ライフサイエンスコーパス: X-linked agammaglobulinemia

1 ongenital asplenia, and 2 of Bruton disease (X-linked agammaglobulinemia).

2 cally normal in BTK, the gene that underlies X-linked agammaglobulinemia.

3 ptor signaling culminate in X-linked and non-X-linked agammaglobulinemia.

4 l blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia.

5 ction and results in a clinical phenotype of X-linked agammaglobulinemia.

6 tions in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency di

7 nase defective in the human immunodeficiency X-linked agammaglobulinemia and in xid mice.

8 Bruton's tyrosine kinase (Btk) causes human X-linked agammaglobulinemia and murine X-linked immunode

9 ain pathological conditions such as myeloma, X-linked agammaglobulinemia, and HIV infection may provi

10 such as common variable immunodeficiency and X-linked agammaglobulinemia, bacterial organisms are the

11 e present the case of a 34-year-old man with X-linked agammaglobulinemia from Australia suffering fro

12 (Btk), which is mutated in the human disease X-linked agammaglobulinemia, has been shown to interact

13 hat results in the immunodeficiency diseases X-linked agammaglobulinemia in humans and X-linked immun

14 illustrated by the primary immune disorder, X-linked agammaglobulinemia in which patients are prone

15 sine kinase (Btk) result in a disease called X-linked agammaglobulinemia, in which there is a profoun

16 X-linked agammaglobulinemia is caused by mutations in Bt

17 Bruton's tyrosine kinase (Btk) is mutated in X-linked agammaglobulinemia patients and plays an essent

18 X-linked agammaglobulinemia patients and X-linked immuno

19 dicated by the X-linked immunodeficiency and X-linked agammaglobulinemia phenotypes of mice and men t

20 Here, we describe a case of X-linked agammaglobulinemia resulting from a GC 5'ss act

21 X-linked agammaglobulinemia syndrome was excluded geneti

22 e development of gene therapy strategies for X-linked agammaglobulinemia, the immunodeficiency associ

23 tor activation was reported in patients with X-linked agammaglobulinemia, underscoring the important

24 sine kinase (BTK) mutations as the cause for X-linked agammaglobulinemia was a milestone in understan

25 dition, a patient previously thought to have X-linked agammaglobulinemia was found to have an amino a

26 mutation of the Btk PH domain, which causes X-linked agammaglobulinemia, was introduced into the flu

27 Seven individuals with the diagnosis of X-linked agammaglobulinemia were analyzed for mutations

28 obulinemia and absent B cells are males with X-linked agammaglobulinemia, which is caused by mutation

29 Control of N addition appears aberrant in X-linked agammaglobulinemia, which may exacerbate the bl

30 -cell development and patients with presumed X-linked agammaglobulinemia who did not have mutations i

31 Severe combined immunodeficiency (SCID) and X-linked agammaglobulinemia (XLA) are inborn errors of i

32 The gene defective in X-linked agammaglobulinemia (XLA) encodes a novel protei

33 Mutation detection for X-linked agammaglobulinemia (XLA) has revealed the heter

34 ed in SLP-76-deficient mice or Btk-deficient X-linked agammaglobulinemia (XLA) human platelets.

35 because mutations in Btk are responsible for X-linked agammaglobulinemia (XLA) in humans and X-linked

36 ion of Bruton's tyrosine kinase (Btk) causes X-linked agammaglobulinemia (XLA) in humans and X-linked

37 in Bruton's tyrosine kinase (Btk) result in X-linked agammaglobulinemia (XLA) in humans and X-linked

38 e (btk) cause the B cell deficiency diseases X-linked agammaglobulinemia (XLA) in humans and X-linked

39 Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked

40 Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked

41 he Bruton's tyrosine kinase (btk) gene cause X-linked agammaglobulinemia (XLA) in humans and X-linked

42 X-linked immunodeficiency (xid) in mice and X-linked agammaglobulinemia (XLA) in humans.

43 Mutations in BTK lead to X-linked agammaglobulinemia (XLA) in humans.

44 X-linked agammaglobulinemia (XLA) is a congenital humora

45 X-linked agammaglobulinemia (XLA) is a human immunodefic

46 X-linked agammaglobulinemia (XLA) is a primary immunodef

47 X-linked agammaglobulinemia (XLA) is an inherited immuno

48 phoblastoid lines derived from patients with X-linked agammaglobulinemia (XLA) lacking Btk expression

49 lines, and cultured cells from patients with X-linked agammaglobulinemia (XLA) suggested defective TL

50 In 1993, two groups showed that X-linked agammaglobulinemia (XLA) was due to mutations i

51 eatment with wortmannin and in patients with X-linked agammaglobulinemia (XLA), a condition caused by

52 The immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutation

53 mutations cause the genetic immunodeficiency X-linked agammaglobulinemia (XLA).

54 amily kinase linked to the B-cell deficiency X-linked agammaglobulinemia (XLA).

55 s associated with the immunological disorder X-linked agammaglobulinemia (XLA).

56 cells isolated from patients suffering from X-linked agammaglobulinemia (XLA).

57 tyrosine kinase (Btk) result in the disorder X-linked agammaglobulinemia (XLA).

58 nked immunodeficiency (XID)-a model of human X-linked agammaglobulinemia (XLA).

59 severe combined immune deficiency (SCID) and X-linked agammaglobulinemia (XLA); however, gain-of-func