ライフサイエンスコーパス: Vd

1 Vd/Vt is predictable from clinically available data.

2 Vd/Vt was calculated using the Enghoff modification of t

3 core, 13 +/- 3.4 vs. 7.7 +/- 0.8; p = .006) (Vd/Vt, 0.68 +/- 0.07 vs. 0.58 +/- 0.07; p = .009) (EVLWp

4 albumin = 25 g/day + (albumin 1 - albumin 2)(Vd)/days, where albumin 1 and 2 are the serum albumin co

5 of 22.8 hours (range, 24.1 to 30.6 hours), a Vd of 9.4 L (range, 4.4 to 19.5 L), and a CL of 0.32 L/h

6 Body weight also affected Vd(ss) (0.1 l increase of Vd(ss) per kilogram above medi

7 nces were significant when Vc > or = 50% and Vd was compared with Va and Vb (P < 0.05).

8 fferences between Va and Vb and Vc > 50% and Vd were significant (P < 0.05).

9 ttle or no avoidance, strikingly, the Dm and Vd were not engaged, despite similar levels of activatio

10 Total clearance was 9.43 mL/h and Vd(ss) was 9.61 l.

11 urs, CL/F (apparent clearance) 28.9 L/h, and Vd/F (apparent volume) 274 L.

12 l nucleus of the ventral telencephalic area (Vd), the teleost anatomical homologs of the mammalian am

13 max, volume of distribution/bioavailability (Vd/F), and elimination half-life (t(1/2)) were not diffe

14 ve undertaken a comparative study of six (D, Vd, Vv, Dm, Dl, Ppa) periventricular zones (PVZs) harbor

15 equation for Vd/Vt using the clinical data: Vd/Vt = 0.32 + 0.0106 (Paco2 - ETCO2) + 0.003 (RR) + 0.0

16 median and minimum values for model-derived Vd were 6.3, 3.7 and 2.11, respectively.

17 , mean half-life and volume of distribution (Vd) in women were 15 days and 72 mL/kg, respectively, af

18 .0 to 80.0 hours), a volume of distribution (Vd) of 10.9 L (range, 3.1 to 34.5 L), and a clearance (C

19 imes increase in the volume of distribution (Vd).

20 eristic curve analysis indicated that EVLWp, Vd/Vt, and extravascular lung water (p = .0005, .009, an

21 rrection for partial volume effect, [11C]FMZ Vd in the body of the epileptogenic hippocampus was redu

22 of [11C]FMZ volume of distribution ([11C]FMZ Vd) obtained in 10 patients with refractory mTLE due to

23 in the [11C]FMZ volume of distribution (FMZ-Vd) before and after correction for partial volume effec

24 cant bilateral reductions of hippocampal FMZ-Vd were detected.

25 s on MRI showed unilateral reductions of FMZ-Vd concordant with the side of the EEG focus.

26 lerosis showed significant reductions of FMZ-Vd in the hippocampus contralateral to the side of the E

27 ts, significant unilateral reductions of FMZ-Vd were found in one of the three patients with bilatera

28 owed significant bilateral reductions of FMZ-Vd, and these were asymmetrical in two.

29 used to construct a predictive equation for Vd/Vt using the clinical data: Vd/Vt = 0.32 + 0.0106 (Pa

30 ent score, dead space-tidal volume fraction (Vd/Vt), and EVLWp were all significantly higher on day 1

31 rmacokinetic profile (F, 82%; t(1/2), 5.6 h; Vd, 0.694 L/kg) with good drug penetration in target tis

32 High Vd/Vt was the most consistent gas exchange abnormality i

33 There was no difference in Vd/Vt or other physiological outcomes.

34 Newborn single-dose half-life, Vd, and clearance were 30 days, 143 mL/kg, and 4 mL/kg/d

35 ight also affected Vd(ss) (0.1 l increase of Vd(ss) per kilogram above median of 75 kg).

36 , which were designated as Pas1c1-Vc, Pas1c1-Vd, and Pas1c1-Ve, respectively.

37 text]co2, dead space to tidal volume ratio (Vd/Vt), and arterial to end-tidal CO2 difference were al

38 iate regions and part of the ventral region, Vd/Vc/Vi, and Vv) expressed high levels of AptCB1R trans

39 the serum sampling intervals, respectively; Vd is the volume of distribution (L); and days relates t

40 Failure Assessment score, lung injury score, Vd/Vt, and PaO2/FIO2.

41 primary end point was pulmonary dead space (Vd/Vt) at 6 hours after esophagectomy or before extubati

42 The volume of distribution at steady-state (Vd(ss)) was 700 L/m2 and the clearance was 300 mL/min/m2

43 and volume of distribution at steady-state (Vd(ss)) were investigated.

44 Within all subjects, Vd/Vt correlated with the [Formula: see text]e/[Formula:

45 1 ng/mL, the Vd was 3.97 +/- 0.95 L, and the Vd/kg was 0.05 +/- 0.01 L/kg.

46 hours, the Cmax was 2,549 +/- 291 ng/mL, the Vd was 3.97 +/- 0.95 L, and the Vd/kg was 0.05 +/- 0.01

47 rst characterization of an F. nucleatum Type Vd phospholipase class A1 autotransporter (strain ATCC 2

48 ct, track, and characterize the role of Type Vd secreted phospholipases in Gram-negative bacteria.

49 Whereas the role of Type Vd secretion in bacteria remains unidentified, we show t

50 , and lateral nucleus of the area ventralis [Vd, Vv, Vc, and Vl, respectively]), as well as preoptic

51 partment 1, the initial distribution volume (Vd) of the antibody, which included serum.

52 (kloss); and the tracer distribution volume (Vd), which is an index of dopamine storage capacity.

53 regional injuries: equation [see text] where Vd is the volume of lung irradiated to dose d, and Rd is

54 sed diffuse endocapillary proliferation, WHO Vd).

55 Relative to acute withdrawal, Vd significantly decreased in the right ventral and dors

56 nalysis of the binding potential [Bmax/(Kd x Vd)] using the assumption of equal partition coefficient