ライフサイエンスコーパス: X-ray crystallography

1 ctures of the key products were confirmed by X-ray crystallography.

2 by UV-vis, EPR, and ENDOR spectroscopies and X-ray crystallography.

3 Predicted binding modes were verified by X-ray crystallography.

4 tructures were determined by solution NMR or X-ray crystallography.

5 n NMR spectroscopy, protein engineering, and X-ray crystallography.

6 d in competing molecular models derived from x-ray crystallography.

7 ructures are determined using single-crystal X-ray crystallography.

8 UV-vis titration, and in the solid state by X-ray crystallography.

9 -protein complex structures well resolved by X-ray crystallography.

10 d palladium complexes, were characterized by X-ray crystallography.

11 far prevented structural characterization by X-ray crystallography.

12 esidues 183-238 and 292-317) not observed by X-ray crystallography.

13 rably complements techniques such as NMR and X-ray crystallography.

14 system was confirmed through single-crystal X-ray crystallography.

15 ced crystals whose structure was revealed by X-ray crystallography.

16 tructure of one of the triads was deduced by X-ray crystallography.

17 characterized by NMR spectroscopy, HRMS, and X-ray crystallography.

18 the ferroxidase sites determined earlier by X-ray crystallography.

19 ing point, and in the case of 1, 2, and 4-8, X-ray crystallography.

20 structures of key products are confirmed by X-ray crystallography.

21 ve resulted from structural perturbations by X-ray crystallography.

22 resolution of a KasA-GSK3011724A complex by X-ray crystallography.

23 g modes of 3FMTDZ and HETDZ were analyzed by X-ray crystallography.

24 , 4-(t)Bu, and 5-Cp* have been elucidated by X-ray crystallography.

25 state packing motifs have been determined by X-ray crystallography.

26 fully characterized by NMR spectroscopy and X-ray crystallography.

27 compounds were profiled using ITC, DSF, and X-ray crystallography.

28 ized, and its stereochemistry established by X-ray crystallography.

29 erotype 3 RNA-dependent RNA polymerase using x-ray crystallography.

30 N-dimethyldodecylamine N-oxide determined by X-ray crystallography.

31 by NMR spectroscopy, mass spectrometry, and X-ray crystallography.

32 in AAV1 and its closely related AAV6, using X-ray crystallography.

33 Structures of 1 and 2 are confirmed by X-ray crystallography.

34 that has not had its structure determined by X-ray crystallography.

35 cent models from electron cryomicroscopy and X-ray crystallography.

36 IR spectroscopy, computational analysis, and X-ray crystallography.

37 and NMR spectroscopy, DFT calculations, and X-ray crystallography.

38 titration calorimetry, NMR spectroscopy, and X-ray crystallography.

39 ed structure was unambiguously determined by X-ray crystallography.

40 pectroscopic analysis, and in the case of 10 X-ray crystallography.

41 terized by multinuclear NMR spectroscopy and X-ray crystallography.

42 actions, which is most commonly performed by X-ray crystallography.

43 he most powerful mutants have been solved by X-ray crystallography.

44 ed and characterized by NMR spectroscopy and X-ray crystallography.

45 ons between Cif and 1a were characterized by X-ray crystallography.

46 atures, and (ii) tested these predictions by X-ray crystallography.

47 iodosobenzene-metal adducts characterized by X-ray crystallography.

48 ied their interaction with the epitope using X-ray crystallography.

49 rized by (1)H and (15)N NMR spectroscopy and X-ray crystallography.

50 mitochondria by a combination of cryo-EM and X-ray crystallography.

51 )arrestins that have recently been solved by X-ray crystallography.

52 naminones was explored through NMR, FTIR and X-ray crystallography.

53 g, was revealed by both AM1 calculations and X-ray crystallography.

54 n historically characterized as homodimer by X-ray crystallography.

55 ance (SPR), dose-rate inhibition assays, and X-ray crystallography.

56 opy, IR spectroscopy, mass spectrometry, and X-ray crystallography.

57 troscopy, and the structure was confirmed by X-ray crystallography.

58 ed and characterized by NMR spectroscopy and X-ray crystallography.

59 c level structures from NMR spectroscopy and x-ray crystallography.

60 ving the native molecular fold, as proven by x-ray crystallography.

61 tein crystals for structure determination by X-ray crystallography.

62 seven kinesin structures were determined by x-ray crystallography.

63 by cyclic voltammetry, EPR spectroscopy, and X-ray crystallography.

64 lorimetry, small-angle X-ray scattering, and X-ray crystallography.

65 ysiological conditions thus inaccessible via X-ray crystallography.

66 th the structures unambiguously confirmed by X-ray crystallography.

67 roposed on the basis of NMR spectroscopy and X-ray crystallography.

68 haracterized by spectroscopic studies and by X-ray crystallography.

69 ifferent affinities was evidenced by NMR and X-ray crystallography.

70 orption spectroscopy, stopped-flow, NMR, and X-ray crystallography.

71 DFT calculations, and, in the case of 4a, by X-ray crystallography.

72 ed and characterized by NMR spectroscopy and X-ray crystallography.

73 allowing for its structural determination by X-ray crystallography.

74 ide of Ku80 at 4.3 angstrom resolution using x-ray crystallography.

75 above and below the Pc core, as confirmed by X-ray crystallography.

76 using cryo-electron microscopy and 3.8 A by X-ray crystallography.

77 icular utility for compounds not amenable to x-ray crystallography.

78 cetate) are characterized using (1)H NMR and X-ray crystallography.

79 for substrate recognition were elucidated by x-ray crystallography.

80 e validated by surface plasmon resonance and X-ray crystallography.

81 troscopic methods, as well as single-crystal X-ray crystallography.

82 HD in complex with the paxillin LD1 motif by X-ray crystallography.

83 mannanases, and their structural analysis by X-ray crystallography.

84 ce of the duplex proximal to the triangle by X-ray crystallography.

85 metry, elemental analysis, and, in one case, X-ray crystallography.

86 characterized by NMR spectroscopy as well as X-ray crystallography.

87 trogen at -35 degrees C and characterized by X-ray crystallography.

88 sultones were established by single-crystal X-ray crystallography.

89 ng in-plane structural order as confirmed by X-ray crystallography.

90 peroxide by using site-directed mutagenesis, X-ray crystallography, (11)B NMR, and computational anal

91 gned proteins CA01 and DA05R1 were solved by x-ray crystallography (2.2 angstrom resolution) and nucl

92 In addition, X-ray crystallography, (57)Fe Mossbauer spectroscopy, an

93 Serial X-ray crystallography allows macromolecular structure de

94 mbined difficulties of crystallizing RNA for X-ray crystallography along with extensive chemical shif

95 X-ray crystallography analysis of intermediate 15 confir

96 ivering microcrystals for serial femtosecond X-ray crystallography analysis that enables studies of c

97 y inter-subunit disulfide bonds, and show by X-ray crystallography and by binding to a panel of human

98 We characterized the PRORP2 structure by X-ray crystallography and by small-angle X-ray scatterin

99 exclusion chromatography, mass spectrometry, X-ray crystallography and ChIP sequencing demonstrate th

100 Here, we have used X-ray crystallography and computational modeling to exam

101 Here, we combine X-ray crystallography and crosslinking mass spectrometry

102 f the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy.

103 Conventional structural methods such as X-ray crystallography and cryo-transmission electron mic

104 itols was established through single crystal X-ray crystallography and detailed NOE studies.

105 (19) F NMR measurements, in combination with X-ray crystallography and DFT calculations, can reliably

106 helating ligands, have been characterized by X-ray crystallography and DFT calculations.

107 erse data from multimodal techniques such as X-ray crystallography and electron microscopy into consi

108 the CL40 and CL59 complexes with gHgL using X-ray crystallography and EM to identify their epitope l

109 In this paper, we used x-ray crystallography and EM to investigate the neutral

110 ical, and cell functional studies, involving X-ray crystallography and EM, we show that PA41 recogniz

111 We report the low pH characterization by X-ray crystallography and EPR spectroscopy of the nitrog

112 ure of the core of the complex determined by X-ray crystallography and identify a broader interface.

113 n serum albumin was investigated by means of X-ray crystallography and inductively coupled plasma mas

114 tein-ligand interactions was performed using X-ray crystallography and isothermal titration calorimet

115 NF8-Ubc13 approximately ubiquitin complex by x-ray crystallography and its functional solution confor

116 X-ray crystallography and modeling were applied to provi

117 Through X-ray crystallography and molecular dynamics studies, we

118 ation interface have been reported, based on X-ray crystallography and multidimensional solution nucl

119 Consistent with prior X-ray crystallography and NMR results, the N-terminal do

120 iazole scaffold with respect to DYRK1A using X-ray crystallography and NMR techniques.

121 The structure was analysed by X-ray crystallography and NMR.

122 r strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance (pr

123 While X-ray crystallography and nuclear magnetic resonance spe

124 X-ray crystallography and other techniques have provided

125 ed by NMR and CD spectroscopy, as well as by X-ray crystallography and quantum chemical calculations.

126 Here we use X-ray crystallography and single-molecule fluorescence r

127 Here, we use the combination of X-ray crystallography and single-molecule FRET analysis

128 We combined X-ray crystallography and single-molecule microscopy to

129 ross-linking coupled with mass spectrometry, X-ray crystallography and single-particle electron micro

130 ning the MO and the CH domains-determined by X-ray crystallography and small angle scattering-as well

131 igand-centered radical has been confirmed by X-ray crystallography and SQUID magnetometry.

132 Here, we used X-ray crystallography and surface plasmon resonance spec

133 ructure in the ground state, as evidenced by X-ray crystallography and transient absorption spectrosc

134 and the IgG1 CH3 homodimer was evidenced by X-ray crystallography and used to engineer examples of b

135 izing N276 glycan-dependent antibody and use X-ray crystallography and viral deep sequencing to descr

136 Both 4 and 5 were characterized by X-ray crystallography and were found to feature the shor

137 ue proteins were determined by quasi-racemic X-ray crystallography and were similar to wild-type ShK.

138 ematically investigated both experimentally (X-ray crystallography) and theoretically (DFT calculatio

139 which are fully characterized, including by X-ray crystallography, and are compared to the "blue sol

140 in binding assays, in structural studies by x-ray crystallography, and by site-directed mutagenesis.

141 n of solid-state nuclear magnetic resonance, X-ray crystallography, and computational chemistry-to in

142 tudied by NMR spectroscopy, IR spectroscopy, X-ray crystallography, and computational methods.

143 metry, optical absorption, EPR spectroscopy, X-ray crystallography, and DFT calculations.

144 rochemistry, Mossbauer and NMR spectroscopy, X-ray crystallography, and DFT calculations.

145 use mass spectrometry, fluorescence binding, x-ray crystallography, and docking experiments to confir

146 SF6 within these materials is elucidated by X-ray crystallography, and it is shown that cooperative

147 coli integral membrane protein YgaP by NMR, X-ray crystallography, and mass spectrometry.

148 the first to utilize direct binding assays, X-ray crystallography, and modeling, to pinpoint factors

149 using steady-state kinetics, high resolution X-ray crystallography, and quantum chemical calculations

150 oton NMR relaxation dispersion measurements, X-ray crystallography, and structure-based chemical shif

151 ]hexane structure using compelling NMR data, X-ray crystallography, and the recent confirmation via f

152 yoEM) can circumvent some of the problems of x-ray crystallography as a pipeline for obtaining the re

153 of a reliable enzymatic assay together with X-ray crystallography as guidance, a series of fragment

154 X-ray crystallography at X-ray free-electron laser sourc

155 We report a method for serial X-ray crystallography at X-ray free-electron lasers (XFE

156 ctures can be easily and rapidly revealed by X-ray crystallography beamlines.

157 which has been extensively characterized by X-ray crystallography, biochemical and biophysical exper

158 (SBDD) guided by structural information from X-ray crystallography, computational studies, and NMR so

159 By means of ligand-based NMR spectroscopy, X-ray crystallography, computer simulations, and isother

160 X-ray crystallography confirmed TFG binding to Zn(2+) in

161 lectrospray ionization mass spectrometry and X-ray crystallography confirmed the formation of the pre

162 X-ray crystallography confirms that the structures overa

163 X-ray crystallography confirms the formation of homochir

164 X-ray crystallography confirms they have the fluorite st

165 erable structural information available from X-ray crystallography, cryo-EM methods can provide usefu

166 mechanism of transport with a combination of X-ray crystallography, cysteine accessibility, and solut

167 X-ray crystallography determined that this enzyme is a h

168 absorption, and UV-vis spectroscopy; ESI-MS; X-ray crystallography; DFT calculations; reactivity, ste

169 (FRET), small-angle x-ray scattering (SAXS), x-ray crystallography, electron microscopy, and two-hybr

170 the Ton complex from Escherichia coli using X-ray crystallography, electron microscopy, double elect

171 Et2O)][Cp''2ThH2]2, 3, which was analyzed by X-ray crystallography, electron paramagnetic resonance a

172 tions of the Cu(II) corresponding complex by X-ray crystallography, EPR, and XAS spectroscopic method

173 Protein X-ray crystallography established that 3-unsubstituted 2

174 ce plasmon resonance (SPR) measurements, and X-ray crystallography experiments.

175 structure was obtained by serial femtosecond X-ray crystallography from microcrystals at an X-ray fre

176 X-ray crystallography further revealed how the active-si

177 In particular, while X-ray crystallography has been a staple of structural bi

178 X-ray crystallography has been applied to the structural

179 To date, X-ray crystallography has been the predominant method us

180 icles from Staphylococcus aureus obtained by X-ray crystallography have shed light on fine details of

181 Cryo-electron microscopy and X-ray crystallography have shown that the pre- and postf

182 X-ray crystallography, HDX-MS and SPR analysis confirmed

183 new cages were characterized by synchrotron X-ray crystallography, high-resolution mass spectrometry

184 tural changes induced by radiation damage in X-ray crystallography hinder the ability to understand t

185 ric complex of vimentin has been obtained by X-ray crystallography in combination with various bioche

186 dynamic regions that proved unresolvable by X-ray crystallography in homologous receptors.

187 ening methods, surface plasmon resonance and X-ray crystallography, in a fragment screening campaign

188 ere shown to possess a novel binding mode by X-ray crystallography, in which the triazolo N1 atom coo

189 NMR and IR spectroscopy and X-ray crystallography indicate that each alkyl ligand co

190 in Escherichia coli Biochemical analyses and x-ray crystallography indicates that this protein functi

191 tion of an allenyl radical by single crystal X-ray crystallography is reported.

192 n analyzing dynamics of crystalline proteins.X-ray crystallography is the main method for protein str

193 X-ray crystallography is the predominant source of struc

194 Molecular replacement in X-ray crystallography is the prime method for establishi

195 plex allosteric mechanisms of rat PheH using X-ray crystallography, isothermal titration calorimetry

196 Here, using X-ray crystallography, isothermal titration calorimetry,

197 Here we show, using X-ray crystallography, molecular dynamics simulations an

198 Here we used glycan arrays, STD NMR, X-ray crystallography, mutagenesis and binding assays to

199 onged approach involving protein expression, X-ray crystallography, mutagenesis experiments and molec

200 Here, we combine X-ray crystallography, native mass spectrometry, single-

201 e mechanism underlying these dynamics, using X-ray crystallography, NMR spectroscopy, and ab initio q

202 We used X-ray crystallography, NMR spectroscopy, and cell-based

203 but generally static structures produced by X-ray crystallography, NMR spectroscopy, and cryo electr

204 The new cages were characterized using X-ray crystallography, NMR spectroscopy, and mass spectr

205 ylcyclohexane, a series of studies including X-ray crystallography, NOE measurements, and DFT calcula

206 Using a combination of X-ray crystallography, nuclear magnetic resonance spectr

207 Freeze-trapping x-ray crystallography, nuclear magnetic resonance, and c

208 X-ray crystallography of DNA gyrase-DNA complexes shows

209 Here we combined x-ray crystallography of Pcore with small angle x-ray sc

210 ty/selectivity were rationalized by means of X-ray crystallography of the adducts of hCA II with seve

211 However, X-ray crystallography of these intermediates is severely

212 allowed full characterization (including by X-ray crystallography) of PAHs containing one or more ap

213 come broad, weak, and often invisible, while X-ray crystallography only provides information on fully

214 We show that a combination of X-ray crystallography performed at 100 K as well as at r

215 with experimental kinetics measurements and X-ray crystallography, promptly checking the protocol's

216 unctional architecture of human NELF through X-ray crystallography, protein crosslinking, biochemical

217 X-ray crystallography provided GPCR molecular architectu

218 X-ray crystallography revealed a binding site at the Glu

219 X-ray crystallography revealed asymmetry in one of the b

220 X-ray crystallography revealed that both inhibitors bind

221 s, deuterium exchange mass spectrometry, and x-ray crystallography revealed that these neutralizing m

222 o identify progressable chemical matter, and X-ray crystallography revealed the location of binding i

223 freebase strain, while DFT calculations and X-ray crystallography revealed the presence of a hydroge

224 al shift calculations, NMR spectroscopy, and X-ray crystallography revealed the strong effect of the

225 cture, determined at 2.30 A resolution using X-ray crystallography, revealed that the overall archite

226 The product's structure was confirmed by X-ray crystallography, revealing an unusual conformation

227 X-ray crystallography reveals an only slightly activated

228 X-ray crystallography reveals that binding of SPAA-based

229 X-ray crystallography reveals that SJB7 resides in the l

230 X-ray crystallography reveals that the macrocyclic beta-

231 By combination of X-ray crystallography, SAXS and EM, together with bioche

232 nanocrystal characterized by single crystal X-ray crystallography (sc-XRD), Au279(SPh-tBu)84 named F

233 ion of 2.3 A, obtained by serial femtosecond X-ray crystallography (SFX) with an X-ray free electron

234 icroscopy, small-angle x-ray scattering, and x-ray crystallography show that 10 designs spanning thre

235 f the bilayers used ( approximately 2.8 nm); X-ray crystallography showed that Aib11 is 2.93 nm long.

236 Binding studies and x-ray crystallography showed that NLPs form complexes wi

237 us and Synechocystis sp. PCC6803 obtained by X-ray crystallography showed two juxtaposed FAD molecule

238 The binding mode of 5 was examined with x-ray crystallography, showing that the only change comp

239 X-ray crystallography shows that X2-Ph crystallizes into

240 Here we applied X-ray crystallography, single-particle electron cryomicr

241 egion of CshA, derived from a combination of X-ray crystallography, small angle X-ray scattering, and

242 Here, we investigate galectin-4 using X-ray crystallography, small- and wide-angle X-ray scatt

243 Using X-ray crystallography, small-angle X-ray scattering, hyd

244 Here we report time-lapse X-ray crystallography snapshots of catalytic events duri

245 Mutagenesis, biochemical, and X-ray crystallography studies demonstrate that the epito

246 I, and IX from conventional/film cryo-EM and X-ray crystallography studies have caused confusion.

247 X-ray crystallography studies indicate the potential imp

248 film cryo-electron microscopy (cryo-EM) and X-ray crystallography studies, but discrepancies exist c

249 nthesized compounds was further confirmed by X-ray crystallography studies.

250 An X-ray crystallography study of the rabbit muscle GPb inh

251 X-ray crystallography suggests that the unpaired electro

252 e show through site-directed mutagenesis and X-ray crystallography that this TPP1 disease mutation de

253 (OB)-fold domain of TPP1 has been solved by X-ray crystallography, the molecular interactions within

254 the structure of NGF has been determined by X-ray crystallography, the structural details for proNGF

255 Employing X-ray crystallography, the structure of these domains wa

256 liganded and holo-ACPP-bound forms solved by X-ray crystallography to 2.05and 4.10A, respectively, re

257 rium Marichromatium purpuratum was solved by X-ray crystallography to 2.75 A resolution providing ins

258 re of the AAV1-SIA complex was determined by X-ray crystallography to 3.0 A.

259 5 complexed with ritonavir was determined by X-ray crystallography to a limiting resolution of 2.91 A

260 Here, we have used x-ray crystallography to analyze the location of Cy3 and

261 tibodies with epitopes defined by cryo-EM or x-ray crystallography to assess the role of epitope spat

262 Here the authors use time-lapse X-ray crystallography to capture the states of pol micro

263 use a combination of biochemical assays and X-ray crystallography to characterize A. thaliana PRORP2

264 tals to yield a high-resolution structure by X-ray crystallography to date.

265 with its substrate octane was determined by X-ray crystallography to define features of the active s

266 We used X-ray crystallography to describe the accurate binding m

267 ight into how this occurs, here we have used X-ray crystallography to describe the structures of pre-

268 XII binding sites and then utilized protein X-ray crystallography to determine the binding pose of p

269 or joint application of NMR spectroscopy and X-ray crystallography to determine the overall structure

270 and use a combination of enzyme kinetics and X-ray crystallography to generate a structure-kinetic re

271 ulses to protein crystals with time-resolved X-ray crystallography to observe conformational changes

272 characterized with infrared spectroscopy and X-ray crystallography to reveal their super high crystal

273 Nevertheless, the use of SAXS and X-ray crystallography together to inspect PAH structure

274 We used x-ray crystallography, together with site-directed mutag

275 saturation transfer difference (STD)-NMR and X-ray crystallography using oligosaccharides obtained by

276 s been studied in detail by a combination of X-ray crystallography, UV-vis and fluorescence spectrosc

277 ecule fluorescence transfer experiments, and X-ray crystallography, we define the specific structural

278 single-particle cryo-electron microscopy and X-ray crystallography, we determine an unexpected octame

279 Using x-ray crystallography, we determined the crystal structu

280 Using X-ray crystallography, we first revealed that Eribulin b

281 s by NMR spectroscopy, mass spectrometry and X-ray crystallography, we now report a unified picture t

282 Here, using X-ray crystallography, we present for the first time str

283 Using X-ray crystallography, we show that Cdt1 contains two wi

284 Using X-ray crystallography, we show that EVT-101, a GluN2B an

285 Here, using genetic analysis and X-ray crystallography, we show that MamO has a degenerat

286 Using time-resolved x-ray crystallography, we show that the phosphoryltransf

287 Using x-ray crystallography, we solved the structure of the hu

288 R spectroscopy, native mass-spectrometry and X-ray crystallography, we studied how bundle formation w

289 (1) H, (13)C, and (31)P NMR spectroscopy and X-ray crystallography, we suspect that this ATRA-active

290 BCATm, which were subsequently progressed to X-ray crystallography, where a number of exemplars showe

291 ethod for protein structure determination is X-ray crystallography which relies on the availability o

292 the sufficient production of the enzyme for X-ray crystallography, which reveals the structural arch

293 Complexes 1 and 2 were characterized by X-ray crystallography, which showed that the U-C bond le

294 ese we were able to confirm the structure by X-ray crystallography, while only one did not crystalliz

295 Thus, combining X-ray crystallography with carbohydrate molecular modeli

296 tial scales from atoms to cells by combining X-ray crystallography with electron cryotomography and s

297 Here, we pair x-ray crystallography with molecular modeling to identif

298 Here, we combined X-ray crystallography, X-ray scattering (SAXS), modeling

299 aracterized in the Ir(V) state, including by X-ray crystallography, XPS, and DFT calculations, all of

300 orating DNA shape information extracted from X-ray crystallography (XRC) data or Molecular Dynamics (