ライフサイエンスコーパス: X chromosome

1 ed on the X Chromosome (demasculinization of X Chromosome).

2 cestry (95 806 participants with data on the X-chromosome).

3 to our knowledge, the first analysis of the X chromosome.

4 ons in the OPN1LW/OPN1MW gene cluster on the X chromosome.

5 3 and Xist lncRNA enrichment on the inactive X chromosome.

6 an be rescued by expressing this gene on the X chromosome.

7 levels in testes; and overrepresented on the X chromosome.

8 t of sex-specific regulatory variants on the X Chromosome.

9 onary recruitment of strong promoters on the X chromosome.

10 the extent of synteny and homology with the X chromosome.

11 ociated antigen D2 (MAGE-D2) and maps to the X chromosome.

12 missense variant in the SMARCA1 gene on the X chromosome.

13 to PRC2 target loci, including the inactive X chromosome.

14 methyl CpG binding protein 2 (MeCP2) on the X chromosome.

15 the three-dimensional (3D) structure of the X chromosome.

16 ch can recombine with similar repeats on the X chromosome.

17 2, encoded by HNRNPH2, a gene located on the X chromosome.

18 he transcriptional silencing of genes on the X chromosome.

19 e events preferentially involve the inactive X chromosome.

20 t dosage imbalance between the autosomes and X chromosome.

21 xpression owing to haploid expression of the X chromosome.

22 lating histones to exclude Pol II across the X chromosome.

23 y targets during propagation of XCI over the X chromosome.

24 Such regions are found exclusively on the X chromosome.

25 RNA Tsix, which represses Xist on the active X chromosome.

26 epigenetic instability, particularly on the X chromosome.

27 ch gene expression is relatively rare on the X chromosome.

28 at a minority of sites, notably the inactive X chromosome.

29 he repressive complex formed by the inactive X chromosome.

30 ycomb repressive complex 2 (PRC2) across the X chromosome.

31 mous substitution ratio than the rest of the X chromosome.

32 f Y-linked alleles, or gene additions to the X chromosome.

33 vels with male cells, which contain a single X chromosome.

34 gene regulation: the dosage-compensated male X chromosome.

35 distributed between males and females on the X chromosome.

36 nvolves up-regulation of genes on the male's X chromosome.

37 ption indicates reactivation of the silenced X chromosome.

38 the methyl-CpG-binding protein MeCP2 on the X chromosome.

39 inconsistent recombination artefacts for the X chromosome.

40 moters of silenced genes across the inactive X chromosome.

41 rg equilibrium with biallelic markers at the X chromosome.

42 histone H4 at lysine 16 specifically on the X Chromosome.

43 ted inactivation of the paternally inherited X chromosome.

44 specifically for dealing with markers on the X chromosome.

45 ed HapMap imputation and did not examine the X-chromosome.

46 re no genome-wide significant signals on the X-chromosome.

47 nalytic methods optimized for markers on the X-chromosome.

48 presses transcription from the hermaphrodite X chromosomes.

49 ns of TADs in human interphase autosomes and X chromosomes.

50 erent conformations for the two female mouse X chromosomes.

51 lity compared with females with two parental X chromosomes.

52 duction of transcribed genes on the inactive X chromosome, a mode of PRC2 function that may apply bro

53 dentify human-specific mechanisms regulating X chromosome activity in early embryonic development.

54 tic activity of XIST and XACT in controlling X chromosome activity in early human embryos, and they h

55 ated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating intera

56 Active and inactive X chromosomes adopt different folding and compartmentali

57 cently demonstrated that the inactive murine X chromosome adopts a bipartite structure using a novel

58 Because female cells carry two X chromosomes, an emerging treatment strategy has been t

59 s suggests a genetic interaction between the X Chromosome and autosomes that is essential for male fe

60 porting an epistatic interaction between the X Chromosome and autosomes.

61 expression, including comparison between the X Chromosome and autosomes.

62 omic strains of mice possessing an identical X chromosome and CNV in Y chromosome multicopy genes exh

63 ons in the moesin (MSN) gene (located on the X chromosome and coding for MSN) in all 7 patients.

64 Reverted ESCs reactivate the silenced X chromosome and contribute to embryos following blastoc

65 y associating domain (TAD) boundaries on the X chromosome and harbor more long-range contacts in a se

66 ly upregulated from the prospective inactive X chromosome and is required in cis for X inactivation.

67 the autosomes and led to feminization of the X chromosome and masculinization of the Y chromosome.

68 application to gene sequences on the papaya X chromosome and protein-coding sequences on the S. lati

69 a contained abundant mCH similar to the male X chromosome and the autosomes.

70 In mammals, one of the female X chromosomes and all imprinted genes are expressed excl

71 ication allows ADMIXTURE to correctly handle X-chromosome (and other haploid) data from both males an

72 )) in the intron of the dystrophin gene DMD (X chromosome), and a suggestive locus on chromosome 7 (r

73 oved assembly and gene annotation of the pig X Chromosome, and a first draft assembly of the pig Y Ch

74 on that encodes an RNA that coats the silent X chromosome, and modulation of regulators of this pathw

75 ain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosop

76 wide insight into how genetic variation, the X Chromosome, and sex shape human gene regulation and di

77 ormones, the presence or absence of a second X chromosome, and sex-specific gut microbiota can influe

78 e composition of autosomal as well as mtDNA, X chromosome, and Y chromosome ancestries.

79 Specifically, X-chromosome aneuploidy accentuated normative rightward

80 ed on the X chromosome, genes located on the X chromosome are also silenced.

81 eolithic/Bronze Age populations, while their X chromosomes are in addition equally closely related to

82 In many organisms, it remains unclear how X chromosomes are specified for dosage compensation, sin

83 X chromosomes are unusual in many regards, not least of

84 otein like 1 (IL1RAPL1) gene, located on the X chromosome, are associated with intellectual disabilit

85 ant with a specific defect in pairing of the X chromosome as a model to investigate the apparent bias

86 No significant X-chromosome associations were detected and X-linked mar

87 atory stocks containing the most widely used X chromosome balancer, First Multiple 7 (FM7).

88 in mCH on the active (Xa) and inactive (Xi) X chromosomes because stochastic X-chromosome inactivati

89 The inactivated X chromosome becomes heterochromatic and visits a specif

90 Here we explore the X chromosome behavior in female and hermaphrodite meiose

91 lance due to the difference in the number of X chromosomes between male and female mammals is remedie

92 troviral transgenes and reactivated silenced X chromosomes, both hallmarks of pluripotent stem cells.

93 that the house fly has retained the ancient X Chromosome, but the ancestral Y was replaced by an X C

94 imply that the DCC reshapes the topology of X chromosomes by forming new TAD boundaries and reinforc

95 The X Chromosome carries 1033 annotated genes, 690 of which

96 some, but the ancestral Y was replaced by an X Chromosome carrying a new male determining gene.

97 s less evidence for de novo mutations on the X chromosome causing ID in females.

98 , elevates X-linked gene expression, reduces X chromosome compaction, and disrupts X chromosome confo

99 educes X chromosome compaction, and disrupts X chromosome conformation by diminishing the formation o

100 Dosage-compensated X chromosomes consist of self-interacting domains ( appr

101 region of the Y(h) chromosome (HSY) and its X chromosome counterpart were sequenced and analyzed pre

102 Doublecortin on the X-chromosome (DCX) is a neuronal microtubule-binding pro

103 lecule family cell surface receptors and the X-chromosome-defined signaling lymphocytic activation mo

104 Y3 transcript exon in a previously described X chromosome deletion associated with autism, and the ce

105 nriched on the autosomes but depleted on the X Chromosome (demasculinization of X Chromosome).

106 that reactivation of gene expression on the X chromosome depends on gene chromosomal position.

107 and add novel insight into the evolution of X-chromosome-derived autosomal retrogenes and their role

108 imental evidence correlating the function of X-chromosome-derived autosomal retrogenes with evolution

109 We demonstrate that the breakpoint on the X chromosome disrupted a gene that encodes an auxiliary

110 re system for functionally exploring the two X chromosome dosage compensation processes in early huma

111 rase 8 (KAT8), an important component of the X chromosome dosage compensation system in Drosophila, r

112 ipt (Xist gene) is responsible for mammalian X-chromosome dosage compensation between the sexes, the

113 Furthermore, our results argue against an X-chromosome dosage compensation model contingent upon r

114 the Y chromosome and instead implicating the X-chromosome dose as the source of the sex-specific diff

115 nt in primary cells of an individual with an X chromosome duplication including MECP2.

116 stone modification H4K20me1 on hermaphrodite X chromosomes during C. elegans dosage compensation and

117 esis resulted in RNA-guided shredding of the X-chromosome during male meiosis and produced extreme ma

118 heles gambiae, by selectively destroying the X-chromosome during spermatogenesis, through the activit

119 The X chromosome-encoded histone demethylase UTX (also known

120 Eif2s3y, by transgenic overexpression of its X chromosome-encoded homolog Eif2s3x.

121 entiation and function are controlled by the X-chromosome-encoded transcription factor Foxp3.

122 ession quantitative trait loci (eQTL) on the X Chromosome, especially among genes under high selectiv

123 The mammalian X chromosome exemplifies this structure-function relatio

124 X chromosome exome sequencing revealed four missense var

125 An X-chromosome exome screen identified a missense mutation

126 mployed massively parallel sequencing of all X-chromosome exons in the index males.

127 e ancestral rate (per promoter) prior to the X chromosome formation, then the X is not a tolerable en

128 hree generations of crosses, we introgressed X chromosomes from each species onto different, mixed ge

129 m cell elimination associated with defective X chromosome gene silencing and sex chromosome condensat

130 on of Y-chromosomes across fly species.While X-chromosome gene content tends to be conserved, Y-chrom

131 young male with a hemizygous mutation in the X-chromosome gene FIGF (c.352 G>A) associated with early

132 However, X chromosomes generally show a deficiency of genes with

133 In mammals, X chromosome genes are present in one copy in males and

134 Six of 783 non-pseudoautosomal region (PAR) X-chromosome genes (ATRX, CNKSR2, DDX3X, KDM5C, KDM6A, a

135 A subset of X-chromosome genes can escape X-inactivation, which woul

136 E-1 transposons are strongly enriched on the X chromosome, genes located on the X chromosome are also

137 The X-chromosome harbors hundreds of disease genes whose ass

138 study, we show that, in hPSCs, the inactive X chromosome has a specific heterochromatin landscape th

139 Specifically, the X chromosome has acquired a paradoxical sex-biased funct

140 inary selectivity of the MSL complex for the X chromosome has never been explained.

141 The testing of markers on the X chromosome has received little attention, and in this

142 small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries.

143 a logistic regression model trained on both X chromosome heterozygosity and Y chromosome missingness

144 for sex inference in GWAS that assesses only X chromosome heterozygosity, seXY achieved marginally be

145 lt in increased expression of OPHN1, a known X-chromosome ID gene.

146 During the past two decades in excess of 100 X-chromosome ID genes have been identified.

147 cing at diverse loci, including the inactive X chromosome, imprinted genes, and the facioscapulohumer

148 fferentially epigenetically regulated beyond X chromosome imprinting.

149 ession fragment from Caenorhabditis briggsae X Chromosome in an otherwise Caenorhabditis nigoni backg

150 ential for dosage compensation of the single X chromosome in Drosophila males, revealed 47 new roX or

151 osage compensation complex to a newly formed X chromosome in Drosophila.

152 Thus, whereas Xist RNA can inactivate the X chromosome in females it may not do so in males.

153 including at genes silenced on the inactive X chromosome in females.

154 of Xist and in turn silencing of the single X chromosome in male embryonic stem cells.

155 fied mutations in more than 100 genes on the X chromosome in males with ID, but there is less evidenc

156 X-chromosome inactivation (XCI) silences one X chromosome in the female mammal and is essential to pe

157 nt leads to transcriptional silencing of one X chromosome in the female.

158 ave been described, but Bayesian work on the X chromosome in this context is lacking.

159 that the deficit of male-biased genes on the X Chromosomes in Anopheles is a conserved feature in thi

160 oding RNAs (lncRNAs) XACT and XIST on active X chromosomes in both early human pre-implantation embry

161 In female mammals, one of the two X chromosomes in each cell is transcriptionally silenced

162 ) silences transcription from one of the two X chromosomes in female mammalian cells to balance expre

163 One of the two X chromosomes in female mammals is inactivated by the no

164 dosage compensation in which one of the two X chromosomes in female mammals is transcriptionally sil

165 transcriptional silencing of one of the two X chromosomes in females.

166 od to compensate for the different number of X chromosomes in males and females.

167 early embryonic development, one of the two X chromosomes in mammalian female cells is inactivated t

168 Here we show that meiotic segregation of X chromosomes in the trioecious nematode Auanema rhodens

169 complex I-associated protein encoded on the X chromosome, in 5 males with a variably syndromic, norm

170 l pathways such as DNA methylation (DNMT3B), X chromosome inactivation (H2AFY), the DNA damage respon

171 stages, including 19 female tissues allowing X chromosome inactivation (XCI) escapers to also be dete

172 ng non-coding RNA essential for establishing X chromosome inactivation (XCI) in early embryos, is con

173 In mice, X chromosome inactivation (XCI) is regulated by the anti

174 X chromosome inactivation (XCI) silences transcription f

175 Female mammals use X chromosome inactivation (XCI) to generate a transcript

176 landscape that predisposes it to erosion of X chromosome inactivation (XCI), a process that occurs s

177 Evidence from epigenetic processes, such as X chromosome inactivation (XCI), indicates that CTCF ass

178 resolution RNA allelotyping method, to study X chromosome inactivation (XCI).

179 perties including differential regulation of X chromosome inactivation and of genes involved in oxida

180 n, which may explain why it does not trigger X chromosome inactivation at this stage.

181 alysis revealed distinct transcriptional and X chromosome inactivation changes associated with the ea

182 Furthermore, skewed X chromosome inactivation has been found in the thyroid

183 nes, in the silencing of transposons, and in X chromosome inactivation in female mammals.

184 X chromosome inactivation is an epigenetic dosage compen

185 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromo

186 ased on information gleaned from imprinting, X chromosome inactivation, and activation and silencing

187 a long noncoding RNA (lncRNA) essential for X chromosome inactivation, folds into evolutionarily con

188 s the "Barr body." Despite the importance of X chromosome inactivation, little is known about this 3D

189 tion between the genders in a process called X chromosome inactivation.

190 role of the nuclear matrix in the process of X chromosome inactivation.

191 uring gastrulation, reminiscent of mammalian X Chromosome inactivation.

192 se of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cel

193 X-chromosome inactivation (XCI) compensates for differen

194 active (Xi) X chromosomes because stochastic X-chromosome inactivation (XCI) confounds allele-specifi

195 o achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals.

196 X-chromosome inactivation (XCI) is the mammalian dosage

197 X-chromosome inactivation (XCI) silences one X chromosom

198 ubiquitin ligase important for initiation of X-chromosome inactivation and XIST transcription in ES c

199 long noncoding RNA (lncRNA) is essential for X-chromosome inactivation during female eutherian mammal

200 circuitry that maintains XIST expression and X-chromosome inactivation in differentiated cells.

201 X-chromosome inactivation is a mechanism of dosage compe

202 X-chromosome inactivation is established during early de

203 X-chromosome inactivation is then reversed in the inner

204 nd hematopoietic precursor cells, before the X-chromosome inactivation process occurs.

205 specific transcript (XIST), a key player in X-chromosome inactivation that encodes an RNA that coats

206 Recent studies have shown that, upon X-chromosome inactivation, active and inactive X chromos

207 of phenomena, including genomic imprinting, X-chromosome inactivation, and cis-regulatory evolution.

208 as previously shown to have diverse roles in X-chromosome inactivation, imprinting and double-strand

209 mechanism leading to genomic imprinting and X-chromosome inactivation, is widely reported at the non

210 male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptiona

211 ral processes such as genomic imprinting and X-chromosome inactivation, the functional significance o

212 ze silencing of X-linked genes in cis during X-chromosome inactivation, which equalizes X-linked gene

213 ary and sufficient for Xist spreading during X-chromosome inactivation.

214 ransposon silencing, genomic imprinting, and X-chromosome inactivation.

215 e 123 (DHR) oxidation data for percentage of X-chromosome inactivation.

216 r silencing by interrogating imprinted mouse X-chromosome inactivation.

217 we show that the DCC remodels hermaphrodite X chromosomes into a sex-specific spatial conformation d

218 ntly, the down-regulated genes caused by the X Chromosome introgressions show a significant enrichmen

219 The X chromosome is a relatively large chromosome, harboring

220 Inactivation of one X chromosome is established early in female mammalian de

221 First, an introgression on the X Chromosome is more likely to produce male sterility th

222 rmutation of cancer driver genes on inactive X chromosomes is a general feature in female cancer geno

223 e sexes, the process by which one of the two X chromosomes is inactivated in the female soma.

224 Consistent with the fact that one of the two X chromosomes is randomly inactivated, X-SPINK1 mice exh

225 ue to the sex-specific data structure of the X chromosome, it has been excluded from most of these an

226 uction in the levels of apoptosis inhibitor, X chromosome-linked inhibitor of apoptosis protein (XIAP

227 est due to its direct involvement in several X chromosome-linked intellectual disabilities, including

228 G1, an Arf-GEF synaptic protein, each led to X-chromosome-linked intellectual disability (XLID).

229 ch was first identified in patients with the X-chromosome-linked Opitz BBB/G (OS) syndrome, interacts

230 chromosome inactivation, active and inactive X chromosomes localize to different subnuclear positions

231 In addition, we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 x 10(-13)) a

232 cohort of patients with genetic evidence for X-chromosome locus involvement may resolve up to 58% of

233 Cumulatively, these loci also predicted X chromosome loss in women (n = 96,123; P = 4 x 10(-6)).

234 the presence of evolutionary strata on their X chromosomes, made possible by the sequencing of sex-li

235 Also, one of the female X chromosomes may be inactivated.

236 Here we show rates for X-chromosome mosaicism are four times higher than mean a

237 across Diptera from ordinary autosomes, and X-chromosomes mostly conserve their ancestral genes.

238 lncRNA Firre helps to position the inactive X chromosome near the nucleolus and to preserve one of i

239 four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individ

240 dosage compensation states are determined by X chromosome number, not phenotypic sex.

241 ivation (XCI) compensates for differences in X-chromosome number between male and female mammals.

242 observed in humans, great apes, and the neo-X chromosome of Drosophila miranda, which show the expec

243 cted by increased expression from the single X chromosome of males, a process known as dosage compens

244 TOPBP1 is essential for localization to the X chromosome of silencing "sensors," including BRCA1, an

245 a polyclonal pattern of inactivation of the X-chromosome of KIT-mutated BM mast cells (64% vs 0%; P

246 o date, most studies have either ignored the X Chromosome or had insufficient power to test for the s

247 pression of maladapted genes [3], and on the X chromosome (or the Z in ZW systems), which may evolve

248 protein-coding sequences on the S. latifolia X chromosome, our method could decipher all known evolut

249 ene with homologies to endopeptidases on the X-chromosome (PHEX).

250 We perform a comparative analysis of X chromosome polymorphism in 10 great ape species, inclu

251 blast cells and EpiSCs harbor an inactivated X chromosome prior to ectopic inactivation of the active

252 ng, the nuclear organization of the inactive X chromosome, recruitment of the polycomb complex and th

253 n the X-linked F8A3-TMLHE region, suggesting X chromosome regulation of SPRY3.

254 t, a large number of families mapping to the X-chromosome remained unresolved suggesting that more XL

255 Whereas X chromosomes segregate following the canonical pattern

256 permatogenesis, the sister chromatids of the X chromosomes separate during meiosis I, and homologous

257 The active X chromosome shows a minor but significant increase in g

258 ESCs or directly from blastocysts, but their X chromosome state has remained unresolved.

259 ible except at imprinted genes, and that the X chromosome status resembles that of the human preimpla

260 distribution of 1.688(X) sequences along the X chromosome suggests that they play a primary role in d

261 itously transcribed tetratricopeptide repeat X chromosome suppressed the induction of IRAK-M in respo

262 ximal expression is three times lower on the X chromosome than on autosomes.

263 region with a low recombination rate on the X chromosome that appears to have two distinct haplotype

264 st evolutionary recent segments of the human X chromosome that are depleted of LINE1 and enriched for

265 Here, we identify a novel lncRNA from the X chromosome that we named lncRHOXF1 and which is abunda

266 ion of 126 mutants in essential genes on the X chromosome to identify candidates that increase or dec

267 male-specific lethal (MSL) complexes to the X chromosome to upregulate expression of X-linked genes

268 experiments further reveal that the ratio of X chromosomes to autosomes dictates methylation levels,

269 st accumulates in cis on the future inactive X chromosome, triggering a cascade of events that provok

270 For markers at the X chromosome, typically the chi(2) or exact test is appl

271 method to integrate human SPINK1 gene on the X chromosome using Cre-loxP technology and thus generate

272 n: low-frequency protein-coding variants and X-chromosome variants.

273 3-fold or more-for transgenes inserted into X chromosome versus autosome locations.

274 An approximately 19 Mb critical region on X chromosome was identified through identity-by-descent

275 We found that the extra X chromosome was preferentially eliminated during anapha

276 known strata on the papaya and S. latifolia X chromosome, was applied to the chromosome 19 of Populu

277 opic inactivation of the active X(DeltaTsix) X chromosome, we propose that the increased expression o

278 al protein-coding genes present on the human X Chromosome were absent from the pig, and 38 pig-specif

279 e genome regions within 14 autosomes and the X chromosome were revealed, in which 18 and 4 were previ

280 on autosomes than the number of genes on the X chromosome where X-inactivation dictates RMAE of X-lin

281 Drosophila melanogaster males have one X chromosome, whereas females have two.

282 The basis for this sex bias lies in the X chromosome, which contains many immunity-related genes

283 lating higher-order chromosome structure and X-chromosome-wide gene expression.

284 In contrast, no analogous X-chromosome-wide mechanism balances transcription betwe

285 fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,0

286 el to compare the sex-specifically-inherited X chromosome with the autosomes in 20 early Neolithic an

287 e resulting naive cells contained two active X chromosomes with XIST expression and chromosome-wide t

288 The X Chromosome, with its unique mode of inheritance, contr

289 cted that females with two different species X chromosomes would suffer reduced fertility and viabili

290 expressed from both the active and inactive X chromosomes (Xa and Xi, respectively) in female cells,

291 tion, how Xist RNA localizes to the inactive X chromosome (Xi) and spreads in cis remains unclear.

292 he extent of reactivation along the inactive X chromosome (Xi) and the determinants of locus suscepti

293 generate a transcriptionally silent inactive X chromosome (Xi) enriched with heterochromatic modifica

294 Reactivation of the inactive X chromosome (Xi) has been used to model epigenetic repr

295 that CIZ1 is highly enriched on the inactive X chromosome (Xi) in mouse and human female cells and is

296 During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent an

297 Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivated in nai

298 the wild-type copy of MeCP2 on the inactive X chromosome (Xi) presents a therapeutic opportunity in

299 The inactive X chromosome (Xi) serves as a model to understand gene s

300 , transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks suc