ライフサイエンスコーパス: WD40 repeat

1 a dominant-negative form containing only the WD40 repeats.

2 kDa protein named PAFAH1B1 containing seven WD40 repeats.

3 , and six tandemly arranged carboxy-terminal WD40 repeats.

4 protein of 341 amino acid residues with four WD40 repeats.

5 rotein (HELP) motif and a variable number of WD40 repeats.

6 itin hydrolase) that interact with the F-box/WD40 repeats.

7 a family of conserved proteins with multiple WD40 repeats.

8 paf-1 through specific interactions with the WD40 repeats.

9 ted factors (DCAFs), including 14 containing WD40 repeats.

10 ino acids and a protein with multiple G-beta WD40 repeats.

11 nly one significant alteration in the WDR36 (WD40-repeat 36) gene.

12 nd subsequent degradation and that Cdt2 is a WD40 repeat adaptor protein for Cullin-4-based ubiquitin

13 FANCL, which possesses three WD40 repeats and a plant homeodomain (PHD), is the putat

14 ients, we confirm the importance of specific WD40 repeats and a putative microtubule-binding domain f

15 SEL-10 bound Notch4 via the WD40 repeats and bound preferentially to a phosphorylate

16 a novel mouse protein, Bop1, which contains WD40 repeats and is highly conserved through evolution.

17 inase (MEKKalpha) that contains an F-box and WD40 repeats and plays a complex role in regulating cell

18 family of proteins that contain an F-box and WD40 repeats and that target specific proteins for degra

19 patients result in truncated protein lacking WD40-repeats and the SH3 domain; disease was hitherto at

20 ACK1-RACK1 dimer-binding site within the 4th WD40 repeat, and application of the 4th WD40 repeat or a

21 in includes putative GTPase, protein kinase, WD40 repeat, and leucine-rich repeat (LRR) domains of un

22 t regions, which do not contain recognizable WD40 repeats, are required for the ability of TRIP-1 to

23 TRAF7 also contains seven WD40 repeats at its C terminus.

24 mediates UV-B-dependent interaction with the WD40 repeats-based predicted beta-propeller domain of CO

25 WD40-repeat beta-propellers are found in a wide range of

26 gene and its mouse homologue contain several WD40 repeats, but lack homology to known proteins.

27 studies, and enzyme assays, we find that the WD40 repeats confer a salt-sensitive second-site binding

28 ll of which disrupt one or more of the seven WD40 repeats contained in the LIS1 protein.

29 The WD40 repeats containing zinc finger protein 106 (ZFP106)

30 We identified WDR20, a WD40-repeat containing protein, as a common binding part

31 of the pathway, FANCD2, is activated by the WD40-repeat containing UAF1 protein through formation of

32 We termed this gene WDR14 (WD40 repeat-containing gene deleted in VCFS).

33 WDR62 is a WD40 repeat-containing protein expressed in neuronal pre

34 WDR34 encodes a WD40 repeat-containing protein orthologous to Chlamydomo

35 rotein TRIP-1 was originally identified as a WD40 repeat-containing protein that has the ability to a

36 rated that Ubp15 physically interacts with a WD40 repeat-containing protein, Cdh1, by copurification

37 WDR48, a WD40 repeat-containing protein, interacts with USP12 and

38 is study, we identified a novel murine F-box/WD40 repeat-containing protein, mHOS (a homologue of HOS

39 nal co-repressors Sin3, Pst1 and Pst2, and a WD40 repeat-containing protein, Prw1.

40 cells containing stoichiometric amounts of a WD40 repeat-containing protein, USP1 associated factor 1

41 e other DUBs that specifically interact with WD40 repeat-containing proteins, Cdh1 does not function

42 The corresponding cDNAs encoded two WD40 repeat-containing proteins, Grg2 and Grg6.

43 sel-10 encodes a WD40-repeat-containing F-box protein that likely mediate

44 king FbxA/ChtA, a previously described F-box/WD40-repeat-containing protein, suggesting CulA and FbxA

45 function as scaffolds that, along with F-box/WD40-repeat-containing proteins, mediate the ubiquitinat

46 ein 1, DDB1, bridges an estimated 90 or more WD40 repeats (DDB1-binding WD40, or DWD proteins) to the

47 rtical region of the cell, whereas the F-box/WD40 repeats direct ubiquitin-mediated MEKKalpha degrada

48 s characterized by a RING-finger motif and a WD40 repeat domain [1].

49 nger followed by a coiled-coil domain, and a WD40 repeat domain at the C-terminus.

50 AgtA possesses a WD40 repeat domain C-terminal to its single catalytic do

51 with and inhibited substrate binding to the WD40 repeat domain of Cdh1.

52 d domain that associates with the C-terminal WD40 repeat domain of KOG1.

53 east to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interac

54 rea of the ss-propeller assembly of the COP1 WD40 repeat domain through both hydrophobic and ionic in

55 otein containing a leucine-rich repeat and a WD40 repeat domain, interacts with the origin replicatio

56 We report that the conserved WD40 repeat domain-containing cartwheel protein Poc1 is

57 a highly conserved, leucine-rich repeats and WD40 repeat domain-containing protein 1 (LRWD1) or ORC-a

58 Here we characterized the WD40 repeat domain-mediated interactions of COP1 with HY

59 0A also alters the ability of the C-terminal WD40-repeat domain of ATG16L1 to interact with an amino

60 description of the architecture of its WD40 (WD40 repeat) domain (Apc1(WD40)).

61 t the region that codes the highly conserved WD40 repeat domains and the C-terminal region of the pro

62 gy to several eukaryotic proteins containing WD40 repeat domains, which commonly have beta-propeller

63 the F-box-containing leucine-rich repeat and WD40 repeat families, but not for the suppressor of cyto

64 more N-terminal missense mutation impairing WD40-repeat formation.

65 r, the PCAF complex has a novel subunit with WD40 repeats having a similarity to hTAF(II)100.

66 uitination and degradation through the F-box/WD40 repeats in a cell-type-specific and temporally regu

67 These results indicate that the WD40 repeats in Elp2 are required neither for subunit-su

68 Our analysis defines the requirement for the WD40 repeats in preserving TFIID and SAGA function, demo

69 The presence of 16 WD40 repeats in the carboxyl terminus of the TEP1 protei

70 are evolutionarily conserved proteins with 5 WD40 repeats in the middle portion of the protein, and a

71 ypeptide of 370 amino acids containing seven WD40 repeats, is highly homologous to proteins of unknow

72 urally similar to Gbeta, each exhibiting the WD40 repeat motif.

73 codes a novel 67-kDa protein containing nine WD40 repeats, motifs that mediate protein-protein intera

74 s a 1749-residue protein that contains seven WD40 repeats near the amino terminus and a putative nucl

75 between Dronc-CARD and both the CARD and the WD40 repeats of a nearby Dark protomer are indispensable

76 WD40 repeats of Cdc20, Cdh1, and Cdc16 and tetratricopep

77 Mutations T1031A and T1040C in one of the WD40 repeats of Eed, which account for the hypomorphic a

78 Here, we demonstrate that the WD40 repeats of FANCL are required for interaction with

79 An amino acid substitution in the WD40 repeats of RFWD3 (I639K) found in a new FA subtype

80 present in effector proteins, as well as the WD40 repeats of WDR5, reveals critical contacts between

81 4th WD40 repeat, and application of the 4th WD40 repeat or a peptide derivative to hippocampal slice

82 We have generated an allelic series for WD40 repeat protein 1 (Wdr1), the mammalian homolog of A

83 We identify the WD40 repeat protein Caf4p as a Fis1p-associated protein

84 pac1 encodes a WD40 repeat protein closely related to anthocyanin regul

85 Here, we reveal that WDR26, a member of the WD40 repeat protein family, directly bound free Gbetagam

86 We have cloned and characterized a WD40 repeat protein gene from Medicago truncatula (MtWD4

87 The WD40 repeat protein Mdv1/Net2 promotes cell death, consi

88 1313-1318) demonstrate that the WD40 repeat protein p55 binds a structured region of H4

89 he function of Arabidopsis thaliana NEDD1, a WD40 repeat protein related to the animal NEDD1/GCP-WD p

90 We show here that the F-box/WD40 repeat protein SEL-10 negatively regulates Notch re

91 ritical region (DGCR) at 22q11 and encodes a WD40 repeat protein similar to yeast Hir1p and Hir2p.

92 We have recently identified WDR26 as a novel WD40 repeat protein that binds Gbetagamma and promotes G

93 Actin-interacting protein 1 (AIP1) is a WD40 repeat protein that enhances actin filament disasse

94 in Drosophila C/D scaRNAs, we purified a fly WD40 repeat protein that UV crosslinks to RNA in a C/D C

95 We previously identified the WD40 repeat protein WDR-23 as a repressor of Caenorhabdi

96 umulation, and activity are repressed by the WD40 repeat protein WDR-23, which interacts with the CUL

97 on: the importin beta homolog Kap122 and the WD40 repeat protein Wtm1.

98 he other encodes a truncated form of a novel WD40 repeat protein, named Bopl, which is conserved from

99 p55, a predicted WD40 repeat protein, recognizes the first helix of histo

100 previously reported the identification of a WD40 repeat protein, STRAP, that associates with both ty

101 of bHLH and MYB transcription factors, and a WD40 repeat protein, TRANSPARENT TESTA GLABRA1 (TTG1), a

102 p36 is a WD40 repeat protein, which is 46% identical to the p39 s

103 Furthermore, Hat2p is a WD40 repeat protein, which is found in many histone modi

104 component: Fizzy-related/Hec1/Cdh1 (Fzr), a WD40 repeat protein.

105 er, sequence analysis indicates that it is a WD40 repeat protein.

106 We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb

107 r results are the first demonstration that a WD40-repeat protein acts as a module for recognition of

108 The WD40-repeat protein DDB2 is essential for efficient reco

109 NLE1 is a member of the large WD40-repeat protein family, and is thought to signal via

110 Slimb, an F-box/WD40-repeat protein functioning in the ubiquitin-proteas

111 GAG3 encodes a novel WD40-repeat protein previously found to interact with Dn

112 The slimb gene encodes a conserved F-box/WD40-repeat protein related to Cdc4p, a protein in buddi

113 in LST8, an essential gene encoding a seven WD40-repeat protein required for targeting of amino acid

114 r NCoR, histone deacetylase 3 (HDAC3), and a WD40-repeat protein TBL1.

115 ecifically recognized by beta-Trcp, an F-box/WD40-repeat protein that also associates with Skp1, an e

116 also depends on its interaction with WDR5, a WD40-repeat protein that exists as part of several chrom

117 lation factor subunit-2 (PFS-2), a conserved WD40-repeat protein that interacts with multiple subcomp

118 hSet1 H3 K4 methyltransferase complexes, the WD40-repeat protein WDR5, directly associates with histo

119 romatin also depends on interaction with the WD40-repeat protein WDR5.

120 tin (Ub) ligase complex containing the F-box/WD40-repeat protein, beta-TrCP, a vertebrate homolog of

121 However, how the WD40 repeat proteins facilitate enzymatic activities of

122 WD40 repeat proteins have been shown to bind the histone

123 ons within each clade have led to additional WD40 repeat proteins in particular species, with all mut

124 findings have several implications: 1) that WD40 repeat proteins may interact with each other; 2) th

125 lear autoantigen (SG2NA), are highly related WD40 repeat proteins of previously unknown function and

126 WD40 repeat proteins regulate biosynthesis of anthocyani

127 urther show, in contrast with COP1, that the WD40 repeat proteins REPRESSOR OF UV-B PHOTOMORPHOGENESI

128 These data demonstrate that WD40 repeat proteins use various surfaces to direct the

129 e Gbeta subunit belongs to a large family of WD40 repeat proteins with a circular beta-bladed propell

130 nd bHLH transcription factors, stabilized by WD40 repeat proteins, regulates gene transcription for p

131 s to build a phylogenetic tree of homologous WD40 repeat proteins, revealing an ancestral gene duplic

132 rating a diversity of histone recognition by WD40 repeat proteins.

133 t CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DT

134 d WDR1 protein has high sequence identity to WD40-repeat proteins in budding yeast (Saccharomyces cer

135 member of a previously undescribed family of WD40-repeat proteins that we demonstrate binds 3-phospho

136 Recently, two highly conserved WD40-repeat proteins, Cdc20 and Cdh1/Hct1, have been ide

137 analysis, we then identify a novel family of WD40-repeat proteins, which directly bind to the double-

138 MSI1 belongs to a family of histone binding WD40-repeat proteins.

139 study of histone binding by chromodomain and WD40-repeat proteins.

140 he C-terminal, two proline-rich regions, one WD40 repeat region and one suppressor of cytokines signa

141 phosphorylated degron motif of TRIM9 and the WD40 repeat region of beta-TrCP prevented beta-TrCP from

142 iled coil for dimerization, and a C-terminal WD40 repeat region that binds Dnm1.

143 o acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1

144 ession of MEKKalpha or MEKKalpha lacking the WD40 repeats results in very delayed development and a s

145 ta-catenin was direct and dependent upon the WD40 repeat sequences in beta-TrCP and on phosphorylatio

146 We show that the WD40 repeats target MEKKalpha to the cortical region of

147 n, with most clustering within the conserved WD40 repeats; thus, the C terminus of TAF90p is required

148 Yeast homologue with 5 WD40 repeats, Trm82, is the non-catalytic subunit of a t

149 1 on RACK1 using peptides encoding the seven WD40 repeat units of human RACK1.

150 The family of WD40-repeat (WDR) proteins is one of the largest in euka

151 The WD40-repeat (WDR) proteins WDR20 and WDR48/UAF1 have bee

152 p80 is a novel protein containing WD40 repeats, which are frequently involved in protein-p