ライフサイエンスコーパス: X-Box binding protein 1

1 (activating transcription factor 6) or XBP1 (X-box-binding protein 1).

2 factors C/EBP homologous protein and spliced X box-binding protein 1.

3 regulatory factor-1, nucleophosmin, and the X-box binding protein-1.

4 y of the UPR and governs expression of XBP1 (X-box binding protein 1), a key transcription factor tha

5 UPR by promoting the nuclear localization of X-box binding protein 1, a transcription factor central

6 ER, regulates the expression and activity of X-box binding protein 1, a transcription factor required

7 revealed upregulation of the spliced form of X-box binding protein-1s, a potent transcription factor

8 hol alone increased messenger RNA of spliced X box-binding protein 1 and decreased SERCA, which were

9 fusion resulted in up-regulations of spliced X-box binding protein 1 and activating transcription fac

10 of HCV E1 and/or E2 also induced splicing of X-box binding protein 1 and transactivation of the unfol

11 The tunicamycin-induced splicing of X-box binding protein-1 and expression of GRP78 and CHOP

12 d decreased expression of the IRE1 substrate X-box-binding protein 1 and its target genes.

13 The transcription factors spliced X-box-binding protein 1 and p65, which are activated by

14 smic reticulum kinase, inositol-requiring 1A/X box binding protein 1, and activating transcription fa

15 1 do not repress Pax5 mRNA and do not induce X-box binding protein 1, and mu secreted mRNA normally,

16 mphocyte inducer of maturation program 1 and X-box binding protein 1, are not up-regulated in secreti

17 breast cancers, including GATA-3, LIV-1, and X-box binding protein 1, did not show a similar pattern

18 ves the messenger RNA (mRNA) encoding XBP-1 (X-box-binding protein 1), enabling splicing and producti

19 eficiency, B cell-specific CD79a-Cre x XBP1 (X-box binding protein-1) floxed mice (XBP1-conditional k

20 c/EBP homologous protein and X box binding protein 1 have been reported to enhance in

21 The transcription factor human X-box binding protein 1 (hXBP-1) is a basic region-leuci

22 bition of FAS also induces the processing of X-box binding protein-1, indicating that the IRE1 arm of

23 VEGF, high glucose, or H2O2 up-regulated the X-box binding protein-1/inositol-requiring protein-1 (IR

24 B cells fail to efficiently induce Blimp-1, X box-binding protein-1, J chain, or secretory Ig mu tra

25 oniae augmented inositol-requiring protein 1/X-box binding protein 1-mediated production of autophagy

26 y quantifying UPR target gene expression and X-box binding protein 1 messenger RNA (mRNA) splicing.

27 Transient expression of ERdj4 and ERdj5 in X-box binding protein 1(-/-) mouse embryonic fibroblasts

28 ha endoriboneclease activities, which led to X-box binding protein 1 mRNA cleavage, an ER stress mark

29 alpha, DNA damage-inducible transcript 3 and X-box binding protein-1 mRNA levels were reduced in both

30 Splicing of X-box-binding protein-1 mRNA, expression of activating t

31 homologous protein), and not parallel XBP1 (X box-binding protein 1) or ATF6 pathways, using siRNA a

32 ose-regulated protein 78 (Grp78) and spliced X-box binding protein-1 (sXBP-1) mRNA levels were reduce

33 se-regulated protein 78 (GRP78), the spliced X-box-binding protein 1 (sXBP-1), the glucose-regulated

34 1alpha resulted in the generation of spliced X-box binding protein 1 (sXBP1) and upregulation of lipi

35 ing enzyme 1alpha (IRE1alpha)-active spliced X-box binding protein 1 (sXBP1) axis and instrumental to

36 location of the transcription factor spliced X-box binding protein-1 (sXBP1) is selectively impaired

37 We demonstrated that the spliced X-box-binding protein-1 (sXBP1) is necessary and suffici

38 (AID) and transcription factors (Blimp-1 and X-box binding protein 1) that are critical to the B cell

39 s led to downregulation of AID, Blimp-1, and X-box binding protein 1, thereby inhibiting CSR, SHM, an

40 teins and activating a transcription factor, X-box-binding protein 1, through endonucleolytic cleavag

41 amazonensismacrophage infection: the role of X-box binding protein 1 transcription factor.

42 ctor 4 (ATF-4), ATF-6, and a spliced form of X-box binding protein 1, were up-regulated in PBMCs from

43 m functional and can lead to the splicing of X-box binding protein 1 (XBP 1) mRNA.

44 antly, B7-2 engagement induced expression of X-box binding protein 1 (XBP-1) and spliced XBP1, eviden

45 e-induced maturation protein 1 (Blimp-1) and X-box binding protein 1 (XBP-1) are required for plasma

46 The transcription factor X-box binding protein 1 (XBP-1) is an essential part of

47 The transcription factor X-box binding protein 1 (XBP-1) is essential for the dif

48 embryonic fibroblasts that are deficient for X-box binding protein 1 (XBP-1), a key transcription fac

49 mas of several IL-4-induced genes, including X-box binding protein 1 (XBP-1), a regulator of the UPR.

50 potential role for a CREB/ATF family member, X-box binding protein 1 (XBP-1), in trans-activating the

51 ull synergistic IFN-beta production requires X-box binding protein 1 (XBP-1), this UPR-regulated tran

52 ted IgM in the endoplasmic reticulum (ER) of X-box binding protein 1 (XBP-1)-deficient B cells has be

53 ced resistance to ER stress dependent on the X-box binding protein 1 (XBP-1)/inositol requiring enzym

54 Despite the fact that X-box binding protein-1 (XBP-1) is one of the main regul

55 R chaperone protein BiP, the spliced form of X-box binding protein-1 (Xbp-1) mRNA, and the transcript

56 iation of B cells into plasma cells requires X-box binding protein-1 (XBP-1).

57 n response (UPR) coupled to mRNA splicing of X-box binding protein-1 (XBP-1).

58 is directly induced by the spliced (active) X-box binding protein-1 (XBP-1s), a transcription factor

59 lymph node B cells express spliced (active) X-box binding protein-1 (XBP-1s).

60 sential role in plasma cell differentiation, X-box-binding protein 1 (XBP-1), also activates the tran

61 X-box-binding protein-1 (XBP-1) is a key transcriptional

62 The transcription factor X-box-binding protein-1 (XBP-1) plays an essential role

63 of carbonic anhydrase VI (CA-VI), and active X-box-binding protein-1 (Xbp-1) were all induced signifi

64 Mice deficient in X-box-binding protein-1 (XBP-1), a transcription factor

65 re we show that p85alphaalpha interacts with X-box-binding protein-1 (XBP-1), a transcriptional media

66 key mediator of the EnR stress response, the X-box-binding protein-1 (XBP-1).

67 in specialized secretory cell types requires X-box-binding protein-1 (Xbp-1).

68 , the only known role of the spliced form of X-box-binding protein-1 (XBP-1s) in metabolic processes

69 ndent messenger RNA splicing (activation) of X-box-binding protein-1 (XBP-1s) to inflammation in peri

70 X box binding protein 1 (XBP1) is a transcription factor

71 tol-requiring enzyme 1-dependent splicing of X box binding protein 1 (XBP1) mRNA, activation of activ

72 highlighted the importance of IRE1alpha and X box binding protein 1 (XBP1), key members of this path

73 vated expression of the transcription factor X box-binding protein 1 (XBP1) in DC appears to play a d

74 folded protein response transcription factor X-box binding protein 1 (XBP1) in liver regeneration usi

75 e present study, we investigated the role of X-box binding protein 1 (XBP1) in retinal adhesion molec

76 ere we report that developmental ablation of X-Box binding protein 1 (XBP1) in the nervous system, a

77 beta activates the ER stress response factor X-box binding protein 1 (XBP1) in transgenic flies and i

78 X-box binding protein 1 (XBP1) is a transcription factor

79 The X-box binding protein 1 (XBP1) is believed to be a signa

80 X-box binding protein 1 (XBP1) is required for the diffe

81 panning 858 nucleotides in the 3' UTR of the X-box binding protein 1 (XBP1) mRNA that regulates its c

82 ain Ig binding protein (BiP) and splicing of X-box binding protein 1 (XBP1) mRNA, but no lung fibrosi

83 ctivity causes sequence-specific cleavage of X-box binding protein 1 (XBP1) mRNA, resulting in upregu

84 me 1alpha (IRE1alpha) is activated to splice X-box binding protein 1 (XBP1) mRNA, thereby increasing

85 The X-box binding protein 1 (XBP1) plays an important role i

86 We investigated the role of X-box binding protein 1 (XBP1), a UPR regulator, in prev

87 Here we have explored the role of X-box binding protein 1 (XBP1), one of three UPR effecto

88 he RNase-inactive IRE1alpha or the activated X-box binding protein 1 (XBP1), the canonical IRE1alpha

89 X-box binding protein 1 (XBP1), which exists in the tran

90 , we developed transgenic mice expressing an X-box binding protein 1 (XBP1)-luciferase construct that

91 P (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1).

92 f the mRNA encoding the transcription factor X-box binding protein 1 (XBP1).

93 nism is mediated by the transcription factor X-box binding protein 1 (XBP1).

94 protein response (UPR) transcription factor X-box binding protein-1 (Xbp1) in intestinal epithelial

95 We found that x-box binding protein-1 (xbp1) is a direct target of Nod

96 Human X-box binding protein-1 (XBP1) is an alternatively splic

97 us podocyte-specific genetic inactivation of X-box binding protein-1 (Xbp1), a transcription factor a

98 ector of the UPR is the transcription factor X-box binding protein-1 (XBP1), which is expressed on ER

99 nase-like ER kinase (PERK), up-regulation of X-box-binding protein 1 (XBP1) and glucose-regulated pro

100 PRNP promoter, is regulated by ER stress and X-box-binding protein 1 (XBP1) but not by activating tra

101 ng enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiat

102 ies are required to splice the mRNA encoding X-box-binding protein 1 (XBP1) for terminal differentiat

103 Anisomycin inhibited X-box-binding protein 1 (XBP1) mRNA splicing and reduced

104 iring enzyme 1 alpha (IRE1alpha) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in adult pr

105 Sustained activation of X-box-binding protein 1 (XBP1) results in endothelial ce

106 on factor 6) and inositol requiring 1 (IRE1)-x-box-binding protein 1 (XBP1) signalings.

107 element (ERSE)-luciferase reporter activity, X-box-binding protein 1 (XBP1) splicing, and immunoglobu

108 nts of ER stress response mediators, such as X-box-binding protein 1 (XBP1), confer genetic risk for

109 mponents, including the transcription factor X-box-binding protein 1 (XBP1), is increased following e

110 pliced form of the transcriptional regulator X-box-binding protein 1 (XBP1).

111 This prompted us to ask if X-box-binding protein-1 (XBP1) plays a role in regulatin

112 The transcription factor, X-box-binding protein-1 (XBP1), controls the development

113 The ER stress response protein, X-box-binding protein-1 (XBP1), was recently shown to re

114 IKKbeta phosphorylates the spliced form of X-Box Binding Protein 1 (XBP1s) and increases the activi

115 p38 MAPK) phosphorylates the spliced form of X-box binding protein 1 (Xbp1s) on its Thr48 and Ser61 r

116 Here, we show that spliced X-box binding protein 1 (Xbp1s), the most conserved sign

117 ing of mice induces up-regulation of spliced X-box binding protein 1 (XBP1s), which regulates the end

118 Nonetheless, X-box binding protein 1s (XBP1s), a key transcription fa

119 he physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription fac

120 A spliced form of the X-box-binding protein-1 (XBP1s), a major proximal effect