ライフサイエンスコーパス: Warburg effect

1 profound effect on aerobic glycolysis (the 'Warburg effect').

2 metabolism (a cancer phenomenon termed the 'Warburg effect').

3 arity to the glycolytic phenotype in cancer (Warburg effect).

4 ism and is up-regulated in cancer cells (the Warburg Effect).

5 e of ATP to fuel cellular proliferation (the Warburg effect).

6 3 and induction of the glycolytic phenotype (Warburg effect).

7 te despite abundant oxygen availability (the Warburg effect).

8 ion due, in part, to respiration injury (the Warburg effect).

9 olytic enzymes and glucose transporters (the Warburg effect).

10 the pathways classically associated with the Warburg effect.

11 n to generate ATP, a phenomenon known as the Warburg effect.

12 tions and therefore do not fully explain the Warburg effect.

13 gely abolishes mutp53 GOF in stimulating the Warburg effect.

14 imiting glycolytic enzyme known to cause the Warburg effect.

15 s a new molecular player contributing to the Warburg effect.

16 in cancer cells, commonly referred to as the Warburg effect.

17 ential use of glucose, which is known as the Warburg effect.

18 tures of tumor cells: glutaminolysis and the Warburg effect.

19 that p53 status is a key determinant of the Warburg effect.

20 oA in the presence of oxygen is known as the Warburg effect.

21 udy of tumor metabolism above and beyond the Warburg effect.

22 iferating cancer cells and contribute to the Warburg effect.

23 ruvate kinase M2 (PKM2) is essential for the Warburg effect.

24 tion of cancerous colonocytes undergoing the Warburg effect.

25 ation in the cell, a phenomenon known as the Warburg effect.

26 es mitochondrial respiration, leading to the Warburg effect.

27 der aerobic conditions characteristic of the Warburg effect.

28 CEFs (Ski-CEFs) do not display the classical Warburg effect.

29 is abundant, a phenomenon referred to as the Warburg effect.

30 lysis for ATP production, referred to as the Warburg effect.

31 ing oxygen consumption, thereby inducing the Warburg effect.

32 erobic glycolysis, a phenomenon known as the Warburg effect.

33 abolism to aerobic glycolysis, the so-called Warburg effect.

34 increase in aerobic glycolysis known as the Warburg effect.

35 ten develop an acidic environment due to the Warburg effect.

36 s glucose uptake and aerobic glycolysis; the Warburg effect.

37 terns of expression were consistent with the Warburg effect.

38 intellectual disability, apoptosis, and the Warburg effect.

39 mmHg, ATP levels rapidly decrease due to the Warburg effect.

40 oxia can explain some characteristics of the Warburg effect.

41 eir energy supply, a phenomenon known as the Warburg effect.

42 ysis, a phenomenon known historically as the Warburg effect.

43 phenomenon that is historically known as the Warburg effect.

44 r 70 years ago and known historically as the Warburg effect.

45 toward aerobic glycolysis, also known as the Warburg effect.

46 the lactate produced by cancer cells in the Warburg effect.

47 ize the potential benefit from targeting the Warburg effect.

48 rosine phosphorylation and gives rise to the Warburg effect.

49 metabolic requirement, a phenomenon known as Warburg effect.

50 on to aerobic glycolysis, referred to as the Warburg effect.

51 vide new insights into the regulation of the Warburg effect.

52 presented by a glycolytic shift known as the Warburg effect.

53 gulate non-cell-cycle functions, such as the Warburg effect.

54 s the glycolytic adaptation described as the Warburg Effect.

55 similar metabolic alterations, including the Warburg effect.

56 utrients for biomass production known as the Warburg effect.

57 as an increased glycolytic rate known as the Warburg effect.

58 ropensity of AKT to modulate elements of the Warburg effect.

59 se M2 isoform (PKM2), a key regulator of the Warburg effect.

60 ert to regulate PDC activity and promote the Warburg effect.

61 ion, activation of the PI3K pathway, and the Warburg effect.

62 ert to regulate PDC activity and promote the Warburg effect.

63 ess, enabling non-invasive monitoring of the Warburg effect.

64 ase in aerobic glycolysis, also known as the Warburg effect.

65 ll of origin, thereby inhibiting a potential Warburg effect.

66 lar composition of PDC and contribute to the Warburg effect.

67 aerobic glycolysis, a phenomenon termed the Warburg effect.

68 onditions, a hallmark of cancer known as the Warburg effect.

69 it a glycolytic phenotype reminiscent of the Warburg effect.

70 f mitochondrial function and is known as the Warburg effect.

71 energy production, a phenomenon known as the Warburg effect.

72 tp53 GOF and a mechanism for controlling the Warburg effect.

73 tic state of aerobic glycolysis known as the Warburg effect.

74 ryos transiently exhibit aerobic glycolysis (Warburg effect), a metabolic adaptation also observed in

75 The Warburg effect, a common metabolic alteration of most tu

76 The Warburg effect adapts cells to tumor environments and is

77 We propose that KSHV induction of the Warburg effect adapts infected cells to tumor microenvir

78 ealing how CD44 could be a gatekeeper of the Warburg effect (aerobic glycolysis) in cancer cells and

79 h HIF-1alpha and N-Myc are essential for the Warburg effect (aerobic glycolysis) in neuroblastomas by

80 aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient wa

81 er normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly corre

82 IF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metab

83 mor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis.

84 h cancer-specific splicing that promotes the Warburg effect and breast cancer progression.

85 ies document a therapeutical approach to the Warburg effect and demonstrate that oxidative stress and

86 In this Essay, we re-examine the Warburg effect and establish a framework for understandi

87 provide a novel mechanistic insight into the Warburg effect and explain how metabolic alteration in c

88 ese results support an interpretation of the Warburg effect and glutamine addiction as features of a

89 Because the Warburg effect and hypoxia are frequently seen in human

90 This phenomenon is known as the Warburg effect and is considered as one of the most fund

91 er cells, SR9243 significantly inhibited the Warburg effect and lipogenesis by reducing glycolytic an

92 duced kinase 1 (PINK1) is a regulator of the Warburg effect and negative regulator of glioblastoma gr

93 tion provides a possible explanation for the Warburg effect and offers new clues as to how p53 might

94 asis, immune escape, tumor angiogenesis, the Warburg effect and oncogene addiction and has been valid

95 s miR-199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strat

96 This results in the reversal of the Warburg effect and the inhibition of breast cancer cell

97 nhances LDH-A enzyme activity to promote the Warburg effect and tumor growth by regulating the NADH/N

98 osphorylation activates PDHK1 to promote the Warburg effect and tumor growth.

99 Today this phenomenon is known as the "Warburg effect" and recognized as a hallmark of cancer.

100 ignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogene

101 t glycolysis even in the presence of oxygen (Warburg effect) and use of glutamine for increased biosy

102 regulating energy metabolism, especially the Warburg effect, and antioxidant defense, and thus the fu

103 t mechanistically connects aberrant ROS, the Warburg effect, and carcinogenesis.

104 suppressor in PCa that prevents EMT and the Warburg effect, and indicates that ABHD5 is a potential

105 y a preference for aerobic glycolysis or the Warburg effect, and the cells resist matrix detachment-i

106 , development of multi-drug resistance, the 'Warburg effect', angiogenesis and cell growth (i.e. dist

107 umption and lactate production, known as the Warburg effect, are almost universal hallmarks of solid

108 that regulate the PI3K pathway, and thus the Warburg effect, are elusive.

109 Drastic metabolic alterations, such as the Warburg effect, are found in most if not all types of ma

110 tivation of either Akt or c-Myc leads to the Warburg effect as indicated by increased cellular glucos

111 M1 (adult) isoform leads to reversal of the Warburg effect, as judged by reduced lactate production

112 ng in Akt activation and aerobic glycolysis (Warburg effect), associated with ulceration.

113 ic metabolism in an aerobic environment, the Warburg effect, but the explanation for this preference

114 wild-type p53 prevents manifestation of the Warburg effect by controlling Pdk2.

115 is an anticancer agent that can reverse the Warburg effect by inhibiting a key enzyme in cancer cell

116 ndicated that CO transiently induces an anti-Warburg effect by rapidly fueling cancer cell bioenerget

117 ain a growth advantage through the so-called Warburg effect by shifting glucose metabolism from oxida

118 Here I show that the Warburg effect can be explained as a form of cooperation

119 Notwithstanding the renewed interest in the Warburg effect, cancer cells also depend on continued mi

120 Due to the Warburg effect, cancerous colonocytes rely on glucose as

121 mediated PKM2 dephosphorylation promotes the Warburg effect, cell proliferation and brain tumorigenes

122 may be an approach for altering the classic Warburg effect characteristic of aberrant metabolism in

123 The Warburg effect contributes to cancer progression and is

124 The Warburg effect defines a pro-oncogenic metabolism switch

125 The classic Warburg effect described in macrophages infected by Myco

126 The Warburg effect describes an increase in aerobic glycolys

127 The "Warburg effect" describes a peculiar metabolic feature o

128 increased glycolysis for ATP generation (the Warburg effect) due in part to mitochondrial respiration

129 llectively, these findings indicate that key Warburg effect enzymes play a central role in mediating

130 mented that methylene blue (MB) reverses the Warburg effect evidenced by the increasing of oxygen con

131 aerobic production of lactate from glucose (Warburg effect), extensive glutamine utilization and imp

132 metabolic genes associated with glycolysis (Warburg effect), fatty acid metabolism (lipogenesis, oxi

133 se findings imply that efforts to target the Warburg effect for cancer prevention are mechanistically

134 oxygen-rich environment, referred to as the Warburg effect, has been noted as a nearly universal bio

135 lls benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact

136 lysis-driven metabolic program, known as the Warburg effect; however, few have been identified.

137 the glycolytic pathway and contribute to the Warburg effect in cancer cells.

138 ase (PKM2), a key enzyme contributing to the Warburg effect in cancer, is significantly induced in DM

139 thod has proven highly useful to monitor the Warburg effect in cancer, through MR detection of increa

140 mitochondrial function, contributing to the Warburg effect in cancer.

141 a lack of a quantitative explanation for the Warburg effect in cancer.

142 estoration of Parkin expression reverses the Warburg effect in cells.

143 43B osteosarcoma (OS) cell lines showing the Warburg effect in comparison with actively respiring Sao

144 that tumour-associated mutp53 stimulates the Warburg effect in cultured cells and mutp53 knockin mice

145 How ACAT1 is "hijacked" to contribute to the Warburg effect in human cancer remains unclear.

146 itochondrial membrane potential-promotes the Warburg effect in leukemia cells, and may contribute to

147 remutation, we evaluated the presence of the Warburg effect in peripheral blood mononuclear cells (PB

148 conserved mammalian UCPs may facilitate the Warburg effect in the absence of permanent respiratory i

149 Known as the Warburg effect in the context of cancer growth, this phe

150 by DERL3 epigenetic loss contributes to the Warburg effect in the studied cells and pinpoints a subs

151 rkin deficiency is a novel mechanism for the Warburg effect in tumors.

152 ory axis is an important determinant for the Warburg effect in tumour cells and provide a mechanistic

153 factor-1alpha's downstream processes and the Warburg effect; induction of autophagy; augmentation of

154 The Warburg effect is a chronic increase in glycolytic index

155 Warburg effect is a hallmark of cancer manifested by con

156 The Warburg effect is a tumorigenic metabolic adaptation pro

157 Although Warburg effect is considered a peculiarity critical for

158 Therefore, similar to cancer cells, the Warburg effect is necessary for maintaining KSHV latentl

159 This study reveals a mechanism that the Warburg effect is regulated by CHIP through its function

160 It remains a matter of debate as to how the Warburg effect is regulated during tumor progression.

161 izing higher-grade tumors, we found that the Warburg effect is relatively more prominent at the expen

162 We demonstrated that "Warburg effect" is not modulated in the initial stage of

163 gulation of glycolysis in cancer cells (the "Warburg effect") is common and has implications for prog

164 Aerobic glycolysis (the Warburg effect) is a metabolic hallmark of activated T c

165 both animal models and patients, glycolysis (Warburg effect) is also an early manifestation of CRPC t

166 e data indicate that aerobic glycolysis (the Warburg effect) is not an intrinsic component of the tra

167 etabolism of most solid tumors, known as the Warburg effect, is associated with resistance to apoptos

168 ilability of oxygen, a phenomenon called the Warburg effect, is important for cancer cell growth.

169 te kinase M2 (PKM2), a glycolytic enzyme for Warburg effect, is strongly upregulated in BC.

170 he degree of aerobic glycolysis-known as the Warburg effect-is thus predicted to represent an adaptat

171 ed role of PKM2 in aerobic glycolysis or the Warburg effect, its non-metabolic functions remain elusi

172 Warburg effect linked to cognitive-executive deficits in

173 Aerobic glycolysis or the Warburg effect links the high rate of glucose fermentati

174 ated aerobic glycolysis in cancer cells (the Warburg effect) may be attributed to respiration injury

175 Reversing this phenomenon, known as the Warburg effect, may offer a generalized anticancer strat

176 t in vitro proof of concept that reversal of Warburg effect might be a novel therapy for GBM.

177 Here we explore how the Warburg effect might be linked to inflammation and infla

178 These results suggest that the Warburg effect, more specifically, diminished glucose ox

179 ation analysis revealed a uniform pattern of Warburg effect mutations influencing prognosis across al

180 e for the pyruvate kinase M2 (PKM2)-mediated Warburg effect, namely aerobic glycolysis, in the regula

181 We suggest that, similar to the Warburg effect observed in tumor cells, starving yeast a

182 Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic

183 tion in aerobic glycolysis counteracting the Warburg effect of cancer cells.

184 to the altered metabolic state known as the Warburg effect; one metabolic pathway, highly dependent

185 etabolic phenotype of cancer is known as the Warburg effect or aerobic glycolysis that consists of in

186 ion, agents that scavenge ROS or reverse the Warburg effect prevent the transformation and malignant

187 umarate and succinate may play a role in the Warburg effect providing that appropriate relative conce

188 r cells rely more on aerobic glycolysis (the Warburg effect) than mitochondrial oxidative phosphoryla

189 c alterations in cancer cells, including the Warburg effect that describes an increased glycolysis in

190 It is unclear how the Warburg effect that exemplifies enhanced glycolysis in t

191 nce of a synaptic activity-mediated neuronal Warburg effect that may promote mitochondrial homeostasi

192 A new parameter measuring the Warburg effect (the ratio of lactate production flux to

193 abolism, notably of aerobic glycolysis (the "Warburg effect"), the potential involvement of hypoxia-i

194 Despite being known for decades (Warburg effect), the molecular mechanisms regulating thi

195 This bioenergetic shift is similar to the Warburg effect, the metabolic signature of cancer cells.

196 Historically known as the Warburg effect, this altered metabolic phenotype has lon

197 Mutp53 stimulates the Warburg effect through promoting GLUT1 translocation to

198 report that loss of PINK1 contributes to the Warburg effect through ROS-dependent stabilization of hy

199 ost tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apo

200 lonocytes and cancerous colonocytes when the Warburg effect was prevented from occurring, whereas it

201 2, a fetal anabolic enzyme implicated in the Warburg effect, was activated by insulin in vivo and in

202 This metabolic change, the Warburg effect, was one of the first alterations in canc

203 Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased me

204 estigate molecular mechanisms underlying the Warburg effect, we first compared oxygen consumption amo

205 rofound metabolic alterations, including the Warburg effect wherein cancer cells oxidize a decreased

206 insights into the regulation of VEGF and the Warburg effect, which describes the propensity for cance

207 ose metabolism in cancer cells is termed the Warburg effect, which describes the propensity of most c

208 eference of aerobic glycolysis, known as the Warburg effect, which facilitates cell proliferation.

209 tochondria (OXPHOS), a phenomenon termed the Warburg effect, which is a general feature of oncogenesi

210 Imaging of the Warburg effect, which is the principal but not the sole

211 This is the Warburg effect, which provides substrates for cell growt

212 ossible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (1

213 ngly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not

214 GT1A_i2 proteins in HT115 cells enforced the Warburg effect, with a higher glycolytic rate at the exp