コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 te telomere attrition in the pathogenesis of Werner syndrome.
2 ularly nonepithelial malignancies typical of Werner syndrome.
3 nuclease, causes the premature aging disease Werner syndrome.
4 the genomic instability progeroid syndrome, Werner syndrome.
5 teristic of cells derived from patients with Werner syndrome.
6 remature ageing phenotypes that characterize Werner syndrome.
7 encodes a RecQ helicase, which is mutated in Werner syndrome.
8 e premature aging and cancer-prone disorder, Werner syndrome.
9 , which is compromised by the loss of WRN in Werner syndrome.
10 one of the clinical findings associated with Werner syndrome.
11 RN), mutated in the premature aging disorder Werner syndrome.
12 iation of WRN, the factor that is mutated in Werner syndrome.
13 manifest as a rare premature aging disorder, Werner syndrome.
14 ilford Progeria Syndrome (HGPS) and Atypical Werner Syndrome.
15 f rapidly dividing cells is not a feature of Werner syndrome.
16 4 complex), and WRN the protein deficient in Werner syndrome.
17 in Hutchinson-Gilford progeria and atypical Werner syndromes.
18 The prototypic example of the former is the Werner syndrome, a condition caused by mutations of the
19 s with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many char
20 3'-->5' exonuclease and helicase mutated in Werner syndrome, a disorder characterized by aberrant te
22 the recent gene-driven phase of research on Werner syndrome, a heritable adult progeroid syndrome wi
24 ion mutations in the WRN helicase gene cause Werner syndrome- a progeroid syndrome with an elevated r
25 tational inactivation of the gene WRN causes Werner syndrome, an autosomal recessive disease characte
30 ns of the WRN and BLM helicases defective in Werner syndrome and Bloom syndrome, respectively, have b
31 Terc mutants but similar to that observed in Werner syndrome and Bloom syndrome, such as bone loss, w
36 ive human genetic disorders (Bloom syndrome, Werner syndrome and Rothmund-Thomson syndrome, respectiv
37 ence of cultured cells from individuals with Werner syndrome and the lack of a disease phenotype in W
40 he varied and complex cellular phenotypes of Werner syndrome are precipitated by exhaustion of telome
42 f BLM, or another G4-unwinding helicase, the Werner syndrome-associated helicase WRN, resulted in inc
43 at three RecQ members (WRN, deficient in the Werner syndrome; BLM, deficient in the Bloom syndrome; a
44 number of human genetic disorders, including Werner Syndrome, Bloom Syndrome and Rothmund-Thomson Syn
45 ated incidence of cancer or premature aging: Werner syndrome, Bloom syndrome, and Rothmund-Thomson sy
46 Hutchinson-Gilford progeria syndrome (HGPS), Werner syndrome, Bloom syndrome, Cockayne syndrome, tric
48 solve these structures in Bloom syndrome and Werner syndrome cells may contribute to genome instabili
49 the replication and recombination defects in Werner syndrome cells may reflect abnormal processing of
50 asmids with noncompatible ends introduced to Werner syndrome cells underwent extensive deletions at n
53 VX-745 against p38alpha MAPK is confirmed in Werner syndrome dermal fibroblasts at 1.0 microM concent
56 WRN protein involved in the premature aging Werner syndrome, do not exhibit the gene cluster instabi
58 mature aging and genome instability disorder Werner syndrome, encodes a protein with DNA helicase and
63 Moreover, it is a homologue of the human Werner syndrome gene product WRN, a protein associated w
67 rectly stimulates transcription of the human Werner syndrome gene, WRN, which encodes a conserved Rec
69 ecQ-like DNA helicases such as the Bloom and Werner syndrome genes, BLM and WRN, have been suggested
72 ify molecules that modulate DNA unwinding by Werner syndrome helicase (WRN), mutated in the premature
74 f, and contrapodal to, the gene encoding the Werner syndrome helicase, Wrn, at human chromosome band
75 of the RecQ DNA helicase WRN protein causes Werner syndrome, in which patients exhibit features of p
95 The premature aging and cancer-prone disease Werner syndrome is caused by loss of function of the Rec
97 in the premature aging disease known as the Werner syndrome is designated WRN and is a member of the
98 The cancer-prone and premature aging disease Werner syndrome is due to loss of WRN gene function.
100 WRN, which is absent in the human progeroid Werner syndrome, is thought to counteract this genomic i
102 The WRN helicase/exonuclease is mutated in Werner syndrome of genomic instability and premature agi
105 In addition to its DNA helicase activity, Werner syndrome protein (WRN) also possesses an exonucle
106 lta processivity was enhanced by full length Werner Syndrome protein (WRN) and by WRN fragments conta
107 in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrov
109 DNA2 acts with RecQ helicases such as the Werner syndrome protein (WRN) and the heterotrimeric euk
112 Our previous studies indicated that the Werner syndrome protein (WRN) interacts with Ku, a heter
119 In this study, we provide evidence that the Werner syndrome protein (WRN) physically interacts with
123 hich hpol kappa activity is modulated by the Werner syndrome protein (WRN), a RecQ helicase known to
124 FEN1, abolished the interaction of FEN1 with Werner syndrome protein (WRN), an interaction that is cr
130 cases, the major one of which is the Xenopus Werner syndrome protein (xWRN), a member of the RecQ hel
131 acts on ssDNA unwound mainly by the Xenopus Werner syndrome protein (xWRN), xEXO1 acts directly on d
132 s (ss-tails) by stimulating both the Xenopus Werner syndrome protein (xWRN)-mediated unwinding of DNA
133 gest that the RNase D family, which includes Werner syndrome protein and the 100 kDa antigenic compon
135 ogy with the FEN-1 interaction domain of the Werner syndrome protein, a RecQ helicase family member h
136 DNA Polymerase delta (Pol delta) and the Werner syndrome protein, WRN, are involved in maintainin
142 rived B cells that contained variants in the Werner syndrome, RecQ helicase-like gene (WRN, encoding
146 The premature aging and cancer-prone disease Werner syndrome stems from loss of WRN protein function.
148 ease nuclear localization of WRN (mutated in Werner syndrome), which is required for processing DSB e
149 are mutated, respectively, in the Bloom and Werner syndromes, whose manifestations include predispos
155 d DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and that it interacts phy
156 d DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and that it interacts phy
157 cosmid clone contig was constructed for the Werner syndrome (WRN) region of chromosome 8p12-p21 and
158 e genes involved in Bloom syndrome (BLM) and Werner syndrome (WRN) show that both are DNA and RNA hel
159 utations in the chromosome 8p WRN gene cause Werner syndrome (WRN), a human autosomal recessive disea
161 Werner protein (WRN), which is defective in Werner syndrome ( WS) patients, belongs to the RecQ fami
162 e accelerated replicative senescence seen in Werner syndrome (WS) fibroblasts is due to accelerated t
206 g and old individuals and from patients with Werner syndrome (WS), a segmental progeroid condition wi
209 associated with a rare, recessive disorder, Werner syndrome (WS), distinguished by premature aging a
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。