ライフサイエンスコーパス: Xenopus embryo

1 same Wnt target genes as beta-catenin in the Xenopus embryo ().

2 ent to induce ectopic Flk1 expression in the Xenopus embryo.

3 the correct establishment of the axes of the Xenopus embryo.

4 e expression in the animal hemisphere of the Xenopus embryo.

5 to the formation of the DMZ of the stage 10 Xenopus embryo.

6 of the nervous system for the 32-cell stage Xenopus embryo.

7 efited from the study of gastrulation in the Xenopus embryo.

8 rm as well as the complete elongation of the Xenopus embryo.

9 ion of gene regulatory networks in the early Xenopus embryo.

10 both endoderm and mesoderm formation by the Xenopus embryo.

11 e rundown and termination of swimming in the Xenopus embryo.

12 appropriate neural tube morphogenesis in the Xenopus embryo.

13 asynchronous and spatially restricted in the Xenopus embryo.

14 been identified as a factor dorsalizing the Xenopus embryo.

15 gh during the rapid cell cycles of the early Xenopus embryo.

16 e to modulation of Hedgehog signaling in the Xenopus embryo.

17 al ectoderm to their proper locations in the Xenopus embryo.

18 resence of an analogous network in the early Xenopus embryo.

19 MOC-1 (XSMOC-1) and explored its function in Xenopus embryos.

20 e kinases are important for Wnt signaling in Xenopus embryos.

21 when expressed as an independent protein in Xenopus embryos.

22 -catenin-induced secondary axis formation in Xenopus embryos.

23 xpression pattern to lambda-olt 2-1 in early Xenopus embryos.

24 s for the successful integration of DNA into Xenopus embryos.

25 , induction of endogenous gene expression in Xenopus embryos.

26 ve neural-restricted transgene expression in Xenopus embryos.

27 le in the early stages of eye development in Xenopus embryos.

28 gs", which are required for wound healing in Xenopus embryos.

29 of Sall1 to repress Gbx2 in cell culture and Xenopus embryos.

30 Drosophila and mammalian cells as well as in Xenopus embryos.

31 s sufficient to induce insulin expression in Xenopus embryos.

32 Hex target in embryonic stem (ES) cells and Xenopus embryos.

33 timing and intensity of Nodal signalling in Xenopus embryos.

34 movements, and eye and brain development in Xenopus embryos.

35 e co-expressed during midline development in Xenopus embryos.

36 velled and JNK is enriched in the nucleus of Xenopus embryos.

37 t, kermit 2/XGIPC has a distinct function in Xenopus embryos.

38 tes in the development of sensory neurons in Xenopus embryos.

39 response to hyperactivated FGF signaling in Xenopus embryos.

40 Smad2/3 in vitro, in mammalian cells and in Xenopus embryos.

41 ional signaling via the ERK pathway in early Xenopus embryos.

42 metric gene expression and of the viscera in Xenopus embryos.

43 dorsal axis is activated extracellularly in Xenopus embryos.

44 , and ciliated epidermal cells of developing Xenopus embryos.

45 cific reporter gene expression in transgenic Xenopus embryos.

46 expression during gastrulation in transgenic Xenopus embryos.

47 ralateral sides of the spinal cord of living Xenopus embryos.

48 l progenitor pool during axial elongation in Xenopus embryos.

49 ogenous BMP signaling activity in transgenic Xenopus embryos.

50 catenin-mediated secondary axis induction in Xenopus embryos.

51 nd severely expanded posterior structures in Xenopus embryos.

52 al crest is involved in heart development in Xenopus embryos.

53 terphase extract isolated from post-gastrula Xenopus embryos.

54 tor were ectopically expressed in developing Xenopus embryos.

55 ally enhanced neuronal induction activity in Xenopus embryos.

56 or (ARF) that binds to the Mix.2 promoter in Xenopus embryos.

57 tudied in insect and mammalian cells, and in Xenopus embryos.

58 vely inhibits nodal but not activin in early Xenopus embryos.

59 of the events of gastrulation in developing Xenopus embryos.

60 lls and characterize the vasculature of live Xenopus embryos.

61 d4, and transcription in mammalian cells and Xenopus embryos.

62 of neural crest induction by the mesoderm in Xenopus embryos.

63 signaling is blocked during gastrulation of Xenopus embryos.

64 ivate signaling and induce secondary axes in Xenopus embryos.

65 or blood and endothelial cells in developing Xenopus embryos.

66 that reported for a p2y receptor cloned from Xenopus embryos.

67 s rapid apoptotic cell death in gastrulating Xenopus embryos.

68 n transcription and induce secondary axis in Xenopus embryos.

69 iation during early myogenesis in vivo using Xenopus embryos.

70 or Notch signaling in mammalian cells and in Xenopus embryos.

71 terior axis of the neural tube in developing Xenopus embryos.

72 ergent extension in explants of gastrulating Xenopus embryos.

73 ding partner, WBP11, in early development of Xenopus embryos.

74 tory pathway by Ctx was not only observed in Xenopus embryos.

75 to recapitulate spindle scaling observed in Xenopus embryos.

76 on and block differentiation in both ESC and Xenopus embryos.

77 4l) has robust neuronal-inducing activity in Xenopus embryos.

78 h showed differential expression patterns in Xenopus embryos.

79 e and extent of injury caused to the skin of Xenopus embryos.

80 1 in morphogenesis during the development of Xenopus embryos.

81 was essential for pronephric development in Xenopus embryos.

82 eta-catenin activation in cultured cells and Xenopus embryos.

83 lent Noonan syndrome and JMML mutations into Xenopus embryos.

84 nction of Arg disrupted axial development in Xenopus embryos.

85 e Wnt11-like proteins in NC specification in Xenopus embryos.

86 and migrating cranial neural crest cells of Xenopus embryos.

87 s greatly synergized in the dorsalization of Xenopus embryos.

88 collective cell movement and ciliogenesis in Xenopus embryos.

89 ng the patterning of left-right asymmetry in Xenopus embryos.

90 these proteins were tested by expression in Xenopus embryos.

91 for proper tight junction function in early Xenopus embryos.

92 ts TGF-beta signaling in mammalian cells and Xenopus embryos.

93 stricted accumulation of the xCR1 protein in Xenopus embryos.

94 igrating cranial neural crest (CNC) cells in Xenopus embryos.

95 e in regulating cell and tissue movements in Xenopus embryos.

96 by overexpression of Kaiso in cell lines and Xenopus embryos.

97 feedback inhibitor in ventral regions of the Xenopus embryo; (2) CV2 complexes with Twisted gastrulat

98 In Xenopus embryos, a dorsal-ventral patterning gradient is

99 We performed several in vivo assays in Xenopus embryos, a functional model of canonical Wnt sig

100 amba et al. reveal, through their studies of Xenopus embryos, a novel mechanism for regulating fibron

101 In Xenopus embryos, Amer2 is expressed mainly in the dorsal

102 8b are expressed in pluripotent cells of the Xenopus embryo and are enriched in cells that respond to

103 - and FGF4-induced mesoderm formation in the Xenopus embryo and FGF-dependent angiogenesis in the chi

104 wn that Smicl is expressed maternally in the Xenopus embryo and is later required for transcription o

105 tension in two very different tissues in the Xenopus embryo and may reflect a general conservation of

106 Wnt signal transduction specificity in both Xenopus embryos and 293T cells.

107 tl4 is expressed in the Spemann organizer of Xenopus embryos and acts as a Wnt antagonist to promote

108 y, we improved immunolocalization methods in Xenopus embryos and analyzed the distribution of endogen

109 In Xenopus embryos and animal caps as well as DLD-1 cells,

110 he embryonic axis upon ventral injections in Xenopus embryos and appears to regulate cell proliferati

111 we examine the function of Oct4 homologs in Xenopus embryos and compare this to the role of Oct4 in

112 ntisense oligos causes hyperdorsalization of Xenopus embryos and ectopic expression of the Wnt/beta-c

113 n of mRNA coding for GFP-tagged Shh in early Xenopus embryos and find that Sulf1 restricts ligand dif

114 In murine embryonic stem cells, Xenopus embryos and human urothelial cells, cyclin E is

115 ecifically blocks BMP-dependent signaling in Xenopus embryos and in a mammalian model of bone formati

116 f expression profiling of Oct4/POUV-depleted Xenopus embryos and in silico analysis of existing mamma

117 ic demethylase 4d removes H3K9me3 marks from Xenopus embryos and inhibits the repression of lambda-ol

118 oreover, KLF4 inhibits the axis formation of Xenopus embryos and inhibits xenograft tumor growth in a

119 here that SOST antagonizes Wnt signaling in Xenopus embryos and mammalian cells by binding to the ex

120 imulate TCF3 phosphorylation in gastrulating Xenopus embryos and mammalian cells.

121 that altering lamin levels in vivo, both in Xenopus embryos and mammalian tissue culture cells, also

122 nd gain- and loss-of-function experiments in Xenopus embryos and mouse P19 cells demonstrated that Ge

123 Cleaving Xenopus embryos and parthenogenetically activated eggs t

124 LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal

125 esses required for normal eye development in Xenopus embryos and specifically requires an Src homolog

126 ability of GSK-3 to block eye development in Xenopus embryos and suggest that GSK-3 regulates eye dev

127 55 reduced XWnt8-induced axis duplication in Xenopus embryos and tamoxifen-induced polyposis formatio

128 of GATA4, 5 and 6 in presumptive endoderm in Xenopus embryos and their induction of endodermal marker

129 n cultured and explanted neurons and in live Xenopus embryos and zebrafish larvae.

130 d marks the extreme anterior ectoderm of the Xenopus embryo, and is determined through the overlap of

131 more, both Shn and hShn1 activate the BRE in Xenopus embryos, and both repress brk and rescue embryon

132 uces ectopic expression of vascular genes in Xenopus embryos, and that combinatorial knockdown of the

133 orrect pattern of cortical actin assembly in Xenopus embryos, and that lysophosphatidic acid (LPA) an

134 eins regulated similar genes in ES cells and Xenopus embryos, and that PouV proteins capable of suppo

135 th the dorsal and ventral sides of the early Xenopus embryo are involved in creating the body plan.

136 olved in organizer and axis formation in the Xenopus embryo are now characterized, the challenge is t

137 Early Xenopus embryos are large, and during the egg to gastrul

138 oggin1 is able to induce a secondary axis in Xenopus embryos argues that N. vectensis could possess a

139 w here, using the developing ectoderm of the Xenopus embryo as a model, that F-actin assembly is a pr

140 Here, we present the ciliated epidermis of Xenopus embryos as a facile model system for in vivo mol

141 pression of a target gene, engrailed-2, in a Xenopus embryo assay.

142 e expressed in the vegetal hemisphere of the Xenopus embryo at the early gastrula stage.

143 ltraviolet cross-linking assays performed on Xenopus embryos at different stages of neural developmen

144 In contrast, cell division failure in early Xenopus embryo blastomeres has been attributed to a role

145 but not embryos, and injection of dmos into Xenopus embryos blocks mitosis and elevates active MAPK

146 In Xenopus embryos, body patterning and cell specification

147 RNA is symmetrically expressed in the 1-cell Xenopus embryo but becomes localized during the first tw

148 umulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed e

149 Cv-2 can weakly antagonise BMP4 activity in Xenopus embryos, but that in other in vitro assays Cv-2

150 Inhibition of MASTR function in the Xenopus embryo by using dominant-negative constructions

151 We have studied this process in Xenopus embryos by analyzing the expression of the bHLH

152 We addressed these issues in Xenopus embryos by manipulating the timing and location

153 ray screen for genes that are upregulated in Xenopus embryos by the transcriptional activator protein

154 tudy, geminin was eliminated from developing Xenopus embryos by using antisense techniques.

155 jection of Plx1NA but not Plx1NAWF mRNA into Xenopus embryos caused cleavage arrest and formation of

156 Similarly, depletion of CCDC11 in Xenopus embryos causes defective assembly and motility o

157 Here, we have analyzed when and how Xenopus embryo cells perceive and interpret a BMP signal

158 When injected into Xenopus embryos, CHL2 RNA induced a secondary axis.

159 we show that addition of recombinant CDC6 to Xenopus embryo cycling extract delays the M-phase entry

160 and dorsal injection of active Jnk mRNA into Xenopus embryos decreases the dorsal marker gene express

161 Xenopus embryos depleted of Lim1 lack anterior head stru

162 In Xenopus embryos, depletion of IQGAP1 reduced Wnt-induced

163 the anterior component of embryonic blood in Xenopus embryos derive from populations of progenitors t

164 lication and leads to mild ventralization in Xenopus embryo development.

165 In Xenopus embryos, disruption of PDGFRalpha signaling caus

166 y morpholino injection) or overexpression in Xenopus embryos disrupts convergent extension, a hallmar

167 ssion of the LIS1 binding domain of mNudE in Xenopus embryos disrupts the architecture and lamination

168 In the Xenopus embryo, DRAGON both reduces the threshold of the

169 Here, we show that wounding of one cell in Xenopus embryos elicits Rho GTPase activation around the

170 quadruple knockdown of ADMP and BMP2/4/7 in Xenopus embryos eliminates self-regulation, causing ubiq

171 In Xenopus embryos, ephrinB1 plays a role in retinal progen

172 ressing a non-Geminin-binding Cdt1 mutant in Xenopus embryos exactly reproduces the phenotype of gemi

173 ween the cytoplasm and nucleus both in early Xenopus embryo explants and in living zebrafish embryos,

174 The early Xenopus embryo expresses three maternally inherited Tcf/

175 is similar to phenotypic effects observed in Xenopus embryos expressing activated FGFR1.

176 e bundles from the spinal cord of transgenic Xenopus embryos expressing green fluorescent protein in

177 ity of Sall1 to repress Gbx2 was impaired in Xenopus embryos expressing mutant forms of Sall1 that ar

178 and its ability to cause cardiac defects in Xenopus; embryos expressing Noonan SHP-2 mutations exhib

179 Experiments in Xenopus embryo extracts reveal that changes in cellular

180 In the absence of CASZ1, Xenopus embryos fail to develop a branched and lumenized

181 ally, we analyze mRNA expression patterns in Xenopus embryos for each TACC protein and observe neural

182 nscription factor VegT, is required in early Xenopus embryos for the formation of both the mesoderm a

183 In Xenopus embryos, for example, transcription is believed

184 Xenopus embryos form two distinct kinds of muscle cells

185 in the developing pancreas of both mouse and Xenopus embryos from early specification onward showing

186 ive domain and other related constructs into Xenopus embryos gave identical phenotypes.

187 In Xenopus embryos, Gdf3 misexpression results in secondary

188 The Xenopus embryo has provided key insights into fate speci

189 neurons in the swimming rhythm generator of Xenopus embryos has been studied using pharmacological b

190 ng dissociated nerve and muscle derived from Xenopus embryos have indicated that the properties of tr

191 BMP activity is upregulated or inhibited in Xenopus embryos hematopoietic precursors are specified p

192 In Xenopus embryos, Hes6 is co-expressed with MyoD in early

193 Similarly, depletion of miR-427 in Xenopus embryos hinders the organizer formation and lead

194 and to visualize long-range signaling in the Xenopus embryo in real time.

195 we have studied neuronal development in the Xenopus embryo in the absence of n1-src, while preservin

196 PCD takes place within the neuroectoderm of Xenopus embryos in a reproducible stereotypic pattern, s

197 ansiently inhibits neural crest migration in Xenopus embryos in a Snail1-dependent manner, indicating

198 an important role for ARF1 and ARF2 in early Xenopus embryos in controlling the convergent extension

199 olarity signaling regulates morphogenesis in Xenopus embryos in part through the assembly of the fibr

200 the regulation of different TCF proteins in Xenopus embryos in vivo.

201 a transcriptomic analysis on gastrula stage Xenopus embryos in which MyoD has been knocked-down.

202 cate that long-range signalling in the early Xenopus embryo, in contrast to some other developmental

203 Cardiogenesis assays in Xenopus embryos indicate that CycD2 enhances the cardiog

204 signaling in cultured mammalian cells and in Xenopus embryos, indicating evolutionary conservation of

205 Injection of CHL RNA into Xenopus embryos induced a secondary axis.

206 Microinjection of synthetic xBtg-x mRNA into Xenopus embryos induced axis duplication and completely

207 Expression of LRRFIP2 in Xenopus embryos induced double axis formation and Wnt ta

208 pe but not mutant NEUROG3 messenger RNA into xenopus embryos induced NEUROD1 expression.

209 Finally, CKIepsilon(MM2) expression in Xenopus embryos induces both axis duplication and additi

210 In ectodermal explants from Xenopus embryos, inhibition of BMP signaling is sufficie

211 Xenopus embryos injected with Mat89Bb morpholinos arrest

212 subset of cleavage stage blastomeres in the Xenopus embryo is competent to contribute cells to the r

213 The ectoderm of the Xenopus embryo is permeated by a network of channels tha

214 o and that the phenotype of Geminin-depleted Xenopus embryos is caused by abnormal Cdt1 regulation.

215 Dorsal axis formation in Xenopus embryos is dependent upon asymmetrical localizat

216 we show that early notochord development in Xenopus embryos is regulated by apoptosis.

217 In Xenopus embryos, it was found that Wnts induce epidermis

218 In Xenopus embryos, knockdown of Chd7 or overexpression of

219 In Xenopus embryos, knockdown of Rusc1 or overexpression of

220 While Xenopus embryos lacking endoderm contain aggregates of a

221 teral and ventral mesoderm in gastrula stage Xenopus embryos, leading us to investigate whether it ha

222 pression of a dominant-negative AP-2alpha in Xenopus embryos led to reduced Fmr1 levels.

223 of sustained maternal JNK activity in early Xenopus embryos may provide a timing mechanism for contr

224 When Foxn4 activity is inhibited in Xenopus embryos, MCCs show transient ciliogenesis defect

225 A recent study of myosin-X function in early Xenopus embryo mitosis now reports that this unconventio

226 Furthermore, when expressed in Xenopus embryos, MTG family members inhibited axis forma

227 in the axonal shaft by expressing GFP-EB1 in Xenopus embryo neurons in culture.

228 In Xenopus embryos, Ngd is found in both neural tube and ne

229 In antiSOX3c-injected Xenopus embryos, normal animal-vegetal patterning of mes

230 ating that long-range signaling in the early Xenopus embryo occurs by diffusion rather than by these

231 Knockdown of Balpha in Xenopus embryos or mammalian tissue culture cells suppre

232 In Xenopus embryos, overexpression of sortilin leads to a d

233 In Xenopus embryos, overexpression of the protein causes fa

234 In Xenopus embryos, PACSIN2 is ubiquitously expressed, sugg

235 ltaNp63 by morpholino injection in the early Xenopus embryo potentiates mesoderm formation whereas ec

236 In cycling extracts from Xenopus embryos, progression into M phase requires the p

237 In the Xenopus embryo, Ptk7 functionally interacts with Ror2 to

238 xpression, we demonstrate that in developing Xenopus embryos, RASSF10 shows a very striking pattern i

239 ble to exert long-range effects in the early Xenopus embryo, reinforcing the view that it functions a

240 ulatory wild-type beta-subunit XKCNE1 in the Xenopus embryo resulted in a striking alteration of the

241 isense morpholino mediated PouV knockdown in Xenopus embryos resulted in severe posterior truncations

242 Inhibition of KLF2 function in the Xenopus embryo results in a dramatic reduction in Flk1 t

243 Ablation of the premigratory neural crest in Xenopus embryos results in abnormal formation of the hea

244 Microinjection of Hes6 RNA in vivo in Xenopus embryos results in an expansion of the myotome,

245 Furthermore, Shox2 overexpression in Xenopus embryos results in extensive repression of Nkx2-

246 Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head st

247 mal cell fate, whereas knockdown of USP12 in Xenopus embryos results in reduction of a subset of meso

248 Studies in Xenopus embryos revealed that Wise either enhances or in

249 Recent work in Xenopus embryos reveals an unexpected developmental role

250 In Xenopus embryos, Ripk4 synergized with coexpressed Xwnt8

251 In Xenopus embryos, SCP2/Os4 and human SCP1, 2, and 3 cause

252 In Xenopus embryos, Smad4 shows stereotyped, uncorrelated b

253 he properties of the ecto-5'-nucleotidase in Xenopus embryo spinal cord.

254 operties and targets of p2y purinoceptors in Xenopus embryo spinal neurons.

255 Xenopus embryos that had endoderm physically removed at

256 hat BMP-3 is a dorso-anteriorizing factor in Xenopus embryos that interferes with both activin and BM

257 In Xenopus embryos that lack Shroom2 function, we observed

258 We demonstrate, using Xenopus embryos, that CTGF also regulates signalling thr

259 In the early Xenopus embryo, the dorsal axis is specified by a Wnt si

260 We conclude that in Xenopus embryos, the BMP pathway is a major physiologica

261 In Xenopus embryos, the cell cycle is driven by an autonomo

262 In Xenopus embryos, the dorso-ventral and antero-posterior

263 In Xenopus embryos, the expression of Pitx2 gene in the lef

264 g dorso-ventral patterning of Drosophila and Xenopus embryos, the formation of the fly wing, and mous

265 Moreover, when injected into Xenopus embryos, the nanocrystal-micelles were stable, n

266 In early Xenopus embryos, the prototypical XFast-1/Smad2/Smad4 co

267 naling is inhibited by both Dkk1 and Dkk2 in Xenopus embryos, the same pathway is activated upon inte

268 In Xenopus embryos, the three TBP family factors are all es

269 mbryos and in the organizer of Lim1-depleted Xenopus embryos; the latter can be rescued to a consider

270 When applied to Xenopus embryos, this system enables blue light-dependen

271 ) regulate convergent extension movements in Xenopus embryos through the noncanonical Wnt/planar cell

272 /BMP complexes; (6) CV2 depletion causes the Xenopus embryo to become hypersensitive to the anti-BMP

273 Exposure of Xenopus embryos to AChE-inhibiting chemicals results in

274 We developed an assay in Xenopus embryos to analyze regulatory sequences of the z

275 Here we use Xenopus embryos to demonstrate in vivo that Xtsulf1 play

276 hase cyclins and cyclin-dependent kinases in Xenopus embryos to determine their effect on early devel

277 ient for perturbing ciliogenesis, sensitized Xenopus embryos to Hh signaling, leading to phenotypes t

278 Inhibition of myocardin activity in Xenopus embryos using morpholino knockdown methods resul

279 A T-box transcription factor identified in Xenopus embryos, VegT, appears to function near the top

280 In Xenopus embryos, ventral injection of BMPER mRNA results

281 lity of CKI to induce secondary body axes in Xenopus embryos was reduced by the B56 regulatory subuni

282 ld regulate dorsal-ventral patterning in the Xenopus embryo, we isolated the Xenopus homologue of the

283 Using gain-of-function approaches in the Xenopus embryo, we show that myocardin is sufficient to

284 l-defined expression pattern in the brain of Xenopus embryos, we analyzed the methylation status of t

285 isense morpholino based knockdown studies in Xenopus embryos, we demonstrate that endogenous XtSulf1

286 By overexpression assays in Xenopus embryos, we found that both RA and FGF receptor

287 In Xenopus embryos, we have shown that ATP, and its antagon

288 t to produce gross phenotypic alterations in Xenopus embryos when overexpressed by mRNA injection.

289 has not demonstrated biological activity in Xenopus embryos when overexpressed by mRNA injection.

290 We took advantage of the Xenopus embryo, which exhibits remarkable capacities to

291 to drive segmental expression in transgenic Xenopus embryos while those from the Xenopus laevis mesp

292 ectopic axes and inhibits head formation in Xenopus embryos, while ectopic HNF3beta inhibits mesoder

293 glutamatergic neurons for the 32-cell stage Xenopus embryo with the goal of determining whether earl

294 the onset of zygotic gene expression in the Xenopus embryo with the translocation of Smicl from cyto

295 Inhibition of endogenous Dlx activity in Xenopus embryos with an EnR-Dlx homeodomain fusion prote

296 Similarly, Xenopus embryos with endogenous TFII-I expression downre

297 show that in gastrula and early-somite stage Xenopus embryos, Wnt/beta-catenin activity must be repre

298 Here we report that in mammalian cells and Xenopus embryos, Wnt/Fz signaling coactivates Rho and Ra

299 In the Xenopus embryo, XProfilin2 is temporally expressed throu

300 Suppressing its expression in Xenopus embryos yields terminally specified neurons with