ライフサイエンスコーパス: VSIV

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1 VSIV-GNJ could infect cells at acidic pHs, while the inf

2 VSIV-GNJ infection was also more sensitive to inhibition

3 phenotype by site-directed mutagenesis of a VSIV-GI full-length cDNA and analysis of the recovered e

4 ure at pH 6.8 resulted in the selection of a VSIV-GI variant (VSIV-6.8) that was similar to VSIV-GNJ

5 ferences in pathogenesis between VSIV-GI and VSIV-GNJ.

6 In mice, VSIV-G(NJ) and VSIV-G(NJ)G(I) were attenuated.

7 Neutralization of infectivity by anti-VSIV G antibodies and inhibition of entry by ammonium ch

8 d to the differences in pathogenesis between VSIV-GI and VSIV-GNJ.

9 IV (VSIV-G(I)), VSNJV (VSIV-G(NJ)), or both (VSIV-G(NJ)G(I)), according to the glycoprotein(s) they e

10 were neutralized by antibodies specific for VSIV (VSIV-G(I)), VSNJV (VSIV-G(NJ)), or both (VSIV-G(NJ

11 ined either (i) one copy of the VSIV G gene (VSIV-G(I)); (ii) two copies of the G gene, one from each

12 of the G(NJ) gene instead of the G(I) gene (VSIV-G(NJ)).

13 f vesicular stomatitis virus (VSV), Indiana (VSIV) and New Jersey (VSNJV).

14 In mice, VSIV-G(NJ) and VSIV-G(NJ)G(I) were attenuated.

15 A further adaptation of VSIV-6.8 to pHs 6.6 and 6.4 resulted in additional amino

16 Sequence analysis of VSIV-6.8 revealed that it had a single amino acid substi

17 el approaches to the rational attenuation of VSIV NV while retaining vector immunogenicity and have l

18 ells at acidic pHs, while the infectivity of VSIV-GI was severely reduced.

19 J gene was more pathogenic than the parental VSIV-GI virus in swine, a natural host (26).

20 We recovered recombinant VSIVs from engineered cDNAs that contained either (i) on

21 opies of the G gene, one from each serotype (VSIV-G(NJ)G(I)); or (iii) a single copy of the G(NJ) gen

22 glycoprotein gene from the Indiana serotype (VSIV-GI) or the heterologous glycoprotein gene from the

23 coprotein gene from the New Jersey serotype (VSIV-GNJ).

24 As that contained either (i) one copy of the VSIV G gene (VSIV-G(I)); (ii) two copies of the G gene,

25 in the N and L genes, and by deletion of the VSIV G gene to generate a replicon that is dependent on

26 We applied selective pressure to VSIV-GI by growing it at successively lower pH values an

27 red for entry into the host cell, similar to VSIV virions.

28 IV-GI variant (VSIV-6.8) that was similar to VSIV-GNJ regarding its pH- and ammonium chloride-depende

29 tion in neuropathology compared to wild-type VSIV and the prototypic rVSIV vaccine vector.

30 ulted in the selection of a VSIV-GI variant (VSIV-6.8) that was similar to VSIV-GNJ regarding its pH-

31 g of the vesicular stomatitis Indiana virus (VSIV) G protein ecto- and transmembrane domains coupled

32 ed to higher titers than the parental virus, VSIV-G(I).

33 neutralized by antibodies specific for VSIV (VSIV-G(I)), VSNJV (VSIV-G(NJ)), or both (VSIV-G(NJ)G(I))

34 bodies specific for VSIV (VSIV-G(I)), VSNJV (VSIV-G(NJ)), or both (VSIV-G(NJ)G(I)), according to the

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