidant activity,

86 C57BL/6 murine Igh locus has >100 functional VH gene segments that can recombine to a rearranged DJH.

87 apture; subsequent emulsion RT-PCR generated VH-VL amplicons for next-generation sequencing.

88 the V genes are more related to IgH V genes (VH) than to TCR V genes.

89 57 (74.8%) patients showed viable HCC (Group VH).

90 NVH (0%) and in 25 (15.9%) patients in Group VH (P=0.003).

91 l injection, or sorafenib, whereas, in Group VH, 110 of the 157 (70.1%) patients received bridging th

92 f 8 eyes (25%) had FP, 1 of 8 eyes (12%) had VH, and 2 of 8 eyes (25%) had TRD.

93 16 eyes (75%) had FP, 3 of 16 eyes (19%) had VH, and 10 of 16 eyes (63%) had TRD.

94 logical mechanisms of visual hallucinations (VHs) in patients with Parkinson disease (PD) by analyzin

95 Visual hallucinations (VHs) occur in macular degeneration patients with poor vi

96 change in visual acuity (VA), vitreous haze (VH), and central macular thickness (CMT) at month 6.

97 each animal to evaluate the villous height (VH) and crypt depth (CD).

98 use in patients with a vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR

99 vitrectomy (PPV): 6 for vitreous hemorrhage (VH), 1 for epiretinal membrane (ERM), and an additional

100 lar proliferation (FP), vitreous hemorrhage (VH), and tractional retinal detachment (TRD) were docume

101 c retinopathy (PDR) and vitreous hemorrhage (VH).

102 n cases of nonresorbing vitreous hemorrhage (VH).

103 ctices in the management of ventral hernias (VH).

104 Nonoperative management of ventral hernias (VHs) is often recommended for patients at increased risk

105 duced Fos expression in ventral hippocampal (VH) neurons projecting to the prelimbic cortex (PL) and

106 ronal population in the ventral hippocampus (VH) projects to both the mPFC and amygdala and is recrui

107 al system involving the ventral hippocampus (VH), nucleus accumbens (NAC), and prefrontal cortex (PFC

108 ecreased from dorsal to ventral hippocampus (VH).

109 lculated in vivo based on virtual histology (VH) intravascular ultrasound and whether PSS varied acco

110 Currently, it is not clear how VH replacement is regulated during early B lineage cell

111 Importantly, however, VH neurons projecting to both PL and BA were more likely

112 Human VH single domains represent a promising class of antibod

113 genic (Tg) mice as functional chimeric human VH 24.3.1-mouse C-region IgG1(a) autoantibody.

114 er, our results demonstrate that fully human VH domains can be constructed that are not only stable a

115 r HIV-1 Env V2 recognition resulted in human VH pairing with mouse lambda L chains instead of allowin

116 Unfortunately, isolated human VH domains also generally display poor biophysical prope

117 Notably, nonproductive human VH rearrangements in the transgenic mice expressed short

118 ast, previously reported structures of human VH single domains had failed to recapitulate this proper

119 2 Abs were isolated that used the same human VH gene segment as an RV144 V2 Ab but paired with a mous

120 n of phage display libraries of stable human VH domains and the selection of binders against a divers

121 the dominance of Vlambda pairing with human VH for HIV-1 Env V2 recognition resulted in human VH pai

122 This study used virtual human (VH) technology to investigate the effects of VH patients

123 nition and quantification of vitreous humor (VH) cystine as well as provide the portability for on sp

124 dysfunction, and visceral hypersensitivity (VH).

125 donors led to a number of key findings: (i) VH and VL gene sequences pair in a combinatorial fashion

126 To this end, we examined 7596 Ig VH (IGHV-IGHD-IGHJ) sequences from 7424 CLL patients, 3

127 d, including a small number of dominating Ig-VH clusters that might represent the most active clonall

128 ntified a large number of closely related Ig-VH clusters that were common to both CSF and peripheral

129 We identified clusters of related Ig-VH transcripts in the CSF of both patients.

130 f IgG heavy chain variable region genes (IgG-VH) in paired cerebrospinal fluid and PB samples from pa

131 ormatics clustering of related IgM-VH or IgG-VH transcripts was used to determine whether active B-ce

132 Bioinformatics clustering of related IgM-VH or IgG-VH transcripts was used to determine whether a

133 Along with IMGT VH 50, other positions are identified that may help to p

134 led to productively rearrange immunoglobulin VH-DJH gene segments.

135 somatic hypermutation in the immunoglobulin VH locus.

136 Fewer mutations within immunoglobulin VH rearrangements of CD19(-) BMPC may indicate their dif

137 c PCs had lower numbers of mutations both in VH and VL genes than in non-TG2-specific PCs.

138 we observed selective amino acid changes in VH and VL and striking CDR3 length and J segment selecti

139 o had the potential for a 2-step decrease in VH demonstrated a 2-step decrease (40% in Group 1 and 46

140 mice, we demonstrate a striking gradient in VH gene use as pre-B cells mature into follicular and th

141 We show that SHM in VH rearranged regions is almost totally abrogated in 3'R

142 ive study comparing management strategies in VH patients with comorbidities.

143 nglia within dopaminergic neurons in vivo in VH 24.3.1 Tg mice.

144 ognitive effects of transiently inactivating VH in rats during a sensitive period of development.

145 from HS or LFM-treated IBS patients, induced VH in rats, which was ameliorated by LPS-RS.

146 BCR signaling-induced VH replacement is dependent on the activation of Syk and

147 cle, we show that cross-linking BCRs induces VH replacement in human EU12 muHC(+) cells and in the ne

148 he full-length Emu region does not influence VH segment usage but ensures efficient Igmu-chain expres

149 rough cyclin D3 (Ccnd3), which also inhibits VH transcription.

150 ent and the conventional RSS of the invading VH gene, leaving behind a footprint of up to five base p

151 ind gp120 at different angles via juxtaposed VH and VL contact surfaces.

152 The crystal structure of the LEDGF-VH complex reveals that the single domain antibody mimic

153 icantly higher than the ones from group LIP (VH: 672.1 +/- 83.3 microm and 528.0 +/- 51.7 microm, res

154 Massive VH-VL repertoire analyses of three human donors provided

155 contextual retrieval of emotional memories, VH neurons with collaterals to both areas may be particu

156 uzumab moiety paired with affinity-modulated VH and VL regions of the anti-EGFR GA201 mAb were tested

157 Moreover, VH-V1a recognizes VEGF by using an unusual paratope cons

158 een January 2008 and January 2015 with a new VH secondary to PDR and treated with IVB were included.

159 , mean luminal area </=4 mm(2), noncalcified VH-defined thin-cap fibroatheroma).

160 93 [6.16-9.46]; P=0.02), and in noncalcified VH-defined thin-cap fibroatheroma (9.23 [7.33-11.44] ver

161 PSS was higher in noncalcified VH-defined thin-cap fibroatheroma compared with thick-ca

162 rehabilitation of patients with nonclearing VH after TS.

163 eyes that presented with a fundus-obscuring VH, defined as vision of 20/400 or worse and requiring a

164 Analysis of VH and VL germline back-mutants reveals binding to H3 an

165 ioxidant power (FRAP) and metal chelation of VH were comparable to those of NH.

166 Each cluster consists of VH, D, and JH segments and six to eight C domain exons.

167 VH) technology to investigate the effects of VH patients' demographic cues on dentists' pain manageme

168 Hence, this compartmentalized examination of VH sequences may pave the way toward a molecular classif

169 nts the first analysis, to our knowledge, of VH-restricted autoreactive B cells specifically expanded

170 st that the pathophysiological mechanisms of VH in PD may include a global loss of network efficiency

171 ibodies are derived from a limited number of VH/VL genes and can bind to and neutralize diverse HIV-1

172 The power of VH theta had only a weak correlation with locomotion vel

173 ntral brain regions, whereas the presence of VH is associated with a more global loss of connectivity

174 risk of PDR whereas 4Q DBH increases risk of VH.

175 is mouse model, we characterized the role of VH replacement in the diversification of the primary Ig

176 Although the nonrandom usage of VH genes is well documented, it is not clear what elemen

177 These factors reduce the use of VH-IVUS plaque classification to guide intervention in a

178 In group LIP/PROB, the mean values of VH and CD of the jejunum were significantly higher than

179 On VH-IVUS, plaque (10.91+/-4.82 versus 8.42+/-4.57 mm(2);

180 We detail clinical observations on VH in five macular degeneration patients treated with pr

181 ific antibody composed of 2 heavy-chain-only VH (VHH) binding domains against both TcdA and TcdB (des

182 and evaluation of a camelid heavy-chain-only VH domain (VHH)-based neutralizing agent (VNA) targeting

183 curs between the cryptic RSS of the original VH element and the conventional RSS of the invading VH g

184 up to five base pairs (bps) of the original VH gene that is often further obscured by exonuclease ac

185 matic hypermutations compared with all other VHs, a characteristic of secondary Ab repertoire diversi

186 Altogether, we analyzed paired VH and VL sequences of 1482 TG2-specific and 1421 non-TG

187 native antibody variable heavy-light pairs (VH-VL pairs) remains a major challenge, and no technolog

188 wet macular degeneration described patterned VHs that were induced or enhanced by oral proton pump in

189 ethods For this retrospective study, 15 PD + VH patients, 40 PD - VH patients, and 15 control partici

190 ents with VH (hereafter, referred to as PD + VH patients) and without VH (hereafter, referred to as P

191 racentral and occipital regions in both PD + VH and PD - VH patients (mean whole-brain functional con

192 In PD + VH patients, nine additional frontal, temporal, occipita

193 whole-brain functional connectivity in PD + VH vs PD - VH, 0.12 +/- 0.01 [standard deviation] vs 0.1

194 icipants (mean of these nine regions in PD + VH, PD - VH, and control 0.12 +/- 0.02, 0.14 +/- 0.03, a

195 spective study, 15 PD + VH patients, 40 PD - VH patients, and 15 control participants from a prospect

196 d occipital regions in both PD + VH and PD - VH patients (mean whole-brain functional connectivity in

197 d without VH (hereafter, referred to as PD - VH patients) and control participants.

198 (mean of these nine regions in PD + VH, PD - VH, and control 0.12 +/- 0.02, 0.14 +/- 0.03, and 0.16 +

199 n functional connectivity in PD + VH vs PD - VH, 0.12 +/- 0.01 [standard deviation] vs 0.14 +/- 0.03,

200 Postoperative VH was not uncommon after initial 23-gauge PPV for diabe

201 re undergoing PPV demonstrated postoperative VH (P = .002).

202 (32%) of 173 eyes demonstrated postoperative VH, categorized as early (8 eyes; 5%), delayed (13 eyes;

203 Other factors associated with postoperative VH included younger age (P = .022) and phakia (P = .036)

204 Preferred VH rearrangements among antigen-binding, naive B cells w

205 cific autoantibody repertoire with preferred VH:VL usage and pairings, limited mutations, clonal domi

206 After productive VH-DJH gene rearrangement, pre-B cell receptor signaling

207 lysed by Virgibacillus sp. SK37 proteinases (VH), Alcalase (AH) and Neutrase (NH) were investigated.

208 skewing toward the incorporation of proximal VH gene segments and a corresponding reduction in distal

209 Different plaque definitions further reduced VH-IVUS-defined thin-capped fibroatheromata numbers by 4

210 g) is effective in improving VA and reducing VH and CMT in eyes with noninfectious intermediate uveit

211 by interrogation of paired H chain V region (VH) and L chain V region (VL) sequences of individual an

212 immunoglobulin heavy chain variable region (VH) sequence for each clone.

213 red heavy- and light-chain variable regions (VH and VL, respectively) from large populations of singl

214 oglobulin (Ig) heavy chain variable regions (VH) from CSF and subsorted peripheral blood B-cell popul

215 CDR residue in heavy chain variable regions (VH), is important for humanization of mouse antibodies.

216 There is restricted VH and VL combination and usage among the antibodies.

217 relative to Abeta monomers, whereas the same VH domains with other polar CDR3 mutations recognize bot

218 nd contains a few rearranging gene segments (VH-D1-D2-JH) with one constant region, mu or omega.

219 natorial phage display, we screened selected VH genes paired with their corresponding VL library for

220 etermine what Igs ABCs express, we sequenced VH and Vkappa rearranged genes from unimmunized 22-mo-ol

221 g-expressing LP B-lineage cells have similar VH repertoires, but significantly different Vkappa reper

222 ibody Capture technology to isolate a single VH antibody domain that binds to LEDGF.

223 e its function, we created a panel of single-VH domain antibodies (VHHs) that recognize distinct epit

224 Although expression of some VH genes was similar in mouse and human (IGHV3-23, IGHV3

225 alyzed the transglutaminase 2 (TG2)-specific VH:VL autoantibody repertoire of celiac disease (CD) pat

226 pe-specific antibody responses with specific VH alleles, and it highlights the importance of germline

227 e plus MARsEmu) in the mouse genome to study VH gene repertoire and IgH expression in developing B-li

228 We constructed libraries of synthetic VH domains and isolated binders with moderate affinity f

229 We have previously demonstrated that VH replacement can efficiently rescue the development of

230 We find that VH expression and solubility are strongly enhanced by in

231 We find that VH-B1a can tolerate significant diversity within all thr

232 Our results indicate that VH replacement occurs before Ig light chain rearrangemen

233 Structural analysis revealed that VH-V1a binds to an epitope that is distinct from the epi

234 We show that VH gene repertoires and somatic hypermutation rates of a

235 These results show that VH replacement is regulated by BCR-mediated signaling in

236 These results suggest that VH-B1a and other autonomous VH domains may be useful sca

237 The VH sequence of this clone showed evidence of somatic mut

238 The VH-CH1-hinge domains of mAb2 are fused through a peptidi

239 , suggesting that they can also activate the VH-mPFC-amygdala pathway.

240 removing clashes between both the VL and the VH, and between the VL and CXCL13.

241 recisely positioned at the elbow between the VH and CH1 domains.

242 The linker between the VH and VL domains exhibits the dominant dynamical respon

243 at there is a linear correlation between the VH cystine concentration and TSD as the concentration of

244 y, in one donor the genomic DNA encoding the VH and CH1 domains was deleted, leading to the productio

245 We further examined the VH repertoire of Ag-specific memory B cells induced by i

246 sitive selection of somatic mutations in the VH CDR and altered VH CDR3 physicochemical properties.

247 any effects, stabilizing any CDR loop in the VH domain triggers a destabilizing response in all CDR l

248 are likely to stabilize all CDR loops in the VH domain, and, when these residues are not buried, the

249 tibodies, we identified key positions in the VH gene encoding CDR1, CDR2, and the immunoglobulin fram

250 n-specific as rats infused with TTX into the VH at PD32, or into the dorsal hippocampus at PD7, exhib

251 ibodies from immunized animals by mining the VH:VL paired antibody repertoire encoded by highly expan

252 A phage-display library consisting of the VH H region contained at least 10(6) individual transfor

253 dependent polypeptides, each composed of the VH of 1 antibody in tandem with the VL of the other anti

254 e show that the optogenetic silencing of the VH prevented the recall of contextual fear memory in mic

255 mutations and maintain the structure of the VH/VL interface.

256 rine protease that is able to cleave off the VH domain of IgG.

257 g a bulky residue at IMGT position 50 on the VH domain.

258 hat the Igh locus superanchor sequesters the VH and DHJH regions into a spatial confined geometric en

259 changes in QSFR quantities indicate that the VH domain is typically rigidified, whereas the VL domain

260 TS13 IgGs of both patients revealed that the VH gene use was limited in our patients to VH1-3 (55%),

261 Third, the VH repertoire of Lin28b-induced BM B1a B cells differs f

262 ld convey contextual information through the VH-mPFC and VH-amygdala pathways.

263 the Igh locus superanchor interacts with the VH region repertoire across vast genomic distances.

264 n of saline or tetrodotoxin (TTX) within the VH to transiently inactivate local circuitry and efferen

265 erse antigens by antibodies encoded by three VH gene segments.

266 e adult donors, we performed high-throughput VH sequencing of human B cell subsets defined by IgD and

267 CDRs) and also within framework 3, and thus, VH-B1a and the Fab are similar in terms of the regions o

268 plaque components with a similar accuracy to VH-IVUS ex vivo.

269 Similarly, 5-year progression to VH varied by baseline DR: no DR (1.1%), mild (2.9%), mod

270 Virtual-histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT) can asse

271 virtual histology intravascular ultrasound (VH-IVUS) can identify plaques at high risk of rupture, s

272 virtual histology intravascular ultrasound (VH-IVUS) in 108 plaques from 57 patients.

273 cts to generate approximately 518,000 unique VH and VL sequences from sorted naive and memory B cell

274 secondary rearrangement in which an upstream VH element recombines with a rearranged VHDHJH joint to

275 Cells whose antibodies use VH genes that encode a more flexible elbow are more like

276 melid (Lama pacos) heavy chain-only variable VH domain (VH H) libraries against antigens in total cel

277 acity of an autonomous heavy chain variable (VH) domain (VH-B1a) to support diversity within its anti

278 opment, immunoglobulin heavy-chain variable (VH), diversity (DH), and joining (JH) segments assemble

279 g antibody region: the heavy-chain variable (VH)-encoded "elbow" between variable and constant domain

280 pacts the 2-Mb region that encodes variable (VH) gene segments.

281 s of mutations acquired by a human variable (VH) domain that was evolved using strong selections for

282 generally positioned over each IgH variable (VH) coding segment, directly adjacent to the recombinati

283 sed V-to-DJ rearrangements and altered Vbeta/VH repertoire.

284 Inefficient Vbeta/VH recombination signal sequences (RSSs) have been hypot

285 Because Vbetas/VHs only recombine to DJ complexes, the Rag1(C/C) phenot

286 ology and compared with coregistered ex vivo VH-IVUS and OCT.

287 s, (ii) docking methodology to refine the VL-VH relative orientation and (iii) de novo prediction of

288 uently than JH locus distal D genes, whereas VH locus proximal D genes were observed more frequently

289 Treatment of cells with VH H B11 fused to the mCherry or green fluorescent prote

290 theroma (80% versus 79%) was comparable with VH-IVUS.

291 2) increases adhesion strength compared with VH, implying roles for both vinculin activation and the

292 ariability was determined by comparison with VH-IVUS core-laboratory analysis, and compared with gray

293 Experts agreed that complications with VH repair (VHR) increase in obese patients (grade A), cu

294 Experts agreed that complications with VH repair (VHR) increase in obese patients (grade A), cu

295 All 7 eyes with VH or ERM had improved vision postoperatively.

296 functional connectivity in PD patients with VH (hereafter, referred to as PD + VH patients) and with

297 ions have in the management of patients with VH secondary to PDR.

298 se Plaque Maps correlated significantly with VH-IVUS-determined plaque component volumes (necrotic co

299 and function are better among patients with VHs managed operatively.

300 referred to as PD + VH patients) and without VH (hereafter, referred to as PD - VH patients) and cont