ライフサイエンスコーパス: Wiskott-Aldrich syndrome

1 including chronic granulomatous disease and Wiskott-Aldrich syndrome.

2 clearance of platelets in a mouse model for Wiskott-Aldrich syndrome.

3 nia and defects in regulatory T cells in the Wiskott-Aldrich syndrome.

4 ked inherited immunodeficiency disorder, the Wiskott-Aldrich syndrome.

5 ct of the gene defective in an Xid disorder, Wiskott-Aldrich syndrome.

6 bute significantly to the immunopathology of Wiskott-Aldrich Syndrome.

7 nce contributes to the bleeding diathesis of Wiskott-Aldrich syndrome.

8 of the use of gene therapy in patients with Wiskott-Aldrich syndrome.

9 The Wiskott-Aldrich syndrome, a primary human immunodeficien

10 We have focused on a murine model of the Wiskott-Aldrich syndrome, an immunodeficiency in which a

11 uccessfully used to treat conditions such as Wiskott-Aldrich syndrome and chronic granulomatous disea

12 ress in understanding the molecular basis of Wiskott-Aldrich syndrome and its ramifications for the c

13 s in the association to the actin-nucleating Wiskott-Aldrich syndrome and SCAR homolog (WASH) complex

14 eatures of immunodeficient patients with the Wiskott-Aldrich syndrome and Wiskott-Aldrich syndrome pr

15 result in four clinical phenotypes: classic Wiskott-Aldrich syndrome and X-linked thrombocytopenia,

16 forms of severe combined immune deficiency, Wiskott-Aldrich syndrome, and chronic granulomatous dise

17 for severe combined immunodeficiency (SCID), Wiskott-Aldrich syndrome, and chronic granulomatous dise

18 acute myelogenous leukemia, Paris-Trousseau, Wiskott-Aldrich syndrome, and the May-Hegglin, Sebastian

19 glycosylated IgA were found in patients with Wiskott-Aldrich syndrome, and these abnormal antibodies

20 with human immunodeficiency virus infection, Wiskott-Aldrich syndrome, and vasculopathy with capillar

21 In this issue of the JCI, Lexmond et al. use Wiskott-Aldrich syndrome as a model disease and establis

22 Humans with Wiskott-Aldrich syndrome display a progressive immunolog

23 The cytoplasmic functions of Wiskott-Aldrich syndrome family (WAS) proteins are well

24 of Rho1 with its downstream effector Wash, a Wiskott-Aldrich syndrome family protein.

25 Wiskott-Aldrich syndrome family proteins act downstream

26 Mutations of the Wiskott-Aldrich syndrome gene (WAS) are responsible for

27 ne defects that result from mutations in the Wiskott-Aldrich syndrome gene (WAS), which have a broad

28 Mutations in the Wiskott-Aldrich syndrome gene either inhibit or dysregul

29 logical disorder associated with compromised Wiskott-Aldrich Syndrome Interacting Protein (WIP) funct

30 Wiskott-Aldrich syndrome is a rare primary immunodeficie

31 Wiskott-Aldrich syndrome is caused by mutations of the W

32 nfused in 7 consecutive patients with severe Wiskott-Aldrich syndrome lacking HLA antigen-matched rel

33 protein (N-WASP), the ubiquitously expressed Wiskott-Aldrich syndrome-like (WASL) protein, in mouse s

34 is decreased, while natural cytotoxicity of Wiskott-Aldrich syndrome-NK cells is maintained.

35 at monocytes/macrophages from WASP-deficient Wiskott-Aldrich syndrome patients are severely defective

36 Macrophages from WASP-deficient Wiskott-Aldrich syndrome patients lack podosomes, result

37 ified up to 4 years after transplant in four Wiskott-Aldrich syndrome patients treated with HSPC gene

38 me platelets, which lack alpha-granules, and Wiskott-Aldrich syndrome platelets, which have cytoskele

39 utoimmune disorders in patients with classic Wiskott-Aldrich syndrome, possibly caused by immune dysr

40 actin-nucleating machine activated by WASp (Wiskott Aldrich syndrome protein).

41 as the levels of F-actin and phosphorylated Wiskott Aldrich syndrome protein, an actin nucleation pr

42 The constitutively active mutant of the Wiskott-Aldrich Syndrome protein (CA-WASp) is the cause

43 tein c-Abl interactor 1 (Abi1) with neuronal Wiskott-Aldrich syndrome protein (N-WASP) (an actin-regu

44 complex was necessary for cdc42 and neuronal Wiskott-Aldrich syndrome protein (N-WASP) activation, ac

45 spatial and temporal regulation of neuronal Wiskott-Aldrich syndrome protein (N-WASP) activity in li

46 nts in the actin regulatory protein neuronal Wiskott-Aldrich syndrome protein (N-WASP) and an SH2 dom

47 474/1 leads to recruitment of Nck and neural Wiskott-Aldrich syndrome protein (N-WASP) and strong act

48 c42), the nucleation-promoting factor neural Wiskott-Aldrich syndrome protein (N-WASP) and the actin

49 zation is mediated by activation of neuronal Wiskott-Aldrich syndrome protein (N-WASp) and the Arp (a

50 iprotein compound containing CrkII, neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and the Arp2/3

51 gulators of actin cytoskeleton dynamics, the Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3

52 ole of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in c

53 and Src family tyrosine kinases, and neural Wiskott-Aldrich syndrome protein (N-WASP) but not the Ar

54 indicates that the nuclear localized neural Wiskott-Aldrich syndrome protein (N-WASP) can induce de

55 Neuronal Wiskott-Aldrich syndrome protein (N-WASP) has an essenti

56 we showed that S. flexneri relies on neural Wiskott-Aldrich Syndrome protein (N-WASP) in HT-29 cells

57 f hyaluronan (HA) and CD44 with the neuronal Wiskott-Aldrich syndrome protein (N-WASP) in regulating

58 f the actin-regulatory protein called neural Wiskott-Aldrich syndrome protein (N-WASP) interacting wi

59 Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is a member of

60 The VCA domain of the neuronal Wiskott-Aldrich syndrome protein (N-WASP) is a potent ac

61 Co et al. now show that the neural Wiskott-Aldrich syndrome protein (N-WASP) mediates dynam

62 er suggests that the actin-regulatory neural Wiskott-Aldrich syndrome protein (N-WASP) mediates the e

63 In this study, we show neural Wiskott-Aldrich syndrome protein (N-WASP) regulates the

64 actin nucleating endocytic protein neuronal Wiskott-Aldrich syndrome protein (N-WASP) to facilitate

65 n activation of the Arp2/3 complex by neural Wiskott-Aldrich Syndrome protein (N-WASP) via Grb2 and N

66 Neural Wiskott-Aldrich syndrome protein (N-WASP), a ubiquitous

67 -mediated EGFR signaling up-regulated neural Wiskott-Aldrich syndrome protein (N-WASP), an actin nucl

68 ched in actin-related protein 3 and neuronal Wiskott-Aldrich syndrome protein (N-WASP), and their ass

69 in-binding and -polymerizing proteins neural Wiskott-Aldrich syndrome protein (N-WASP), cortactin, an

70 ockout approach to assess the role of neural Wiskott-Aldrich syndrome protein (N-WASP), the ubiquitou

71 s, we have analysed the dynamics of neuronal Wiskott-Aldrich syndrome protein (N-WASP), WASP-interact

72 We altered the function of neural Wiskott-Aldrich syndrome protein (N-WASP), which induces

73 nce microscopy, we demonstrate that neuronal Wiskott-Aldrich syndrome protein (N-WASP), which is coex

74 Here, we demonstrate that neuronal Wiskott-Aldrich syndrome protein (N-WASP), which promote

75 M. avium led to the recruitment of neuronal Wiskott-Aldrich syndrome protein (N-WASp), which was not

76 Neuronal Wiskott-Aldrich syndrome protein (N-WASP)-activated acti

77 nd like IcsA, YapV recruits mammalian neural Wiskott-Aldrich syndrome protein (N-WASP).

78 Nck and the actin nucleation promoter neural Wiskott-Aldrich syndrome protein (N-WASP).

79 karyotic sorting nexin 9 (SNX9) and neuronal Wiskott-Aldrich syndrome protein (N-WASP).

80 the actin polymerization catalyst, neuronal Wiskott-Aldrich syndrome protein (N-WASP).

81 The Wiskott-Aldrich syndrome protein (WASP) and its homolog

82 The Wiskott-Aldrich syndrome protein (WASP) and neural WASP

83 The WIP C-terminal domain binds to Wiskott-Aldrich syndrome protein (WASp) and regulates it

84 ctivation, when it is able to associate with Wiskott-Aldrich syndrome protein (WASp) and the actin fi

85 Actin polymerization mediated by Wiskott-Aldrich syndrome protein (WASp) and the actin-re

86 Nodule formation is dependent on Wiskott-Aldrich syndrome protein (WASp) and the ARP2/3 c

87 in polymerization through Arp2/3 nucleation, Wiskott-Aldrich syndrome protein (WASP) and WASP family

88 actin polymerization in pseudopods, whereas Wiskott-Aldrich syndrome protein (WASP) assembles actin

89 the SRC homology 3 (SH3) domain and impairs Wiskott-Aldrich syndrome protein (WASP) binding, but it

90 tative model of allosteric regulation of the Wiskott-Aldrich syndrome protein (WASP) by the Rho GTPas

91 the formation of endogenous Lck-Dlgh1-Zap70-Wiskott-Aldrich syndrome protein (WASp) complexes in whi

92 Wiskott-Aldrich syndrome protein (WASP) deficiency in mi

93 which are caused by WAS mutations affecting Wiskott-Aldrich syndrome protein (WASp) expression or ac

94 rimary immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) expression, resu

95 The proteins of the Wiskott-Aldrich syndrome protein (WASP) family are activ

96 Members of the Wiskott-Aldrich syndrome protein (WASP) family control a

97 Members of the Wiskott-Aldrich syndrome protein (WASP) family control c

98 We recently showed that the Wiskott-Aldrich syndrome protein (WASP) family member, W

99 d by different human proteins, including the Wiskott-Aldrich syndrome protein (WASp) family members.

100 w that mycolactone operates by hijacking the Wiskott-Aldrich syndrome protein (WASP) family of actin-

101 Wiskott-Aldrich syndrome protein (WASP) family verprolin

102 , and acidic (VCA) region of proteins in the Wiskott-Aldrich syndrome protein (WASp) family, Arp2/3 c

103 in response to signals from proteins in the Wiskott-Aldrich syndrome protein (WASP) family.

104 controls actin by activating members of the Wiskott-Aldrich syndrome protein (WASP) family.

105 the actin machinery, such as members of the Wiskott-Aldrich syndrome protein (WASp) family.

106 WAS and XLT are caused by mutations of the Wiskott-Aldrich syndrome protein (WASP) gene which encod

107 Wiskott-Aldrich syndrome protein (WASP) has emerged as a

108 No defects related to deficiency of the Wiskott-Aldrich Syndrome protein (WASp) have been descri

109 f formins, known filament nucleators use the Wiskott-Aldrich syndrome protein (WASP) homology 2 (WH2

110 A role for Wiskott-Aldrich syndrome protein (WASP) in chemotaxis to

111 The role of the Wiskott-Aldrich syndrome protein (WASp) in platelet func

112 Wiskott-Aldrich Syndrome protein (WASp) is a hematopoiet

113 The Wiskott-Aldrich syndrome protein (WASP) is a key cytoske

114 The Wiskott-Aldrich syndrome protein (WASp) is a key regulat

115 The Wiskott-Aldrich syndrome protein (WASP) is a product of

116 In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential

117 We demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an important

118 Wiskott-Aldrich syndrome protein (WASp) is essential for

119 The Wiskott-Aldrich syndrome protein (WASp) is important for

120 previously that tyrosine phosphorylation of Wiskott-Aldrich syndrome protein (WASP) is important for

121 Wiskott-Aldrich syndrome protein (WASP) is in a complex

122 The Wiskott-Aldrich syndrome protein (WASp) regulates actin

123 utation (Leu270Pro) in the gene encoding the Wiskott-Aldrich syndrome protein (WASp) resulting in an

124 The Wiskott-Aldrich Syndrome protein (WASp) serves as a cruc

125 fic mutations in the human gene encoding the Wiskott-Aldrich syndrome protein (WASp) that compromise

126 LN) is caused by activating mutations in the Wiskott-Aldrich syndrome protein (WASP) that result in a

127 Here we have used cells deficient in the Wiskott-Aldrich syndrome protein (WASp) to demonstrate t

128 etal dysfunction caused by deficiency of the Wiskott-Aldrich syndrome protein (WASp) to explore the c

129 r receptor-bound protein 2 (Grb2) and to the Wiskott-Aldrich syndrome protein (WASp) to form a hetero

130 Defects in Wiskott-Aldrich Syndrome protein (WASp) underlie develop

131 ds through its BAR domain and interacts with Wiskott-Aldrich Syndrome Protein (WASP) via its SRC homo

132 roteins involved in actin dynamics including Wiskott-Aldrich syndrome protein (WASp) were regulated b

133 ed via the phagocyte-specific kinase Hck and Wiskott-Aldrich syndrome protein (WASP), 2 major regulat

134 we demonstrated that ACK1 phosphorylates the Wiskott-Aldrich syndrome protein (WASP), a Cdc42 effecto

135 s, develop in patients and mice deficient in Wiskott-Aldrich syndrome protein (WASP), a hematopoietic

136 tients bearing inactivating mutations in the Wiskott-Aldrich syndrome protein (WASP), a key regulator

137 onsisting of WASp-interacting protein (WIP), Wiskott-Aldrich syndrome protein (WASp), actin, and myos

138 f, required an activating factor such as the Wiskott-Aldrich syndrome protein (WASP), and might exhib

139 rcent of natural killer (NK) cells expressed Wiskott-Aldrich syndrome protein (WASP), and NK cells co

140 HS1 interacts with Wiskott-Aldrich syndrome protein (WASp), another key act

141 teractions with a wide network of molecules: Wiskott-Aldrich syndrome protein (WASp), Grb2, ribosomal

142 se pulldown analyses show Robo4 binding to a Wiskott-Aldrich syndrome protein (WASP), neural Wiskott-

143 we provide evidence that Kit signals through Wiskott-Aldrich syndrome protein (WASP), the central hem

144 e B (PhyB) and fused the Cdc42 effector, the Wiskott-Aldrich Syndrome Protein (WASP), to the light-de

145 Two such adaptor proteins, Nck and the Wiskott-Aldrich syndrome protein (WASp), were recruited

146 Podosome formation requires the Wiskott-Aldrich syndrome protein (WASP), which is a prod

147 hat branching occurs when Arp2/3 is bound to Wiskott-Aldrich syndrome protein (WASP), which is in tur

148 Here we show that deficiency of Wiskott-Aldrich syndrome protein (WASp), which signals t

149 edly reduced in macrophages deficient in the Wiskott-Aldrich syndrome protein (WASP), which still con

150 WAVE1--the Wiskott-Aldrich syndrome protein (WASP)--family verproli

151 tients with the Wiskott-Aldrich syndrome and Wiskott-Aldrich syndrome protein (WASP)-deficient mice,

152 Wiskott-Aldrich syndrome protein (WASP)-deficient T cell

153 Here, we show that Wiskott-Aldrich syndrome protein (WASP)-family verprolin

154 P) intracellular domain (AICD) downregulates Wiskott-Aldrich syndrome protein (WASP)-family verprolin

155 Wiskott-Aldrich syndrome protein (WASP)-homology domain

156 Here, we demonstrate that Wiskott-Aldrich syndrome protein (WASp)-interacting prot

157 s, where it was activated by p78/83, a viral Wiskott-Aldrich syndrome protein (WASP)-like protein.

158 recognize other motility proteins, like the Wiskott-Aldrich syndrome protein (WASP).

159 inase (ACK), p21-activated kinase (PAK), and Wiskott-Aldrich syndrome protein (WASP).

160 r of the actin cytoskeleton and activator of Wiskott-Aldrich syndrome protein (WASP).

161 The gene defective in WAS encodes Wiskott-Aldrich syndrome protein (WASP).

162 ematopoietic-specific cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASP).

163 lex by the actin nucleation-promoting factor Wiskott-Aldrich Syndrome protein (WASp).

164 olled by signaling pathways that include the Wiskott-Aldrich syndrome protein (WASP).

165 inhibit the ability of Nwk-SH3a to activate Wiskott-Aldrich syndrome protein (WASp)/actin related pr

166 mparable to podosomes in the localization of Wiskott-Aldrich syndrome protein (WASP)/matrix metallopr

167 Nucleation-promoting factors (NPFs) of the Wiskott-Aldrich syndrome protein (WASP)/Scar family are

168 lex must bind ATP, protein activators [e.g., Wiskott-Aldrich syndrome protein (WASp)], and the side o

169 Wiskott-Aldrich syndrome protein (WASPs) control actin d

170 /3 complex activation domain (WCA) of Las17 (Wiskott-Aldrich syndrome protein [WASp] homologue) fused

171 ngagement increases actin polymerization and Wiskott-Aldrich syndrome protein activation in a Btk-dep

172 achment but inhibits ingestion by decreasing Wiskott-Aldrich syndrome protein activation, and hence a

173 contractility, independent of its effects on Wiskott-Aldrich syndrome protein and p21-activated kinas

174 t complex and the endosomal Arp2/3 activator Wiskott-Aldrich syndrome protein and Scar homolog (WASH)

175 l. and Gomez and Billadeau reveal that WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) activ

176 WASH (Wiskott-Aldrich Syndrome Protein and SCAR Homolog) is an

177 Wiskott-Aldrich syndrome protein and SCAR homologue (WAS

178 The Arp2/3-activator Wiskott-Aldrich syndrome protein and Scar homologue (WAS

179 FAM21, which also binds retromer, within the Wiskott-Aldrich syndrome protein and SCAR homologue (WAS

180 w that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott-Aldrich syndrome protein and SCAR homologue (WAS

181 JIPs are recruited by Wiskott-Aldrich syndrome protein and scar homologue (WAS

182 dc42 may regulate the activation of neuronal Wiskott-Aldrich syndrome protein and the actin related p

183 ptor that replaces toca-1 to mobilize neural Wiskott-Aldrich syndrome protein and the Arp2/3 complex.

184 Mutations of the Wiskott-Aldrich syndrome protein can result in highly va

185 ely in hematopoietic stem cells, and because Wiskott-Aldrich syndrome protein exerts a strong selecti

186 Recombinant Arc40 bound the VCA domain of Wiskott-Aldrich syndrome protein family activators at a

187 The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) direct

188 Wiskott-Aldrich syndrome protein family verprolin homolo

189 binding regions of TOCA1 and a member of the Wiskott-Aldrich syndrome protein family, N-WASP.

190 NK cell function relies on Wiskott-Aldrich syndrome protein for filamentous actin (

191 Wiskott-Aldrich syndrome protein gene mutations result i

192 drich syndrome is caused by mutations of the Wiskott-Aldrich syndrome protein gene, which codes for a

193 he discovery of unique functional domains of Wiskott-Aldrich syndrome protein has been instrumental i

194 ress made in dissecting the functions of the Wiskott-Aldrich syndrome protein has direct implications

195 g a proline-rich domain and an actin-binding Wiskott-Aldrich syndrome protein homology 2 (WH2) domain

196 y relies on a cluster of three actin-binding Wiskott-Aldrich syndrome protein homology 2 (WH2) domain

197 length short (SALS) is a recently identified Wiskott-Aldrich syndrome protein homology 2 (WH2) domain

198 despite having only a single G-actin-binding Wiskott-Aldrich syndrome protein Homology 2 (WH2) domain

199 autoregulatory domain (DAD) that resembles a Wiskott-Aldrich syndrome protein homology 2 (WH2) sequen

200 variable was the presence or absence of the Wiskott-Aldrich syndrome protein in the lymphoid cells f

201 Wiskott-Aldrich syndrome protein is a signaling molecule

202 Since Wiskott-Aldrich syndrome protein is expressed exclusivel

203 In addition, the Wiskott-Aldrich syndrome protein is required for natural

204 mphiphysin-RVS-domain protein Rvs167 and the Wiskott-Aldrich syndrome protein Las17 at the point of p

205 ed that C. parvum activates the Cdc42/neural Wiskott-Aldrich syndrome protein network in host cells r

206 Neuronal Wiskott-Aldrich syndrome protein regulates TGF-beta1-med

207 WASH is an Arp2/3 activator of the Wiskott-Aldrich syndrome protein superfamily that functi

208 ve studies of patients with mutations of the Wiskott-Aldrich syndrome protein unequivocally demonstra

209 The actin-modulating protein Wiskott-Aldrich syndrome protein verprolin homologous-1

210 The direct interaction of Skap2 with the Wiskott-Aldrich syndrome protein via its SH3 domain is c

211 ctin dynamics and Ag transport by activating Wiskott-Aldrich syndrome protein via Vav and phosphatidy

212 Finally, the Wiskott-Aldrich syndrome protein was shown to play an im

213 hat drive actin polymerization such as WASp (Wiskott-Aldrich syndrome protein) and HS1 (hematopoietic

214 mbly protein Las17 (a yeast homolog of human Wiskott-Aldrich syndrome protein) and participate in the

215 for actin binding (profilin or the WH2 from Wiskott-Aldrich syndrome protein) decrease full-length I

216 EspF(U) potently activates the host WASP (Wiskott-Aldrich syndrome protein) family of actin-nuclea

217 proteins 2/3) complex is activated by WASP (Wiskott-Aldrich syndrome protein) family proteins to nuc

218 tant manner, bound actin monomer via a WASP (Wiskott-Aldrich syndrome protein) homology 2 domain, bou

219 nucleation-promoting protein N-WASP (Neural Wiskott-Aldrich syndrome protein) is up-regulated in bre

220 n with the nucleation-promoting factor Wasp (Wiskott-Aldrich syndrome protein).

221 ctin dynamics through the Nck/N-WASp (neural Wiskott-Aldrich syndrome protein)/Arp2/3 pathway is esse

222 exists in a macromolecular complex with the Wiskott-Aldrich syndrome protein, an actin nucleation-pr

223 kott-Aldrich syndrome protein (WASP), neural Wiskott-Aldrich syndrome protein, and WASP-interacting p

224 cell division cycle 42, which, together with Wiskott-Aldrich syndrome protein, coordinates F-actin re

225 such as integrin beta1, cortactin, neuronal Wiskott-Aldrich syndrome protein, membrane type 1 metall

226 sion required actin polymerization, neuronal Wiskott-Aldrich syndrome protein, myosin II and Rho GTPa

227 the microtubule-organizing center, F-actin, Wiskott-Aldrich syndrome protein, nor proline rich tyros

228 became more tightly associated with neuronal Wiskott-Aldrich syndrome protein, promoting actin-relate

229 This includes Wiskott-Aldrich syndrome protein, Wiskott-Aldrich syndro

230 Studies of Wiskott-Aldrich syndrome protein-deficient cell lines an

231 Wiskott-Aldrich syndrome protein-deficient neutrophils a

232 ition, Arp3-silenced cells expressing neural Wiskott-Aldrich syndrome protein-derived peptides that i

233 Further, CYFIP2 is part of the Wiskott-Aldrich syndrome protein-family verprolin-homolo

234 Wiskott-Aldrich syndrome protein-interacting protein (WI

235 s includes Wiskott-Aldrich syndrome protein, Wiskott-Aldrich syndrome protein-interacting protein, co

236 fining mechanisms that control activation of Wiskott-Aldrich syndrome protein.

237 se 1, Grb2-associated protein 2 (Grap2), and Wiskott-Aldrich syndrome protein.

238 ft microdomain along with Arp2/3 complex and Wiskott-Aldrich syndrome protein.

239 adhesion kinase, Rho GTPase Rac1, and neural Wiskott-Aldrich syndrome protein.

240 e cytoskeleton by binding and activating the Wiskott-Aldrich syndrome protein.

241 suring vector copy numbers and expression of Wiskott-Aldrich syndrome protein.

242 onse to signals that locally activate neural Wiskott-Aldrich-syndrome protein (N-WASP) and the Arp2/3

243 The Src family kinase Hck, Wiskott-Aldrich-syndrome protein, and phospholipase Cgam

244 Wiskott-Aldrich syndrome proteins (WASP) are a family of

245 ycolactone-mediated activation of neural (N) Wiskott-Aldrich syndrome proteins (WASP) induces defects

246 to which we apply these ideas is that of the Wiskott-Aldrich Syndrome Proteins as activators of actin

247 cytoskeletal regulator WASP, mutated in the Wiskott-Aldrich syndrome, provides selective advantage f

248 The Wiskott-Aldrich syndrome-related protein WAVE2 promotes

249 The activity of the Wiskott-Aldrich syndrome-related WAVE3 protein is critic

250 m patients with X-linked thrombocytopenia or Wiskott-Aldrich syndrome, respectively.

251 cluding common variable immunodeficiency and Wiskott-Aldrich syndrome, to explain the occurrence of a

252 Wiskott Aldrich syndrome (WAS) is caused by mutations in

253 Wiskott Aldrich syndrome (WAS), an X-linked immunodefici

254 nsitization in patients with food allergy or Wiskott-Aldrich syndrome (WAS) and defined whether spont

255 Because Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytop

256 Wiskott-Aldrich Syndrome (WAS) family proteins are Arp2/

257 Scar/WAVE proteins, members of the conserved Wiskott-Aldrich syndrome (WAS) family, promote actin pol

258 Patients with the immunodeficiency Wiskott-Aldrich syndrome (WAS) frequently develop system

259 Patients with Wiskott-Aldrich syndrome (WAS) have numerous immune cell

260 dividuals with the X-linked immunodeficiency Wiskott-Aldrich syndrome (WAS) have opposite alterations

261 The Wiskott-Aldrich syndrome (WAS) interacting protein (WIP)

262 Wiskott-Aldrich syndrome (WAS) is a platelet/immunodefic

263 Wiskott-Aldrich syndrome (WAS) is a primary immunodefici

264 Wiskott-Aldrich syndrome (WAS) is a primary immunodefici

265 Wiskott-Aldrich syndrome (WAS) is a rare X-linked primar

266 Wiskott-Aldrich syndrome (WAS) is a severe X-linked immu

267 Wiskott-Aldrich syndrome (WAS) is an inherited immunodef

268 Wiskott-Aldrich syndrome (WAS) is an X-linked immunodefi

269 Wiskott-Aldrich syndrome (WAS) is an X-linked immunodefi

270 Wiskott-Aldrich syndrome (WAS) is an X-linked immunodefi

271 The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive

272 Wiskott-Aldrich syndrome (WAS) is associated with mutati

273 Wiskott-Aldrich syndrome (WAS) is caused by loss-of-func

274 Wiskott-Aldrich syndrome (WAS) is caused by mutations in

275 The Wiskott-Aldrich syndrome (WAS) is characterized by defec

276 The immunodeficiency disorder Wiskott-Aldrich syndrome (WAS) leads to life-threatening

277 sequences of immunodeficiency, patients with Wiskott-Aldrich syndrome (WAS) often suffer from poorly

278 al allospecific T-cell clones derived from a Wiskott-Aldrich syndrome (WAS) patient identified by flo

279 ar density to be reduced on lymphocytes from Wiskott-Aldrich syndrome (WAS) patient, we find no such

280 Wiskott-Aldrich syndrome (WAS) patients have loss-of-fun

281 Mutations in Wiskott-Aldrich syndrome (WAS) protein (WASp), a regulat

282 all Rho GTPase Cdc42, known to interact with Wiskott-Aldrich syndrome (WAS) protein, is an important

283 rich syndrome gene (WAS) are responsible for Wiskott-Aldrich syndrome (WAS), a disease characterized

284 Wiskott-Aldrich syndrome (WAS), an immunodeficiency diso

285 y affected in macrophages from patients with Wiskott-Aldrich syndrome (WAS), an X chromosome-linked i

286 ng severe combined immune deficiency (SCID), Wiskott-Aldrich syndrome (WAS), and chronic granulomatou

287 The Wiskott-Aldrich syndrome (WAS), caused by mutations in t

288 In Wiskott-Aldrich syndrome (WAS), immunodeficiency and aut

289 f consanguineous parents, showed features of Wiskott-Aldrich syndrome (WAS), including recurrent infe

290 ysis of the French Registry of patients with Wiskott-Aldrich Syndrome (WAS), Mahlaoui et al have iden

291 f a nationwide database of 160 patients with Wiskott-Aldrich syndrome (WAS), we identified a subset o

292 e precisely identify the B-cell phenotype in Wiskott-Aldrich syndrome (WAS), we used 3 distinct murin

293 Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopeni

294 etic and immunologic symptoms reminiscent of Wiskott-Aldrich syndrome (WAS).

295 splantation was the only curative option for Wiskott-Aldrich syndrome (WAS).

296 tions thereof contribute to the pathology of Wiskott-Aldrich syndrome (WAS).

297 ts with a genetic immunodeficiency disorder, Wiskott-Aldrich syndrome (WAS).

298 tenuation of blood-cell disorders, including Wiskott-Aldrich syndrome (WAS).

299 erization by activating Rho-like GTPases and Wiskott-Aldrich syndrome (WASp) family proteins.

300 tanding of the distinct clinical phenotypes (Wiskott-Aldrich syndrome/X-linked thrombocytopenia; inte