ライフサイエンスコーパス: WEEV

1 WEEV is an important cause of viral encephalitis in huma

2 lting in 10-fold improvement in potency in a WEEV replicon assay and up to 40-fold increases in half-

3 mmune CD-1 mice conferred protection against WEEV challenge, indicating that antibody is sufficient f

4 The recombination allowed WEEV to acquire capsid protein functioning in transcript

5 VEEV and WEEV are mosquito-borne viruses causing sporadic epidemi

6 ntranasal (i.n.) route, showed that VEEV and WEEV enter the brain through olfactory sensory neurons (

7 Histological examination supported VEEV and WEEV entering the brain of mice at specific sites where

8 inescent and fluorescent markers of VEEV and WEEV replication and infection.

9 op CNS disease after infection with VEEV and WEEV.

10 he earliest signs of infection with VEEV and WEEV.

11 estern equine encephalitis viruses (VEEV and WEEV; Alphavirus; Togaviridae) are mosquito-borne pathog

12 3 function enhanced virus-mediated injury by WEEV and the unrelated flavivirus St.

13 3 function enhanced virus-mediated injury by WEEV and the unrelated flavivirus St. Louis encephalitis

14 HIV vectors pseudotyped by WEEV GP may be a useful tool for characterizing WEEV cel

15 V GP may be a useful tool for characterizing WEEV cell binding and entry and screening for small-mole

16 Immunization with the CLNC-WEEV E1ecto mixture (lipid-antigen-nucleic acid complexe

17 BLM imaging detected WEEV and VEEV at 12 h postinoculation (hpi) at the injec

18 ging supported our BLM findings by detecting WEEV in the CVOs prior to spreading along the neuronal a

19 The estimated WEEV population size dropped in the 1990s, with only the

20 BLM from WEEV.McM-fLUC and VEEV.3908-fLUC injections was initiall

21 Sera from WEEV-infected mice specifically neutralized these pseudo

22 e encephalitis virus envelope glycoproteins (WEEV GP) to pseudotype lentiviral vectors.

23 ion to spreading via mosquito vectors, human WEEV infections can potentially occur directly via aeros

24 Thus, to image WEEV and other BSL-3 agents, we have constructed a first

25 nts, it has not been possible to investigate WEEV's structure or assembly mechanism using standard st

26 eased survival of CD-1 mice following lethal WEEV infection.

27 sulted in the increased genetic diversity of WEEV in North America, followed by genetic constriction

28 acid complexes (CLNCs) and the ectodomain of WEEV E1 protein (E1ecto).

29 Understanding the evolution of WEEV over the past century provides a unique opportunity

30 nformation exists regarding the evolution of WEEV, we analyzed 33 complete genome sequences and condu

31 nformation exists regarding the evolution of WEEV, we analyzed the genomic sequences of 33 low-passag

32 cryoEM images of WEEV were used to determine the first three-dimensional

33 Surprisingly, the nucleocapsid of WEEV, a New World virus, is more similar to the Old Worl

34 The overall organization of WEEV is similar to those of other alphaviruses, consiste

35 The titers of WEEV GP-pseudotyped human immunodeficiency virus type 1

36 In this study, we injected VEEV or WEEV, engineered to express bioluminescent or fluorescen

37 injected the mouse footpad with recombinant WEEV (McMillan) or VEEV (subtype IC strain 3908) express

38 ially controlled by IRF-3-dependent signals, WEEV also disrupted antiviral responses by inhibiting pa

39 We found that WEEV activated IRF-3-mediated neuronal innate immune pat

40 We found that WEEV activated IRF-3-mediated neuronal innate immune pat

41 Our results indicated that WEEV is a highly conserved alphavirus with only approxim

42 Both the WEEV replicon and combination V/W/E vaccination, however

43 This antagonist activity was mapped to the WEEV capsid gene, which disrupted signal transduction do

44 er, elicited poor neutralizing antibodies to WEEV in macaques, and the protection conferred was not a

45 rve as a useful model of aerosol exposure to WEEV for the evaluation of potential vaccine candidates.

46 subcutaneous or aerosol challenge with VEEV, WEEV, or EEEV was demonstrated out to 12 months after va

47 ue to its aerosol infectivity and virulence, WEEV is thus classified as a biological safety level 3 (

48 Western equine encephalitis virus (WEEV) and eastern equine encephalitis virus (EEEV), two

49 h include western equine encephalitis virus (WEEV) and Fort Morgan virus, are mosquito-borne pathogen

50 EEV), and western equine encephalitis virus (WEEV) are arthropod-borne positive-strand RNA viruses th

51 mation of western equine encephalitis virus (WEEV) from SINV- and EEEV-like ancestors.

52 Western equine encephalitis virus (WEEV) has caused several epidemics that resulted in the

53 s such as western equine encephalitis virus (WEEV) in cultured cells.

54 Western equine encephalitis virus (WEEV) is an arbovirus from the genus Alphavirus, family

55 s (VEEV), western equine encephalitis virus (WEEV), and eastern equine encephalitis virus (EEEV).

56 s (VEEV), western equine encephalitis virus (WEEV), or eastern equine encephalitis virus (EEEV) when

57 lphavirus western equine encephalitis virus (WEEV).

58 strain of western equine encephalitis virus (WEEV).

59 Western equine encephalitis virus (WEEV; Togaviridae, Alphavirus) is an enveloped RNA virus

60 s [EEEV], Western equine encephalitis virus [WEEV], Venezuelan equine encephalitis virus [VEEV], and

61 ided 100% protection in mice challenged with WEEV subcutaneously, intranasally, or via mosquito.

62 Mice were also injected in the footpad with WEEV.McM expressing DsRed (Discosoma sp.) and imaged by