ライフサイエンスコーパス: Y-linked gene

1 ively recent, loss of at least one conserved Y-linked gene.

2 Y-linked gene, or to a deletion of a single Y-linked gene.

3 an adaptation to the decay of a homologous, Y-linked gene.

4 attern of X-linked genes < autosomal genes < Y-linked genes.

5 sition must be the main source of Drosophila Y-linked genes.

6 this species missed unexpressed, degenerate Y-linked genes.

7 e of an intragenomic conflict between X- and Y-linked genes.

8 during spermatogenesis in the mouse of three Y-linked genes, 11 X-linked genes and 22 autosomal genes

9 f the early stages of the establishment of a Y-linked gene and demonstrates how the Drosophila Y has

10 somes has led to loss and differentiation of Y-linked genes and haplo-insufficiency for X-linked gene

11 Thus, if they invade Y-linked genes and selection against their insertion is

12 e latifolia, this largely involved losses of Y-linked genes, and not suppressed expression of Y-linke

13 Most Y-linked genes are expressed during spermatogenesis, and

14 sex-linked genes, and it is unclear whether Y-linked genes are losing full function.

15 About one-third of all neo-Y-linked genes are nonfunctional, containing either prem

16 This revealed that 45% of Y-linked genes are not expressed, and 23% are interrupte

17 runs counter to this hypothesis, most unique Y-linked genes are not situated in palindromes and have

18 ed the sex, or XY, body, within which X- and Y-linked genes are transcriptionally repressed.

19 e assessed mRNA expression in brain of eight Y-linked genes as well as their X-linked homologues, at

20 g of genes precede and expedite the decay of Y-linked genes at the amino acid level?

21 from the rest of the genome, with only seven Y-linked genes being gained over the past 63 million yea

22 herians, which also possessed a very similar Y-linked gene; both characteristics were retained in mos

23 This is the first study demonstrating that Y-linked genes can exclusively impact Valpha14i NK T dev

24 Because they lack recombination, Y-linked genes cannot be mapped genetically, leaving phy

25 Despite almost no overlap in Y-linked gene content in different species with independ

26 lain why plants retain hundreds of expressed Y-linked genes despite millions of years of Y chromosome

27 The coupling of Y-linked gene duplication and gene conversion between pa

28 ted by the observation that, among primates, Y-linked genes evolved more rapidly than homologous X-li

29 t manner, consistent with previously defined Y-linked gene functions.

30 n mammalian lineages where the corresponding Y-linked gene has been lost.

31 Most of the Y-linked genes have autosomal paralogs, so autosome-to-Y

32 ndently formed sex-chromosomes, we find that Y-linked genes have evolved convergent gene functions as

33 gence in both systems, we find evidence that Y-linked genes have started to undergo gene loss, causin

34 een in mammalian sex chromosomes, where most Y-linked genes have X-linked homologs, the Drosophila X

35 cific nucleotide variation associated with a Y-linked gene in five members of the Drosophila melanoga

36 htrog use a subtraction pipeline to identify Y-linked genes in 22 Diptera species, revealing patterns

37 uncover rapid and extensive degeneration of Y-linked genes in a plant species, Silene latifolia, tha

38 cally comparing the DNA sequences of unique, Y-linked genes in chimpanzee and human, which diverged a

39 ate that the rate of genetic degeneration of Y-linked genes in S. latifolia is as fast as in animals,

40 lar to what has been found for several other Y-linked genes in S. latifolia, and consistent with the

41 transcriptional inactivation of degenerating Y linked genes is an accidental by-product of mutation a

42 e longer-term estimate, the fate of most new Y-linked genes is defined by rapid degeneration and pseu

43 more, the rate of synonymous substitution in Y-linked genes is not significantly different from that

44 Loss of functional Y-linked genes is partly compensated for by gene-specifi

45 ty on the Y chromosome, and complete loss of Y-linked genes is possible if autosomal genes take over

46 dies have demonstrated that the diversity of Y-linked genes is substantially lower than that of their

47 Thus, Y-linked gene loss emerges as an additional driver of ge

48 Rescue of Y-linked gene loss through transposition to autosomes ha

49 miranda, which show the expected pattern of Y-linked genes < X-linked genes < autosomal genes; papay

50 polymorphisms (SNPs), we identify three new Y-linked genes, one being duplicated on the Y chromosome

51 ure has been traced to a point mutation in a Y-linked gene, or to a deletion of a single Y-linked gen

52 is asynapsis triggers inactivation of X- and Y-linked genes, or meiotic sex chromosome inactivation (

53 nd divergence in a recently described X- and Y-linked gene pair (SLX-1 and SLY-1) of the plant Silene

54 Y-linked genes show faster accumulation of amino-acid re

55 ed dogma of mammalian sex determination, the Y-linked gene SRY initiates male development by inducing

56 mmalian sex determination, expression of the Y-linked gene Sry shifts the bipotential gonad toward a

57 For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli ce

58 mammalian gonad requires the expression of a Y-linked gene, Sry, during a brief window of time to ens

59 geted gene disruptions and insertions in two Y-linked genes--Sry and Uty.

60 Our results show that a Y-linked gene that does not differ among the tested stra

61 stages, we identified a small repertoire of Y-linked genes that lack X gametologs and are not Y-link

62 Amongst Y-linked genes that were downregulated due to LOY, KDM5D

63 Our results show that Y-linked gene traffic, and the molecular mechanisms gove

64 method provides a powerful means to identify Y-linked gene transfers and will help illuminate the evo

65 Despite all Y-linked gene transfers being evolutionarily recent (<1

66 In this species, many Y-linked genes were rescued by transposition to new geno

67 ound limited variation in the copy number of Y-linked genes, which raises the possibility of selectiv

68 Previous work showed that Y-linked genes Zfy1 and Zfy2 act as 'executioners' for t