ライフサイエンスコーパス: ZIP kinase

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1 ic genes (e.g., death-associated kinase-3 or ZIP kinase).

2 obably induced by the Ca2+-independent MLCK, ZIP kinase.

3 s whereby ROCK1 phosphorylates and regulates ZIP kinase.

4 -life of p21(WAF1[T145A]) is not effected by ZIP kinase.

5 te alter its ability to be phosphorylated by ZIP kinase.

6 diminish ZIP kinase content, suggesting that ZIP kinase associates with the filamentous component in

7 nase responsible for the phosphorylation was ZIP kinase because (a) the kinase in the cell extracts p

8 (T/S) consensus motif, alternate contacts in ZIP kinase binding are implicated, since amino acid resi

9 ed smooth muscle zipper-interacting protein (ZIP) kinase cDNA.

10 n subjected to phage-peptide display and one ZIP kinase consensus peptide motif was identified in p21

11 Thus, although ZIP kinase consensus sites were then defined as containi

12 Triton X-100 skinning did not diminish ZIP kinase content, suggesting that ZIP kinase associate

13 in II kinase activity; and (c) disruption of ZIP kinase expression by RNA interference diminished myo

14 Native ZIP kinase fractions were then subjected to phage-peptid

15 with similar potency; (b) immunodepletion of ZIP kinase from the cell extracts markedly diminished it

16 ear member of the DAPK family named DAPK3 or ZIP kinase had direct links to the p53 pathway.

17 of myosin increased significantly following ZIP kinase-induced phosphorylation.

18 Introduction of ZIP kinase into Triton X-100-permeabilized rabbit mesent

19 ified by Akt kinase, thus demonstrating that ZIP kinase is a bona fide MDM2-binding protein.

20 These results suggest that ZIP kinase is critical for myosin phosphorylation and ne

21 ZIP kinase is present in various smooth muscle tissues i

22 These results suggest that ZIP kinase is responsible for Ca(2+) independent myosin

23 ZIP kinase phosphorylated myosin light chain at both Ser

24 Smooth muscle ZIP kinase phosphorylated smooth muscle myosin as well a

25 ZIP kinase phosphorylates p21(WAF1) at Thr145 and alanin

26 e, we found that zipper-interacting protein (ZIP) kinase plays a predominant role in myosin II phosph

27 was identical to the sensitivity of isolated ZIP kinase to these inhibitors.

28 ZIP kinase was cloned, purified, and the enzyme was able

29 ZIP kinase (ZIPK) is a proapoptotic protein kinase with

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