ライフサイエンスコーパス: Werner

1 Werner and Bloom syndromes are genetic RecQ helicase dis

2 Werner and Bloom syndromes are human diseases characteri

3 Werner protein (WRN) is a member of the recQ gene family

4 Werner syndrome (WRN) is an uncommon autosomal recessive

5 Werner syndrome (WRN) is an uncommon autosomal recessive

6 Werner syndrome (WS) is a genetic premature aging disord

7 Werner syndrome (WS) is a human genetic disorder charact

8 Werner Syndrome (WS) is a human genetic disorder with ma

9 Werner syndrome (WS) is a human premature aging disorder

10 Werner syndrome (WS) is a human premature aging disorder

11 Werner Syndrome (WS) is a human progeroid disorder chara

12 Werner syndrome (WS) is a human progeroid syndrome chara

13 Werner syndrome (WS) is a premature aging disorder cause

14 Werner syndrome (WS) is a premature aging disorder where

15 Werner syndrome (WS) is a premature aging disorder, disp

16 Werner syndrome (WS) is a premature aging syndrome cause

17 Werner syndrome (WS) is a progeroid-like syndrome caused

18 Werner syndrome (WS) is a rare autosomal recessive disor

19 Werner syndrome (WS) is a rare disease caused by the lac

20 Werner syndrome (WS) is a rare human premature aging dis

21 Werner syndrome (WS) is a rare progeroid disorder charac

22 Werner syndrome (WS) is a recessive disorder characteriz

23 Werner syndrome (WS) is an accelerated ageing disorder w

24 Werner syndrome (WS) is an autosomal recessive disease c

25 Werner syndrome (WS) is an autosomal recessive disease c

26 Werner syndrome (WS) is an autosomal recessive disease t

27 Werner syndrome (WS) is an autosomal recessive disease w

28 Werner syndrome (WS) is an autosomal recessive disease,

29 Werner syndrome (WS) is an autosomal recessive disorder

30 Werner syndrome (WS) is an autosomal recessive genetic d

31 Werner syndrome (WS) is an inherited disease characteriz

32 Werner Syndrome (WS) is an inherited disease characteriz

33 Werner syndrome (WS) is an inherited disorder characteri

34 Werner syndrome (WS) is an uncommon autosomal recessive

35 Werner syndrome (WS) is characterized by features of pre

36 Werner Syndrome (WS) is characterized by premature aging

37 Werner syndrome (WS) is characterized by premature onset

38 Werner syndrome (WS) is characterized by the early onset

39 Werner syndrome (WS) is marked by early onset of feature

40 Werner syndrome (WS) is the canonical adult human proger

41 Werner syndrome (WS) is the hallmark premature aging dis

42 Werner syndrome (WS), caused by loss of function of the

43 Werner syndrome and Bloom syndrome result from defects i

44 Werner syndrome arises through mutations in the WRN gene

45 Werner syndrome is a disorder characterized by genomic i

46 Werner syndrome is a genetic condition of young adults c

47 Werner syndrome is a genetic disorder characterized by g

48 Werner syndrome is a hereditary disorder characterized b

49 Werner syndrome is a hereditary premature aging disorder

50 Werner syndrome is a hereditary premature aging disorder

51 Werner syndrome is a human disorder characterized by pre

52 Werner syndrome is a human premature aging disorder disp

53 Werner syndrome is a Mendelian disorder of man that prod

54 Werner syndrome is a premature aging and cancer-prone he

55 Werner Syndrome is a premature aging disorder characteri

56 Werner Syndrome is a premature aging disorder characteri

57 Werner syndrome is a rare autosomal recessive disease ch

58 Werner syndrome is a rare human disease characterized by

59 Werner syndrome is an autosomal recessive disorder assoc

60 Werner syndrome is an inherited disease characterized by

61 Werner syndrome is an inherited disease displaying a pre

62 Werner syndrome is associated with mutations in the DNA

63 Werner syndrome is associated with premature aging and i

64 Werner syndrome is genetically linked to mutations in WR

65 Werner syndrome protein (WRN) is a RecQ-type DNA helicas

66 Werner syndrome, caused by mutations of the WRN gene, mi

67 Werner's syndrome (WS) and Bloom's syndrome (BS) are can

68 Werner's syndrome (WS) is a human disease with manifesta

69 Werner's syndrome (WS) is an autosomal recessive disorde

70 Werner's syndrome (WS) is an inherited disease character

71 Werner's syndrome is a progeroid syndrome caused by muta

72 The chromosome 8p11-12 Werner syndrome (WRN ) locus encodes a RecQ helicase pro

73 In addition to its DNA helicase activity, Werner syndrome protein (WRN) also possesses an exonucle

74 WRN protein involved in the premature aging Werner syndrome, do not exhibit the gene cluster instabi

75 ated incidence of cancer or premature aging: Werner syndrome, Bloom syndrome, and Rothmund-Thomson sy

76 Alfred Werner defined the basics of coordination chemistry, wor

77 Alfred Werner's complexes of formula [M(III)(NH(3))(6-n)X(n)]X(

78 As reported by Alfred Werner in 1911-1912, salts of the formally D3 symmetric

79 rma overlap syndrome 100 kDa autoantigen and Werner syndrome protein.

80 ence with the RecQ helicases Bloom (Blm) and Werner (Wrn).

81 e genes involved in Bloom syndrome (BLM) and Werner syndrome (WRN) show that both are DNA and RNA hel

82 icases, which includes the Bloom's (BLM) and Werner's (WRN) syndrome gene products, are apparently un

83 (G4 resolvase 1), Bloom helicase (BLM), and Werner helicase (WRN).

84 Here we show that purified Bloom and Werner helicases can unwind a DNA triple helix.

85 ecQ-like DNA helicases such as the Bloom and Werner syndrome genes, BLM and WRN, have been suggested

86 line mutations are responsible for Bloom and Werner syndromes, respectively.

87 are mutated, respectively, in the Bloom and Werner syndromes, whose manifestations include predispos

88 cQ helicases, which are mutated in Bloom and Werner's syndrome, respectively, and associated with chr

89 e (BS), Rothmund-Thomson syndrome (RTS), and Werner syndrome (WS).

90 family helicases encoded by the Bloom's and Werner's syndrome genes are likely to act in concert wit

91 BLM and WRN, the products of the Bloom's and Werner's syndrome genes, are members of the RecQ family

92 RecQ helicases such as the human Bloom's and Werner's syndrome proteins and that copies of the helica

93 ve implications for the basis of Bloom's and Werner's syndromes, which are caused by mutations in DNA

94 ed DNA-binding protein RPA, and the Srs2 and Werner/Bloom helicases, but not Ku and ligase 4.

95 Bloom syndrome and Werner syndrome are genome instability disorders, which

96 solve these structures in Bloom syndrome and Werner syndrome cells may contribute to genome instabili

97 e products of the human Bloom's syndrome and Werner's syndrome genes.

98 d the products of human Bloom's syndrome and Werner's syndrome genes.

99 that includes the human Bloom's syndrome and Werner's syndrome proteins.

100 utated in patients with Bloom's syndrome and Werner's syndrome respectively.

101 m, Cockayne's syndrome, Bloom's syndrome and Werner's syndrome, have been linked to defects in specif

102 and cancer susceptibility syndrome known as Werner syndrome (WS).

103 es associated with premature ageing, such as Werner's syndrome and Hutchinson-Gilford progeria syndro

104 th the human RecQ helicase diseases, such as Werner, Bloom, and Rothmund-Thomson syndromes, are also

105 mology to the WRN exonuclease domain, atWEX (Werner-like Exonuclease).

106 ilford Progeria Syndrome (HGPS) and Atypical Werner Syndrome.

107 in Hutchinson-Gilford progeria and atypical Werner syndromes.

108 ions and were categorised as having atypical Werner's syndrome on the basis of molecular criteria.

109 sequenced LMNA in individuals with atypical Werner's syndrome (wild-type WRN).

110 Individuals with atypical Werner's syndrome with mutations in LMNA had a more seve

111 In four (15%) of 26 patients with atypical Werner's syndrome, we noted heterozygosity for novel mis

112 in humans, which include RECQ1, Bloom (BLM), Werner (WRN), RECQ4, and RECQ5.

113 licase family that includes the human Bloom, Werner, and Rothmund-Thompson syndrome proteins.

114 hat include the determinants of human Bloom, Werner, and Rothmund-Thomson syndromes, the shortened li

115 Five paralogues (RecQ1, Bloom, Werner, RecQ4, and RecQ5) are found in human cells, with

116 ify molecules that modulate DNA unwinding by Werner syndrome helicase (WRN), mutated in the premature

117 utations in the chromosome 8p WRN gene cause Werner syndrome (WRN), a human autosomal recessive disea

118 Mutations in the WRN gene cause Werner syndrome, a genetic disorder characterized by pre

119 ion mutations in the WRN helicase gene cause Werner syndrome- a progeroid syndrome with an elevated r

120 Mutations of wrn cause Werner syndrome (WS), an autosomal recessive premature a

121 WRN protein loss causes Werner syndrome (WS), which is characterized by prematur

122 of the RecQ DNA helicase WRN protein causes Werner syndrome, in which patients exhibit features of p

123 tational inactivation of the gene WRN causes Werner syndrome, an autosomal recessive disease characte

124 remature ageing phenotypes that characterize Werner syndrome.

125 t), telomere dysfunction elicits a classical Werner-like premature aging syndrome typified by prematu

126 or metal ions, forming normally coordinative Werner-type bonds by utilizing the N donor atoms of the

127 Acrolein decreased Werner's syndrome protein (WRN), a member of the RecQ he

128 n (WRN) leads to the premature aging disease Werner syndrome (WS).

129 The cancer-prone and premature aging disease Werner syndrome is due to loss of WRN gene function.

130 nuclease, causes the premature aging disease Werner syndrome.

131 The premature aging and cancer-prone disease Werner syndrome is caused by loss of function of the Rec

132 The premature aging and cancer-prone disease Werner syndrome stems from loss of WRN protein function.

133 he premature aging and cancer-prone diseases Werner and Bloom syndromes are caused by loss of functio

134 The human premature aging disorder Werner syndrome (WS) is associated with a large number o

135 s a hallmark of the premature aging disorder Werner syndrome (WS).

136 RN), mutated in the premature aging disorder Werner syndrome.

137 mature aging and genome instability disorder Werner syndrome, encodes a protein with DNA helicase and

138 n causes the cancer-prone progeroid disorder Werner syndrome (WS).

139 The segmental, progeroid disorder Werner syndrome results from loss of the Werner syndrome

140 manifest as a rare premature aging disorder, Werner syndrome.

141 e premature aging and cancer-prone disorder, Werner syndrome.

142 associated with a rare, recessive disorder, Werner syndrome (WS), distinguished by premature aging a

143 e responsible for the cancer-prone disorders Werner syndrome and Bloom syndrome.

144 damage that has previously been observed for Werner's syndrome cells.

145 a- and UV-irradiation, suggesting a role for Werner protein in stress-induced gene expression.

146 from normal (young and old) donors and from Werner syndrome (WS) patients.

147 Cells from Werner syndrome patients are characterized by slow growt

148 We recently discovered that cells from Werner syndrome patients displayed a deficiency in p53-m

149 s with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many char

150 We argue that Heinz Werner's classical research on the physiognomic properti

151 me result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display

152 Here, Werner protein (WRN) was identified as a novel target fo

153 Herlyn-Werner-Wunderlich syndrome is a rare congenital urogenit

154 maging modalities in diagnosis of the Herlyn-Werner-Wunderlich syndrome with a review of literature.

155 Hutchinson-Gilford progeria syndrome (HGPS), Werner syndrome, Bloom syndrome, Cockayne syndrome, tric

156 This review discusses how Werner coordination chemistry plays a role in three dise

157 Human Werner Syndrome is characterized by early onset of aging

158 es, such as human Bloom's syndrome and human Werner's syndrome helicases.

159 These adducts inhibited the human Werner (WRN) syndrome helicase activity in a strand-spec

160 licases, including yeast Sgs1p and the human Werner and Bloom syndrome proteins, participate in telom

161 The human Werner and Bloom syndromes (WS and BS) are caused by def

162 Moreover, it is a homologue of the human Werner syndrome gene product WRN, a protein associated w

163 rectly stimulates transcription of the human Werner syndrome gene, WRN, which encodes a conserved Rec

164 The human Werner syndrome protein, WRN, is a member of the RecQ he

165 factor contributing to accelerated aging in Werner and Bloom syndromes, but not XFE progeroid syndro

166 VX-745 against p38alpha MAPK is confirmed in Werner syndrome dermal fibroblasts at 1.0 microM concent

167 and BLM gene products that are defective in Werner and Bloom syndromes, disorders which share many p

168 Werner protein (WRN), which is defective in Werner syndrome ( WS) patients, belongs to the RecQ fami

169 ns of the WRN and BLM helicases defective in Werner syndrome and Bloom syndrome, respectively, have b

170 the replication and recombination defects in Werner syndrome cells may reflect abnormal processing of

171 4 complex), and WRN the protein deficient in Werner syndrome.

172 ligase IIIalpha, and the protein deleted in Werner syndrome, WRN, are up-regulated.

173 utations that occur at elevated frequency in Werner syndrome cells.

174 The gene mutated in Werner syndrome encodes both a 3' --> 5' DNA helicase an

175 The WRN helicase/exonuclease is mutated in Werner syndrome of genomic instability and premature agi

176 ease nuclear localization of WRN (mutated in Werner syndrome), which is required for processing DSB e

177 3'-->5' exonuclease and helicase mutated in Werner syndrome, a disorder characterized by aberrant te

178 encodes a RecQ helicase, which is mutated in Werner syndrome.

179 iation of WRN, the factor that is mutated in Werner syndrome.

180 Terc mutants but similar to that observed in Werner syndrome and Bloom syndrome, such as bone loss, w

181 structures that resemble defects observed in Werner syndrome, a premature ageing disorder.

182 ontribute to the various defects observed in Werner's and Bloom's syndromes.

183 mic instability and cancer predisposition in Werner syndrome cells.

184 in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrov

185 genomic instability, which are prominent in Werner and Bloom syndromes.

186 Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which

187 e accelerated replicative senescence seen in Werner syndrome (WS) fibroblasts is due to accelerated t

188 , which is compromised by the loss of WRN in Werner syndrome.

189 number of human genetic disorders, including Werner Syndrome, Bloom Syndrome and Rothmund-Thomson Syn

190 lta processivity was enhanced by full length Werner Syndrome protein (WRN) and by WRN fragments conta

191 er predisposition and/or shortened lifespan (Werner, Bloom, and Rothmund-Thomson syndromes).

192 Mgs1, the budding yeast homolog of mammalian Werner helicase-interacting protein 1 (WRNIP1/WHIP), con

193 function of the RecQ helicase family member Werner syndrome protein (WRN).

194 d DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and that it interacts phy

195 d DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and that it interacts phy

196 c disruption of the WRN gene is the cause of Werner disease.

197 national registry for molecular diagnosis of Werner's syndrome, 26 (20%) had wildtype WRN coding regi

198 f rapidly dividing cells is not a feature of Werner syndrome.

199 Thus, manifestations of Werner syndrome may reflect an impaired ability of slowl

200 roposed to contribute to the pathogenesis of Werner syndrome (WS), a premature-aging disorder.

201 nction may contribute to the pathogenesis of Werner syndrome and Bloom syndrome.

202 te telomere attrition in the pathogenesis of Werner syndrome.

203 The clinical phenotype of Werner Syndrome (WRN) includes features reminiscent of a

204 Cellular phenotypes of Werner syndrome and Bloom syndrome, including genomic in

205 he varied and complex cellular phenotypes of Werner syndrome are precipitated by exhaustion of telome

206 To map regions of Werner syndrome helicase (WRN) that interact with RPA, y

207 ularly nonepithelial malignancies typical of Werner syndrome.

208 osine (dA) or N(2) of deoxyguanosine (dG) on Werner (WRN) syndrome helicase activity.

209 the recent gene-driven phase of research on Werner syndrome, a heritable adult progeroid syndrome wi

210 bility, perhaps in concert with the Bloom or Werner syndrome DNA helicases.

211 cs of cells from individuals with Bloom's or Werner's syndrome.

212 In particular, Werner syndrome helicase and related genes are different

213 One in particular, Werner syndrome, provides evidence to support the hypoth

214 WRN, which is absent in the human progeroid Werner syndrome, is thought to counteract this genomic i

215 ions on the catalytic activities of purified Werner (WRN) and Bloom (BLM) DNA helicases.

216 RN and RECQ4 genes are defective in Bloom's, Werner's and Rothmund-Thomson syndromes, respectively.

217 een linked to three human diseases: Bloom's, Werner's and Rothmund-Thomson's syndromes.

218 BLM, WRN, and RECQL4 are mutated in Bloom's, Werner, and Rothmund Thomson syndromes, respectively.

219 er predisposition diseases, causing Bloom's, Werner, and Rothmund-Thomson syndromes.

220 2F3.1); and (4) the WRN subgroup (H. sapiens Werner and C. elegans F18C5.2).

221 ive human genetic disorders (Bloom syndrome, Werner syndrome and Rothmund-Thomson syndrome, respectiv

222 the genomic instability progeroid syndrome, Werner syndrome.

223 instability/cancer predisposition syndromes Werner syndrome and Bloom syndrome.

224 Our findings indicate that Werner's syndrome is molecularly heterogeneous, and a su

225 The Werner and Bloom syndromes are caused by loss-of-functio

226 The Werner protein (WRN) belongs to the RecQ family of DNA h

227 The Werner protein (WRN), which is defective in Werner syndr

228 The Werner syndrome (WS) is a prototypic adult Mendelian pro

229 The Werner syndrome (WS) is an autosomal recessive segmental

230 The Werner syndrome and the Nijmegen breakage syndrome are r

231 The Werner syndrome gene (WRN) has recently been cloned.

232 The Werner syndrome helicase (WRN) participates in DNA repli

233 The Werner syndrome protein (WRN) is a caretaker of the huma

234 The Werner syndrome protein (WRN) is a RecQ family helicase

235 The Werner syndrome protein (WRN) is the only known member o

236 The Werner syndrome protein (WRN) suppresses the loss of tel

237 The Werner syndrome protein, WRN, is a member of the RecQ fa

238 the RNA-dependent RNA polymerase QDE-1, the Werner and Bloom RecQ DNA helicase homologue QDE-3 and d

239 In addition, the Werner syndrome protein (WRN) possesses an exonuclease a

240 ction between the AAA ATPase p97/VCP and the Werner protein (WRNp), a member of the RecQ helicase fam

241 stability of the multicopy transgene and the Werner Syndrome gene.

242 human DNA polymerase eta (hpol eta) and the Werner syndrome protein (WRN).

243 DNA Polymerase delta (Pol delta) and the Werner syndrome protein, WRN, are involved in maintainin

244 members include the Bloom's syndrome and the Werner's syndrome gene products.

245 the human Bloom's syndrome gene BLM and the Werner's syndrome gene WRN.

246 in the premature aging disease known as the Werner syndrome is designated WRN and is a member of the

247 DNA2 acts with RecQ helicases such as the Werner syndrome protein (WRN) and the heterotrimeric euk

248 Mutations at the Werner helicase locus (WRN) are responsible for the Wern

249 hich hpol kappa activity is modulated by the Werner syndrome protein (WRN), a RecQ helicase known to

250 from a 1.4-Mb genomic region containing the Werner syndrome gene (WRN).

251 We now report that Ku enables the Werner exonuclease to digest through regions of DNA cont

252 f, and contrapodal to, the gene encoding the Werner syndrome helicase, Wrn, at human chromosome band

253 helicase locus (WRN) are responsible for the Werner syndrome (WS).

254 f BLM, or another G4-unwinding helicase, the Werner syndrome-associated helicase WRN, resulted in inc

255 xonuclease domain of DNA polymerase I in the Werner syndrome gene product.

256 A defect in the Werner syndrome protein (WRN) leads to the premature agi

257 Cells deficient in the Werner syndrome protein (WRN) or BRCA1 are hypersensitiv

258 rived B cells that contained variants in the Werner syndrome, RecQ helicase-like gene (WRN, encoding

259 at three RecQ members (WRN, deficient in the Werner syndrome; BLM, deficient in the Bloom syndrome; a

260 Q DNA helicase family that also includes the Werner syndrome protein, WRN.

261 useful in association studies involving the Werner syndrome (WRN) gene.

262 te here that the stimulating activity is the Werner syndrome protein (WRN).

263 The prototypic example of the former is the Werner syndrome, a condition caused by mutations of the

264 e helicase and exonuclease activities of the Werner protein (WRN) suggest that it functions in DNA tr

265 The yeast homologue of the Werner protein (WRN), Sgs1, is required for recombinatio

266 WRN) and a deficiency in the function of the Werner protein (WRN).

267 FFA-1 is the orthologue of the Werner syndrome gene product (WRN), a member of the RecQ

268 thods and present a transcription map of the Werner syndrome gene region.

269 der Werner syndrome results from loss of the Werner syndrome protein (WRN).

270 ogy with the FEN-1 interaction domain of the Werner syndrome protein, a RecQ helicase family member h

271 Mutants for sgs1, the yeast homolog of the Werner's syndrome gene, accumulate ERCs more rapidly, le

272 Research on the Werner syndrome and a surprising number of other progero

273 Evidence suggests that the Werner syndrome protein (WRN) contributes to the mainten

274 Our previous studies indicated that the Werner syndrome protein (WRN) interacts with Ku, a heter

275 In this study, we provide evidence that the Werner syndrome protein (WRN) physically interacts with

276 We show here that the Werner syndrome protein (WRN), a member of the RecQ fami

277 se activity and ability to interact with the Werner protein (WRN) and telomere-binding protein (TRF2)

278 during S phase when it colocalizes with the Werner syndrome gene product, WRN, in the nucleolus.

279 Ku70/80 interacts with the Werner syndrome protein (WRN) and stimulates WRN exonucl

280 asmids with noncompatible ends introduced to Werner syndrome cells underwent extensive deletions at n

281 the human WRN gene, whose mutation leads to Werner syndrome resembling premature aging.

282 ny-forming assay in which a SV40-transformed Werner fibroblast cell line is 6-18-fold more sensitive

283 in the human RECQ3 gene result in truncated Werner protein (WRN) and manifest as a rare premature ag

284 The wild type Werner syndrome protein (WRN) has been demonstrated to e

285 (NO3 )6 (M=Al, Ga) can be synthesized using Werner's century-old cluster as a substitutable framewor

286 one of the clinical findings associated with Werner syndrome.

287 s, including the WRN protein associated with Werner's syndrome, might also adopt ring structures.

288 FEN1, abolished the interaction of FEN1 with Werner syndrome protein (WRN), an interaction that is cr

289 fibroblasts cultured from an individual with Werner's syndrome.

290 ence of cultured cells from individuals with Werner syndrome and the lack of a disease phenotype in W

291 g and old individuals and from patients with Werner syndrome (WS), a segmental progeroid condition wi

292 n profiles occur in cells from patients with Werner syndrome and from normally aged individuals.

293 teristic of cells derived from patients with Werner syndrome.

294 Persons with Werner syndrome displays premature aging of the skin, va

295 we identified the DNA repair protein WRNIP1 (Werner helicase-interacting protein 1), along with nucle

296 Mechanistically, Xenopus Werner syndrome protein (xWRN) is required for the unwin

297 cases, the major one of which is the Xenopus Werner syndrome protein (xWRN), a member of the RecQ hel

298 acts on ssDNA unwound mainly by the Xenopus Werner syndrome protein (xWRN), xEXO1 acts directly on d

299 s (ss-tails) by stimulating both the Xenopus Werner syndrome protein (xWRN)-mediated unwinding of DNA

300 We also found that the Xenopus Werner syndrome protein, a member of the RecQ helicase f