1 munological synapse and its association with ZAP-70 kinase.

2 ed with complete failure to activate Fyn and ZAP-70 kinases.

3 ->A correlated with up-regulation of Fyn and ZAP-70 kinase activities.

4 s to propagate TCR signals in the absence of ZAP-70 kinase activity despite tyrosine phosphorylation

5 he coexpression of Lck and the initiation of ZAP-70 kinase activity.

6  phosphorylation of ZAP-70 from induction of ZAP-70 kinase activity.

7 R) phospho-zeta species, and lack associated ZAP-70 kinase activity.

8 SHP-1 phosphatase activity and a decrease in ZAP-70 kinase activity.

9 aled phosphorylation of the DAP12-associated ZAP-70 kinase and IFN-gamma release of CAR-engineered ce

10 allosteric inhibitors of the Akt-1 (PKB) and Zap-70 kinases, and previously undisclosed antagonists o

11 horylation of the TCR and recruitment of the ZAP-70 kinase, but the pattern of TCR phosphorylation wa

12        The crystal structure shows that this ZAP-70 kinase domain is in an active-like conformation d

13 hin the highly conserved DLAARN motif in the ZAP-70 kinase domain.

14 hantavirus ITAM coprecipitated Lyn, Syk, and ZAP-70 kinases from T or B cells, while mutagenesis of t

15 t in part, by PI3K and is independent of Syk/Zap-70 kinases; however, the exact mechanism by which DA

16 del in which the tyrosine kinase activity of ZAP-70 kinase is critical for regulation of beta(1) inte

17 ization of Cdc42-GTP, and functional Lck and Zap-70 kinases were required.

18 well as the association of nonphosphorylated ZAP-70 kinase with the receptor.