ライフサイエンスコーパス: VLA-1

1 VLA-1 expression, by immunohistochemistry, was increased

2 e alpha1beta1 integrin, very late antigen-1 (VLA-1), is a collagen receptor expressed in many CD4+ T

3 Importantly, the activated VLA-1+ and VLA-1- cells can be isolated and maintained i

4 The alpha1beta1 (VLA-1) integrin is a cell-surface receptor for collagen

5 Importantly, the activated VLA-1+ and VLA-1- cells can be isolated and maintained in culture a

6 ve intraperitoneal injections of VEGFR-3 and VLA-1-neutralizing antibodies or their controls twice a

7 ar endothelial growth factor receptor-3) and VLA-1 (very late antigen-1) promotes high-risk transplan

8 act as rapid effectors upon reinfection, and VLA-1 expression is integral to their accumulation in th

9 red to controls whereas alpha(v) subunit and VLA-1 were increased.

10 Alpha(v) and VLA-1 on intercellular junctions may participate in re-e

11 ent to and on luminal surfaces; alpha(v) and VLA-1 were on intercellular junctions.

12 nificantly less at day 32 in rats given anti-VLA-1 (P = 0.002).

13 educed in glomeruli and interstitium in anti-VLA-1-treated animals (P = 0.0006).

14 In anti-VLA-1-treated rats, serum creatinine was significantly l

15 Anti-VLA-5 (CD49e) but not anti-VLA-1 through VLA-4 and VLA-6, blocked the effect of Fn

16 a receptors, whereas anti-VLA-6 but not anti-VLA-1 through VLA-5 blocked the effect of Ln on IL-1 bet

17 d in the glomeruli of rats treated with anti-VLA-1.

18 6 and alpha(v) were the same as controls but VLA-1 remained increased.

19 alpha(1)beta(1) and alpha(2)beta(1) (CD49a, VLA-1 and CD49b, VLA-2, respectively), on CD4 and CD8 T

20 aques persistently elevated endothelial cell VLA-1 correlates with long-standing endothelial cell and

21 etimes expressing CD69 but not CD25, HLA-DR, VLA-1, or effector cytokines.

22 proximately 1-4% of the CD4+ T cells express VLA-1, and following T cell receptor activation ex vivo,

23 n-specific respiratory CD8 T cells expressed VLA-1, a marker that is associated with heterologous inf

24 th a recall antigen, are highly enriched for VLA-1+ cells.

25 he collagen-binding alpha(1)beta(1) integrin VLA-1 is essential for the development of memory CD8(+)

26 The alpha 1 beta 1 integrin (VLA-1) is a major collagen/laminin receptor that regulat

27 t the collagen binding alpha1beta1 integrin, VLA-1, is expressed by the majority of influenza-specifi

28 By immunoelectron microscopy VLA-1, VLA-6, beta1, and laminin were distributed throug

29 Moreover, VLA-1 gene depletion led to a marked inhibition of lymph

30 est the effect of systemic administration of VLA-1-neutralizing antibody on lymphatic formation and m

31 Antibody treatment or genetic deficiency of VLA-1 decreased virus-specific CTL in the lung and other

32 ure system was used to examine the effect of VLA-1 gene depletion on lymphatic endothelial cell funct

33 ing T cell activation favor the emergence of VLA-1+ cells.

34 Here we show that the expression of VLA-1 is a stable marker of a distinct subset of CD4+ me

35 Moreover, depletion of the small fraction of VLA-1+ cells present in CD4+ PBLs prior to stimulation s

36 lomerulonephritis and that neutralization of VLA-1, which enhanced expression of matrix metalloprotei

37 ceptor activation ex vivo, the percentage of VLA-1+ cells increases within the CD45RO+ population.

38 We investigated the role of VLA-1 on virus-specific CD4(+) T cells during and after

39 alpha-chain of the type IV collagen receptor VLA-1, and these cells were highly activated, producing

40 These data suggest VLA-1 expression defines a population of tissue memory C

41 We conclude that VLA-1 mediates both glomerular and interstitial fibrosis

42 These novel findings together indicate that VLA-1 is critically involved in the processes of lymphan

43 This suggests that VLA-1 is responsible for retaining protective memory CD8

44 data demonstrated, for the first time, that VLA-1 blockade significantly suppressed corneal lymphang

45 We propose that TNFR-II and the VLA-1 synergize to protect effector CD8 T cells in the i

46 Notably, the VLA-1+ cells in fresh CD4+ PBLs are composed of resting

47 Interestingly, this VLA-1+ subset is enriched for Th1-type cells, and Th1-po

48 Thus, VLA-1 expression is a stable marker of a unique subset o

49 s and rats were given monoclonal antibody to VLA-1 (Ha31/8), 2.5 mg/kg, on alternate days.

50 e have examined the effect of an antibody to VLA-1 in crescentic glomerulonephritis.