ライフサイエンスコーパス: X chromosome inactivation

1 ompensation of X-linked genes is achieved by X chromosome inactivation.

2 uring gastrulation, reminiscent of mammalian X Chromosome inactivation.

3 nism to anchor Xist to the Xi and facilitate X chromosome inactivation.

4 pending on which X chromosome is silenced by X chromosome inactivation.

5 long been studied in genomic imprinting and X chromosome inactivation.

6 tion/repression, insulation, imprinting, and X chromosome inactivation.

7 into account the dosage effect due to female X chromosome inactivation.

8 ed a novel function unique to the process of X chromosome inactivation.

9 cell proliferation, early embryogenesis and X chromosome inactivation.

10 chromatin remodeling, genomic imprinting and X chromosome inactivation.

11 ship between chromosomal characteristics and X chromosome inactivation.

12 ring in the choice and counting functions of X chromosome inactivation.

13 ng epigenetic control of gene imprinting and X chromosome inactivation.

14 chromosomes to determine whether to initiate X chromosome inactivation.

15 d in epigenetic regulation of imprinting and X chromosome inactivation.

16 n epigenetic gene-silencing events including X chromosome inactivation.

17 hromosome reveal that TCEAL7 is subjected to X chromosome inactivation.

18 erian characteristic of determinate paternal X chromosome inactivation.

19 and genes subject to genomic imprinting and X chromosome inactivation.

20 ) repeats may be mediators for the spread of X chromosome inactivation.

21 ted L1s, may have a role in the spreading of X chromosome inactivation.

22 face of vast amounts of repetitive DNA, and X chromosome inactivation.

23 iable degree of normal CD40L based on random X chromosome inactivation.

24 the genes on one X chromosome; it is called X chromosome inactivation.

25 s of rod degeneration consistent with random X chromosome inactivation.

26 e mechanism and is a feature of silencing in X chromosome inactivation.

27 tion between the genders in a process called X chromosome inactivation.

28 role of the nuclear matrix in the process of X chromosome inactivation.

29 sal of the mechanism for PRC2 recruitment in X chromosome inactivation.

30 of somatic cells, including the reversal of X chromosome inactivation.

31 osage relative to XY males, a process termed X chromosome inactivation.

32 gene expression that is critical to maintain X chromosome inactivation.

33 ary and sufficient for Xist spreading during X-chromosome inactivation.

34 e 123 (DHR) oxidation data for percentage of X-chromosome inactivation.

35 rangements at the two alleles in response to X-chromosome inactivation.

36 hat has properties consistent with a role in X-chromosome inactivation.

37 ist that together regulate the initiation of X-chromosome inactivation.

38 ortant genetic elements or genes involved in X-chromosome inactivation.

39 egulation, heterochromatin organization, and X-chromosome inactivation.

40 nous X-X pairing and block the initiation of X-chromosome inactivation.

41 one X chromosome are silenced as a result of X-chromosome inactivation.

42 r silencing by interrogating imprinted mouse X-chromosome inactivation.

43 posed role as way stations in the process of X-chromosome inactivation.

44 ANCB, is localized at Xp22.31 and subject to X-chromosome inactivation.

45 he binding reaction of Xist is necessary for X-chromosome inactivation.

46 o the IKK signaling pathway, is dependent on X-chromosome inactivation.

47 eas female carriers show a skewed pattern of X-chromosome inactivation.

48 s display a phenotype consistent with random X-chromosome inactivation.

49 icular for studies on genomic imprinting and X-chromosome inactivation.

50 ransposon silencing, genomic imprinting, and X-chromosome inactivation.

51 l for both the random and imprinted forms of X-chromosome inactivation.

52 ures in surviving animals, apparently due to X-chromosome inactivation.

53 mCH signature that identifies genes escaping X-chromosome inactivation.

54 or long-range epigenetic regulation such as X-chromosome inactivation.

55 late gene expression, genome imprinting, and X-chromosome inactivation.

56 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromo

57 Recent studies have shown that, upon X-chromosome inactivation, active and inactive X chromos

58 Indirect X chromosome-inactivation analyses have demonstrated tha

59 X chromosome inactivation analysis showed a discordant p

60 In addition, X chromosome inactivation analysis was done on the tumor

61 X-chromosome inactivation analysis indicated that this f

62 were additionally assessed for clonality by X-chromosome inactivation analysis.

63 sion that are seen during differentiation or X chromosome inactivation and are not dependent on dynam

64 future analyses into the genetic control of X chromosome inactivation and defines a 1.85-Mb interval

65 ression of Cbx7 inhibits differentiation and X chromosome inactivation and enhances ESC self-renewal.

66 thylation-sensitive insulators that regulate X chromosome inactivation and expression of imprinted ge

67 X chromosome inactivation and genomic imprinting are cla

68 hoblast giant cell differentiation, paternal X chromosome inactivation and histone H3K27 tri-methylat

69 perties including differential regulation of X chromosome inactivation and of genes involved in oxida

70 ripotency, cell fate, cell cycle regulation, X chromosome inactivation and parental imprinting.

71 , such as cis-regulation of gene expression, X chromosome inactivation and random monoallelic express

72 We show that both genes are subject to X-chromosome inactivation and are polymorphic in all maj

73 lecular mechanism of chromosome silencing in X-chromosome inactivation and focus on topics where new

74 es crucial in mammalian development, such as X-chromosome inactivation and gene imprinting.

75 ntial allelic gene expression resulting from X-chromosome inactivation and genomic imprinting, a larg

76 stable transcriptional silencing, such as in X-chromosome inactivation and genomic imprinting.

77 s, Xlr3b, Xlr4b and Xlr4c, is independent of X-chromosome inactivation and has a dynamic and complex

78 best defined in epigenetic phenomena such as X-chromosome inactivation and imprinting, different clas

79 The patterns of mutation, X-chromosome inactivation and phenotypic manifestations

80 ion of Hox genes and animal body patterning, X-chromosome inactivation and possibly maintenance of em

81 , Rsx is silenced, linking Rsx expression to X-chromosome inactivation and reactivation.

82 RNA Xist has been shown to be essential for X-chromosome inactivation and to coat the inactive X-chr

83 ks ranging from heterochromatin formation to X-chromosome inactivation and transcriptional regulation

84 To explore the relationship between skewed X-chromosome inactivation and X-linked mental retardatio

85 ubiquitin ligase important for initiation of X-chromosome inactivation and XIST transcription in ES c

86 therefore have a conserved role in imprinted X-chromosome inactivation and, ultimately, in sex chromo

87 ased on information gleaned from imprinting, X chromosome inactivation, and activation and silencing

88 ologic processes such as genomic imprinting, X chromosome inactivation, and silencing of repeat eleme

89 normal processes such as gene imprinting and X-chromosome inactivation, and aberrant CpG island hyper

90 of phenomena, including genomic imprinting, X-chromosome inactivation, and cis-regulatory evolution.

91 ent, tissue homeostasis, genomic imprinting, X-chromosome inactivation, and germ cell differentiation

92 tion is essential for mammalian development, X-chromosome inactivation, and imprinting yet aberrant m

93 including embryonic development, imprinting, X-chromosome inactivation, and stem cell differentiation

94 Furthermore, using X-chromosome inactivation assays and tissue-specific del

95 n, which may explain why it does not trigger X chromosome inactivation at this stage.

96 analysis of the MEN1 locus, and analysis of X-chromosome inactivation at the human androgen receptor

97 Concordant genetic alterations and X chromosome inactivation between small-cell carcinoma a

98 We investigated whether genes escape X chromosome inactivation by positioning outside of the

99 chromosome to inactivate is normally random, X chromosome inactivation can be skewed in F1 hybrid mic

100 he Xce to candidate regions that overlap the X chromosome inactivation center (Xic), which includes t

101 etween this region and a region in the mouse X chromosome inactivation center between the 3' end of t

102 ic elements located in a region known as the X chromosome inactivation center, and is regulated by a

103 ntifying Tsix regulatory elements within the X chromosome inactivation center.

104 the mouse genome and, in particular, of the X chromosome inactivation center.

105 alysis revealed distinct transcriptional and X chromosome inactivation changes associated with the ea

106 As a result of the process of X chromosome inactivation, chromatinon the mammalian ina

107 Using X-chromosome inactivation, clonality was detectable in 1

108 green cones and (ii) tissue mosaicism due to X chromosome inactivation could be one mechanism for dri

109 Clonality assays, based on X-chromosome inactivation, discriminate active from inac

110 long noncoding RNA (lncRNA) is essential for X-chromosome inactivation during female eutherian mammal

111 The reprogramming of X-chromosome inactivation during the acquisition of plur

112 e of potential phenotypic variability due to X chromosome inactivation effects.

113 X chromosome inactivation ensures equal dosage of X-link

114 normal reprogramming of telomere length and X chromosome inactivation, epigenetic information establ

115 X-chromosome inactivation equalizes the dosage of X-link

116 Whereas X chromosome inactivation evolved to solve the problem o

117 a long noncoding RNA (lncRNA) essential for X chromosome inactivation, folds into evolutionarily con

118 his report we demonstrate primary non-random X chromosome inactivation following targeted mutagenesis

119 atus and controls heterochromatin formation, X-chromosome inactivation, genome imprinting, DNA repair

120 ocesses including heterochromatin formation, X-chromosome inactivation, genome imprinting, DNA repair

121 l pathways such as DNA methylation (DNMT3B), X chromosome inactivation (H2AFY), the DNA damage respon

122 Furthermore, skewed X chromosome inactivation has been found in the thyroid

123 stem for understanding epigenetic silencing, X chromosome inactivation has been previously linked to

124 nance, Polycomb-mediated gene silencing, and X chromosome inactivation have been elusive.

125 f how both the imprinted and random forms of X chromosome inactivation have come about.

126 Several studies suggest that highly skewed X chromosome inactivation (HSXI) is associated with recu

127 as previously shown to have diverse roles in X-chromosome inactivation, imprinting and double-strand

128 is involved in epigenetic processes such as X-chromosome inactivation, imprinting and silencing of t

129 s in gene silencing during processes such as X-chromosome inactivation, imprinting, and silencing of

130 tin), the maintenance of DNA methylation and X chromosome inactivation in female cells (facultative h

131 enomenon occurs, in a random fashion, during X chromosome inactivation in female cells.

132 mammals, dosage compensation is achieved by X chromosome inactivation in female cells.

133 in imprinted gene expression and erosion of X chromosome inactivation in female hiPSCs and how under

134 nes, in the silencing of transposons, and in X chromosome inactivation in female mammals.

135 us plays a central role in the regulation of X chromosome inactivation in mammals, although its exact

136 locus is a cis-acting switch that regulates X chromosome inactivation in mammals.

137 henotype is likely to reflect the pattern of X chromosome inactivation in relevant tissues, although

138 ve cases and concordant pattern of nonrandom X chromosome inactivation in the four remaining informat

139 X chromosome inactivation in the patient's blood cells w

140 Carriers of mutated WASP have nonrandom X chromosome inactivation in their blood cells and are d

141 sis showed a discordant pattern of nonrandom X chromosome inactivation in two of six informative case

142 e the first examples of abnormal escape from X chromosome inactivation in untransformed human fibrobl

143 male mammals, up-regulation of Xist triggers X-chromosome inactivation in cis.

144 circuitry that maintains XIST expression and X-chromosome inactivation in differentiated cells.

145 X-chromosome inactivation in eutherian mammals is mediat

146 Eed is implicated in regulation of imprinted X-chromosome inactivation in extraembryonic cells but no

147 In addition, the hybrids display skewing of X-chromosome inactivation in favour of the expression of

148 However, unlike X-chromosome inactivation in female embryonic cells, whe

149 ls achieve gene dosage control by (1) random X-chromosome inactivation in females, (2) parental origi

150 Our findings permit comparative studies of X-chromosome inactivation in mammals and pose questions

151 l loci or whole chromosomes, as in imprinted X-chromosome inactivation in mammals, is established and

152 omenon that occurs on a scale second only to X-chromosome inactivation in mammals.

153 Skewed X-chromosome inactivation in peripheral blood granulocyt

154 r X-chromosome imprinting, however, concerns X-chromosome inactivation in specific circumstances and

155 made novel predictions of genes that escape X-chromosome inactivation in specific tissues.

156 patient for loss of heterozygosity (LOH) and X chromosome inactivation (in female patients).

157 Intriguingly, whereas some iPSCs maintained X chromosome inactivation, in others the X chromosome wa

158 X chromosome inactivation involves multiple levels of ch

159 ch the silencing of the HPRT promoter during X chromosome inactivation involves remodeling a transcri

160 X chromosome inactivation is an epigenetic dosage compen

161 X chromosome inactivation is initiated from a segment of

162 X chromosome inactivation is most commonly studied in th

163 X chromosome inactivation is the silencing mechanism eut

164 male active X chromosome and, in response to X chromosome, inactivation is organized into euchromatin

165 X-chromosome inactivation is a mechanism of dosage compe

166 X-chromosome inactivation is a striking example of epige

167 pose questions about the mechanisms by which X-chromosome inactivation is achieved in eutherians.

168 X-chromosome inactivation is established during early de

169 found in metatherians (marsupials), and how X-chromosome inactivation is initiated in these mammals

170 Skewed X-chromosome inactivation is the likely cause of parkins

171 X-chromosome inactivation is then reversed in the inner

172 X-chromosome inactivation is widely believed to be rando

173 on-equivalence, rather than being limited to X-chromosome inactivation, is a fundamental property of

174 mechanism leading to genomic imprinting and X-chromosome inactivation, is widely reported at the non

175 men and variable in women because of skewed X-chromosome inactivation; its extensive/massive involve

176 s the "Barr body." Despite the importance of X chromosome inactivation, little is known about this 3D

177 se of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cel

178 lippines, the epigenetic factor of nonrandom X-chromosome inactivation may contribute to the skewing

179 These data are incompatible with simple X chromosome inactivation models.

180 s influence processes including development, X chromosome inactivation, obesity, schizophrenia, and d

181 r gene (HUMARA), we analyzed the patterns of X-chromosome inactivation of multiple distinct foci of w

182 e histone macroH2A1.2 has been implicated in X chromosome inactivation on the basis of its accumulati

183 eracting RNAs), position effect variegation, X-chromosome inactivation, parental imprinting, and para

184 ce is significantly correlated with a clonal X chromosome inactivation pattern (XCIP).

185 Furthermore, a severely skewed X chromosome inactivation pattern is found in women with

186 e-phenotype correlation studies suggest that X chromosome inactivation patterns have a more prominent

187 Clonality detection based on X-chromosome inactivation patterns (XCIP) requires discr

188 terogeneous with respect to natural history, X-chromosome inactivation patterns (XCIPs), and presence

189 Clonality analysis using X-chromosome inactivation patterns has revealed apparent

190 X-chromosome inactivation patterns were analyzed using l

191 mouse chromosome 11 was correlated with the X chromosome inactivation phenotype of (C57BL/6-Pgk1(a)

192 henotypic clonality methods are based on the X-chromosome inactivation principle.

193 nd hematopoietic precursor cells, before the X-chromosome inactivation process occurs.

194 d to recombinant males, we have measured the X chromosome inactivation ratio using allele-specific ex

195 pVNTR alleles of MAOA did not correlate with X-chromosome inactivation ratios, determined at the X-li

196 ping with the possibility that the choice of X chromosome inactivation reflects stabilization of a hi

197 ncy and chromatin factors are illustrated by X chromosome inactivation, regulatory control by noncodi

198 X chromosome inactivation silences one of two X chromoso

199 dependent manner, is sufficient to determine X chromosome inactivation status.

200 ue in tumor biology, has been analyzed using X-chromosome inactivation studies based on the different

201 ments, mitochondrial DNA (mtDNA) sequencing, X-chromosome inactivation study, global gene expression

202 MLS-affected females have severe skewing of X chromosome inactivation, suggesting that mutations in

203 Here, we introduce a new model of X chromosome inactivation that aims to account for the f

204 specific transcript (XIST), a key player in X-chromosome inactivation that encodes an RNA that coats

205 silenced in each female cell as a result of X chromosome inactivation, the mammalian dosage compensa

206 tination in Hox gene silencing as well as in X-chromosome inactivation, the enzyme(s) involved in H2A

207 male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptiona

208 ral processes such as genomic imprinting and X-chromosome inactivation, the functional significance o

209 Owing to extremely skewed (98%:2%) X-chromosome inactivation, the patient expressed almost

210 oles in diverse biological processes such as X chromosome inactivation, transposable element repressi

211 X chromosome inactivation triggered by Xist RNA can only

212 es in the regulation of Hox gene expression, X-chromosome inactivation, tumorigenesis, and stem cell

213 From the time X chromosome inactivation was initially described, it wa

214 Similarly, the same pattern of nonrandom X chromosome inactivation was present in both carcinoma

215 Using loss of heterozygosity (LOH) and X-chromosome inactivation, we compared peripheral blood

216 Smchd1 promotes X chromosome inactivation, whereas Chd7 regulates expres

217 netic changes, including DNA methylation and X chromosome inactivation, which create a robust epigene

218 ze silencing of X-linked genes in cis during X-chromosome inactivation, which equalizes X-linked gene

219 female XLP carrier showed completely skewed X chromosome inactivation within NKT cells, but not T or

220 urprisingly, in the protan carrier, in which X-chromosome inactivation would favor L- or M-cone clump

221 Murine Xist is an essential transcript for X chromosome inactivation (X inactivation).

222 X chromosome inactivation (XCI) achieves dosage balance

223 In the early mammalian embryo, X chromosome inactivation (XCI) achieves dosage parity b

224 man ESCs (hESCs) invariably exhibit signs of X chromosome inactivation (XCI) and are considered devel

225 nscriptional aberrations in genes subject to X chromosome inactivation (XCI) and genomic imprinting,

226 embryonic stem cells (ESCs) with non-random X chromosome inactivation (XCI) and polymorphic X chromo

227 X chromosome inactivation (XCI) depends on a noncoding s

228 X chromosome inactivation (XCI) depends on the long nonc

229 X chromosome inactivation (XCI) equalizes gene expressio

230 stages, including 19 female tissues allowing X chromosome inactivation (XCI) escapers to also be dete

231 ect sequencing and determined the pattern of X chromosome inactivation (XCI) in 39 RTT patients.

232 ng non-coding RNA essential for establishing X chromosome inactivation (XCI) in early embryos, is con

233 In early development, delayed and incomplete X chromosome inactivation (XCI) in some species causes v

234 X chromosome inactivation (XCI) is an epigenetic mechani

235 X chromosome inactivation (XCI) is an essential mechanis

236 X chromosome inactivation (XCI) is controlled by a compl

237 In marsupials and in the early mouse embryo, X chromosome inactivation (XCI) is imprinted to occur se

238 In female marsupials, X chromosome inactivation (XCI) is imprinted, affecting

239 X chromosome inactivation (XCI) is initiated by expressi

240 In mice, X chromosome inactivation (XCI) is regulated by the anti

241 X chromosome inactivation (XCI) is the most dramatic exa

242 X chromosome inactivation (XCI) is the phenomenon throug

243 In mammals, X chromosome inactivation (XCI) is triggered by Xist RNA

244 ablished female XX hESC lines have undergone X chromosome inactivation (XCI) prior to differentiation

245 X chromosome inactivation (XCI) reduces the number of ac

246 X chromosome inactivation (XCI) silences transcription f

247 We compared the distribution of X chromosome inactivation (XCI) skewing percentages (ran

248 Random X chromosome inactivation (XCI) takes place in the ICM l

249 Female eutherian mammals use X chromosome inactivation (XCI) to epigenetically regula

250 Female mammals use X chromosome inactivation (XCI) to generate a transcript

251 n in the XIST promoter results in skewing of X chromosome inactivation (XCI) towards the inactive X c

252 In this study, a thorough analysis of X chromosome inactivation (XCI) was performed in both pr

253 landscape that predisposes it to erosion of X chromosome inactivation (XCI), a process that occurs s

254 Because of X chromosome inactivation (XCI), cells within RTT female

255 Evidence from epigenetic processes, such as X chromosome inactivation (XCI), indicates that CTCF ass

256 Xist, an essential lncRNA for X chromosome inactivation (XCI), interacts with 81 prote

257 Through the process of X chromosome inactivation (XCI), somatic cells of mammal

258 volved in the propagation and maintenance of X chromosome inactivation (XCI), the 21.4-kb chicken lys

259 During X chromosome inactivation (XCI), the Polycomb Repressive

260 Specifically, they are required for X chromosome inactivation (XCI), the random transcriptio

261 In X chromosome inactivation (XCI), unfavorable XCI ratios

262 ryos, somatic cells undergo a random form of X chromosome inactivation (XCI), whereas extraembryonic

263 ellular differentiation is tightly linked to X chromosome inactivation (XCI), whereas reprogramming t

264 resolution RNA allelotyping method, to study X chromosome inactivation (XCI).

265 time in culture they undergo an "erosion" of X chromosome inactivation (XCI).

266 between XX and XY individuals occurs through X chromosome inactivation (XCI).

267 The phenomena of X-chromosome inactivation (XCI) and autosomal imprinting

268 Tsix controls X-chromosome inactivation (XCI) by blocking the accumula

269 X-chromosome inactivation (XCI) compensates for differen

270 active (Xi) X chromosomes because stochastic X-chromosome inactivation (XCI) confounds allele-specifi

271 Two forms of X-chromosome inactivation (XCI) ensure the selective sil

272 In female mice, two forms of X-chromosome inactivation (XCI) ensure the selective sil

273 X-chromosome inactivation (XCI) ensures the equality of

274 In mammals, X-chromosome inactivation (XCI) equalizes X-linked gene

275 How and why female somatic X-chromosome inactivation (XCI) evolved in mammals remai

276 chromosome in female cells is a hallmark of X-chromosome inactivation (XCI) in eutherians.

277 o achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals.

278 a few genes in diverse species suggests that X-chromosome inactivation (XCI) in marsupials is charact

279 mammals, dosage compensation is achieved by X-chromosome inactivation (XCI) in the female.

280 is considered a prerequisite to reversal of X-chromosome inactivation (XCI) in the mouse inner cell

281 epigenetic reprogramming, as exemplified by X-chromosome inactivation (XCI) in which one female X ch

282 X-chromosome inactivation (XCI) is a classic epigenetic

283 X-chromosome inactivation (XCI) is initiated by expressi

284 X-chromosome inactivation (XCI) is initiated by the long

285 os that are mutated for the PcG protein Eed, X-chromosome inactivation (XCI) is not stably maintained

286 Extreme skewing of X-chromosome inactivation (XCI) is rare in the normal fe

287 X-chromosome inactivation (XCI) is the mammalian dosage

288 X-chromosome inactivation (XCI) is the process in which

289 In mammals, the silencing step of the X-chromosome inactivation (XCI) process is initiated by

290 X-chromosome inactivation (XCI) silences one X chromosom

291 c analysis of chromatin modifications during X-chromosome inactivation (XCI) suggests that the silenc

292 ization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-me

293 Due to random X-chromosome inactivation (XCI), most RTT patients are f

294 ls with classic RTT have a random pattern of X-chromosome inactivation (XCI), nonbalanced patterns ha

295 long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which ma

296 X-chromosome inactivation (XCI), the random transcriptio

297 , we use tools of the epigenetic phenomenon, X-chromosome inactivation (XCI), to investigate their ep

298 ge with XY males in a process referred to as X-chromosome inactivation (XCI).

299 reimplantation phases to establish imprinted X-chromosome inactivation (XCI).

300 Indeed, lncRNAs dominate control of random X-chromosome inactivation (XCI).